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Cover Image for <sup>13</sup>C-glucose-fructose labeling reveals comparable exogenous CHO oxidation during exercise when consuming 120 g/h in fluid, gel, jelly chew, or coingestion View Article
<sup>13</sup>C-glucose-fructose labeling reveals comparable exogenous CHO oxidation during exercise when consuming 120 g/h in fluid, gel, jelly chew, or coingestion
Mark A. Hearris, Jamie N. Pugh, Carl Langan-Evans, Stephen J. Mann, Louise Burke, Trent Stellingwerff, Javier T. Gonzalez, James P. Morton
Jun 01, 2022

We examined the effects of carbohydrate (CHO) delivery form on exogenous CHO oxidation, gastrointestinal discomfort, and exercise capacity. In a randomized repeated-measures design [after 24 h of high CHO intake (8 g·kg...

Fructose maltodextrin metabolism stable isotopes
Cover Image for <sup>13</sup>C-glucose-fructose labeling reveals comparable exogenous CHO oxidation during exercise when consuming 120 g/h in fluid, gel, jelly chew, or coingestion View Article
<sup>13</sup>C-glucose-fructose labeling reveals comparable exogenous CHO oxidation during exercise when consuming 120 g/h in fluid, gel, jelly chew, or coingestion
Mark A. Hearris, Jamie N. Pugh, Carl Langan-Evans, Stephen J. Mann, Louise Burke, Trent Stellingwerff, Javier T. Gonzalez, James P. Morton
Jun 01, 2022

We examined the effects of carbohydrate (CHO) delivery form on exogenous CHO oxidation, gastrointestinal discomfort, and exercise capacity. In a randomized repeated-measures design [after 24 h of high CHO intake (8 g·kg...

Fructose maltodextrin metabolism stable isotopes
Cover Image for Effects of immediate postexercise carbohydrate ingestion with and without protein on neutrophil degranulation View Article
Effects of immediate postexercise carbohydrate ingestion with and without protein on neutrophil degranulation
R J S Costa, R Walters, James L J Bilzon, N P Walsh
Jun 01, 2011
The purpose of the study was to determine the effects of carbohydrate (CHO) intake, with and without protein (PRO), immediately after prolonged strenuous exercise on circulating bacterially stimulated neutrophil degranulation....
Cover Image for Effects of immediate postexercise carbohydrate ingestion with and without protein on neutrophil degranulation View Article
Effects of immediate postexercise carbohydrate ingestion with and without protein on neutrophil degranulation
R J S Costa, R Walters, James L J Bilzon, N P Walsh
Jun 01, 2011
The purpose of the study was to determine the effects of carbohydrate (CHO) intake, with and without protein (PRO), immediately after prolonged strenuous exercise on circulating bacterially stimulated neutrophil degranulation....
Cover Image for Ketone monoester ingestion alters metabolism and simulated rugby performance in professional players View Article
Ketone monoester ingestion alters metabolism and simulated rugby performance in professional players
Oliver Peacock, Javier Gonzalez, Simon Roberts, Alan Smith, Scott Drawer, Keith Stokes
Sep 01, 2022

Ketone ingestion can alter metabolism but effects on exercise performance are unclear, particularly with regard to the impact on intermittent-intensity exercise and team-sport performance. Nine professional male rugby union...

Athletes exercise performance Glycerol lactate team sport β-hydroxybutyrate
Cover Image for Ketone monoester ingestion alters metabolism and simulated rugby performance in professional players View Article
Ketone monoester ingestion alters metabolism and simulated rugby performance in professional players
Oliver Peacock, Javier Gonzalez, Simon Roberts, Alan Smith, Scott Drawer, Keith Stokes
Sep 01, 2022

Ketone ingestion can alter metabolism but effects on exercise performance are unclear, particularly with regard to the impact on intermittent-intensity exercise and team-sport performance. Nine professional male rugby union...

