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Cover Image for The SOFA score-development, utility and challenges of accurate assessment in clinical trials. View Article
The SOFA score-development, utility and challenges of accurate assessment in clinical trials.
Simon Lambden, Pierre Francois Laterre, Mitchell M Levy, Bruno Francois
Jan 02, 2020
The Sequential Organ Failure Assessment or SOFA score was developed to assess the acute morbidity of critical illness at a population level and has been widely validated as a tool for this purpose across a range of healthcare...
Sepsis Multiple Organ Failure Clinical Trials Surrogate Endpoints SoFa Sequential Organ Failure Assessment Critical Care Trials
Cover Image for AN ASSESSMENT OF FRANCOIS BERNIER’S TRAVEL ACCOUNT View Article
AN ASSESSMENT OF FRANCOIS BERNIER’S TRAVEL ACCOUNT
Sakul Kundra
Dec 14, 2019
French commercial and, later, political expansion in South Asia from 1600 to 1800 has attracted the attention of many historians. French travellers played a significant part in exploring overseas markets and establishing...
Published by: Department of History, University of Karachi
Cover Image for The SOFA score-development, utility and challenges of accurate assessment in clinical trials. View Article
The SOFA score-development, utility and challenges of accurate assessment in clinical trials.
Simon Lambden, Pierre Francois Laterre, Mitchell M Levy, Bruno Francois
Nov 26, 2020
The Sequential Organ Failure Assessment or SOFA score was developed to assess the acute morbidity of critical illness at a population level and has been widely validated as a tool for this purpose across a range of healthcare...
Clinical Trials Critical Care Trials Multiple Organ Failure SoFa Sepsis Sequential Organ Failure Assessment Surrogate Endpoints Clinical Trials as Topic Humans Organ Dysfunction Scores Program Development Research Severity of Illness Index
Cover Image for An age structured demographic theory of technological change View Article
An age structured demographic theory of technological change
Jean-Francois Mercure
Jun 23, 2015
Technology transitions Lotka-Volterra Replicator dynamics Evolutionary economics Discrete choice theory
Cover Image for Structural biology of DOCK-family guanine nucleotide exchange factors. View Article
Structural biology of DOCK-family guanine nucleotide exchange factors.
Andreas Boland, Jean-Francois Côté, David Barford
Nov 04, 2022
DOCK proteins are a family of multi-domain guanine nucleotide exchange factors (GEFs) that activate the RHO GTPases CDC42 and RAC1, thereby regulating several RHO GTPase-dependent cellular processes. DOCK proteins are...
Cdc42 DOCK proteins Rac1 Guanine Nucleotide Exchange Factors Guanine Nucleotide Exchange Factors cdc42 GTP-Binding Protein rho GTP-Binding Proteins Signal Transduction Nucleotides Biology rac1 GTP-Binding Protein
Cover Image for Designing E-Government Legal Institutions View Article
Designing E-Government Legal Institutions
Francois Duhamel, Rodrigo Sandoval-Almazán
Jan 01, 2021
The aim of this article is to understand the way digital government laws are designed through the analysis and comparison of general objectives, governance mechanisms and roles assigned to stakeholders of six local state digital...
Public & Sector Management Government and Law Electronic Government
Published by: IGI Global Scientific Publishing
