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Anti-ALK Antibodies in Patients with ALK-Positive Malignancies Not Expressing NPM-ALK.
The missing subject
Ayesha Siddiqi
Apr 21, 2022
Abstract: This paper suggests that the dominance of one debate on climate related conflict – establishing whether climate change leads to conflict, or not ‐ is the product of Imperial knowledge produced in the Global North...
Supporting the working but vulnerable
Ayesha Siddiqi
Mar 13, 2020
Disasters in conflict areas
Ayesha Siddiqi
Mar 13, 2020
Despite some 50 years of research, relatively little is known about how disasters in conflict areas are created and discursively framed, and how information on them is publicly consumed. The emphasis in disaster studies has...
Formulating Expectations for Future Water Availability through Infrastructure Development Decisions in Arid Regions
Water resources development options are usually selected on a least-cost basis. While economic considerations are dominant in choosing projects, there are also a mix of other factors including social demands,
political...
Politicized Policing in Pakistan
Unable to exorcise its nightmarish traits inherited as colonial legacy, police in Punjab is still seen as a publicfrightening rather than a public-friendly organization, which continues to promote a sense of fear rather than...
Scales of disaster
Geographical scholarship highlights social contracts as a valuable lens on the dynamic and contested balance of rights and responsibilities between risk governance players. We apply this lens to post-disaster response...
Stories from the frontlines
Disasters are framed as political moments when states are unable to provide security to their citizens, causing disruption and a possible 'break' in the state-citizen social contract. Evidence from the frontlines of insurgency...
Scientific Wealth in Middle East and North Africa
Several developing countries seek to build knowledge-based economies by attempting to expand scientific research capabilities. Characterizing the state and direction of progress in this arena is challenging but important. Here...
Politicized Policing in Pakistan
Unable to exorcise its nightmarish traits inherited as colonial legacy, police in Punjab is still seen as a publicfrightening rather than a public-friendly organization, which continues to promote a sense of fear rather than...
Situational and Trans-Situational Correlates of Public Energy Literacy
Background: Recent push for ‘energy democracy’ necessitates a well-informed citizenry vis-à-vis energy policy, especially in the wake of ideologically charged and divergent views about the existence and severity of climate...
The Chromatin Protein DUET/MMD1 Controls Expression of the Meiotic Gene TDM1 during Male Meiosis in Arabidopsis.
Meiosis produces haploid cells essential for sexual reproduction. In yeast, entry into meiosis activates transcription factors which trigger a transcriptional cascade that results in sequential co-expression of early, middle and...
Situational and Trans-Situational Correlates of Public Energy Literacy
Background: Recent push for ‘energy democracy’ necessitates a well-informed citizenry vis-à-vis energy policy, especially in the wake of ideologically charged and divergent views about the existence and severity of climate...
Is Ubiquitous Technology for Needs Data Management a Game Changer in Humanitarian Arena?
One in every 70 people around the world is caught up in a crisis (natural disasters, conflict, climate change, etc.) and urgently needs humanitarian assistance and protection according to the OCHA. The humanitarian community...
Published by: IGI Global Scientific Publishing
Design and development of a nozzle-free electrospinning device for the high-throughput production of biomaterial nanofibers
Muhammad Waqas, Antonios Keirouz, Maria Kana Sanira Putri, Faraz Fazal, Francisco Javier Diaz Sanchez, Dipa Ray, Vasileios Koutsos, Norbert Radacsi
Jun 30, 2021
This technical note provides a step-by-step guide for the design and construction of a temperature-controlled nozzle-free electrospinning device. The equipment uses a rotating mandrel partially immersed within a polymer...
Does the availability of a South Asian language in practices improve reports of doctor-patient communication from South Asian patients? Cross sectional analysis of a national patient survey in English general practices.
BACKGROUND: Ethnic minorities report poorer evaluations of primary health care compared to White British patients. Emerging evidence suggests that when a doctor and patient share ethnicity and/or language this is associated with...
Leucine Signals to mTORC1 via Its Metabolite Acetyl-Coenzyme A.
Sung Min Son, So Jung Park, Huikyong Lee, Farah Siddiqi, Jong Eun Lee, Fiona M Menzies, David C Rubinsztein
Sep 21, 2018
The mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) is a master regulator of cell growth and metabolism. Leucine (Leu) activates mTORC1 and many have tried to identify the mechanisms whereby cells sense Leu in this...
Exploring the structural basis of conformational heterogeneity and autoinhibition of human cGMP-specific protein kinase Iα through computational modelling and molecular dynamics simulations.
Arooma Maryam, Rana Rehan Khalid, Sundeep Chaitanya Vedithi, Abdulilah Ece, Suleyman Selim Çınaroğlu, Abdul Rauf Siddiqi, Tom L Blundell
Aug 04, 2020
Protein kinase Iα (PKGIα) is a pivotal cyclic guanosine monophosphate (cGMP) signalling protein. Major steps related to the structural plasticity of PKGIα have been inferred but the structural aspects of the auto-inhibition and...
LC3-positive structures are prominent in autophagy-deficient cells
Gautam Runwal, Eleanna Stamatakou, Farah H. Siddiqi, Claudia Puri, Ye Zhu, David C. Rubinsztein
Jul 11, 2020
Abstract: Autophagy is an evolutionarily conserved process across eukaryotes that degrades cargoes like aggregate-prone proteins, pathogens, damaged organelles and macromolecules via delivery to lysosomes. The process involves...
mTORC2 Assembly Is Regulated by USP9X-Mediated Deubiquitination of RICTOR.
Lidia Wrobel, Farah H Siddiqi, Sandra M Hill, Sung Min Son, Cansu Karabiyik, Hyunjeong Kim, David C Rubinsztein
Jan 19, 2021
The mechanistic target of rapamycin complex 2 (mTORC2) controls cell metabolism and survival in response to environmental inputs. Dysregulation of mTORC2 signaling has been linked to diverse human diseases, including cancer and...
RICTOR USP9X growth factor signaling mTORC2 Mechanistic Target of Rapamycin Complex 2 posttranslational modification ubiquitin-specific protease 9X Animals Cell Line Tumor Female Gene Expression Regulation Gene Knockdown Techniques HEK293 Cells HeLa Cells Humans Intercellular Signaling Peptides and Proteins Male Mechanistic Target of Rapamycin Complex 2 Mice Mice Inbred C57BL Protein Binding Protein Processing Post-Translational Rapamycin-Insensitive Companion of mTOR Protein Signal Transduction Ubiquitin Thiolesterase Ubiquitination
LC3-positive structures are prominent in autophagy-deficient cells.
Gautam Runwal, Eleanna Stamatakou, Farah H Siddiqi, Claudia Puri, Ye Zhu, David C Rubinsztein
Jul 02, 2019
Prospects for policy advances in science and technology in the Gulf Arab States
Science, technology, engineering and mathematics (STEM) policies in the Gulf Arab States are as diverse as the individual economies and political processes that characterize its member states. During the past decade, a number of...
XIAP and cIAP1 amplifications induce Beclin 1-dependent autophagy through NFκB activation.
Fang Lin, Ghita Ghislat, Shouqing Luo, Maurizio Renna, Farah Siddiqi, David C Rubinsztein
May 05, 2015
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