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Genome-wide analysis of differential transcriptional and epigenetic variability across human immune cell types
Simone Ecker, Lu Chen, Vera Pancaldi, Frederik O Bagger, José M Fernández, Enrique Carrillo de Santa Pau, David Juan, Alice L Mann, Stephen Watt, Francesco P Casale, Nikos Sidiropoulos, Nicolas Rapin, Angelika Merkel, Hendrik G Stunnenberg, Oliver Stegle, Mattia Frontini, Kate Downes, Tomi Pastinen, Taco W Kuijpers, Daniel Rico, Alfonso Valencia, Stephan Beck, Nicole Soranzo, Dirk S Paul
Jan 27, 2017
Abstract
Background
A healthy immune system requires immune cells that adapt rapidly to environmental challenges. This phenotypic plasticity can be mediated by transcriptional and...
Modernity, gender and the spectre of coloniality in the "Moroccan Texts" of Carmen de Burgos and Aurora Bertrana
B Epps
Jan 10, 2017
This article examines two works by Carmen de Burgos and Aurora Bertrana situated in Morocco—En la guerra, from 1909, and El Marroc sensual i fanatic from 1936—in the light of three interrelated questions: gender, nationality and...
Desgarraduras del cuerpo y degolladuras de la voz
B Epps
Aug 24, 2017
El mismo mar de todos los veranos de Esther Tusquets narra la tormentosa relación erótica y emocional de una mujer de la alta burguesía catalana, casada y desencantada, que ejerce de profesora de literatura, con una joven...
Pictures with Santa, Kwanzaa Celebration and More Kick Off Winthrop's Holiday Season
Winthrop University
Jan 01, 0001
The holiday's first event, Pictures with Santa, will be at 11 a.m. for faculty, staff and students on Nov. 21 in the DiGiorgio Campus Center lobby.
Published by: Winthrop University
Los Matices Varios del Feminismo en las Comunidades Indígenas de América Latina: Yorkín, Costa Rica y Santa Anita, Guatemala
Roseangela G Hartford
Jan 01, 0001
This project investigates gender constructs and the complex assigned gender roles in settings of female indigenous leadership in Latin America. It examines two distinct indigenous communities, including the BriBri society in...
indigenous peoples Guatemala feminism masculine domination Femininity Costa Rica leadership Arts and Humanities Feminist, Gender, and Sexuality Studies Latin American Studies Leadership Studies Spanish and Portuguese Language and Literature
Published by: Ursinus College
Confinement in nonlocal interaction equations
We investigate some dynamical properties of nonlocal interaction equations. We consider sets of particles interacting pairwise via a potential W, as well as continuum descriptions of such systems. The typical potentials we...
Confinement in nonlocal interaction equations
We investigate some dynamical properties of nonlocal interaction equations. We consider sets of particles interacting pairwise via a potential W, as well as continuum descriptions of such systems. The typical potentials we...
De la philosophie de la religion dans l’oeuvre de Landgrebe
Sylvain Camilleri
Apr 22, 2021
Nombreux sont les premiers disciples de Husserl à s’être intéressés de prèsà la religion. Landgrebe ne fait pas exception à la règle, même si j’entendsmontrer qu’il constitue plutôt un cas à part. Pourquoi donc ? Parce que...
Published by: Memorial University of Newfoundland
De la philosophie de la religion dans l’oeuvre de Landgrebe
Sylvain Camilleri
Apr 22, 2021
Nombreux sont les premiers disciples de Husserl à s’être intéressés de prèsà la religion. Landgrebe ne fait pas exception à la règle, même si j’entendsmontrer qu’il constitue plutôt un cas à part. Pourquoi donc ? Parce que...
Published by: Memorial University of Newfoundland
Intolerancia en Tiempos de Crisis: Hacia una Literatura Transgresora en El sitio de los sitios de Juan Goytisolo
Oscar Ivan Useche
Jan 01, 0001
Este artículo propone entender la novela de Goytisolo como una respuesta cultural a la crisis de los modelos de racionalidad occidental. Se estudian las dinámicas de descomposición social de la globalización y la aparición...
Juan Goytisolo globalization Sarajevo historical memory memoria historica globalizacion State of Siege fiction Modern Literature Spanish and Portuguese Language and Literature
Published by: Ursinus College
Digital Humanities
Enrique Wulff
Jul 01, 2024
The National Library of Spain (NLS, Biblioteca Nacional de España [BNE]) for the target audience of digital humanities (DH), within the last two decades, has taken up major challenges to be into line with other main national...
Global Information Technology Computer Science and Information Technology Global Information Technology Physical Sciences and Engineering Business and Management
Published by: IGI Global Scientific Publishing
Augmented Hill-Climb increases reinforcement learning efficiency for language-based de novo molecule generation.
A plethora of AI-based techniques now exists to conduct de novo molecule generation that can devise molecules conditioned towards a particular endpoint in the context of drug design. One popular approach is using reinforcement...
