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Wet winter pore pressures in railway embankments
This paper demonstrates the influence of extreme wet winter weather on pore water pressures within clay fill railway embankments, using field monitoring data and numerical modelling. Piezometer readings taken across the London...
Mechanical and hydrological impacts of tree removal on a clay fill railway embankment
Seasonal shrinkage and swelling of clay fill railway embankments can disturb the track geometry, resulting in train speed restrictions that disrupt normal operations. Such movements are exacerbated by vegetation, but reliable...
Wet winter pore pressures in railway embankments
This paper demonstrates the influence of extreme wet winter weather on pore water pressures within clay fill railway embankments, using field monitoring data and numerical modelling. Piezometer readings taken across the London...
Interpreting the influence of tree root water uptake on the long term hydrology of a clay fill railway embankment
This paper uses a numerical model to investigate the influence of tree root water uptake on pore water pressures and the vertical displacement of a clay fill railway embankment. The simulated results of soil wetting and drying...
climate model Embankment Railway Trees vegetation /dk/atira/pure/subjectarea/asjc/1900/1909 name=Geotechnical Engineering and Engineering Geology /dk/atira/pure/subjectarea/asjc/2200/2205 name=Civil and Structural Engineering /dk/atira/pure/sustainabledevelopmentgoals/climate_action name=SDG 13 - Climate Action
Mechanical and hydrological impacts of tree removal on a clay fill railway embankment
Seasonal shrinkage and swelling of clay fill railway embankments can disturb the track geometry, resulting in train speed restrictions that disrupt normal operations. Such movements are exacerbated by vegetation, but reliable...
Managing the extent of tree removal from railway earthwork slopes
Trees cover the slopes of many earthworks (embankments and cuttings) supporting the UK’s rail network. Trees provide ecological and slope stability benefits to earthwork slopes but they can also cause seasonal shrinking and...
Single-Cell Transcriptomics of Regulatory T Cells Reveals Trajectories of Tissue Adaptation.
Ricardo J Miragaia, Tomás Gomes, Agnieszka Chomka, Laura Jardine, Angela Riedel, Ahmed N Hegazy, Natasha Whibley, Andrea Tucci, Xi Chen, Ida Lindeman, Guy Emerton, Thomas Krausgruber, Jacqueline Shields, Muzlifah Haniffa, Fiona Powrie, Sarah A Teichmann
Mar 05, 2019
Non-lymphoid tissues (NLTs) harbor a pool of adaptive immune cells with largely unexplored phenotype and development. We used single-cell RNA-seq to characterize 35,000 CD4+ regulatory (Treg) and memory (Tmem) T cells in mouse...
Managing the extent of tree removal from railway earthwork slopes
Trees cover the slopes of many earthworks (embankments and cuttings) supporting the UK’s rail network. Trees provide ecological and slope stability benefits to earthwork slopes but they can also cause seasonal shrinking and...
Deconvolution of monocyte responses in inflammatory bowel disease reveals an IL-1 cytokine network that regulates IL-23 in genetic and acquired IL-10 resistance.
Dominik Aschenbrenner, Maria Quaranta, Soumya Banerjee, Nicholas Ilott, Joanneke Jansen, Boyd Steere, Yin-Huai Chen, Stephen Ho, Karen Cox, Carolina V Arancibia-Cárcamo, Mark Coles, Eamonn Gaffney, Simon PL Travis, Lee Denson, Subra Kugathasan, Jochen Schmitz, Fiona Powrie, Stephen N Sansom, Holm H Uhlig
Jul 01, 2021
OBJECTIVE: Dysregulated immune responses are the cause of IBDs. Studies in mice and humans suggest a central role of interleukin (IL)-23-producing mononuclear phagocytes in disease pathogenesis. Mechanistic insights into the...
inflammatory bowel disease Interleukins Mucosal immunology Adolescent Adult Aged Aged 80 and over Autocrine Communication Cells Cultured Drug Resistance Female Gene Expression Gene Expression Regulation Gene Regulatory Networks Homeostasis Humans Inflammatory Bowel Diseases Interleukin-10 Interleukin-1alpha Interleukin-1beta Interleukin-23 Subunit p19 Lipopolysaccharides Male Middle Aged Monocytes Paracrine Communication Receptors Interleukin-10 Signal Transduction Transcriptome Tumor Necrosis Factor-alpha Young Adult
Interpreting the influence of tree root water uptake on the long term hydrology of a clay fill railway embankment
This paper uses a numerical model to investigate the influence of tree root water uptake on pore water pressures and the vertical displacement of a clay fill railway embankment. The simulated results of soil wetting and drying...
climate model Embankment Railway Trees vegetation /dk/atira/pure/subjectarea/asjc/1900/1909 name=Geotechnical Engineering and Engineering Geology /dk/atira/pure/subjectarea/asjc/2200/2205 name=Civil and Structural Engineering /dk/atira/pure/sustainabledevelopmentgoals/climate_action name=SDG 13 - Climate Action
Circulating and Tissue-Resident CD4+ T Cells With Reactivity to Intestinal Microbiota Are Abundant in Healthy Individuals and Function Is Altered During Inflammation.
