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Results: 493
Knock-in models related to Alzheimer's disease
Diana P Benitez, Shenyi Jiang, Jack Wood, Rui Wang, Chloe M Hall, Carlijn Peerboom, Natalie Wong, Katie M Stringer, Karina S Vitanova, Victoria C Smith, Dhaval Joshi, Takashi Saito, Takaomi C Saido, John Hardy, Jörg Hanrieder, Bart De Strooper, Dervis A Salih, Takshashila Tripathi, Frances A Edwards, Damian M Cummings
Aug 16, 2021
BACKGROUND: Microglia are active modulators of Alzheimer's disease but their role in relation to amyloid plaques and synaptic changes due to rising amyloid beta is unclear. We add novel findings concerning these relationships...
Ageing Alzheimer’s disease amyloid beta Gene Expression Microglia neurodegeneration Plaques synaptic plasticity Synaptic Transmission TREM2 Alzheimer Disease Amyloid beta-Protein Precursor Animals Disease Models Animal Gene Knock-In Techniques Humans Mice Microglia Plaque Amyloid Synaptic Transmission
The methyl binding domain 3/nucleosome remodelling and deacetylase complex regulates neural cell fate determination and terminal differentiation in the cerebral cortex.
Erin Knock, João Pereira, Patrick D Lombard, Andrew Dimond, Donna Leaford, Frederick J Livesey, Brian Hendrich
Jun 08, 2015
Animals Cell Count Cell Cycle Cell Lineage Cerebral Cortex DNA-Binding Proteins Eye Proteins Gene Expression Profiling Gene Expression Regulation Developmental Homeodomain Proteins Mi-2 Nucleosome Remodeling and Deacetylase Complex Mice Mice Knockout Neural Stem Cells Neurogenesis Neurons Nucleosomes PAX6 Transcription Factor Paired Box Transcription Factors Repressor Proteins T-Box Domain Proteins Transcription Factors Transcription Genetic Transgenes
A comparative study into the effects of pre and post catalyst exhaust gas recirculation on the onset of knock
Exhaust gas recirculation (EGR) is proven as a valuable technology for controlling knock whilst maintaining lambda one operation, and is also capable of providing efficiency gains at low load. Despite this few studies in the...
EGR GDI catalysed combustion exhaust gas recirculation Gasoline knock /dk/atira/pure/subjectarea/asjc/2200/2203 name=Automotive Engineering /dk/atira/pure/subjectarea/asjc/2200/2202 name=Aerospace Engineering /dk/atira/pure/subjectarea/asjc/2200/2212 name=Ocean Engineering /dk/atira/pure/subjectarea/asjc/2200/2210 name=Mechanical Engineering
A comparative study into the effects of pre and post catalyst exhaust gas recirculation on the onset of knock
Exhaust gas recirculation (EGR) is proven as a valuable technology for controlling knock whilst maintaining lambda one operation, and is also capable of providing efficiency gains at low load. Despite this few studies in the...
EGR GDI catalysed combustion exhaust gas recirculation Gasoline knock /dk/atira/pure/subjectarea/asjc/2200/2203 name=Automotive Engineering /dk/atira/pure/subjectarea/asjc/2200/2202 name=Aerospace Engineering /dk/atira/pure/subjectarea/asjc/2200/2212 name=Ocean Engineering /dk/atira/pure/subjectarea/asjc/2200/2210 name=Mechanical Engineering
Knock-on damage in bilayer graphene
We study by high-resolution transmission electron microscopy the structural response of bilayer graphene to electron irradiation with energies below the knock-on damage threshold of graphene. We observe that one type of...
The Grizzly, March 3, 1997
Jared Rakes, Taneille Smith, Marshalee Clarke, Teresa Green, Todd Brenneman, Brian Hamrick, Jen Mintzer, Joseph Catalfano, Trish Daley, Erin Gambeski, Cristin Veit, Angie Kurtz, Joel Schofer, Hera Walker
Jan 01, 0001
China Mourns the Loss of a Leader Pipes Lectures on Mid-East Opinion: The Liberal Arts Education Part I, Multiculturalism and Diversity; What is There to Hide? Unobtainable Security Reports Make Us Feel Unsafe; Pledging and...