Genome-wide analysis of differential transcriptional and epigenetic variability across human immune cell types
S Ecker, L Chen, V Pancaldi, FO Bagger, JM Fernández, E Carrillo de Santa Pau, D Juan, AL Mann, S Watt, FP Casale, N Sidiropoulos, N Rapin, A Merkel, BLUEPRINT Consortium, HG Stunnenberg, O Stegle, M Frontini, K Downes, T Pastinen, TW Kuijpers, D Rico, A Valencia, S Beck, N Soranzo, DS Paul
Mar 23, 2017
Determinantes de la movilidad ocupacional segmentada de los inmigrantes no comunitarios en España
La literatura sobre la integración económica de los inmigrantes ha destacado la existencia de un patrón de movilidad en forma de «U». En este artículo discutimos esta argumentación partiendo de las teorías de la segmentación del...
Economic Integration of Immigrants International Migration Labor Market Segmentation Segmented Occupational Mobility Spain Anthropology Social and Cultural Anthropology Sociology
Published by: Winthrop University
Le Diable dans la bibliothèque
Dans Thinking with Demons (1997), Stuart Clark a montré que la démonologie, cette composante essentielle de la pensée de la première modernité, n’était pas une affaire de spécialistes: ‘penser avec le diable’ était une activité...
Christian de Duve, 1963
The Rockefeller University
Jan 01, 0001
Christian de Duve. The separation and characterization of subcellular particles.
Lecture delivered November 21, 1963
Posted with permission
Published by: Academic Press
Dynamics of Transcription Regulation in Human Bone Marrow Myeloid Differentiation to Mature Blood Neutrophils.
Luigi Grassi, Farzin Pourfarzad, Sebastian Ullrich, Angelika Merkel, Felipe Were, Enrique Carrillo-de-Santa-Pau, Guoqiang Yi, Ida H Hiemstra, Anton TJ Tool, Erik Mul, Juliane Perner, Eva Janssen-Megens, Kim Berentsen, Hinri Kerstens, Ehsan Habibi, Marta Gut, Marie Laure Yaspo, Matthias Linser, Ernesto Lowy, Avik Datta, Laura Clarke, Paul Flicek, Martin Vingron, Dirk Roos, Timo K van den Berg, Simon Heath, Daniel Rico, Mattia Frontini, Myrto Kostadima, Ivo Gut, Alfonso Valencia, Willem H Ouwehand, Hendrik G Stunnenberg, Joost HA Martens, Taco W Kuijpers
Nov 22, 2018
Neutrophils are short-lived blood cells that play a critical role in host defense against infections. To better comprehend neutrophil functions and their regulation, we provide a complete epigenetic overview, assessing important...
Augmented Hill-Climb increases reinforcement learning efficiency for language-based de novo molecule generation.
A plethora of AI-based techniques now exists to conduct de novo molecule generation that can devise molecules conditioned towards a particular endpoint in the context of drug design. One popular approach is using reinforcement...
The management of acute knee dislocations
PURPOSE: Great variety and controversies surround the management strategies of acute multiligament knee injuries (aMKLIs) and no established guidelines exist for resource-limited practices. The aim of this study was to compare...
De novo design of potent and selective mimics of IL-2 and IL-15.
Daniel-Adriano Silva, Shawn Yu, Umut Y Ulge, Jamie B Spangler, Kevin M Jude, Carlos Labão-Almeida, Lestat R Ali, Alfredo Quijano-Rubio, Mikel Ruterbusch, Isabel Leung, Tamara Biary, Stephanie J Crowley, Enrique Marcos, Carl D Walkey, Brian D Weitzner, Fátima Pardo-Avila, Javier Castellanos, Lauren Carter, Lance Stewart, Stanley R Riddell, Marion Pepper, Gonçalo JL Bernardes, Michael Dougan, K Christopher Garcia, David Baker
Jan 29, 2019
We describe a de novo computational approach for designing proteins that recapitulate the binding sites of natural cytokines, but are otherwise unrelated in topology or amino acid sequence. We use this strategy to design mimics...
Amino Acid Sequence Animals Binding Sites Colonic Neoplasms Computer Simulation Crystallography X-Ray Disease Models Animal Drug Design Humans Interleukin-15 Interleukin-2 Interleukin-2 Receptor alpha Subunit Melanoma Mice Models Molecular Molecular Mimicry Protein Stability Receptors Interleukin-2 Signal Transduction
Geographies of conservation I
WM ADAMS
Apr 22, 2016
© The Author(s) 2016. Extinction has long been a central concern in biodiversity conservation. Today, de-extinction offers interesting possibilities of restoring charismatic species and ecosystem function, but also risks and...
De-globalisation and decoupling
P Williamson
Feb 19, 2021
It has become fashionable to argue that the post-coronavirus world will see an acceleration in de-globalisation and decoupling and that companies will substantively re-localise their supply chains (Javorcik, 2020; McKinsey...
The tour de France
From its initial inception in 1903 as a race premised on a publicity stunt to sell newspapers, the Tour de France had grown and evolved over time to become one of the most difficult and heralded sporting events in the world....
The tour de France
From its initial inception in 1903 as a race premised on a publicity stunt to sell newspapers, the Tour de France had grown and evolved over time to become one of the most difficult and heralded sporting events in the world....
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