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The nuclear-encoded glycyl-tRNA synthetase gene (GARS) is essential for protein translation in both cytoplasm and mitochondria. In contrast, different genes encode the mitochondrial and cytosolic forms of most other tRNA...

Animals Endoplasmic Reticulum Glycine-tRNA Ligase Humans Mice Mitochondria Mutation Neurons Signal Transduction Stem Cells Vesicular Transport Proteins

Red blood cells are produced by terminal erythroid differentiation, which involves the dramatic morphological transformation of erythroblasts into enucleated reticulocytes. Microtubules are important for enucleation, but it is...

Blood Centrosome enucleation Erythropoiesis mitotic spindle Anemia Macrocytic Animals Cell Cycle Proteins Centrosome Chromosome Segregation Mice Microtubules Mitosis Spindle Apparatus

Animals Cell Cycle Proteins Cell Line Centrosome Chickens Cluster Analysis Humans Intracellular Signaling Peptides and Proteins Kinesins Mice Mutation Neoplasms Nerve Tissue Proteins Protein Binding Protein Interaction Maps Protein Structure Tertiary Spindle Poles

Domestication dramatically changes behaviour, including communication, as seen in the case of dogs (Canis familiaris) and wolves (Canis lupus). We tested the hypothesis that domestication may affect an ancient, shared...

Animals Canidae Dogs Wolves Vocalization Animal Species Specificity domestication

Dogs Animals Wolves Vocalization Animal Canidae domestication Species Specificity

Argonaute Proteins Cell Cycle GTP-Binding Protein gamma Subunits Humans Oligonucleotide Array Sequence Analysis Protein Isoforms RNA Interference RNA Polymerase III RNA Long Noncoding rho GTP-Binding Proteins

CRISPR-Cas Systems Gene Expression Profiling Gene Knockdown Techniques HEK293 Cells HeLa Cells Humans Oligonucleotides Oligonucleotides Antisense Proteins RNA Interference RNA Long Noncoding Transcription Genetic

Abstract: Genome stability relies on proper coordination of mitosis and cytokinesis, where dynamic microtubules capture and faithfully segregate chromosomes into daughter cells. With a high-content RNAi imaging screen targeting...

article /631/1647/2163 /631/208/200 /631/337/641/1655 /631/337/384/2568 /14 /14/32 /14/63 /38 /38/89 /38/91 /49 /13 article

Ciliopathies are a group of genetic disorders caused by a failure to form functional cilia. Due to a lack of structural information, it is currently poorly understood how ciliopathic mutations affect protein functionality to...

CEP120 JATD Jeuene syndrome Joubert syndrome basal body centriole Centrosome Cilia ciliopathy Amino Acid Sequence Animals Cell Cycle Cell Cycle Proteins Cell Line Centrioles Centrosome Cilia Mice Models Molecular Mutation Organogenesis Protein Domains Protein Stability Temperature Zebrafish

Genome stability relies on proper coordination of mitosis and cytokinesis, where dynamic microtubules capture and faithfully segregate chromosomes into daughter cells. With a high-content RNAi imaging screen targeting more than...

Centrioles are cylindrical assemblies whose peripheral microtubule array displays a 9-fold rotational symmetry that is established by the scaffolding protein SAS6. Centriole symmetry can be broken by centriole-associated...

CCDC61 Chlamydomonas Sas6 VFL3 XRCC4 basal body centriole Centrosome Cilia microtubule structural biology Algal Proteins Cell Cycle Proteins Cell Line Chlamydomonas Cilia Crystallography X-Ray HEK293 Cells Humans Microtubule-Associated Proteins Microtubules Models Molecular Phylogeny Protein Conformation Protein Domains Protein Multimerization

Animals Brain Child Chlorocebus aethiops Female Genome Viral HEK293 Cells Humans Male Microcephaly Mutation Nerve Tissue Proteins Neural Stem Cells RNA-Binding Proteins Vero Cells Virus Replication Zika Virus Zika Virus Infection

Genome stability relies on proper coordination of mitosis and cytokinesis, where dynamic microtubules capture and faithfully segregate chromosomes into daughter cells. With a high-content RNAi imaging screen targeting more than...

Cell Division HeLa Cells High-Throughput Screening Assays Humans Mitosis Proteins RNA Interference RNA Long Noncoding

Aurora-A regulates the recruitment of TACC3 to the mitotic spindle through a phospho-dependent interaction with clathrin heavy chain (CHC). Here, we describe the structural basis of these interactions, mediated by three motifs...

disorder–order transition Intrinsically Disordered Protein Phosphorylation Protein Kinase protein–protein interaction Aurora Kinase A Cell Line Humans Microtubule-Associated Proteins Protein Conformation alpha-Helical Spindle Apparatus