Ursinus College Collegeville Pennsylvania newspaper Basketball Steve Gilbert study abroad German Club fraternities sororities campus security Diversity pledging Daniel Pipes cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
The Grizzly, April 18, 2002
Anne Antanavage, '04, Cornota Harkins, Christine Ginty, Syreeta Dixon, Quinn Dinsmore, Nicole Gaughan, Katie Petersen, Kelly Gray, Sarah Ewald, Katie Lambert, Bill Stiles, Harry Michel, Joyce Koubouralis, Erin Fitzgerald, Julie Micklos, Mary Sim
Jan 01, 0001
From the B-52's to the Beach Boys: Airband was a Huge Success ProTheatre Stages History with Twilight: Los Angeles this Weekend Students Rave About the Pat McGee Band in Concert Adolph Reed to Deliver Pancoast Lecture ...
Ursinus College Collegeville Pennsylvania newspaper lacrosse softball Rugby baseball field hockey Katie Dougherty Erin Fitzgerald Kappa Alpha Psi Y100 Parking student housing Adolph Reed Airband ProTheatre cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
MRI-guided histology of TDP-43 knock-in mice implicates parvalbumin interneuron loss, impaired neurogenesis and aberrant neurodevelopment in amyotrophic lateral sclerosis-frontotemporal dementia.
Ziqiang Lin, Eugene Kim, Mohi Ahmed, Gang Han, Camilla Simmons, Yushi Redhead, Jack Bartlett, Luis Emiliano Pena Altamira, Isobel Callaghan, Matthew A White, Nisha Singh, Stephen Sawiak, Tara Spires-Jones, Anthony C Vernon, Michael P Coleman, Jeremy Green, Christopher Henstridge, Jeffrey S Davies, Diana Cash, Jemeen Sreedharan
Jul 28, 2021
Amyotrophic lateral sclerosis and frontotemporal dementia are overlapping diseases in which MRI reveals brain structural changes in advance of symptom onset. Recapitulating these changes in preclinical models would help to...
TDP-43 gains function due to perturbed autoregulation in a Tardbp knock-in mouse model of ALS-FTD.
Matthew A White, Eosu Kim, Amanda Duffy, Robert Adalbert, Benjamin U Phillips, Owen M Peters, Jodie Stephenson, Sujeong Yang, Francesca Massenzio, Ziqiang Lin, Simon Andrews, Anne Segonds-Pichon, Jake Metterville, Lisa M Saksida, Richard Mead, Richard R Ribchester, Youssef Barhomi, Thomas Serre, Michael P Coleman, Justin R Fallon, Timothy J Bussey, Robert H Brown, Jemeen Sreedharan
Jun 13, 2018
Amyotrophic lateral sclerosis-frontotemporal dementia (ALS-FTD) constitutes a devastating disease spectrum characterized by 43-kDa TAR DNA-binding protein (TDP-43) pathology. Understanding how TDP-43 contributes to...
Amyotrophic Lateral Sclerosis Animals Brain Choice Behavior Cognition Disorders Conditioning Operant DNA-Binding Proteins Dementia Disease Models Animal Female Gene Expression Regulation Male Memory Disorders Mice Mice Inbred C57BL Mice Transgenic Motor Activity Mutation Neuromuscular Junction Psychomotor Performance Reaction Time
Temperature and territoriality in the Duke of Burgundy butterfly, Hamearis lucina
Abstract: The Duke of Burgundy butterfly (Hamearis lucina) has undergone severe declines over the last four decades. However, in recent years the UK population appears to have begun expanding again. This is likely to be due to...
Fall Theatre and Dance Season Opens with Drama ''The Yellow Boat''
Winthrop University
Jan 01, 0001
David Saar's drama "The Yellow Boat" will run Sept. 29-Oct. 3 in Johnson Studio Theatre. Erin Lee, a senior theatre major from Lexington, S.C., will direct the play.
Published by: Winthrop University
Age-related axonal swellings precede other neuropathological hallmarks in a knock-in mouse model of Huntington's disease.
Martina Marangoni, Robert Adalbert, Lucie Janeckova, Jane Patrick, Jaskaren Kohli, Michael P Coleman, Laura Conforti
May 24, 2018
Axon degeneration precedes cell body death in many age-related neurodegenerative disorders, often determining symptom onset and progression. A sensitive method for revealing axon pathology could indicate whether this is the case...
Writing Self-Efficacy and Performance Among Students in an Online Doctoral Program
Writing an argument is an essential skill for doctoral students in achieving academic and occupational success. Writing an argument effectively requires the ability to use correct writing mechanics, but doctoral students may...
Published by: IGI Global Scientific Publishing
Winthrop Alums Among Top U.S. Graduate Students Meeting Nobel Laureates
Winthrop University
Jan 01, 0001
Erin White Wilson and Matt Wilson, both chemistry majors in the class of 2009 and now in graduate school at the University of Notre Dame, are among nearly 550 young researchers from 78 countries who will attend the week-long...
