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Exploring the molecular interface between hypoxia-inducible factor signalling and mitochondria.
Oxygen is required for the survival of the majority of eukaryotic organisms, as it is important for many cellular processes. Eukaryotic cells utilize oxygen for the production of biochemical energy in the form of adenosine...
What Training, Support, and Resourcing Do Health Professionals Need to Support People Using a Closed-Loop System? A Qualitative Interview Study with Health Professionals Involved in the Closed Loop from Onset in Type 1 Diabetes (CLOuD) Trial.
Barbara Kimbell, David Rankin, Nicole L Ashcroft, Lidiya Varghese, Janet M Allen, Charlotte K Boughton, Fiona Campbell, Atrayee Ghatak, Tabitha Randell, Rachel EJ Besser, Nicola Trevelyan, Roman Hovorka, Julia Lawton
Feb 17, 2020
Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion.
Elisa Vergari, Jakob G Knudsen, Reshma Ramracheya, Albert Salehi, Quan Zhang, Julie Adam, Ingrid Wernstedt Asterholm, Anna Benrick, Linford JB Briant, Margarita V Chibalina, Fiona M Gribble, Alexander Hamilton, Benoit Hastoy, Frank Reimann, Nils JG Rorsman, Ioannis I Spiliotis, Andrei Tarasov, Yanling Wu, Frances M Ashcroft, Patrik Rorsman
Feb 12, 2019
Hypoglycaemia (low plasma glucose) is a serious and potentially fatal complication of insulin-treated diabetes. In healthy individuals, hypoglycaemia triggers glucagon secretion, which restores normal plasma glucose levels by...
Animals Benzhydryl Compounds Blood Glucose Diabetes mellitus Female Glucagon Glucagon-Secreting Cells Glucosides Humans Hypoglycemia Insulin Male Mice Mice Inbred C57BL Mice Knockout Receptor Insulin Receptors Somatostatin Sodium-Glucose Transporter 2 Sodium-Glucose Transporter 2 Inhibitors Somatostatin
Akt2
Metastasis in breast cancer significantly increases morbidity and mortality. The 5-year survival rate reduces from 90% for localised disease to about 20% once metastasis has taken place. The phosphoinositide 3-kinase/Akt...
The Contextual Essentiality of Mitochondrial Genes in Cancer
Mitochondria are key organelles in eukaryotic evolution that perform crucial roles as metabolic and cellular signaling hubs. Mitochondrial function and dysfunction are associated with a range of diseases, including cancer....
Chemotherapy-mediated p53-dependent DNA damage response in clear cell renal cell carcinoma
The DNA-damaging agent camptothecin (CPT) and its analogs demonstrate clinical utility for the treatment of advanced solid tumors, and CPT-based nanopharmaceuticals are currently in clinical trials for advanced kidney cancer;...
Apigenin Apoptosis Basic Helix-Loop-Helix Transcription Factors camptothecin Carcinoma Renal Cell Cell Hypoxia Cell Line Tumor DNA Damage endothelin-1 Gene Expression Regulation Neoplastic Humans Hypoxia-Inducible Factor 1 alpha Subunit Kidney Neoplasms Mechanistic Target of Rapamycin Complex 1 Mechanistic Target of Rapamycin Complex 2 Multiprotein Complexes Protein Biosynthesis RNA Messenger Signal Transduction TOR Serine-Threonine Kinases Tumor Suppressor Protein p53
Inactivation of the von Hippel-Lindau tumour suppressor gene induces Neuromedin U expression in renal cancer cells.
BACKGROUND: 209 000 new cases of renal carcinoma are diagnosed each year worldwide and new therapeutic targets are urgently required. The great majority of clear cell renal cancer involves inactivation of VHL, which acts as a...
Adult onset global loss of the fto gene alters body composition and metabolism in the mouse.
Fiona McMurray, Chris D Church, Rachel Larder, George Nicholson, Sara Wells, Lydia Teboul, YC Loraine Tung, Debra Rimmington, Fatima Bosch, Veronica Jimenez, Giles SH Yeo, Stephen O'Rahilly, Frances M Ashcroft, Anthony P Coll, Roger D Cox
Jan 18, 2021
The strongest BMI-associated GWAS locus in humans is the FTO gene. Rodent studies demonstrate a role for FTO in energy homeostasis and body composition. The phenotypes observed in loss of expression studies are complex with...