Athletes exercise performance Glycerol lactate team sport β-hydroxybutyrate
Cover Image for Impact of muscle glycogen availability on the capacity for repeated exercise in man View Article
Impact of muscle glycogen availability on the capacity for repeated exercise in man
Abdullah Alghannam, Dawid Jedrzejewski, Mark G. Tweddle, Hannah Gribble, James Bilzon, Dylan Thompson, Kostas Tsintzas, James A. Betts
Jan 01, 2016
Purpose: To examine whether muscle glycogen availability is associated with fatigue in a repeated exercise bout following short-term recovery. Methods: Ten endurance-trained individuals underwent two trials in a repeated...
Nutrition metabolism Performance Sucrose
Cover Image for Co-ingestion of whey protein with a carbohydrate-rich breakfast boes not affect glycemia, insulinemia or subjective appetite following a subsequent meal in healthy males View Article
Co-ingestion of whey protein with a carbohydrate-rich breakfast boes not affect glycemia, insulinemia or subjective appetite following a subsequent meal in healthy males
Dean M. Allerton, Matthew D. Campbell, Javier T. Gonzalez, Penny L. S. Rumbold, Daniel J. West, Emma J. Stevenson
Feb 25, 2016
We aimed to assess postprandial metabolic and appetite responses to a mixed-macronutrient lunch following prior addition of whey protein to a carbohydrate-rich breakfast. Ten healthy males (age: 24 ± 1 y; body mass index (BMI)...
whey protein Appetite breakfast Glycaemia insulinaemia
Cover Image for The effects of postexercise feeding on saliva antimicrobial proteins View Article
The effects of postexercise feeding on saliva antimicrobial proteins
R J S Costa, M B Fortes, K Richardson, James L J Bilzon, N P Walsh
Jan 01, 0001
The purpose of this study was to determine the effects of a carbohydrate (CHO) and protein (PRO) drink consumed immediately after endurance exercise on saliva antimicrobial proteins known to be important for host defense. Eleven...
Cover Image for The effects of postexercise feeding on saliva antimicrobial proteins View Article
The effects of postexercise feeding on saliva antimicrobial proteins
R J S Costa, M B Fortes, K Richardson, James L J Bilzon, N P Walsh
Jan 01, 0001
The purpose of this study was to determine the effects of a carbohydrate (CHO) and protein (PRO) drink consumed immediately after endurance exercise on saliva antimicrobial proteins known to be important for host defense. Eleven...
Cover Image for G-Force PD View Article
G-Force PD
Roger A Barker, Lorenz Studer, Elena Cattaneo, Jun Takahashi, G-Force PD consortium
Aug 20, 2015
G-Force PD consortium
Cover Image for G-Quadruplexes View Article
G-Quadruplexes
Chun Kit Kwok, Catherine J Merrick
Mar 18, 2019
Guanine (G)-rich sequences in nucleic acids can assemble into G-quadruplex structures that involve G-quartets linked by loop nucleotides. The structural and topological diversity of G-quadruplexes have attracted great attention...
G-quadruplex aptamer biosensing cell imaging next-generation sequencing nucleic acid structure Animals Biomedical Research Biosensing Techniques G-Quadruplexes Humans
Cover Image for Impact of muscle glycogen availability on the capacity for repeated exercise in man View Article
Impact of muscle glycogen availability on the capacity for repeated exercise in man
Abdullah Alghannam, Dawid Jedrzejewski, Mark G. Tweddle, Hannah Gribble, James Bilzon, Dylan Thompson, Kostas Tsintzas, James A. Betts
Jan 01, 2016
Purpose: To examine whether muscle glycogen availability is associated with fatigue in a repeated exercise bout following short-term recovery. Methods: Ten endurance-trained individuals underwent two trials in a repeated...
Nutrition metabolism Performance Sucrose
Cover Image for Co-ingestion of whey protein with a carbohydrate-rich breakfast boes not affect glycemia, insulinemia or subjective appetite following a subsequent meal in healthy males View Article
Co-ingestion of whey protein with a carbohydrate-rich breakfast boes not affect glycemia, insulinemia or subjective appetite following a subsequent meal in healthy males
Dean M. Allerton, Matthew D. Campbell, Javier T. Gonzalez, Penny L. S. Rumbold, Daniel J. West, Emma J. Stevenson
Feb 25, 2016
We aimed to assess postprandial metabolic and appetite responses to a mixed-macronutrient lunch following prior addition of whey protein to a carbohydrate-rich breakfast. Ten healthy males (age: 24 ± 1 y; body mass index (BMI)...
whey protein Appetite breakfast Glycaemia insulinaemia
Cover Image for Synthesis of Novel Regenerable 13X Zeolite-Polyimide Adsorbent Foams View Article
Synthesis of Novel Regenerable 13X Zeolite-Polyimide Adsorbent Foams
Ramya G, Barry Crittenden, Martin Smith, Olivier Camus, Yong-Min Chew, Semali Perera
Apr 01, 2019

