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Expanding the build plate
Evripides Loukaides
Jun 04, 2020

Certain types of patterned metamaterials—gridshells and honeycombs—are capable of bistable behavior through a tailored combination of local and global geometric parameters. This is an alternative to prestressed or composite...

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Expanding the build plate
Evripides Loukaides
Jun 04, 2020

Certain types of patterned metamaterials—gridshells and honeycombs—are capable of bistable behavior through a tailored combination of local and global geometric parameters. This is an alternative to prestressed or composite...

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Classification and Selection of Sheet Forming Processes with Machine Learning
Sheet metal forming is a critical component of modern manufacturing. The procedure for selecting a suitable manufacturing process to achieve the final geometry of a metal part is unstructured and heavily reliant on human...
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Classification and Selection of Sheet Forming Processes with Machine Learning
Sheet metal forming is a critical component of modern manufacturing. The procedure for selecting a suitable manufacturing process to achieve the final geometry of a metal part is unstructured and heavily reliant on human...
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Folding-shearing

50% of all sheet metal is scrapped, mainly by trimming following deep-drawing. To combat this a novel process inspired by the mechanics of spinning is proposed and its feasibility is tested with a novel experimental rig. A...

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Folding-shearing

50% of all sheet metal is scrapped, mainly by trimming following deep-drawing. To combat this a novel process inspired by the mechanics of spinning is proposed and its feasibility is tested with a novel experimental rig. A...

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G-Quadruplexes
Guanine (G)-rich sequences in nucleic acids can assemble into G-quadruplex structures that involve G-quartets linked by loop nucleotides. The structural and topological diversity of G-quadruplexes have attracted great attention...
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Remote stereocontrol in [3,3]-sigmatropic rearrangements
The Ireland - Claisen [3,3]-sigmatropic rearrangement has been used to access biologically important β,β′-dihydroxy α-amino acids. The rearrangement reported is highly stereoselective and offers excellent levels of remote...
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RNA promotes phase separation of glycolysis enzymes into yeast G bodies in hypoxia.
In hypoxic stress conditions, glycolysis enzymes assemble into singular cytoplasmic granules called glycolytic (G) bodies. G body formation in yeast correlates with increased glucose consumption and cell survival. However, the...
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Remote stereocontrol in [3,3]-sigmatropic rearrangements
The Ireland - Claisen [3,3]-sigmatropic rearrangement has been used to access biologically important β,β′-dihydroxy α-amino acids. The rearrangement reported is highly stereoselective and offers excellent levels of remote...
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Modelling and simulation of biased agonism dynamics at a G protein-coupled receptor.
Theoretical models of G protein-coupled receptor (GPCR) concentration-response relationships often assume an agonist producing a single functional response via a single active state of the receptor. These models have largely...
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Stacking sequence selection for defect-free forming of uni-directional ply laminates

In order to meet demands for increased production rates of laminated composite components, aerospace manufacturing is being forced towards highly automated production processes such as forming. However, such automated...

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Stacking sequence selection for defect-free forming of uni-directional ply laminates

In order to meet demands for increased production rates of laminated composite components, aerospace manufacturing is being forced towards highly automated production processes such as forming. However, such automated...

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Amino-Acid-Derived Naphthalenediimides as Versatile G-Quadruplex Binders

The design and synthesis of water soluble, amino-acid-functionalised naphthalenediimides (NDIs) as potential ligands of native G-quadruplexes is reported. The NDIs were tested on a panel of oncogene promoters, on the human...

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Amino-Acid-Derived Naphthalenediimides as Versatile G-Quadruplex Binders

The design and synthesis of water soluble, amino-acid-functionalised naphthalenediimides (NDIs) as potential ligands of native G-quadruplexes is reported. The NDIs were tested on a panel of oncogene promoters, on the human...

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