Pharmacological activation of a novel p53-dependent S-phase checkpoint involving CHK-1.
We have recently shown that induction of the p53 tumour suppressor protein by the small-molecule RITA (reactivation of p53 and induction of tumour cell apoptosis; 2,5-bis(5-hydroxymethyl-2-thienyl)furan) inhibits...
Apoptosis Ataxia Telangiectasia Breast Neoplasms Cell Cycle Proteins Cell Line Tumor Checkpoint Kinase 1 Colorectal Neoplasms DNA Damage DNA Replication Female Furans Gene Knockdown Techniques Histones Humans Hypoxia Hypoxia-Inducible Factor 1 alpha Subunit Osteosarcoma Phosphorylation Protein Kinase Inhibitors Protein Kinases Replication Origin S Phase Signal Transduction Transfection Tumor Suppressor Protein p53
The Grizzly, October 25, 2018
Courtney A DuChene, Shelsea Deravil, Madison Rodak, Mark LeDuc, Kevin Leon, Sophia DiBattista, Daniel Walker, Gabriela Howell, Sam Rosenthal
Jan 01, 0001
New Discriminatory Act Policy Draws Criticism Radium Girls Will Take the Stage this November Good and Bad News on Campus Safety Dr. Tristan Ashcroft Receives Teaching Excellence Award L.A.X. Strives to Meet the Need for...
Ursinus College Collegeville Pennsylvania newspaper discrimination theater Meghan Brodie campus safety Tristan Ashcroft Latinx Quinn Gilman-Forlini Rugby Football Kirk Cherneskie cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
2013 LEWIS THOMAS PRIZE
The Rockefeller University
Jan 01, 0001
Frances Ashcroft, Ph.D., recipient of the 2013 Lewis Thomas Prize
Singing the Body Electric
The Lewis Thomas Prize for Writing about Science is an international award that honors the "scientist as poet" and recognizes "the rare...
Published by: The Rockefeller University
Spatial distribution of clinical computer systems in primary care in England in 2016 and implications for primary care electronic medical record databases
Evangelos Kontopantelis, Richard John Stevens, Peter J Helms, Duncan Edwards, Tim Doran, Darren M Ashcroft
Jul 18, 2018
OBJECTIVES: UK primary care databases (PCDs) are used by researchers worldwide to inform clinical practice. These databases have been primarily tied to single clinical computer systems, but little is known about the adoption of...
Genome-wide CRISPR/Cas9 deletion screen defines mitochondrial gene essentiality and identifies routes for tumour cell viability in hypoxia
Luke W. Thomas, Cinzia Esposito, Rachel E. Morgan, Stacey Price, Jamie Young, Steven P. Williams, Lucas A. Maddalena, Ultan McDermott, Margaret Ashcroft
May 21, 2021
Hypoxia-induced nitric oxide production and tumour perfusion is inhibited by pegylated arginine deiminase (ADI-PEG20).
Natalie Burrows, Gaelle Cane, Mathew Robson, Edoardo Gaude, William J Howat, Peter W Szlosarek, R Barbara Pedley, Christian Frezza, Margaret Ashcroft, Patrick H Maxwell
Mar 01, 2016
Animals Arginine Argininosuccinate Synthase Basic Helix-Loop-Helix Transcription Factors Blotting Western Cell Hypoxia Cell Line Tumor HCT116 Cells Humans Hydrolases Hypoxia Hypoxia-Inducible Factor 1 alpha Subunit Mechanistic Target of Rapamycin Complex 1 Mice SCID Multiprotein Complexes Neoplasms Nitric oxide Nitric Oxide Synthase Type II Perfusion Polyethylene Glycols TOR Serine-Threonine Kinases Tumor Burden Unfolded Protein Response Vascular Endothelial Growth Factor A Xenograft Model Antitumor Assays
Factor inhibiting HIF (FIH-1) promotes renal cancer cell survival by protecting cells from HIF-1α-mediated apoptosis.