Published by: Winthrop University
Interview with Herbert Chisholm
Herbert Chisholm
Jan 01, 0001
In his March 6, 2004 interview with Erin Robinson, Herbert Chisholm recollects stories of his time in the Army in Africa and Europe during WWII. Chisholm recalls life as a black soldier and living conditions for all soldiers....
Published by: Winthrop University
Consistent oviposition preferences of the Duke of Burgundy butterfly over 14 years on a chalk grassland reserve in Bedfordshire, UK
M. P. Hayes, E. Ashe-Jepson, G. E. Hitchcock, R. I. Knock, C. B. H. Lucas, A. J. Bladon, E. C. Turner
Jul 28, 2021
Increase in Tau Pathology in P290S Mapt Knock-In Mice Crossed with App NL-G-F Mice.
Melissa Huang, Jennifer Macdonald, Isabelle Lavenir, Renren Chen, Molly Craxton, Elizabeth Slavik-Smith, Stephen W Davies, Michel Goedert
Feb 12, 2023
Alzheimer's Disease (AD) is characterized by the pathologic assembly of amyloid β (Aβ) peptide, which deposits into extracellular plaques, and tau, which accumulates in intraneuronal inclusions. To investigate the link between...
Meeting in the Middle
As institutions of higher education began their full returns to campus in Fall 2021, questions arose about continuing the flexible student support services that emerged during the pandemic, the expectations students might have...
Higher Education Education Higher Education Social Sciences and Humanities Library and Information Science
Published by: IGI Global Scientific Publishing
Hemopoietic-specific Sf3b1-K700E knock-in mice display the splicing defect seen in human MDS but develop anemia without ring sideroblasts.
A Mupo, M Seiler, V Sathiaseelan, A Pance, Y Yang, AA Agrawal, F Iorio, R Bautista, S Pacharne, K Tzelepis, N Manes, P Wright, E Papaemmanuil, DG Kent, PC Campbell, S Buonamici, N Bolli, GS Vassiliou
Feb 05, 2019
Heterozygous somatic mutations affecting the spliceosome gene SF3B1 drive age-related clonal hematopoiesis, myelodysplastic syndromes (MDS) and other neoplasms. To study their role in such disorders, we generated knock-in mice...
GFAP Expression of Radial Glial Cells of the Regenerating Spinal Cord of Axolotls
Erin Fowler
Jan 01, 0001
Unlike humans, axolotls (Ambystoma mexicanum) possess the ability to completely regenerate their spinal cord following injury. It is theorized that the population of radial glial cells in the spinal cord act as the progenitors...
Published by: Ursinus College
Consistent oviposition preferences of the Duke of Burgundy butterfly over 14 years on a chalk grassland reserve in Bedfordshire, UK.
ABSTRACT: The Duke of Burgundy butterfly (Hamearis lucina) is known to have specific habitat requirements for its larval foodplants. However, no studies have yet investigated whether these preferences vary over time or in...
Sphingosylphosphorylcholine potentiates vasoreactivity and voltage-gated Ca2+ entry via NOX1 and reactive oxygen species
Yasin Shaifta, Vladimir A. Snetkov, Jesus Prieto-Lloret, Greg A. Knock, Sergey V. Smirnov, Philip I. Aaronson, Jeremy P. T. Ward
Apr 01, 2015
AIMS: Sphingosylphosphorylcholine (SPC) elicits vasoconstriction at micromolar concentrations. At lower concentrations (≤1 µmol/l) however it does not constrict intrapulmonary arteries (IPA), but strongly potentiates...
Sphingosylphosphorylcholine potentiates vasoreactivity and voltage-gated Ca2+ entry via NOX1 and reactive oxygen species
Yasin Shaifta, Vladimir A. Snetkov, Jesus Prieto-Lloret, Greg A. Knock, Sergey V. Smirnov, Philip I. Aaronson, Jeremy P. T. Ward
Apr 01, 2015
AIMS: Sphingosylphosphorylcholine (SPC) elicits vasoconstriction at micromolar concentrations. At lower concentrations (≤1 µmol/l) however it does not constrict intrapulmonary arteries (IPA), but strongly potentiates...
Invasion VII
Erin Mitchell
Jan 01, 0001
Artwork
Magazine Literary Magazine Arts Magazine art poetry prose Creative Nonfiction Photography Creative Writing Art and Design Printmaking
Published by: Winthrop University
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