Search
Results: 45
Behaviorally consequential astrocytic regulation of neural circuits.
Jun Nagai, Xinzhu Yu, Thomas Papouin, Eunji Cheong, Marc R Freeman, Kelly R Monk, Michael H Hastings, Philip G Haydon, David Rowitch, Shai Shaham, Baljit S Khakh
Jan 21, 2021
Astrocytes are a large and diverse population of morphologically complex cells that exist throughout nervous systems of multiple species. Progress over the last two decades has shown that astrocytes mediate developmental...
Flt3 signaling-dependent dendritic cells protect against atherosclerosis
Early events in atherosclerosis occur in the aortic intima and involve monocytes that become macrophages. We looked for these cells in the steady state adult mouse aorta, and surprisingly, we found a dominance of dendritic cells...
Published by: Rockefeller University
Cutting edge: Langerin/CD207 receptor on dendritic cells mediates efficient antigen presentation on MHC I and II products in vivo
The targeted delivery of Ags to dendritic cell (DCs) in vivo greatly improves the efficiency of Ag presentation to T cells and allows an analysis of receptor function. To evaluate the function of Langerin/CD207, a receptor...
Published by: Rockefeller University
Volumetric growth rates of meningioma and its correlation with histological diagnosis and clinical outcome
Daniel M Fountain, Wai Cheong Soon, Tomasz Matys, Mathew R Guilfoyle, Ramez Kirollos, Thomas Santarius
Feb 05, 2018
INTRODUCTION: Tumour growth has been used to successfully predict progression-free survival in low-grade glioma. This systematic review sought to establish the evidence base regarding the correlation of volumetric growth rates...
A mutational signature in gastric cancer suggests therapeutic strategies.
Ludmil B Alexandrov, Serena Nik-Zainal, Hoi Cheong Siu, Suet Yi Leung, Michael R Stratton
Nov 01, 2018
Targeting defects in the DNA repair machinery of neoplastic cells, for example, those due to inactivating BRCA1 and/or BRCA2 mutations, has been used for developing new therapies in certain types of breast, ovarian and...
Microbial stimulation fully differentiates monocytes to DC-SIGN/CD209 + dendritic cells for immune T cell areas
Dendritic cells (DCs), critical antigen-presenting cells for immune control, normally derive from bone marrow precursors distinct from monocytes. It is not yet established if the large reservoir of monocytes can develop into...
Published by: Rockefeller University
Identification of antigen-presenting dendritic cells in mouse aorta and cardiac valves
Presumptive dendritic cells (DCs) bearing the CD11c integrin and other markers have previously been identified in normal mouse and human aorta. We used CD11c promoter-enhanced yellow fluorescent protein (EYFP) transgenic mice to...
Published by: Rockefeller University
Adverse childhood experiences (ACEs) and later-life depression
OBJECTIVE: To investigate associations between adverse childhood experiences (ACEs) and later-life depressive symptoms; and to explore whether perceived social support (PSS) moderates these. METHOD: We analysed baseline data...
adverse childhood experience depression and mood disorders Mental Health Adolescent Adult Survivors of Child Abuse Aged Child Child Abuse Child Preschool Cohort Studies Depression Depressive Disorder Family Characteristics Family Relations Humans Ireland Life Change Events Logistic Models Middle Aged Perception Protective factors Self Report social support Surveys and Questionnaires
Definition of the estrogen negative feedback pathway controlling the GnRH pulse generator in female mice.
H James McQuillan, Jenny Clarkson, Alexia Kauff, Su Young Han, Siew Hoong Yip, Isaiah Cheong, Robert Porteous, Alison K Heather, Allan E Herbison
Jan 04, 2023
Highly redundant neuropeptide volume co-transmission underlying episodic activation of the GnRH neuron dendron.
Xinhuai Liu, Shel-Hwa Yeo, H James McQuillan, Michel K Herde, Sabine Hessler, Isaiah Cheong, Robert Porteous, Allan E Herbison
Apr 12, 2021
The necessity and functional significance of neurotransmitter co-transmission remains unclear. The glutamatergic 'KNDy' neurons co-express kisspeptin, neurokinin B (NKB), and dynorphin and exhibit a highly stereotyped...
Allopurinol in Patients with Pulmonary Hypertension Associated with Chronic Lung Disease.
Patrick Sk Liu-Shiu-Cheong, Brian J Lipworth, Jonathan R Weir-McCall, J Graeme Houston, Allan D Struthers
Oct 05, 2020
BACKGROUND: Oxidative stress (OS) has been implicated in the development of pulmonary hypertension (PH) and ventricular hypertrophy. Xanthine oxidase is a well-recognised source of reactive oxygen species, which lead to OS. The...
