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Retinal regions shape human and murine Müller cell proteome profile and functionality.
Lew Kaplan, Corinne Drexler, Anna M Pfaller, Santra Brenna, Kirsten A Wunderlich, Andrea Dimitracopoulos, Juliane Merl-Pham, Maria-Theresa Perez, Ursula Schlötzer-Schrehardt, Volker Enzmann, Marijana Samardzija, Berta Puig, Peter Fuchs, Kristian Franze, Stefanie M Hauck, Antje Grosche
Nov 05, 2022
The human macula is a highly specialized retinal region with pit-like morphology and rich in cones. How Müller cells, the principal glial cell type in the retina, are adapted to this environment is still poorly understood. We...
The Trope of Silence in the Work of Herta Müller
P Shopin
Aug 09, 2017
With reference to Herta Müller’s fiction and non-fiction, my essay explores how the trope of silence is engaged to make sense of more abstract concepts. Drawing on conceptual metaphor theory, I argue that Müller uses silence as...
Language as a force for good in the work of Herta Müller
P Shopin
Oct 02, 2017
Herta Müller creates sophisticated metaphors to convey her vision of language and its relationship to suffering and subjugation. With reference to both her fiction and non‐fiction, this essay explores how she uses the idea of...
Worldwide surveillance of self-reported sitting time
M. Mclaughlin, A. J. Atkin, L. Starr, A. Hall, L. Wolfenden, R. Sutherland, J. Wiggers, A. Ramirez, P. Hallal, M. Pratt, B. M. Lynch, K. Wijndaele, Saiful Adli, Paul A. Gardiner, Ciaran B. Doyle, Angela Meadows, Ruth M. Mabry, Alberto Florez Pregonero, Kabir P. Sadarangani, Nyssa T. Hadgraft, Terry Boyle, Nicolas Aguilar Farias, Jacqueline L. Mair, Siosaia F. Hafoka, Gregore Iven Mielke, Selina Khoo Phaik Lin, Vienna R. McLeod, Chathuranga Ranasinghe, Paul C. Storning, Ing-Mari Dohrn, Falk Müller-Riemenschnieder, Lyutha Al Subhi, Anne Chu Hin Yee, Mayuri Gad, Adilson Marques, Elli Kontostoli
Sep 03, 2020
Abstract: Background: Prolonged sitting time is a risk factor for chronic disease, yet recent global surveillance is not well described. The aims were to clarify: (i) the countries that have collected country-level data on...
IL-33 deficiency causes persistent inflammation and severe neurodegeneration in retinal detachment.
Josy Augustine, Sofia Pavlou, Imran Ali, Kevin Harkin, Ema Ozaki, Matthew Campbell, Alan W Stitt, Heping Xu, Mei Chen
Jan 20, 2020
BACKGROUND: Interleukin-33 (IL-33) belongs to the IL-1 cytokine family and resides in the nuclei of various cell types. In the neural retina, IL-33 is predominately expressed in Müller cells although its role in health and...
The scholar as craftsman
Seb Falk
Sep 05, 2018
The Royal Society Conversaziones were biannual social evenings at which distinguished guests could learn about the latest scientific developments. The Conversazione in May 1952 featured an object that came to be called King...
Worldwide surveillance of self-reported sitting time
M. Mclaughlin, A. J. Atkin, L. Starr, A. Hall, L. Wolfenden, R. Sutherland, J. Wiggers, A. Ramirez, P. Hallal, M. Pratt, B. M. Lynch, K. Wijndaele, Saiful Adli, Paul A. Gardiner, Ciaran B. Doyle, Angela Meadows, Ruth M. Mabry, Alberto Florez Pregonero, Kabir P. Sadarangani, Nyssa T. Hadgraft, Terry Boyle, Nicolas Aguilar Farias, Jacqueline L. Mair, Siosaia F. Hafoka, Gregore Iven Mielke, Selina Khoo Phaik Lin, Vienna R. McLeod, Chathuranga Ranasinghe, Paul C. Storning, Ing-Mari Dohrn, Falk Müller-Riemenschnieder, Lyutha Al Subhi, Anne Chu Hin Yee, Mayuri Gad, Adilson Marques, Elli Kontostoli
Sep 03, 2021
Abstract: Background: Prolonged sitting time is a risk factor for chronic disease, yet recent global surveillance is not well described. The aims were to clarify: (i) the countries that have collected country-level data on...
‘El Capri Kylex’
This article examines the role of memory techniques in medieval astronomy. Using a mnemonic written by a Franciscan friar c. 1330 as a case study, it shows how astronomers and astrologers simplified the sky for...
S Falk
Aug 12, 2021
Rabies Elimination
Rabies is a vaccine-preventable fatal viral disease that is zoonotic in nature. In this article, we provide a justification why the agreement of the World Health Organization (WHO), the Food and Agriculture Organization (FAO)...
Collected marine litter - A growing waste challenge
Marine litter, in particular plastic debris, poses a serious
threat to marine life, human health and the economy. In order to reduce
its impact, marine litter collections such as beach clean-ups are
frequently...
threat to marine life, human health and the economy. In order to reduce
its impact, marine litter collections such as beach clean-ups are
frequently...
Collection Life-cycle Marine litter Systems perspective Waste treatment /dk/atira/pure/subjectarea/asjc/1900/1910 name=Oceanography /dk/atira/pure/subjectarea/asjc/1100/1104 name=Aquatic Science /dk/atira/pure/subjectarea/asjc/2300/2310 name=Pollution /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being /dk/atira/pure/sustainabledevelopmentgoals/life_below_water name=SDG 14 - Life Below Water
HIF-1alpha and HIF-2alpha are differentially activated in distinct cell populations in retinal ischaemia.