A new generic synthesis method is presented for the production of a polyimide (PI)/adsorbent (80 wt% 13X zeolite) regenerable foam filter. The method uses a dual parallel reaction foaming process comprising CO 2...

Adsorbent foam Adsorption Air Filters Isotherms modelling Polyimide
Cover Image for Synthesis of Novel Regenerable 13X Zeolite-Polyimide Adsorbent Foams View Article
Synthesis of Novel Regenerable 13X Zeolite-Polyimide Adsorbent Foams
Ramya G, Barry Crittenden, Martin Smith, Olivier Camus, Yong-Min Chew, Semali Perera
Apr 01, 2019

A new generic synthesis method is presented for the production of a polyimide (PI)/adsorbent (80 wt% 13X zeolite) regenerable foam filter. The method uses a dual parallel reaction foaming process comprising CO 2...

Adsorbent foam Adsorption Air Filters Isotherms modelling Polyimide
Cover Image for Remote stereocontrol in [3,3]-sigmatropic rearrangements View Article
Remote stereocontrol in [3,3]-sigmatropic rearrangements
Nathan W G Fairhurst, Mary F Mahon, R H Munday, David R Carbery
Feb 03, 2012
The Ireland - Claisen [3,3]-sigmatropic rearrangement has been used to access biologically important β,β′-dihydroxy α-amino acids. The rearrangement reported is highly stereoselective and offers excellent levels of remote...
Cover Image for RNA promotes phase separation of glycolysis enzymes into yeast G bodies in hypoxia. View Article
RNA promotes phase separation of glycolysis enzymes into yeast G bodies in hypoxia.
Gregory G Fuller, Ting Han, Mallory A Freeberg, James J Moresco, Amirhossein Ghanbari Niaki, Nathan P Roach, John R Yates, Sua Myong, John K Kim
Apr 17, 2020
In hypoxic stress conditions, glycolysis enzymes assemble into singular cytoplasmic granules called glycolytic (G) bodies. G body formation in yeast correlates with increased glucose consumption and cell survival. However, the...
RNA S. cerevisiae Cell Biology Glycolysis Hypoxia phase separation Cytoplasmic Granules Endoribonucleases Glycolysis RNA Fungal Saccharomyces cerevisiae Saccharomyces cerevisiae Proteins
Cover Image for Interleukin-2 induces the in vitro maturation of human pluripotent stem cell-derived intestinal organoids. View Article
Interleukin-2 induces the in vitro maturation of human pluripotent stem cell-derived intestinal organoids.
Kwang Bo Jung, Hana Lee, Ye Seul Son, Mi-Ok Lee, Young-Dae Kim, Soo Jin Oh, Ohman Kwon, Sunwha Cho, Hyun-Soo Cho, Dae-Soo Kim, Jung-Hwa Oh, Matthias Zilbauer, Jeong-Ki Min, Cho-Rok Jung, Janghwan Kim, Mi-Young Son
Nov 21, 2018
Human pluripotent stem cell (hPSC)-derived intestinal organoids (hIOs) form 3D structures organized into crypt and villus domains, making them an excellent in vitro model system for studying human intestinal development and...
Biomarkers Cell Differentiation Coculture Techniques Humans Interleukin-2 Intestines Organoids Pluripotent Stem Cells STAT3 Transcription Factor Signal Transduction T-Lymphocytes
Cover Image for Modelling and simulation of biased agonism dynamics at a G protein-coupled receptor. View Article
Modelling and simulation of biased agonism dynamics at a G protein-coupled receptor.
LJ Bridge, J Mead, E Frattini, I Winfield, G Ladds
Mar 16, 2018
Theoretical models of G protein-coupled receptor (GPCR) concentration-response relationships often assume an agonist producing a single functional response via a single active state of the receptor. These models have largely...
Biased signalling G protein-coupled receptors Mathematical pharmacology ordinary differential equations Receptor theory Algorithms Animals GTP-Binding Proteins Humans Ligands Models Biological Receptors G-Protein-Coupled Signal Transduction
Cover Image for Remote stereocontrol in [3,3]-sigmatropic rearrangements View Article
Remote stereocontrol in [3,3]-sigmatropic rearrangements
Nathan W G Fairhurst, Mary F Mahon, R H Munday, David R Carbery
Feb 03, 2012
The Ireland - Claisen [3,3]-sigmatropic rearrangement has been used to access biologically important β,β′-dihydroxy α-amino acids. The rearrangement reported is highly stereoselective and offers excellent levels of remote...
Cover Image for Interactive effects of acute exercise and carbohydrate-energy replacement on insulin sensitivity in healthy adults View Article
Interactive effects of acute exercise and carbohydrate-energy replacement on insulin sensitivity in healthy adults
Drusus Johnson-Bonson, Ben J. Narang, Russell Davies, Aaron Hengist, Harry Smith, Jon Watkins, Harry Taylor, Jean-Philippe Walhin, Javier Gonzalez, James Betts
Oct 01, 2021

