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Junction Electronic and Optoelectronic Devices from Transition Metal Dichalcogenide Lateral Heterostructures Grown by One‐Pot Chemical Vapor Deposition Synthesis
Emad Najafidehaghani, Ziyang Gan, Antony George, Tibor Lehnert, Gia Quyet Ngo, Christof Neumann, Tobias Bucher, Isabelle Staude, David Kaiser, Tobias Vogl, Uwe Hübner, Ute Kaiser, Falk Eilenberger, Andrey Turchanin
May 04, 2021
Patterned Growth of Transition Metal Dichalcogenide Monolayers and Multilayers for Electronic and Optoelectronic Device Applications.
Ziyang Gan, Emad Najafidehaghani, Seung Heon Han, Sai Shradha, Fatemeh Abtahi, Christof Neumann, Julian Picker, Tobias Vogl, Uwe Hübner, Falk Eilenberger, Antony George, Andrey Turchanin
Aug 12, 2022
The scholar as craftsman
Seb Falk
Sep 05, 2018
The Royal Society Conversaziones were biannual social evenings at which distinguished guests could learn about the latest scientific developments. The Conversazione in May 1952 featured an object that came to be called King...
‘El Capri Kylex’
This article examines the role of memory techniques in medieval astronomy. Using a mnemonic written by a Franciscan friar c. 1330 as a case study, it shows how astronomers and astrologers simplified the sky for...
S Falk
Aug 12, 2021
Rabies Elimination
Rabies is a vaccine-preventable fatal viral disease that is zoonotic in nature. In this article, we provide a justification why the agreement of the World Health Organization (WHO), the Food and Agriculture Organization (FAO)...
Collected marine litter - A growing waste challenge
Marine litter, in particular plastic debris, poses a serious
threat to marine life, human health and the economy. In order to reduce
its impact, marine litter collections such as beach clean-ups are
frequently...
threat to marine life, human health and the economy. In order to reduce
its impact, marine litter collections such as beach clean-ups are
frequently...
Collection Life-cycle Marine litter Systems perspective Waste treatment /dk/atira/pure/subjectarea/asjc/1900/1910 name=Oceanography /dk/atira/pure/subjectarea/asjc/1100/1104 name=Aquatic Science /dk/atira/pure/subjectarea/asjc/2300/2310 name=Pollution /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being /dk/atira/pure/sustainabledevelopmentgoals/life_below_water name=SDG 14 - Life Below Water
Collected marine litter - A growing waste challenge
Marine litter, in particular plastic debris, poses a serious
threat to marine life, human health and the economy. In order to reduce
its impact, marine litter collections such as beach clean-ups are
frequently...
threat to marine life, human health and the economy. In order to reduce
its impact, marine litter collections such as beach clean-ups are
frequently...
Collection Life-cycle Marine litter Systems perspective Waste treatment /dk/atira/pure/subjectarea/asjc/1900/1910 name=Oceanography /dk/atira/pure/subjectarea/asjc/1100/1104 name=Aquatic Science /dk/atira/pure/subjectarea/asjc/2300/2310 name=Pollution /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being /dk/atira/pure/sustainabledevelopmentgoals/life_below_water name=SDG 14 - Life Below Water
Collagen-Inspired Self-Assembly of Twisted Filaments.
Collagen consists of three peptides twisted together through a periodic array of hydrogen bonds. Here we use this as inspiration to find design rules for programmed specific interactions for self-assembling synthetic...
C-mannosylation supports folding and enhances stability of thrombospondin repeats.
Aleksandra Shcherbakova, Matthias Preller, Manuel H Taft, Jordi Pujols, Salvador Ventura, Birgit Tiemann, Falk Fr Buettner, Hans Bakker
Jan 11, 2020
Previous studies demonstrated importance of C-mannosylation for efficient protein secretion. To study its impact on protein folding and stability, we analyzed both C-mannosylated and non-C-mannosylated thrombospondin type 1...