Ahmed N Hegazy, Nathaniel R West, Michael JT Stubbington, Emily Wendt, Kim IM Suijker, Angeliki Datsi, Sebastien This, Camille Danne, Suzanne Campion, Sylvia H Duncan, Benjamin MJ Owens, Holm H Uhlig, Andrew McMichael, Oxford IBD Cohort Investigators, Andreas Bergthaler, Sarah A Teichmann, Satish Keshav, Fiona Powrie
May 14, 2019
BACKGROUND & AIMS: Interactions between commensal microbes and the immune system are tightly regulated and maintain intestinal homeostasis, but little is known about these interactions in humans. We investigated responses of...
Cytokines immune regulation Microbiota Tissue-resident Memory T cells Bacteria CD4 Lymphocyte Count CD4-Positive T-Lymphocytes Case-Control Studies Cell Line Colitis Ulcerative Crohn Disease Gastrointestinal Microbiome Host-Pathogen Interactions Humans Immunity mucosal Immunologic Memory Interleukin-17 Intestines Phenotype Receptors Antigen T-Cell alpha-beta Th17 Cells
Deconvolution of monocyte responses in inflammatory bowel disease reveals an IL-1 cytokine network that regulates IL-23 in genetic and acquired IL-10 resistance
Dominik Aschenbrenner, Maria Quaranta, Soumya Banerjee, Nicholas Ilott, Joanneke Jansen, Boyd Steere, Yin-Huai Chen, Stephen Ho, Karen Cox, Carolina V Arancibia-Cárcamo, Mark Coles, Eamonn Gaffney, Simon PL Travis, Lee Denson, Subra Kugathasan, Jochen Schmitz, Fiona Powrie, Stephen N Sansom, Holm H Uhlig
Jun 29, 2021
Objective: Dysregulated immune responses are the cause of IBDs. Studies in mice and humans suggest a central role of interleukin (IL)-23-producing mononuclear phagocytes in disease pathogenesis. Mechanistic insights into the...
Deconvolution of monocyte responses in inflammatory bowel disease reveals an IL-1 cytokine network that regulates IL-23 in genetic and acquired IL-10 resistance
Dominik Aschenbrenner, Maria Quaranta, Soumya Banerjee, Nicholas Ilott, Joanneke Jansen, Boyd Steere, Yin-Huai Chen, Stephen Ho, Karen Cox, Carolina V Arancibia-Cárcamo, Mark Coles, Eamonn Gaffney, Simon PL Travis, Lee Denson, Subra Kugathasan, Jochen Schmitz, Fiona Powrie, Stephen N Sansom, Holm H Uhlig
Oct 13, 2020
Objective: Dysregulated immune responses are the cause of IBDs. Studies in mice and humans suggest a central role of interleukin (IL)-23-producing mononuclear phagocytes in disease pathogenesis. Mechanistic insights into the...
Interleukin-22 promotes phagolysosomal fusion to induce protection against Salmonella enterica Typhimurium in human epithelial cells.
Jessica L Forbester, Emily A Lees, David Goulding, Sally Forrest, Amy Yeung, Anneliese Speak, Simon Clare, Eve L Coomber, Subhankar Mukhopadhyay, Judith Kraiczy, Fernanda Schreiber, Trevor D Lawley, Robert EW Hancock, Holm H Uhlig, Matthias Zilbauer, Fiona Powrie, Gordon Dougan
Feb 15, 2019
Intestinal epithelial cells (IECs) play a key role in regulating immune responses and controlling infection. However, the direct role of IECs in restricting pathogens remains incompletely understood. Here, we provide evidence...
β-cell specific T-lymphocyte response has a distinct inflammatory phenotype in children with Type 1 diabetes compared with adults.
S Arif, VB Gibson, V Nguyen, PJ Bingley, JA Todd, C Guy, DB Dunger, CM Dayan, J Powrie, A Lorenc, M Peakman
May 13, 2016
The disputed sound of the aurora borealis
Fiona Amery
Aug 18, 2021
This paper discusses heightened interest in the potential audibility of the aurora borealis during the First and Second International Polar Years (IPYs) of 1882–3 and 1932–3. Galvanized by a growing volume of local accounts...
Third molar development in a London population of White British and Black British or other Black ethnicity.
18-year-old threshold African ancestry Black British and White British ethnic groups Demirjian stages London population dental age estimation Ethnicity forensic odontology third molar development Adolescent Age Determination by Teeth Anodontia Ethnicity Female Humans Infant London Male Molar Third Radiography Panoramic
The disputed sound of the aurora borealis
This paper discusses heightened interest in the potential audibility of the aurora borealis during the First and Second International Polar Years (IPYs) of 1882–3 and 1932–3. Galvanized by a growing volume...
Fiona Amery
Feb 02, 2022
The disputed sound of the aurora borealis
This paper discusses heightened interest in the potential audibility of the aurora borealis during the First and Second International Polar Years (IPYs) of 1882–3 and 1932–3. Galvanized by a growing volume...
Fiona Amery
Aug 26, 2021
Study protocol: the effectiveness and cost effectiveness of an employer-led intervention to increase walking during the daily commute
Fiona Gillison
Feb 18, 2015
Background
Physical inactivity increases the risk of many chronic diseases including coronary heart disease, type 2 diabetes and some cancers. It is recommended that adults should undertake at least 150 minutes of moderate...
Physical inactivity increases the risk of many chronic diseases including coronary heart disease, type 2 diabetes and some cancers. It is recommended that adults should undertake at least 150 minutes of moderate...
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