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Results: 200
Activation of the GPR35 pathway drives angiogenesis in the tumour microenvironment
Ester Pagano, Joshua E Elias, Georg Schneditz, Svetlana Saveljeva, Lorraine M Holland, Francesca Borrelli, Tom H Karlsen, Arthur Kaser, Nicole Kaneider
Mar 25, 2021
Experiments on the Keto-cleavage of D1 (2-cyanoethyl) Acetoacetic Ester
Charles W. Huff
Jan 01, 0001
This 12 page thesis examines effects of the addition of acrylo-nitrile to acetoacetic ester.
Acrylonitrile Esters acid cleavage Hydrolysis hydrogen bromide Synthesis Chemistry Physical Sciences and Mathematics
Published by: Ursinus College
Activation of the GPR35 pathway drives angiogenesis in the tumour microenvironment
Ester Pagano, Joshua E Elias, Georg Schneditz, Svetlana Saveljeva, Lorraine M Holland, Francesca Borrelli, Tom H Karlsen, Arthur Kaser, Nicole C Kaneider
Apr 13, 2021
Activation of the GPR35 pathway drives angiogenesis in the tumour microenvironment.
Ester Pagano, Joshua E Elias, Georg Schneditz, Svetlana Saveljeva, Lorraine M Holland, Francesca Borrelli, Tom H Karlsen, Arthur Kaser, Nicole C Kaneider
Mar 15, 2021
Isopeptide and Ester Bond Ubiquitination Regulate Degradation of the Human Dopamine Receptor 4
Jennifer C Peeler
Jan 01, 0001
The human dopamine receptor 4 (hD4R) is a seven-transmembrane helical G protein-coupled receptor (GPCR) found in neural synaptic membranes. The neurotransmitter dopamine binds to and activates the hD4R, which is involved in...
Published by: Rockefeller University
GPR35 promotes glycolysis, proliferation, and oncogenic signaling by engaging with the sodium potassium pump.
Georg Schneditz, Joshua E Elias, Ester Pagano, M Zaeem Cader, Svetlana Saveljeva, Kathleen Long, Subhankar Mukhopadhyay, Maryam Arasteh, Trevor D Lawley, Gordon Dougan, Andrew Bassett, Tom H Karlsen, Arthur Kaser, Nicole C Kaneider
Dec 20, 2018
Exploring Metagenomic Enzymes
Enzyme-mediated esterification reactions can be a promising alternative to produce esters of commercial interest, replacing conventional chemical processes. The aim of this work was to verify the potential of an esterase...
Thaís Carvalho Maester, Mariana Rangel Pereira, Aliandra M Gibertoni Malaman, Janaina Pires Borges, Pâmela Aparecida Maldaner Pereira, Eliana GM Lemos
Sep 24, 2020
Single-site binding of pyrene to poly(ester-imide)s incorporating long spacer-units
Marcus Knappert, Tianqi Jin, Scott D Midgley, Guanglu Wu, Oren A Scherman, Ricardo Grau-Crespo, Howard M Colquhoun
Jul 28, 2021
Co-polycondensation of the diimide-based diols N,N'-bis(2-hydroxyethyl)hexafluoroisopropylidene-diphthalimide, (HFDI), and N,N'-bis(2-hydroxy-ethyl)naphthalene-1,4,5,8-tetracarboxylic-diimide, (NDI)...
Published by: Chemical science
The mechanisms of boronate ester formation and fluorescent turn-on in ortho-aminomethylphenylboronic acids
Xiaolong Sun, Brette M. Chapin, Pedro Metola, Byron Collins, Binghe Wang, Tony D. James, Eric V. Anslyn
Sep 01, 2019
ortho-Aminomethylphenylboronic acids are used in receptors for carbohydrates and various other compounds containing vicinal diols. The presence of the o-aminomethyl group enhances the affinity towards diols at neutral pH, and...
The mechanisms of boronate ester formation and fluorescent turn-on in ortho-aminomethylphenylboronic acids
Xiaolong Sun, Brette M. Chapin, Pedro Metola, Byron Collins, Binghe Wang, Tony D. James, Eric V. Anslyn
Sep 01, 2019
ortho-Aminomethylphenylboronic acids are used in receptors for carbohydrates and various other compounds containing vicinal diols. The presence of the o-aminomethyl group enhances the affinity towards diols at neutral pH, and...