Cover Image for The Lantern Vol. 27, No. 3, Fall 1960 View Article
The Lantern Vol. 27, No. 3, Fall 1960
Joel Roberts, Phil Rowe, Phyllis W. Furst, Steve Dearsley, Carol Flood, Jill Springer, Naomi Ruth Herre, Betty Heale, J. H. Ryan, Bea Hauer, Michael Boris, Pete Vennema, Anne Mendelson, Sandy L. Pfaffhausen, Timothy H. C. R. Combe
Jan 01, 0001
Thoughts in DaVinici's Coffeehouse Kinesiology Class No One is Named Alistair The Beat Generation The Super Highway Blues Panic and the Mountain Peak The Lake Later Ares The Light The Room Thoughts After...
Ursinus College Collegeville Pennsylvania Lantern Literary Magazine poetry fiction Creative Nonfiction religion James L. Boswell Arts and Humanities Creative Writing fiction illustration Nonfiction poetry
Published by: Ursinus College
Cover Image for The Ursinus Weekly, March 4, 1929 View Article
The Ursinus Weekly, March 4, 1929
C. Richard Snyder, Malcolm E. Barr, George Leslie Omwake
Jan 01, 0001
Ursinus represented at luncheon given in honor of Mary E. Wooley Contracts awarded for 1930 Ruby work Week of prayer led by Mr. Phillips Elliott an inspiring event Co-eds basketball team bows to Cedar Crest college College...
Ursinus College Collegeville Pennsylvania newspaper Basketball Poems scarlet fever cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
Cover Image for Cinematic Interpretation of Spatiality View Article
Cinematic Interpretation of Spatiality
Janina SCHUPP, Andong LU, Francois Penz
Aug 05, 2019
Cinematic expression of spatiality Practice-based participatory research The everyday Chinese gardens Spatial cultural differences
Cover Image for Health Determinants among North Americans Experiencing Homelessness and Traumatic Brain Injury View Article
Health Determinants among North Americans Experiencing Homelessness and Traumatic Brain Injury
Kaitlin J Zeiler, Alwyn Gomez, Francois Mathieu, Frederick A Zeiler
Jan 28, 2022
Traumatic brain injury (TBI) in those experiencing homelessness has been described in recent literature as a contributor to increased morbidity, decreased functional independence, and early mortality. In this systematically...
North America Determinants of health Homeless Traumatic brain injury
Cover Image for The behavioural aspect of green technology investments View Article
The behavioural aspect of green technology investments
Florian Knobloch, Jean-Francois Mercure
Mar 30, 2016
green technologies technology adoption energy efficiency gap policy assessment behavioural science
Cover Image for Centrosome centering and decentering by microtubule network rearrangement. View Article
Centrosome centering and decentering by microtubule network rearrangement.
Gaëlle Letort, Francois Nedelec, Laurent Blanchoin, Manuel Théry
Jul 29, 2020
The centrosome is positioned at the cell center by pushing and pulling forces transmitted by microtubules (MTs). Centrosome decentering is often considered to result from asymmetric, cortical pulling forces exerted in particular...
Animals Cell Membrane Cell Polarity Centrosome Computer Simulation Dyneins Humans Microtubules Molecular Motor Proteins Spindle Apparatus
Cover Image for Field evidence of swash groundwater circulation in the microtidal rousty beach, France View Article
Field evidence of swash groundwater circulation in the microtidal rousty beach, France
Damien Sous, Lise Petitjean, Frédéric Bouchette, Vincent Rey, Samuel Meulé, Francois Sabatier, Kévin Martins
Nov 01, 2016

