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Dynamic structure mediates halophilic adaptation of a DNA polymerase from the deep-sea brines of the Red Sea.
Masateru Takahashi, Etsuko Takahashi, Luay I Joudeh, Monica Marini, Gobind Das, Mohamed M Elshenawy, Anastassja Akal, Kosuke Sakashita, Intikhab Alam, Muhammad Tehseen, Mohamed A Sobhy, Ulrich Stingl, Jasmeen S Merzaban, Enzo Di Fabrizio, Samir M Hamdan
Nov 05, 2018
The deep-sea brines of the Red Sea are remote and unexplored environments characterized by high temperatures, anoxic water, and elevated concentrations of salt and heavy metals. This environment provides a rare system to study...
Five-dimensional path integrals for six-dimensional conformal field theories
In this paper we derive Ward-Takahashi identities from the path integral of
supersymmetric five-dimensional field theories with an $SU(1,3)$ spacetime
symmetry in the presence of instantons. We explicitly show how $SU(1,3)$...
Five-Dimensional Path Integrals for Six-Dimensional Conformal Field
Theories
In this paper we derive Ward-Takahashi identities from the path integral of
supersymmetric five-dimensional field theories with an $SU(1,3)$ spacetime
symmetry in the presence of instantons. We explicitly show how $SU(1,3)$...
Validation of a desktop-Type magnet providing a quasi-microgravity space in a room-Temperature bore of a high-gradient trapped field magnet (HG-TFM)
Abstract
The concept of a high-gradient trapped field magnet (HG-TFM), which incorporates a hybrid system of two (RE)BaCuO superconducting bulk components with different functions...
Separation in the visual field has divergent effects on discriminating the speed and the direction of motion.
Local motion in a visual scene allows the detection of prey or predator and predicts their future positions. Relative motion segregates objects and reveals their 3D relationships. 'Optic flow' - the motion of texture across the...
A conceptual study of a high gradient trapped field magnet (HG-TFM) toward providing a quasi-zero gravity space on Earth
Abstract: In this work, we propose a new concept of a high gradient trapped field magnet (HG-TFM). The HG-TFM is made from (RE)BaCuO bulk superconductors, in which slit ring bulks (slit-TFMs) are tightly stacked with TFM...
How does the human visual system compare the speeds of spatially separated objects?
We measured psychophysical thresholds for discriminating the speeds of two arrays of moving dots. The arrays could be juxtaposed or could be spatially separated by up to 10 degrees of visual angle, eccentricity being held...
Flux jump-assisted pulsed field magnetisation of high-$J_c$ bulk high-temperature superconductors
Investigating, predicting and optimising practical magnetisation techniques for charging bulk superconductors is a crucial prerequisite to their use as high performance ‘psuedo’ permanent magnets. The leading technique for such...
A spontaneous genetically induced epiallele at a retrotransposon shapes host genome function
Tessa M Bertozzi, Nozomi Takahashi, Geula Hanin, Anastasiya Kazachenka, Anne C Ferguson-Smith
Apr 29, 2021
Intracisternal A-particles (IAPs) are endogenous retroviruses (ERVs) responsible for most insertional mutations in the mouse. Full-length IAPs harbour genes flanked by long terminal repeats (LTRs). Here, we identify a solo LTR...
A conceptual study of a high gradient trapped field magnet (HG-TFM) toward providing a quasi-zero gravity space on Earth
Abstract: In this work, we propose a new concept of a high gradient trapped field magnet (HG-TFM). The HG-TFM is made from (RE)BaCuO bulk superconductors, in which slit ring bulks (slit-TFMs) are tightly stacked with TFM...
The Vesicle Priming Factor CAPS Functions as a Homodimer via C2 Domain Interactions to Promote Regulated Vesicle Exocytosis.
Matt Petrie, Joseph Esquibel, Greg Kabachinski, Stephanie Maciuba, Hirohide Takahashi, J Michael Edwardson, Thomas FJ Martin
Sep 20, 2018
Neurotransmitters and peptide hormones are secreted by regulated vesicle exocytosis. CAPS (also known as CADPS) is a 145-kDa cytosolic and peripheral membrane protein required for vesicle docking and priming steps that precede...
Crystallinity of Double-Stranded RNA-Antimicrobial Peptide Complexes Modulates Toll-Like Receptor 3-Mediated Inflammation.
Ernest Y Lee, Toshiya Takahashi, Tine Curk, Jure Dobnikar, Richard L Gallo, Gerard CL Wong
Jan 22, 2018
Double-stranded RNA (dsRNA) induces production of pro-inflammatory cytokines in normal human epidermal keratinocytes (NHEK) by specific binding to endosomal Toll-like receptor-3 (TLR3). Recently, it has been shown that...
Regulation of cargo-selective endocytosis by dynamin 2 GTPase-activating protein girdin.
Liang Weng, Atsushi Enomoto, Hiroshi Miyoshi, Kiyofumi Takahashi, Naoya Asai, Nobuhiro Morone, Ping Jiang, Jian An, Takuya Kato, Keisuke Kuroda, Takashi Watanabe, Masato Asai, Maki Ishida-Takagishi, Yoshiki Murakumo, Hideki Nakashima, Kozo Kaibuchi, Masahide Takahashi
May 28, 2019
In clathrin-mediated endocytosis (CME), specificity and selectivity for cargoes are thought to be tightly regulated by cargo-specific adaptors for distinct cellular functions. Here, we show that the actin-binding protein girdin...
NATIONWIDE POST EVENT SURVEY AND ANALYSIS OF THE 2011 TOHOKU EARTHQUAKE TSUNAMI
At 14:46 local time on March 11, 2011, a magnitude 9.0 earthquake occurred off the coast of northeast Japan. This earthquake generated a tsunami that struck Japan as well as various locations around the Pacific Ocean. With the...
Subnuclear localisation is associated with gene expression more than parental origin at the imprinted Dlk1-Dio3 locus.
Rahia Mashoodh, Lisa C Hülsmann, Frances L Dearden, Nozomi Takahashi, Carol Edwards, Anne C Ferguson-Smith
May 24, 2022
At interphase, de-condensed chromosomes have a non-random three-dimensional architecture within the nucleus, however, little is known about the extent to which nuclear organisation might influence expression or vice versa. Here...
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