C-mannosylation C. elegans D. melanogaster Biochemistry Cell Biology chemical biology Glycosylation Protein Folding Protein Stability thrombospondin type 1 repeats tryptophan-arginine ladder Animals Arginine Caenorhabditis elegans Caenorhabditis elegans Proteins Cysteine Disulfides Drosophila melanogaster Endoplasmic Reticulum Glycosylation Hydrogen Bonding Mannose Membrane Proteins Molecular Dynamics Simulation Protein Conformation Protein Folding Receptors Cell Surface Thrombospondins Tryptophan
The double-stranded DNA-binding proteins TEBP-1 and TEBP-2 form a telomeric complex with POT-1.
Sabrina Dietz, Miguel Vasconcelos Almeida, Emily Nischwitz, Jan Schreier, Nikenza Viceconte, Albert Fradera-Sola, Christian Renz, Alejandro Ceron-Noriega, Helle D Ulrich, Dennis Kappei, René F Ketting, Falk Butter
Oct 25, 2021
Telomeres are bound by dedicated proteins, which protect them from DNA damage and regulate telomere length homeostasis. In the nematode Caenorhabditis elegans, a comprehensive understanding of the proteins interacting with the...
Mechanical factors contributing to the Venus flytrap's rate-dependent response to stimuli.
Eashan Saikia, Nino F Läubli, Hannes Vogler, Markus Rüggeberg, Hans J Herrmann, Ingo Burgert, Jan T Burri, Bradley J Nelson, Ueli Grossniklaus, Falk K Wittel
Nov 22, 2021
Epigenetic homogeneity in histone methylation underlies sperm programming for embryonic transcription
Mami Oikawa, Angela Simeone, Eva Hormanseder, Marta Teperek, Vincent Gaggioli, Alan O’Doherty, Emma Falk, Matthieu Sporniak, Clive D’Santos, Valar Nila Roamio Franklin, Kamal Kishore, Charles R. Bradshaw, Declan Keane, Thomas Freour, Laurent David, Adrian T. Grzybowski, Alexander J. Ruthenburg, John Gurdon, Jerome Jullien
Jul 13, 2020
Abstract: Sperm contributes genetic and epigenetic information to the embryo to efficiently support development. However, the mechanism underlying such developmental competence remains elusive. Here, we investigated whether all...
The RNA polymerase II subunit RPB-9 recruits the integrator complex to terminate Caenorhabditis elegans piRNA transcription.
Ahmet C Berkyurek, Giulia Furlan, Lisa Lampersberger, Toni Beltran, Eva-Maria Weick, Emily Nischwitz, Isabela Cunha Navarro, Fabian Braukmann, Alper Akay, Jonathan Price, Falk Butter, Peter Sarkies, Eric A Miska
Mar 19, 2021
PIWI-interacting RNAs (piRNAs) are genome-encoded small RNAs that regulate germ cell development and maintain germline integrity in many animals. Mature piRNAs engage Piwi Argonaute proteins to silence complementary transcripts...
The double-stranded DNA-binding proteins TEBP-1 and TEBP-2 form a telomeric complex with POT-1
Sabrina Dietz, Miguel Vasconcelos Almeida, Emily Nischwitz, Jan Schreier, Nikenza Viceconte, Albert Fradera-Sola, Christian Renz, Alejandro Ceron-Noriega, Helle D. Ulrich, Dennis Kappei, René F. Ketting, Falk Butter
May 11, 2021
Abstract: Telomeres are bound by dedicated proteins, which protect them from DNA damage and regulate telomere length homeostasis. In the nematode Caenorhabditis elegans, a comprehensive understanding of the proteins interacting...
The double-stranded DNA-binding proteins TEBP-1 and TEBP-2 form a telomeric complex with POT-1.