This manuscript reports on a novel field experiment carried out on a microtidal beach in Camargue, France. For the first time in the field, a comprehensive description of the groundwater dynamics under sandy beach swash zone...

Groundwater circulation porous media Sand beach Swash zone
Cover Image for Field evidence of swash groundwater circulation in the microtidal rousty beach, France View Article
Field evidence of swash groundwater circulation in the microtidal rousty beach, France
Damien Sous, Lise Petitjean, Frédéric Bouchette, Vincent Rey, Samuel Meulé, Francois Sabatier, Kévin Martins
Nov 01, 2016

This manuscript reports on a novel field experiment carried out on a microtidal beach in Camargue, France. For the first time in the field, a comprehensive description of the groundwater dynamics under sandy beach swash zone...

Groundwater circulation porous media Sand beach Swash zone
Cover Image for Epidemiology of intra-abdominal infection and sepsis in critically ill patients View Article
Epidemiology of intra-abdominal infection and sepsis in critically ill patients
Stijn Blot, Massimo Antonelli, Kostoula Arvaniti, Koen Blot, Ben Creagh-Brown, Dylan de Lange, Jan De Waele, Mieke Deschepper, Yalim Dikmen, George Dimopoulos, Christian Eckmann, Guy Francois, Massimo Girardis, Despoina Koulenti, Sonia Labeau, Jeffrey Lipman, Fernando Lipovestky, Emilio Maseda, Philippe Montravers, Adam Mikstacki, José-Artur Paiva, Cecilia Pereyra, Jordi Rello, Jean-Francois Timsit, Dirk Vogelaers, Abdominal Sepsis Study (AbSeS) group on behalf of the Trials Group of the European Society of Intensive Care Medicine
Jan 09, 2020
PURPOSE: To describe the epidemiology of intra-abdominal infection in an international cohort of ICU patients according to a new system that classifies cases according to setting of infection acquisition (community-acquired...
Intensive Care Intra-abdominal infection Mortality multidrug resistance Peritonitis Sepsis Aged Cause of Death Cohort Studies Critical Illness Epidemiologic Studies Female Humans Intraabdominal Infections Male Middle Aged Risk Factors Sepsis
Cover Image for Geometrical and mechanical properties control actin filament organization. View Article
Geometrical and mechanical properties control actin filament organization.
Gaëlle Letort, Antonio Z Politi, Hajer Ennomani, Manuel Théry, Francois Nedelec, Laurent Blanchoin
Jul 29, 2020
The different actin structures governing eukaryotic cell shape and movement are not only determined by the properties of the actin filaments and associated proteins, but also by geometrical constraints. We recently demonstrated...
Actin Cytoskeleton Animals Biomechanical Phenomena Computational Biology Computer Simulation Humans In Vitro Techniques Models Molecular Protein Multimerization
Cover Image for Rationale and protocol for the efficacy, safety and tolerability of nangibotide in patients with septic shock (ASTONISH) phase IIb randomised controlled trial. View Article
Rationale and protocol for the efficacy, safety and tolerability of nangibotide in patients with septic shock (ASTONISH) phase IIb randomised controlled trial.
Bruno Francois, Simon Lambden, Sebastien Gibot, Marc Derive, Aurelie Olivier, Valerie Cuvier, Stephan Witte, Jean-Marie Grouin, Jean Jacques Garaud, Margarita Salcedo-Magguilli, Mitchell Levy, Pierre-François Laterre
Aug 11, 2021
INTRODUCTION: Septic shock is the subgroup of patients with sepsis, which presents as vasopressor dependence, an elevated blood lactate concentration and is associated with a mortality of at least 30%. Expression of the...
adult intensive & critical care Clinical Trials Infectious Diseases Belgium Finland France Humans Ireland Randomized Controlled Trials as Topic Shock Septic Spain Treatment Outcome
Cover Image for Preliminary Design of DC Resistive Superconducting Fault Current Limiter for ASCEND View Article
Preliminary Design of DC Resistive Superconducting Fault Current Limiter for ASCEND
Jintao Hu, Jiawen Xi, Zhongying Wang, Vincent Zeng, Emelie Nilsson, Jean Francois Rouquette, Ludovic Ybanez, Xiaoze Pei
May 01, 2024

Airbus UpNext has launched an Advanced Superconducting and Cryogenic Experimental powertraiN Demonstrator (ASCEND) project in 2021 to develop a superconducting electric aircraft propulsion system. The demonstrator system...

Resistive superconducting fault current limiter (RSFCL) Electric aircraft sub-cooled liquid nitrogen
Cover Image for Integration of Superconducting Fault Current Limiter and DC Circuit Breaker for Electric Aircraft DC Network View Article
Integration of Superconducting Fault Current Limiter and DC Circuit Breaker for Electric Aircraft DC Network
Jiawen Xi, Zhongying Wang, Jintao Hu, Xianwu Zeng, Emelie Nilsson, Ludovic Ybanez, Jean Francois Rouquette, Xiaoze Pei
May 01, 2024

Large-scale electric aircraft are a promising technology that could revolutionise air travel to reduce the environmental impact. Fault current limitation and interruption technology is crucial to realise the safety and...