Definition of the estrogen negative feedback pathway controlling the GnRH pulse generator in female mice
H. James McQuillan, Jenny Clarkson, Alexia Kauff, Su Young Han, Siew Hoong Yip, Isaiah Cheong, Robert Porteous, Alison K. Heather, Allan E. Herbison
Dec 22, 2022
The mechanisms underlying the homeostatic estrogen negative feedback pathway central to mammalian fertility have remained unresolved. Direct measurement of gonadotropin-releasing hormone (GnRH) pulse generator activity in freely...
Published by: Nature Publishing Group UK
Germline and somatic imprinting in the nonhuman primate highlights species differences in oocyte methylation.
Clara Y Cheong, Keefe Chng, Shilen Ng, Siew Boom Chew, Louiza Chan, Anne C Ferguson-Smith
Jun 11, 2015
Animals Base Sequence DNA Methylation DNA-Binding Proteins Female Genomic Imprinting Humans Inositol Polyphosphate 5-Phosphatases Kruppel-Like Transcription Factors Macaca fascicularis Male Mice Molecular Sequence Data Oocytes Organ Specificity Phosphoric Monoester Hydrolases RNA Long Noncoding Species Specificity
Definition of the estrogen negative feedback pathway controlling the GnRH pulse generator in female mice
H. James McQuillan, Jenny Clarkson, Alexia Kauff, Su Young Han, Siew Hoong Yip, Isaiah Cheong, Robert Porteous, Alison K. Heather, Allan E. Herbison
Dec 08, 2022
The mechanisms underlying the homeostatic estrogen negative feedback pathway central to mammalian fertility have remained unresolved. Direct measurement of gonadotropin-releasing hormone (GnRH) pulse generator activity in freely...
Published by: Nature Publishing Group UK
Pulmonary arterial stiffening in COPD and its implications for right ventricular remodelling.
Jonathan R Weir-McCall, Patrick Sk Liu-Shiu-Cheong, Allan D Struthers, Brian J Lipworth, J Graeme Houston
Oct 03, 2019
BACKGROUND: Pulmonary pulse wave velocity (PWV) allows the non-invasive measurement of pulmonary arterial stiffening, but has not previously been assessed in COPD. The aim of the current study was to assess PWV in COPD and its...
Heart Ventricles Magnetic Resonance Imaging Pulmonary arteries Pulmonary Disease Chronic Obstructive Pulse-wave analysis Aged Female Heart Ventricles Humans Magnetic Resonance Imaging Male Middle Aged Pulmonary Artery Pulmonary Disease Chronic Obstructive Pulse Wave Analysis Respiratory Function Tests Ventricular Remodeling
Disconnection of pulmonary and systemic arterial stiffness in COPD.
Jonathan R Weir-McCall, Patrick Sk Liu-Shiu-Cheong, Allan D Struthers, Brian J Lipworth, J Graeme Houston
Sep 30, 2019
BACKGROUND: Both pulmonary arterial stiffening and systemic arterial stiffening have been described in COPD. The aim of the current study was to assess pulse wave velocity (PWV) within these two arterial beds to determine...
COPD arterial compliance Cardiovascular pulmonary vascular Ventricular Function Adult Aged Aged 80 and over Case-Control Studies Forced Expiratory Volume Germany Heart Humans Magnetic Resonance Imaging Male Middle Aged Organ Size Pulmonary Disease Chronic Obstructive Pulse Wave Analysis Spirometry Vascular Stiffness
Scope, limitations and mechanistic analysis of the HyperBTM-catalyzed acylative kinetic resolution of tertiary heterocyclic alcohols
Sam Smith, Mark Greenhalgh, Taisiia Feoktistova, Daniel Walden, James Taylor, David Cordes, Alexandra Slawin, Paul Ha-Yeon Cheong, Andrew Smith
Jan 11, 2022
The full scope and limitations of the catalytic acylative kinetic resolution of a range of tertiary heterocyclic alcohols (78 examples, s up to >200) is reported under operationally-simple conditions, using low loadings of...
Scope, limitations and mechanistic analysis of the HyperBTM-catalyzed acylative kinetic resolution of tertiary heterocyclic alcohols
Sam Smith, Mark Greenhalgh, Taisiia Feoktistova, Daniel Walden, James Taylor, David Cordes, Alexandra Slawin, Paul Ha-Yeon Cheong, Andrew Smith
Jan 11, 2022
The full scope and limitations of the catalytic acylative kinetic resolution of a range of tertiary heterocyclic alcohols (78 examples, s up to >200) is reported under operationally-simple conditions, using low loadings of...