Sabrina Dietz, Miguel Vasconcelos Almeida, Emily Nischwitz, Jan Schreier, Nikenza Viceconte, Albert Fradera-Sola, Christian Renz, Alejandro Ceron-Noriega, Helle D Ulrich, Dennis Kappei, René F Ketting, Falk Butter
Jun 12, 2021
Telomeres are bound by dedicated proteins, which protect them from DNA damage and regulate telomere length homeostasis. In the nematode Caenorhabditis elegans, a comprehensive understanding of the proteins interacting with the...
Germ Cells Telomere Animals Animals Genetically Modified Caenorhabditis elegans Multiprotein Complexes DNA-Binding Proteins Telomere-Binding Proteins Caenorhabditis elegans Proteins Protein Isoforms DNA Microscopy Fluorescence Phylogeny Binding Sites Base Sequence Protein Binding Mutation
Published by: Nature Communications
Transcriptional activity and epigenetic regulation of transposable elements in the symbiotic fungus Rhizophagus irregularis.
Alexandra Dallaire, Bethan F Manley, Maya Wilkens, Iliana Bista, Clement Quan, Edouard Evangelisti, Charles R Bradshaw, Navin B Ramakrishna, Sebastian Schornack, Falk Butter, Uta Paszkowski, Eric A Miska
Sep 17, 2021
Caldera resurgence during the 2018 eruption of Sierra Negra volcano, Galápagos Islands.
Andrew F Bell, Peter C La Femina, Mario Ruiz, Falk Amelung, Marco Bagnardi, Christopher J Bean, Benjamin Bernard, Cynthia Ebinger, Matthew Gleeson, James Grannell, Stephen Hernandez, Machel Higgins, Céline Liorzou, Paul Lundgren, Nathan J Meier, Martin Möllhoff, Sarah-Jaye Oliva, Andres Gorki Ruiz, Michael J Stock
Apr 19, 2021
Recent large basaltic eruptions began after only minor surface uplift and seismicity, and resulted in caldera subsidence. In contrast, some eruptions at Galápagos Island volcanoes are preceded by prolonged, large amplitude...
Epigenetic homogeneity in histone methylation underlies sperm programming for embryonic transcription
Mami Oikawa, Angela Simeone, Eva Hormanseder, Marta Teperek, Vincent Gaggioli, Alan O’Doherty, Emma Falk, Matthieu Sporniak, Clive D’Santos, Valar Nila Roamio Franklin, Kamal Kishore, Charles R. Bradshaw, Declan Keane, Thomas Freour, Laurent David, Adrian T. Grzybowski, Alexander J. Ruthenburg, John Gurdon, Jerome Jullien
Jul 28, 2021
Abstract: Sperm contributes genetic and epigenetic information to the embryo to efficiently support development. However, the mechanism underlying such developmental competence remains elusive. Here, we investigated whether all...
Age-related pathological impairments in directly reprogrammed dopaminergic neurons derived from patients with idiopathic Parkinson's disease.
Janelle Drouin-Ouellet, Emilie M Legault, Fredrik Nilsson, Karolina Pircs, Julie Bouquety, Florence Petit, Shelby Shrigley, Marcella Birtele, Maria Pereira, Petter Storm, Yogita Sharma, Andreas Bruzelius, Romina Vuono, Malin Kele, Thomas B Stoker, Daniella Rylander Ottosson, Anna Falk, Johan Jakobsson, Roger A Barker, Malin Parmar
Oct 24, 2022
We have developed an efficient approach to generate functional induced dopaminergic (DA) neurons from adult human dermal fibroblasts. When performing DA neuronal conversion of patient fibroblasts with idiopathic Parkinson's...