Optimization of a continuous flow electrocoagulation as pretreatment for membrane distillation of the waste stream in vinyl ester resin production
Vinyl ester resin production wastewater (VERW) contains high concentrations of organics particularly, methacrylic acid and bisphenol A, which are hazardous chemicals and harmful to the aquatic environment. Therefore, there is...
DCMD EC Peroxi-electrocoagulation Saline high organic wastewater VERW /dk/atira/pure/subjectarea/asjc/1600/1602 name=Analytical Chemistry /dk/atira/pure/subjectarea/asjc/1500/1506 name=Filtration and Separation /dk/atira/pure/sustainabledevelopmentgoals/responsible_consumption_and_production name=SDG 12 - Responsible Consumption and Production
Structural and Mechanistic Analysis of the Choline Sulfatase from Sinorhizobium melliloti
Bert van Loo, Markus Schober, Eugene Valkov, Magdalena Heberlein, Erich Bornberg-Bauer, Kurt Faber, Marko Hyvönen, Florian Hollfelder
May 02, 2018
Hydrolysis of organic sulfate esters proceeds by two distinct mechanisms, water attacking at either sulfur (S-O bond cleavage) or carbon (C-O bond cleavage). In primary and secondary alkyl sulfates, attack at carbon is favored...
Protein-Truncating Variants at the Cholesteryl Ester Transfer Protein Gene and Risk for Coronary Heart Disease.
Akihiro Nomura, Hong-Hee Won, Amit V Khera, Fumihiko Takeuchi, Kaoru Ito, Shane McCarthy, Connor A Emdin, Derek Klarin, Pradeep Natarajan, Seyedeh M Zekavat, Namrata Gupta, Gina M Peloso, Ingrid B Borecki, Tanya M Teslovich, Rosanna Asselta, Stefano Duga, Piera A Merlini, Adolfo Correa, Thorsten Kessler, James G Wilson, Matthew J Bown, Alistair S Hall, Peter S Braund, David J Carey, Michael F Murray, H Lester Kirchner, Joseph B Leader, Daniel R Lavage, J Neil Manus, Dustin N Hartze, Nilesh J Samani, Heribert Schunkert, Jaume Marrugat, Roberto Elosua, Ruth McPherson, Martin Farrall, Hugh Watkins, Jyh-Ming J Juang, Chao A Hsiung, Shih-Yi Lin, Jun-Sing Wang, Hayato Tada, Masa-Aki Kawashiri, Akihiro Inazu, Masakazu Yamagishi, Tomohiro Katsuya, Eitaro Nakashima, Masahiro Nakatochi, Ken Yamamoto, Mitsuhiro Yokota, Yukihide Momozawa, Jerome I Rotter, Eric S Lander, Daniel J Rader, John Danesh, Diego Ardissino, Stacey Gabriel, Cristen J Willer, Goncalo R Abecasis, Danish Saleheen, Michiaki Kubo, Norihiro Kato, Yii-Der Ida Chen, Frederick E Dewey, Sekar Kathiresan
Aug 02, 2021
RATIONALE: Therapies that inhibit CETP (cholesteryl ester transfer protein) have failed to demonstrate a reduction in risk for coronary heart disease (CHD). Human DNA sequence variants that truncate the CETP gene may provide...
DDX3X RNA helicase affects breast cancer cell cycle progression by regulating expression of KLF4.
DDX3X is a multifunctional RNA helicase with documented roles in different cancer types. Here, we demonstrate that DDX3X plays an oncogenic role in breast cancer cells by modulating the cell cycle. Depletion of DDX3X in MCF7...
Optimization of a continuous flow electrocoagulation as pretreatment for membrane distillation of the waste stream in vinyl ester resin production
Vinyl ester resin production wastewater (VERW) contains high concentrations of organics particularly, methacrylic acid and bisphenol A, which are hazardous chemicals and harmful to the aquatic environment. Therefore, there is...