A C=O⋅⋅⋅Isothiouronium Interaction Dictates Enantiodiscrimination in Acylative Kinetic Resolutions of Tertiary Heterocyclic Alcohols
Mark D. Greenhalgh, Samuel M. Smith, Daniel M. Walden, James E. Taylor, Zamira Brice, Emily R.T. Robinson, Charlene Fallan, David B. Cordes, Alexandra M.Z. Slawin, H. Camille Richardson, Markas A. Grove, Paul Ha Yeon Cheong, Andrew D. Smith
Mar 07, 2018
A combination of experimental and computational studies have identified a C=O⋅⋅⋅isothiouronium interaction as key to efficient enantiodiscrimination in the kinetic resolution of tertiary heterocyclic alcohols bearing up to...
A Perspective on Cell Therapy and Cancer Vaccine in Biliary Tract Cancers (BTCs).
Shuting Han, Suat Ying Lee, Who-Whong Wang, Yu Bin Tan, Rachel Hui Zhen Sim, Rachael Cheong, Cherlyn Tan, Richard Hopkins, John Connolly, Wai Ho Shuen, Han Chong Toh
Nov 19, 2020
Biliary tract cancer (BTC) is a rare, but aggressive, disease that comprises of gallbladder carcinoma, intrahepatic cholangiocarcinoma and extrahepatic cholangiocarcinoma, with heterogeneous molecular profiles. Advanced disease...
Biotic interactions as drivers of algal origin and evolution
Juliet Brodie, Steven G Ball, François-Yves Bouget, Cheong Xin Chan, Olivier De Clerck, J Mark Cock, Claire Gachon, Arthur R Grossman, Thomas Mock, John A Raven, Mahasweta Saha, Alison G Smith, Assaf Vardi, Hwan Su Yoon, Debashish Bhattacharya
Nov 24, 2017
Biotic interactions underlie life's diversity and are the lynchpin to understanding its complexity and resilience within an ecological niche. Algal biologists have embraced this paradigm, and studies building on the explosive...
The Algal Revolution.
Juliet Brodie, Cheong Xin Chan, Olivier De Clerck, J Mark Cock, Susana M Coelho, Claire Gachon, Arthur R Grossman, Thomas Mock, John A Raven, Alison G Smith, Hwan Su Yoon, Debashish Bhattacharya
May 08, 2018
Algae are (mostly) photosynthetic eukaryotes that occupy multiple branches of the tree of life, and are vital for planet function and health. In this review, we highlight a transformative period in studies of the evolution and...
A C=O⋅⋅⋅Isothiouronium Interaction Dictates Enantiodiscrimination in Acylative Kinetic Resolutions of Tertiary Heterocyclic Alcohols
Mark D. Greenhalgh, Samuel M. Smith, Daniel M. Walden, James E. Taylor, Zamira Brice, Emily R.T. Robinson, Charlene Fallan, David B. Cordes, Alexandra M.Z. Slawin, H. Camille Richardson, Markas A. Grove, Paul Ha Yeon Cheong, Andrew D. Smith
Mar 07, 2018
A combination of experimental and computational studies have identified a C=O⋅⋅⋅isothiouronium interaction as key to efficient enantiodiscrimination in the kinetic resolution of tertiary heterocyclic alcohols bearing up to...
Dynamics of multiple resistance mechanisms in plasma DNA during EGFR-targeted therapies in non-small cell lung cancer.
Dana Wai Yi Tsui, Muhammed Murtaza, Alvin Seng Cheong Wong, Oscar M Rueda, Christopher G Smith, Dineika Chandrananda, Ross A Soo, Hong Liang Lim, Boon Cher Goh, Carlos Caldas, Tim Forshew, Davina Gale, Wei Liu, James Morris, Francesco Marass, Tim Eisen, Tan Min Chin, Nitzan Rosenfeld
Aug 15, 2018
Circulating tumour DNA Liquid biopsy Lung cancer resistance mechanisms targeted therapy Antineoplastic Agents Carcinoma Non-Small-Cell Lung DNA Copy Number Variations DNA Mutational Analysis DNA Neoplasm Drug Resistance Neoplasm ErbB Receptors Gefitinib Humans Hydroxychloroquine Longitudinal Studies Lung Neoplasms Mutation Prognosis Survival Analysis Treatment Outcome Tumor Suppressor Protein p53
|
|< |
< |
1 |