This study investigated whether carbohydrate-energy replacement immediately after prolonged endurance exercise attenuates insulin sensitivity the following morning, and whether exercise improves insulin sensitivity the...

activité physique carbohydrate availability deficit disponibilité en glucides déficit Energy Glycaemia Glycaemic glycemic glycémie glycémique Insulin Resistance metabolism métabolisme physical activity refeeding réalimentation résistance à l’insuline énergie
Cover Image for Carbohydrate-protein ingestion improves subsequent running capacity towards the end of a football-specific intermittent exercise View Article
Carbohydrate-protein ingestion improves subsequent running capacity towards the end of a football-specific intermittent exercise
Abdullah F Alghannam
Jan 01, 0001
The majority of football players succumb to fatigue towards the end of the game. This study was designed to examine the influence of protein coingestion with carbohydrate (CHO) vs. an isocaloric CHO supplement on subsequent...
Cover Image for Carbohydrate-protein ingestion improves subsequent running capacity towards the end of a football-specific intermittent exercise View Article
Carbohydrate-protein ingestion improves subsequent running capacity towards the end of a football-specific intermittent exercise
Abdullah F Alghannam
Jan 01, 0001
The majority of football players succumb to fatigue towards the end of the game. This study was designed to examine the influence of protein coingestion with carbohydrate (CHO) vs. an isocaloric CHO supplement on subsequent...
Cover Image for Amino-Acid-Derived Naphthalenediimides as Versatile G-Quadruplex Binders View Article
Amino-Acid-Derived Naphthalenediimides as Versatile G-Quadruplex Binders
Dora-Maria Rasadean, Bin Sheng, Jyotirmayee Dash, G. Dan Pantos
Jun 23, 2017

The design and synthesis of water soluble, amino-acid-functionalised naphthalenediimides (NDIs) as potential ligands of native G-quadruplexes is reported. The NDIs were tested on a panel of oncogene promoters, on the human...

Circular dichroism DNA G-quadruplex naphthalenediimide structure–activity relationships

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