Aircraft capacitors circuit breakers cryogenic DC circuit breaker Fault currents high-temperature superconductors MOSFET Prototypes sub-cooled liquid nitrogen Superconducting fault current limiter
Cover Image for Evolution of large males is associated with female-skewed adult sex ratios in amniotes View Article
Evolution of large males is associated with female-skewed adult sex ratios in amniotes
András Liker, Veronika Bókony, Ivett Pipoly, Jean Francois Lemaître, Jean Michel Gaillard, Tamás Székely, Robert P. Freckleton
Jul 19, 2021

Body size often differs between the sexes (leading to sexual size dimorphism, SSD), as a consequence of differential responses by males and females to selection pressures. Adult sex ratio (ASR, the proportion of males in the...

comparative method mating competition mating opportunity sex-biased mortality sexual selection
Cover Image for Evolution of large males is associated with female-skewed adult sex ratios in amniotes View Article
Evolution of large males is associated with female-skewed adult sex ratios in amniotes
András Liker, Veronika Bókony, Ivett Pipoly, Jean Francois Lemaître, Jean Michel Gaillard, Tamás Székely, Robert P. Freckleton
Jul 19, 2021

Body size often differs between the sexes (leading to sexual size dimorphism, SSD), as a consequence of differential responses by males and females to selection pressures. Adult sex ratio (ASR, the proportion of males in the...

comparative method mating competition mating opportunity sex-biased mortality sexual selection
Cover Image for Gate Driver Design for Cryogenically Cooled Power Electronic Converters View Article
Gate Driver Design for Cryogenically Cooled Power Electronic Converters
Adel Deriszadeh, Xianwu Zeng, Ravi-Kiran Surapaneni, Gowtham Galla, Emelie Nilsson, Jean Francois Rouquette, Ludovic Ybanez, Xiaoze Pei
May 01, 2024

This article explores the design and experimental validation of an isolated half-bridge DC-DC converter customized for cryogenic environments, addressing the challenges posed by extreme low temperatures. The key contribution...

DC-DC converter Cryogenic Power Electronics Electric aircraft half-bridge converter isolated gate driver
Cover Image for Integration of Superconducting Fault Current Limiter and DC Circuit Breaker for Electric Aircraft DC Network View Article
Integration of Superconducting Fault Current Limiter and DC Circuit Breaker for Electric Aircraft DC Network
Jiawen Xi, Zhongying Wang, Jintao Hu, Xianwu Zeng, Emelie Nilsson, Ludovic Ybanez, Jean Francois Rouquette, Xiaoze Pei
May 01, 2024

Large-scale electric aircraft are a promising technology that could revolutionise air travel to reduce the environmental impact. Fault current limitation and interruption technology is crucial to realise the safety and...

Aircraft capacitors circuit breakers cryogenic DC circuit breaker Fault currents high-temperature superconductors MOSFET Prototypes sub-cooled liquid nitrogen Superconducting fault current limiter
Cover Image for Preliminary Design of DC Resistive Superconducting Fault Current Limiter for ASCEND View Article
Preliminary Design of DC Resistive Superconducting Fault Current Limiter for ASCEND
Jintao Hu, Jiawen Xi, Zhongying Wang, Vincent Zeng, Emelie Nilsson, Jean Francois Rouquette, Ludovic Ybanez, Xiaoze Pei
May 01, 2024

Airbus UpNext has launched an Advanced Superconducting and Cryogenic Experimental powertraiN Demonstrator (ASCEND) project in 2021 to develop a superconducting electric aircraft propulsion system. The demonstrator system...

Resistive superconducting fault current limiter (RSFCL) Electric aircraft sub-cooled liquid nitrogen
Cover Image for Development and performance of a parsimonious model to estimate temperature in sewer networks View Article
Development and performance of a parsimonious model to estimate temperature in sewer networks
Jorge A. Elías-Maxil, Jan Hofman, Bas Wols, Francois Clemens, Jan Peter Van Der Hoek, Luuk Rietveld
Jan 01, 0001
This paper presents a model (inspired in another model) to calculate water temperature in free-surface flow with two main innovations: the convective heat transfer occurs only at the wetted perimeter of pipes, and the model was...

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