Freya M Mowat, Ulrich FO Luhmann, Alexander J Smith, Clemens Lange, Yanai Duran, Sarah Harten, Deepa Shukla, Patrick H Maxwell, Robin R Ali, James WB Bainbridge
Mar 18, 2019
BACKGROUND: Hypoxia plays a key role in ischaemic and neovascular disorders of the retina. Cellular responses to oxygen are mediated by hypoxia-inducible transcription factors (HIFs) that are stabilised in hypoxia and induce the...
Collected marine litter - A growing waste challenge
Marine litter, in particular plastic debris, poses a serious
threat to marine life, human health and the economy. In order to reduce
its impact, marine litter collections such as beach clean-ups are
frequently...
threat to marine life, human health and the economy. In order to reduce
its impact, marine litter collections such as beach clean-ups are
frequently...
Collection Life-cycle Marine litter Systems perspective Waste treatment /dk/atira/pure/subjectarea/asjc/1900/1910 name=Oceanography /dk/atira/pure/subjectarea/asjc/1100/1104 name=Aquatic Science /dk/atira/pure/subjectarea/asjc/2300/2310 name=Pollution /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being /dk/atira/pure/sustainabledevelopmentgoals/life_below_water name=SDG 14 - Life Below Water
Collagen-Inspired Self-Assembly of Twisted Filaments.
Collagen consists of three peptides twisted together through a periodic array of hydrogen bonds. Here we use this as inspiration to find design rules for programmed specific interactions for self-assembling synthetic...
C-mannosylation supports folding and enhances stability of thrombospondin repeats.
Aleksandra Shcherbakova, Matthias Preller, Manuel H Taft, Jordi Pujols, Salvador Ventura, Birgit Tiemann, Falk Fr Buettner, Hans Bakker
Jan 11, 2020
Previous studies demonstrated importance of C-mannosylation for efficient protein secretion. To study its impact on protein folding and stability, we analyzed both C-mannosylated and non-C-mannosylated thrombospondin type 1...
C-mannosylation C. elegans D. melanogaster Biochemistry Cell Biology chemical biology Glycosylation Protein Folding Protein Stability thrombospondin type 1 repeats tryptophan-arginine ladder Animals Arginine Caenorhabditis elegans Caenorhabditis elegans Proteins Cysteine Disulfides Drosophila melanogaster Endoplasmic Reticulum Glycosylation Hydrogen Bonding Mannose Membrane Proteins Molecular Dynamics Simulation Protein Conformation Protein Folding Receptors Cell Surface Thrombospondins Tryptophan
The double-stranded DNA-binding proteins TEBP-1 and TEBP-2 form a telomeric complex with POT-1.
Sabrina Dietz, Miguel Vasconcelos Almeida, Emily Nischwitz, Jan Schreier, Nikenza Viceconte, Albert Fradera-Sola, Christian Renz, Alejandro Ceron-Noriega, Helle D Ulrich, Dennis Kappei, René F Ketting, Falk Butter
Oct 25, 2021
Telomeres are bound by dedicated proteins, which protect them from DNA damage and regulate telomere length homeostasis. In the nematode Caenorhabditis elegans, a comprehensive understanding of the proteins interacting with the...
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Junction Electronic and Optoelectronic Devices from Transition Metal Dichalcogenide Lateral Heterostructures Grown by One‐Pot Chemical Vapor Deposition Synthesis
Emad Najafidehaghani, Ziyang Gan, Antony George, Tibor Lehnert, Gia Quyet Ngo, Christof Neumann, Tobias Bucher, Isabelle Staude, David Kaiser, Tobias Vogl, Uwe Hübner, Ute Kaiser, Falk Eilenberger, Andrey Turchanin
May 04, 2021
Genetic control of cellular morphogenesis in Müller glia.
Small-Molecule Activation of YAP for Inner-Ear Regeneration and Beyond
Nathaniel Kastan
Jan 01, 0001
Hippo signaling is an evolutionarily conserved pathway that restricts organ growth during development and suppresses regeneration in mature organs. Using a highthroughput phenotypic screen, we have identified a potent...
Published by: Rockefeller University
Modelling Charcot-Marie-Tooth disease in a dish reveals common cell type-specific alterations.
This scientific commentary refers to ‘Induced pluripotent stem cell-derived motor neurons of CMT type 2 patients reveal progressive mitochondrial dysfunction’, by Van Lent et al. (doi:10.1093/brain/awab226).
Small Molecule Activation of Yap for Inner-Ear Regeneration and Beyond
Nathaniel Kastan
Jan 01, 0001
Hippo signaling is an evolutionarily conserved pathway that restricts organ growth during development and suppresses regeneration in mature organs. Using a highthroughput phenotypic screen, we have identified a potent...
Published by: Rockefeller University
Gedanken über die Religion: Der “stille” Krieg zwischen Schelling und Schleiermacher (1799–1807), by Ryan Scheerlinck, Stuttgart-Bad Cannstatt
Vicki Müller-Lüneschloß
Apr 05, 2022
The title of Scheerlinck’s study on the relationship between two of the most important thinkers of Romanticism, the philosopher F.W.J. Schelling and the theologian F.D.E. Schleiermacher, undoubtedly alludes to the latter’s main...
Published by: Memorial University Libraries
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