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Results: 99
Oligomer Diversity during the Aggregation of the Repeat Region of Tau.
Magnus Kjaergaard, Alexander J Dear, Franziska Kundel, Seema Qamar, Georg Meisl, Tuomas PJ Knowles, David Klenerman
Sep 20, 2018
aggregation mechanism amyloid oligomers Kinetic modeling single-molecule FRET Tau Amyloid beta-Peptides Codon Fluorescence Resonance Energy Transfer Genes Synthetic Humans Kinetics Models Molecular Neurofibrillary Tangles Polymers protein aggregation Pathological single molecule imaging tau Proteins
Insoluble tau aggregates induce neuronal death through modification of membrane ion conductance, activation of voltage-gated calcium channels and NADPH oxidase.
Noemi Esteras, Franziska Kundel, Giuseppe F Amodeo, Evgeny V Pavlov, David Klenerman, Andrey Y Abramov
May 11, 2020
BLM NADPH oxidase insoluble tau nifedipine voltage-gated calcium channels Amyloid beta-Peptides Animals Animals Newborn Astrocytes Calcium Calcium Channels Cell Death Coculture Techniques Gene Expression Regulation Humans NADPH Oxidases Neurons Nifedipine Oxidation-Reduction Primary Cell Culture Protein Aggregates Rats Rats Sprague-Dawley Reactive Oxygen Species Thapsigargin Verapamil tau Proteins
Shedding light on aberrant interactions - a review of modern tools for studying protein aggregates.
Franziska Kundel, Laura Tosatto, Daniel R Whiten, David C Wirthensohn, Mathew H Horrocks, David Klenerman
May 16, 2018
The link between protein aggregation and neurodegenerative disease is well established. However, given the heterogeneity of species formed during the aggregation process, it is difficult to delineate details of the molecular...
Hsp70 Inhibits the Nucleation and Elongation of Tau and Sequesters Tau Aggregates with High Affinity.
Franziska Kundel, Suman De, Patrick Flagmeier, Mathew H Horrocks, Magnus Kjaergaard, Sarah L Shammas, Sophie E Jackson, Christopher M Dobson, David Klenerman
Mar 13, 2018
Measurement of Tau Filament Fragmentation Provides Insights into Prion-like Spreading.
Franziska Kundel, Liu Hong, Benjamin Falcon, William A McEwan, Thomas CT Michaels, Georg Meisl, Noemi Esteras, Andrey Y Abramov, Tuomas JP Knowles, Michel Goedert, David Klenerman
Jul 13, 2018
The ordered assembly of amyloidogenic proteins causes a wide spectrum of common neurodegenerative diseases, including Alzheimer's and Parkinson's diseases. These diseases share common features with prion diseases, in which...
Nanoscopic Characterisation of Individual Endogenous Protein Aggregates in Human Neuronal Cells.
Daniel R Whiten, Yukun Zuo, Laura Calo, Minee-Liane Choi, Suman De, Patrick Flagmeier, David C Wirthensohn, Franziska Kundel, Rohan T Ranasinghe, Santiago E Sanchez, Dilan Athauda, Steven F Lee, Christopher M Dobson, Sonia Gandhi, Maria-Grazia Spillantini, David Klenerman, Mathew H Horrocks
Sep 05, 2018
Heritage Websites as a Useful Addition to the Planning Toolkit in Singapore
This article analyses the extent to which heritage websites serve as a useful addition to the heritage planning toolkit in Singapore. Drawing on questionnaire surveys and interviews with 26 public servants in Singapore's public...
Published by: IGI Global Scientific Publishing
Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms.
Suman De, David C Wirthensohn, Patrick Flagmeier, Craig Hughes, Francesco A Aprile, Francesco S Ruggeri, Daniel R Whiten, Derya Emin, Zengjie Xia, Juan A Varela, Pietro Sormanni, Franziska Kundel, Tuomas PJ Knowles, Christopher M Dobson, Clare Bryant, Michele Vendruscolo, David Klenerman
Mar 15, 2019
Auditory Predictions and Prediction Errors in Response to Self-Initiated Vowels.
It has been suggested that speech production is accomplished by an internal forward model, reducing processing activity directed to self-produced speech in the auditory cortex. The current study uses an established...
Automatic Identification of Players in the Flavonoid Biosynthesis with Application on the Biomedicinal Plant Croton tiglium.
The flavonoid biosynthesis is a well-characterised model system for specialised metabolism and transcriptional regulation in plants. Flavonoids have numerous biological functions such as UV protection and pollinator attraction...
Subjective Impact of the COVID-19 Pandemic on Schizotypy and General Mental Health in Germany and the United Kingdom, for Independent Samples in May and in October 2020
Studies reported a strong impact on mental health during the first wave of the COVID-19 pandemic in March–June, 2020. In this study, we assessed the impact of the pandemic on mental health in general and on schizotypal traits in...
The impact of the COVID-19 pandemic on mental health in the general population
BACKGROUND: The COVID-19 pandemic has led to dramatic social and economic changes in daily life. First studies report an impact on mental health of the general population showing increased levels of anxiety, stress and...
Sheep recognize familiar and unfamiliar human faces from two-dimensional images.
One of the most important human social skills is the ability to recognize faces. Humans recognize familiar faces easily, and can learn to identify unfamiliar faces from repeatedly presented images. Sheep are social animals that...
Equal accuracy for Andrew and Abubakar-detecting and mitigating bias in name-ethnicity classification algorithms.
UNLABELLED: Uncovering the world's ethnic inequalities is hampered by a lack of ethnicity-annotated datasets. Name-ethnicity classifiers (NECs) can help, as they are able to infer people's ethnicities from their names. However...
Subjective Impact of the COVID-19 Pandemic on Schizotypy and General Mental Health in Germany and the United Kingdom, for Independent Samples in May and in October 2020.
Studies reported a strong impact on mental health during the first wave of the COVID-19 pandemic in March-June, 2020. In this study, we assessed the impact of the pandemic on mental health in general and on schizotypal traits in...
Multimodal Feature Integration in the Angular Gyrus during Episodic and Semantic Retrieval.
Sheep recognize familiar and unfamiliar human faces from two-dimensional images.
© 2017 The Authors. One of the most important human social skills is the ability to recognize faces. Humans recognize familiar faces easily, and can learn to identify unfamiliar faces from repeatedly presented images. Sheep are...
Published by: Royal Society open science
The effects of bilingualism on cognition and behaviour in individuals with attention deficits
BACKGROUND: Weaknesses in executive function have persistently been found to be associated with Attention Deficit Hyperactivity Disorder (ADHD), while bilinguals have been argued to show advantages in executive functions. While...
Survey of German medical students during the COVID-19 pandemic
Lorenz Mihatsch, Mira von der Linde, Franziska Knolle, Benjamin Luchting, Konstantinos Dimitriadis, Jens Heyn
May 26, 2021
Due to the spread of COVID-19, a key challenge was to reduce potential staff shortages in the healthcare sector. Besides recruiting retired healthcare workers, medical students were considered to support this task. Commitment of...
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