DCMD EC Peroxi-electrocoagulation Saline high organic wastewater VERW /dk/atira/pure/subjectarea/asjc/1600/1602 name=Analytical Chemistry /dk/atira/pure/subjectarea/asjc/1500/1506 name=Filtration and Separation /dk/atira/pure/sustainabledevelopmentgoals/responsible_consumption_and_production name=SDG 12 - Responsible Consumption and Production
Is there evidence for man-made nanoparticles in the Dutch environment?
Patrick Bauerlein, Erik Emke, Peter Tromp, Johannes Hofman, Andrea Carboni, Ferry Schooneman, Pim de Voogt, Annemarie van Wezel
Jan 15, 2017
Only very limited information is available on measured environmental concentrations of nanoparticles. In this study, several environmental compartments in The Netherlands were probed for the presence of nanoparticles. Different...
Lipoprotein signatures of cholesteryl ester transfer protein and HMG-CoA reductase inhibition.
Johannes Kettunen, Michael V Holmes, Elias Allara, Olga Anufrieva, Pauli Ohukainen, Clare Oliver-Williams, Qin Wang, Therese Tillin, Alun D Hughes, Mika Kähönen, Terho Lehtimäki, Jorma Viikari, Olli T Raitakari, Veikko Salomaa, Marjo-Riitta Järvelin, Markus Perola, George Davey Smith, Nish Chaturvedi, John Danesh, Emanuele Di Angelantonio, Adam S Butterworth, Mika Ala-Korpela
Jan 27, 2020
Cholesteryl ester transfer protein (CETP) inhibition reduces vascular event risk, but confusion surrounds its effects on low-density lipoprotein (LDL) cholesterol. Here, we clarify associations of genetic inhibition of CETP on...
Ireland-Claisen rearrangement of ynamides
The Ireland-Claisen rearrangement of propargyl ynamido ester substrates is reported. The expected allenamide carboxylic acid products from [3,3]-sigmatropic rearrangement are not isolated, with 2-amidodienes alternatively formed...
Can it be harmful for parents to talk to their child about their weight? A meta-analysis
Many parents express concern that raising the issue of weight risks harming their child’s physical self-perceptions and wellbeing. Such concerns can deter families from engaging with weight management services. This systematic...
Misfolded protein oligomers induce an increase of intracellular Ca2+ causing an escalation of reactive oxidative species.
Giulia Fani, Chiara Ester La Torre, Roberta Cascella, Cristina Cecchi, Michele Vendruscolo, Fabrizio Chiti
Sep 02, 2022
Can E-Government Serve as a Tool for Public Authorities to Manage Public Resources More Efficiently?
Innovations in the field of telecommunications and technological development in information processing affect the provision of public services. One of the main priorities of governments is to achieve greater efficiency in the...
Published by: IGI Global Scientific Publishing
Boronic Acid Mediated Coupling of Catechols and N-Hydroxylamines
An irreversible, three-component assembly with 2-formylphenylboronic acid, catechol, and N-hydroxylamines was achieved in aqueous media. The boronate ester product was formed with substituted catechols including l-DOPA....
Is there evidence for man-made nanoparticles in the Dutch environment?
Patrick Bauerlein, Erik Emke, Peter Tromp, Johannes Hofman, Andrea Carboni, Ferry Schooneman, Pim de Voogt, Annemarie van Wezel
Jan 15, 2017
Only very limited information is available on measured environmental concentrations of nanoparticles. In this study, several environmental compartments in The Netherlands were probed for the presence of nanoparticles. Different...
Site-selective installation of an electrophilic handle on proteins for bioconjugation.
Site-selective protein modification strategies can be used to insert non-natural functional groups into protein structures. Herein, we report on the use of the bis-electrophile 3-bromo-2-bromomethyl-1-propene as a reagent to...
Validation of a commercial 1,2-o-dilauryl-rac-glycero glutaric acid-(6'-methylresorufin) ester lipase assay for diagnosis of canine pancreatitis.
Emily L Goodband, Gonçalo Serrano, Fernando Constantino-Casas, Joy Archer, Penny J Watson, Tim L Williams
Apr 19, 2018
The objectives of this study were fourfold: technical validation of a commercial canine 1,2-o-dilauryl-rac-glycero glutaric acid-(6'-methylresorufin) ester (DGGR) lipase assay, to calculate a reference interval for DGGR lipase...
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