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Single-cell multi-omics profiling links dynamic DNA methylation to cell fate decisions during mouse early organogenesis.
Stephen J Clark, Ricard Argelaguet, Tim Lohoff, Felix Krueger, Deborah Drage, Berthold Göttgens, John C Marioni, Jennifer Nichols, Wolf Reik
Oct 11, 2022
BACKGROUND: Perturbation of DNA methyltransferases (DNMTs) and of the active DNA demethylation pathway via ten-eleven translocation (TET) methylcytosine dioxygenases results in severe developmental defects and embryonic...
Single-cell multi-omics profiling links dynamic DNA methylation to cell fate decisions during mouse early organogenesis.
Stephen J Clark, Ricard Argelaguet, Tim Lohoff, Felix Krueger, Deborah Drage, Berthold Göttgens, John C Marioni, Jennifer Nichols, Wolf Reik
Sep 26, 2022
BACKGROUND: Perturbation of DNA methyltransferases (DNMTs) and of the active DNA demethylation pathway via ten-eleven translocation (TET) methylcytosine dioxygenases results in severe developmental defects and embryonic...
The Lantern Vol. 66, No. 2, Spring 1999
Oana Nechita, Monica Stahl, Jill Gonzales, Mike Edwards, Benjamin Jackendoff, Leah Miller, Karen Hollinger, Jilda Hodges, Nathan Rosen, Ashley Claus, Robert Cerrone, Genevieve Romeo, Thomas Lipschultz, Jeffrey Church, Gregory Klein, Tom Howard, Corey Taylor, Carolyn Harfman, Daniel Gallagher, Andrew Gerchak, Lou Nemphos, Raquel Pidal, Paul Guidry
Jan 01, 0001
Dowry The Ballad of the Lonely Thinker Dissipation Parliament Light Reflecting Hood Tonight Decree Not Yet The Man in the Moon The Sound and/or Fury Uh Huh Watch The Futility of a Drizzle in a Worsening...
Ursinus College Collegeville Pennsylvania Lantern Literary Magazine poetry fiction Creative Nonfiction Arts and Humanities Creative Writing fiction illustration Nonfiction poetry
Published by: Ursinus College
Creating cellular diversity through transcription factor competition.
Berthold Göttgens
Apr 22, 2015
Drosophila phosphatidylinositol-4 kinase fwd promotes mitochondrial fission and can suppress Pink1/parkin phenotypes.
Animals Cytoskeletal Proteins Disease Models Animal Drosophila Proteins Drosophila melanogaster GTP-Binding Proteins Gene Expression Regulation Humans Locomotion Mitochondria Mitochondrial Dynamics mitophagy Mutant Proteins Nerve Degeneration Parkinson Disease Phosphotransferases (Alcohol Group Acceptor) Protein Serine-Threonine Kinases Ubiquitin-Protein Ligases
Lesions of abdominal connectives reveal a conserved organization of the calling song central pattern generator (CPG) network in different cricket species.
Although crickets move their front wings for sound production, the abdominal ganglia house the network of the singing central pattern generator. We compared the effects of specific lesions to the connectives of the abdominal...
Corollary discharge inhibition of wind-sensitive cercal giant interneurons in the singing field cricket.
Gryllus bimaculatus cercal escape pathway corollary discharge postsynaptic inhibition stridulation Action Potentials Animals Auditory Pathways Escape Reaction Gryllidae Interneurons Male Mechanoreceptors Motor Activity Neural Inhibition Physical Stimulation Presynaptic Terminals Vocalization Animal Wind
Behavioural integration of auditory and antennal stimulation during phonotaxis in the field cricket Gryllus bimaculatus.
Sorting apples from oranges in single-cell expression comparisons.
Two methods for comparing single-cell expression datasets help address the challenge of integrating data across conditions and experiments.
Dysregulation of haematopoietic stem cell regulatory programs in acute myeloid leukaemia.
Haematopoietic stem cells (HSC) are situated at the apex of the haematopoietic differentiation hierarchy, ensuring the life-long supply of mature haematopoietic cells and forming a reservoir to replenish the haematopoietic...
Surface electrodes record and label brain neurons in insects.
We used suction electrodes to reliably record the activity of identified ascending auditory interneurons from the anterior surface of the brain in crickets. Electrodes were gently attached to the sheath covering the projection...
auditory neurons Brain electrophoretic staining single cell recordings suction electrodes Acoustic Stimulation Action Potentials Animals Auditory Perception Brain Electrodes Female Fluorescent Dyes Gryllidae Neuroanatomical Tract-Tracing Techniques Neurons Restraint Physical Signal Processing Computer-Assisted
Feedforward discharges couple the singing central pattern generator and ventilation central pattern generator in the cricket abdominal central nervous system
Abstract: We investigated the central nervous coordination between singing motor activity and abdominal ventilatory pumping in crickets. Fictive singing, with sensory feedback removed, was elicited by eserine-microinjection into...
Structure, Activity and Function of a Singing CPG Interneuron Controlling Cricket Species-Specific Acoustic Signaling.
The evolution of species-specific song patterns is a driving force in the speciation of acoustic communicating insects. It must be closely linked to adaptations of the neuronal network controlling the underlying singing motor...
Reconstructing Gene Regulatory Networks That Control Hematopoietic Commitment.
Feedforward discharges couple the singing central pattern generator and ventilation central pattern generator in the cricket abdominal central nervous system
Abstract: We investigated the central nervous coordination between singing motor activity and abdominal ventilatory pumping in crickets. Fictive singing, with sensory feedback removed, was elicited by eserine-microinjection into...
Single cell genomics and developmental biology
Major developmental processes such as gastrulation and early embryogenesis rely on a complex network of cell-cell interactions, chromatin remodeling, and transcriptional regulators. This makes it challenging to study early...
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