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Results: 96
Pros and cons of different therapeutic antibody formats for recombinant antivenom development.
Andreas H Laustsen, José María Gutiérrez, Cecilie Knudsen, Kristoffer H Johansen, Erick Bermúdez-Méndez, Felipe A Cerni, Jonas A Jürgensen, Line Ledsgaard, Andrea Martos-Esteban, Mia Øhlenschlæger, Urska Pus, Mikael R Andersen, Bruno Lomonte, Mikael Engmark, Manuela B Pucca
Jun 19, 2018
Antibody technologies are being increasingly applied in the field of toxinology. Fuelled by the many advances in immunology, synthetic biology, and antibody research, different approaches and antibody formats are being...
Adverse reactions Animal envenoming Antibodies Antibody expression Antivenom Antivenom design Biotechnology Immunogenicity Neglected tropical diseases pharmacodynamics Pharmacokinetics Recombinant antivenom Scorpion sting Snakebite Spider bite Venom Venom neutralization Animals Antibodies Antivenins Camelus Humans Recombinant Proteins Venoms
The evolving view of the hematopoietic stem cell niche.
Hematopoietic stem cells (HSCs) reside in specialized microenvironments known as niches. The niche is essential to support HSC function and to maintain a correct balance between self-renewal and differentiation. Recent advances...
Methodology for the analysis and comparison of protocols for glycaemic control in intensive care.
Rocío Fernández-Méndez, Sancho Rodríguez-Villar, Pablo F Méndez, Richard Windle, Gary George Adams
Feb 18, 2019
RATIONALE, AIMS, AND OBJECTIVES: The practice of glycaemic control of critically ill patients admitted to intensive care units (ICUs) is guided by clinical management protocols, designed locally by the ICUs. These protocols...
Geospatial distributions reflect temperatures of linguistic features.
Quantifying the speed of linguistic change is challenging because the historical evolution of languages is sparsely documented. Consequently, traditional methods rely on phylogenetic reconstruction. Here, we propose a...
HSCs revive their niche after transplantation.
Simón Méndez-Ferrer
Dec 11, 2020
Golan K, Singh AK et al.1 describe how mitochondrial transfer from hematopoietic stem cells (HSCs) to bone marrow (BM) mesenchymal stem cells (MSCs) helps to regenerate the stroma and its capacity to sustain hematopoietic...
Impact of GAN-based lesion-focused medical image super-resolution on the robustness of radiomic features.
Erick Costa de Farias, Christian di Noia, Changhee Han, Evis Sala, Mauro Castelli, Leonardo Rundo
Oct 18, 2021
Robust machine learning models based on radiomic features might allow for accurate diagnosis, prognosis, and medical decision-making. Unfortunately, the lack of standardized radiomic feature extraction has hampered their...
Chaotic-Integrable Transition in the Sachdev-Ye-Kitaev Model.
Quantum chaos is one of the distinctive features of the Sachdev-Ye-Kitaev (SYK) model, N Majorana fermions in 0+1 dimensions with infinite-range two-body interactions, which is attracting a lot of interest as a toy model for...
Impact of GAN-based lesion-focused medical image super-resolution on the robustness of radiomic features
Erick Costa de Farias, Christian di Noia, Changhee Han, Evis Sala, Mauro Castelli, Leonardo Rundo
Nov 01, 2021
Abstract: Robust machine learning models based on radiomic features might allow for accurate diagnosis, prognosis, and medical decision-making. Unfortunately, the lack of standardized radiomic feature extraction has hampered...
The practice of glycaemic control in intensive care units
Molecular interactome between HSCs and their niches.
Simón Méndez-Ferrer
Nov 18, 2019
Because hematopoietic stem cells (HSCs) were found to require a bone marrow (BM) habitat for long-term function, many studies have attempted to dissect key cellular and molecular interactions between HSCs and their BM...
Mini-Mental State Examination (MMSE) for the detection of Alzheimer's disease and other dementias in people with mild cognitive impairment (MCI).
Ingrid Arevalo-Rodriguez, Nadja Smailagic, Marta Roqué I Figuls, Agustín Ciapponi, Erick Sanchez-Perez, Antri Giannakou, Olga L Pedraza, Xavier Bonfill Cosp, Sarah Cullum
Oct 10, 2018
BACKGROUND: Dementia is a progressive global cognitive impairment syndrome. In 2010, more than 35 million people worldwide were estimated to be living with dementia. Some people with mild cognitive impairment (MCI) will progress...
Cellular Heterogeneity of Mesenchymal Stem/Stromal Cells in the Bone Marrow
Mesenchymal stem/stromal cells (MSCs) are present in various body tissues and help in maintaining homeostasis. The stemness of MSCs has been evaluated in vitro. In addition, analyses of cell surface antigens and gene expression...
Neuronal regulation of bone marrow stem cell niches.
The bone marrow (BM) is the primary site of postnatal hematopoiesis and hematopoietic stem cell (HSC) maintenance. The BM HSC niche is an essential microenvironment which evolves and responds to the physiological demands of...
Human and mouse leukocytes
Simón Méndez-Ferrer
Mar 19, 2018
In this issue of Blood, Zhao et al use a humanized mouse model to investigate the mechanisms driving daily oscillations in circulating human and murine leukocytes.1 In the same mice, they find human and murine circulating...
Cellular Heterogeneity of Mesenchymal Stem/Stromal Cells in the Bone Marrow.
Mesenchymal stem/stromal cells (MSCs) are present in various body tissues and help in maintaining homeostasis. The stemness of MSCs has been evaluated in vitro. In addition, analyses of cell surface antigens and gene expression...
Microenvironmental contributions to hematopoietic stem cell aging.
Hematopoietic stem cell (HSC) aging was originally thought to be essentially an HSC-autonomous process, which is the focus of another review in the same issue of Haematologica However, studies on the microenvironment that...
The Autonomic Nervous System Pulls the Strings to Coordinate Circadian HSC Functions.
As for many other adult stem cells, the behavior of hematopoietic stem and progenitor cells (HSPCs) is subjected to circadian regulatory patterns. Multiple HSPC functions, such as proliferation, differentiation or trafficking...
adrenergic Autonomic Nervous System cholinergic Circadian hematopoietic (stem) cells Adrenergic Neurons Animals Autonomic Nervous System Bone Marrow Cell Differentiation Cell Proliferation Cholinergic Neurons Circadian Rhythm Gene Expression Regulation Hematopoietic Stem Cells Humans Periodicity Signal Transduction Stem Cell Niche Suprachiasmatic Nucleus Time Factors
Improvement of the Efficiency and Completeness of Neuro-Oncology Patient Referrals to a Tertiary Center Through the Implementation of an Electronic Referral System
Rocío Fernández-Méndez, Mei Yin Wong, Rebecca J Rastall, Samuel Rebollo-Díaz, Ingela Oberg, Stephen J Price, Alexis J Joannides
Dec 19, 2019
Current epidemiology of cerebrospinal fluid shunt surgery in the UK and Ireland (2004-2013).
Rocío Fernández-Méndez, Hugh K Richards, Helen M Seeley, John D Pickard, Alexis J Joannides, UKSR collaborators
Feb 18, 2019
Analyzing multitarget activity landscapes using protein-ligand interaction fingerprints
Oscar Méndez-Lucio, Albert J Kooistra, Chris de Graaf, Andreas Bender, José L Medina-Franco
Apr 17, 2015
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