MN Khan, T Bhattacharyya, P Andrikopoulos, MA Esteban, R Barod, T Connor, M Ashcroft, PH Maxwell, S Kiriakidis
Mar 21, 2019
BACKGROUND: Clear cell renal cell carcinoma (CCRCC) is the commonest form of kidney cancer. Up to 91% have biallelic inactivation of VHL, resulting in stabilisation of HIF-α subunits. Factor inhibiting HIF-1 is an enzyme that...
Psychological Well-Being of Parents of Very Young Children With Type 1 Diabetes – Baseline Assessment
Carine de Beaufort, Ineke M. Pit-ten Cate, Ulrike Schierloh, Nathan Cohen, Charlotte K. Boughton, Martin Tauschmann, Janet M. Allen, Katrin Nagl, Maria Fritsch, James Yong, Emily Metcalfe, Dominique Schaeffer, Muriel Fichelle, Alena G. Thiele, Daniela Abt, Kerstin Faninger, Julia K. Mader, Sonja Slegtenhorst, Nicole Ashcroft, Malgorzata E. Wilinska, Judy Sibayan, Craig Kollman, Sabine E. Hofer, Elke Fröhlich-Reiterer, Thomas M. Kapellen, Carlo L. Acerini, Fiona Campbell, Birgit Rami-Merhar, Roman Hovorka
Aug 27, 2021
Background: Type 1 diabetes in young children is a heavy parental burden. As part of pilot phase of the KIDSAP01 study, we conducted a baseline assessment in parents to study the association between hypoglycemia fear, parental...
Genome-wide CRISPR/Cas9 deletion screen defines mitochondrial gene essentiality and identifies routes for tumour cell viability in hypoxia.
Luke W Thomas, Cinzia Esposito, Rachel E Morgan, Stacey Price, Jamie Young, Steven P Williams, Lucas A Maddalena, Ultan McDermott, Margaret Ashcroft
Jun 22, 2021
Mitochondria are typically essential for the viability of eukaryotic cells, and utilize oxygen and nutrients (e.g. glucose) to perform key metabolic functions that maintain energetic homeostasis and support proliferation. Here...
Published by: Communications biology
CHCHD4 regulates tumour proliferation and EMT-related phenotypes, through respiratory chain-mediated metabolism.
Luke W Thomas, Cinzia Esposito, Jenna M Stephen, Ana SH Costa, Christian Frezza, Thomas S Blacker, Gyorgy Szabadkai, Margaret Ashcroft
Jun 28, 2019
BACKGROUND: Mitochondrial oxidative phosphorylation (OXPHOS) via the respiratory chain is required for the maintenance of tumour cell proliferation and regulation of epithelial to mesenchymal transition (EMT)-related phenotypes...
Diminished macrophage apoptosis and reactive oxygen species generation after phorbol ester stimulation in Crohn's disease.
Christine D Palmer, Farooq Z Rahman, Gavin W Sewell, Afshan Ahmed, Margaret Ashcroft, Stuart L Bloom, Anthony W Segal, Andrew M Smith
Jul 17, 2020
BACKGROUND: Crohn's Disease (CD) is a chronic relapsing disorder characterized by granulomatous inflammation of the gastrointestinal tract. Although its pathogenesis is complex, we have recently shown that CD patients have a...
CHCHD4 regulates tumour proliferation and EMT-related phenotypes, through respiratory chain-mediated metabolism
Luke W. Thomas, Cinzia Esposito, Jenna M. Stephen, Ana S. H. Costa, Christian Frezza, Thomas S. Blacker, Gyorgy Szabadkai, Margaret Ashcroft
Jul 15, 2020
Abstract: Background: Mitochondrial oxidative phosphorylation (OXPHOS) via the respiratory chain is required for the maintenance of tumour cell proliferation and regulation of epithelial to mesenchymal transition (EMT)-related...
CHCHD4 confers metabolic vulnerabilities to tumour cells through its control of the mitochondrial respiratory chain.
Luke W Thomas, Jenna M Stephen, Cinzia Esposito, Simon Hoer, Robin Antrobus, Afshan Ahmed, Hasan Al-Habib, Margaret Ashcroft
Feb 15, 2019
BACKGROUND: Tumour cells rely on glycolysis and mitochondrial oxidative phosphorylation (OXPHOS) to survive. Thus, mitochondrial OXPHOS has become an increasingly attractive area for therapeutic exploitation in cancer. However...
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