Diagnosis of 'possible' mitochondrial disease
Sumit Parikh, Amel Karaa, Amy Goldstein, Enrico Silvio Bertini, Patrick F Chinnery, John Christodoulou, Bruce H Cohen, Ryan L Davis, Marni J Falk, Carl Fratter, Rita Horvath, Mary Kay Koenig, Michaelangelo Mancuso, Shana McCormack, Elizabeth M McCormick, Robert McFarland, Victoria Nesbitt, Manuel Schiff, Hannah Steele, Silvia Stockler, Carolyn Sue, Mark Tarnopolsky, David R Thorburn, Jerry Vockley, Shamima Rahman
Mar 15, 2019
Primary genetic mitochondrial diseases are often difficult to diagnose, and the term 'possible' mitochondrial disease is used frequently by clinicians when such a diagnosis is suspected. There are now many known phenocopies of...
HOT1 is a mammalian direct telomere repeat-binding protein contributing to telomerase recruitment.
Dennis Kappei, Falk Butter, Christian Benda, Marion Scheibe, Irena Draškovič, Michelle Stevense, Clara Lopes Novo, Claire Basquin, Masatake Araki, Kimi Araki, Dragomir Blazhev Krastev, Ralf Kittler, Rolf Jessberger, J Arturo Londoño-Vallejo, Matthias Mann, Frank Buchholz
Jun 28, 2019
Telomeres are repetitive DNA structures that, together with the shelterin and the CST complex, protect the ends of chromosomes. Telomere shortening is mitigated in stem and cancer cells through the de novo addition of telomeric...
Epigenetic homogeneity in histone methylation underlies sperm programming for embryonic transcription.
Mami Oikawa, Angela Simeone, Eva Hormanseder, Marta Teperek, Vincent Gaggioli, Alan O'Doherty, Emma Falk, Matthieu Sporniak, Clive D'Santos, Valar Nila Roamio Franklin, Kamal Kishore, Charles R Bradshaw, Declan Keane, Thomas Freour, Laurent David, Adrian T Grzybowski, Alexander J Ruthenburg, John Gurdon, Jerome Jullien
Aug 13, 2020
Sperm contributes genetic and epigenetic information to the embryo to efficiently support development. However, the mechanism underlying such developmental competence remains elusive. Here, we investigated whether all sperm...
ATG16L1 orchestrates interleukin-22 signaling in the intestinal epithelium via cGAS-STING.
Konrad Aden, Florian Tran, Go Ito, Raheleh Sheibani-Tezerji, Simone Lipinski, Jan W Kuiper, Markus Tschurtschenthaler, Svetlana Saveljeva, Joya Bhattacharyya, Robert Häsler, Kareen Bartsch, Anne Luzius, Marlene Jentzsch, Maren Falk-Paulsen, Stephanie T Stengel, Lina Welz, Robin Schwarzer, Björn Rabe, Winfried Barchet, Stefan Krautwald, Gunther Hartmann, Manolis Pasparakis, Richard S Blumberg, Stefan Schreiber, Arthur Kaser, Philip Rosenstiel
Sep 08, 2018
A coding variant of the inflammatory bowel disease (IBD) risk gene ATG16L1 has been associated with defective autophagy and deregulation of endoplasmic reticulum (ER) function. IL-22 is a barrier protective cytokine by inducing...
Pharmacodynamic evaluation and safety assessment of treatment with antibodies to serum amyloid P component in patients with cardiac amyloidosis
Ashutosh Wechalekar, Gunnar Antoni, Wasfi Al Azzam, Mats Bergström, Swethajit Biswas, Chao Chen, Joseph Cheriyan, Matthew Cleveland, Louise Cookson, Paul Galette, Robert L Janiczek, Raymond Y Kwong, Mary Ann Lukas, Helen Millns, Duncan Richards, Ian Schneider, Scott D Solomon, Jens Sörensen, James Storey, Douglas Thompson, Guus van Dongen, Danielle J Vugts, Anders Wall, Gerhard Wikström, Rodney H Falk
Feb 14, 2022
BACKGROUND: In a Phase I study treatment with the serum amyloid P component (SAP) depleter miridesap followed by monoclonal antibody to SAP (dezamizumab) showed removal of amyloid from liver, spleen and kidney in patients with...
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