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Remote stereocontrol in [3,3]-sigmatropic rearrangements
The Ireland - Claisen [3,3]-sigmatropic rearrangement has been used to access biologically important β,β′-dihydroxy α-amino acids. The rearrangement reported is highly stereoselective and offers excellent levels of remote...
Using generalized linear models to implement g-estimation for survival data with time-varying confounding.
Using data from observational studies to estimate the causal effect of a time-varying exposure, repeatedly measured over time, on an outcome of interest requires careful adjustment for confounding. Standard regression adjustment...
Remote stereocontrol in [3,3]-sigmatropic rearrangements
The Ireland - Claisen [3,3]-sigmatropic rearrangement has been used to access biologically important β,β′-dihydroxy α-amino acids. The rearrangement reported is highly stereoselective and offers excellent levels of remote...
Using generalized linear models to implement g‐estimation for survival data with time‐varying confounding
Using data from observational studies to estimate the causal effect of a time‐varying exposure, repeatedly measured over time, on an outcome of interest requires careful adjustment for confounding. Standard regression adjustment...
RESEARCH ARTICLE RESEARCH ARTICLES Aalen's additive model accelerated failure time model Causal effect marginal structural model structural nested cumulative failure time model time‐varying confounding
Published by: Statistics in Medicine
RNA promotes phase separation of glycolysis enzymes into yeast G bodies in hypoxia.
Gregory G Fuller, Ting Han, Mallory A Freeberg, James J Moresco, Amirhossein Ghanbari Niaki, Nathan P Roach, John R Yates, Sua Myong, John K Kim
Apr 17, 2020
In hypoxic stress conditions, glycolysis enzymes assemble into singular cytoplasmic granules called glycolytic (G) bodies. G body formation in yeast correlates with increased glucose consumption and cell survival. However, the...
Inspiratory muscle warm-up does not improve cycling time-trial performance
PURPOSE:
This study examined the effects of an active cycling warm-up, with and without the addition of an inspiratory muscle warm-up (IMW), on 10-km cycling time-trial performance.
METHODS:
Ten cyclists (VO₂ = 65 ±...
This study examined the effects of an active cycling warm-up, with and without the addition of an inspiratory muscle warm-up (IMW), on 10-km cycling time-trial performance.
METHODS:
Ten cyclists (VO₂ = 65 ±...
G-Quadruplexes
Guanine (G)-rich sequences in nucleic acids can assemble into G-quadruplex structures that involve G-quartets linked by loop nucleotides. The structural and topological diversity of G-quadruplexes have attracted great attention...
Inspiratory muscle warm-up does not improve cycling time-trial performance
PURPOSE:
This study examined the effects of an active cycling warm-up, with and without the addition of an inspiratory muscle warm-up (IMW), on 10-km cycling time-trial performance.
METHODS:
Ten cyclists (VO₂ = 65 ±...
This study examined the effects of an active cycling warm-up, with and without the addition of an inspiratory muscle warm-up (IMW), on 10-km cycling time-trial performance.
METHODS:
Ten cyclists (VO₂ = 65 ±...
Segmentation of Pectoral Muscle in Mammograms Using Granular Computing
In this paper, pectoral muscle segmentation was performed to study the presence of malignancy in the pectoral muscle region in mammograms. A combined approach involving granular computing and layering was employed to locate the...
Published by: IGI Global Scientific Publishing
R/BHC
BACKGROUND: Although the use of clustering methods has rapidly become one of the standard computational approaches in the literature of microarray gene expression data analysis, little attention has been paid to uncertainty in...
Synthesis of Novel Regenerable 13X Zeolite-Polyimide Adsorbent Foams
A new generic synthesis method is presented for the production of a polyimide (PI)/adsorbent (80 wt% 13X zeolite) regenerable foam filter. The method uses a dual parallel reaction foaming process comprising CO 2...
Adsorbent foam Adsorption Air Filters Isotherms modelling Polyimide /dk/atira/pure/subjectarea/asjc/1600/1600 name=General Chemistry /dk/atira/pure/subjectarea/asjc/2300/2304 name=Environmental Chemistry /dk/atira/pure/subjectarea/asjc/1500/1500 name=General Chemical Engineering /dk/atira/pure/subjectarea/asjc/2200/2209 name=Industrial and Manufacturing Engineering
Synthesis of Novel Regenerable 13X Zeolite-Polyimide Adsorbent Foams
A new generic synthesis method is presented for the production of a polyimide (PI)/adsorbent (80 wt% 13X zeolite) regenerable foam filter. The method uses a dual parallel reaction foaming process comprising CO 2...
Adsorbent foam Adsorption Air Filters Isotherms modelling Polyimide /dk/atira/pure/subjectarea/asjc/1600/1600 name=General Chemistry /dk/atira/pure/subjectarea/asjc/2300/2304 name=Environmental Chemistry /dk/atira/pure/subjectarea/asjc/1500/1500 name=General Chemical Engineering /dk/atira/pure/subjectarea/asjc/2200/2209 name=Industrial and Manufacturing Engineering
Receptor- G Protein Interactions in the Visual System: A Study of Structures and Mechanisms That Couple the Cytoplasmic Surface of Rhodopsin to the Nucleotide-Binding Pocket of Transducin
Ethan P Marin
Jan 01, 0001
The intermolecular interaction between the photoreceptor rhodopsin and the heterotrimeric G protein transducin (Gt) initiates the vertebrate phototransduction cascade. This interaction also serves as a model system for the study...
Published by: Rockefeller University
rpsftm
Treatment switching in a randomised controlled trial occurs when participants change from their randomised treatment to the other trial treatment during the study. Failure to account for treatment switching in the analysis (i.e....
Plasmodium falciparum GBP2 Is a Telomere-Associated Protein That Binds to G-Quadruplex DNA and RNA
In the early-diverging protozoan parasite Plasmodium , few telomere-binding proteins have been identified and several are unique. Plasmodium telomeres, like those of...
James Edwards-Smallbone, Anders L Jensen, Lydia E Roberts, Francis Isidore G Totañes, Sarah R Hart, Catherine J Merrick
Mar 08, 2022
Obsessive-compulsive disorder in adults with high-functioning autism spectrum disorder
Background: Little is known about the symptom profile of obsessive-compulsive disorder (OCD) in individuals who have autism spectrum disorders (ASD). It is also unknown whether self-report questionnaires are useful in measuring...
Structural basis of G-quadruplex unfolding by the DEAH/RHA helicase DHX36.
Michael C Chen, Ramreddy Tippana, Natalia A Demeshkina, Pierre Murat, Shankar Balasubramanian, Sua Myong, Adrian R Ferré-D'Amaré
Aug 03, 2018
Guanine-rich nucleic acid sequences challenge the replication, transcription, and translation machinery by spontaneously folding into G-quadruplexes, the unfolding of which requires forces greater than most polymerases can...
Small molecule inhibitors of regulators of G protein signaling (RGS) proteins
Recently, regulators of G protein signaling (RGS) proteins have emerged as potential therapeutic targets since they provide an alternative method of modulating the activity of G protein-coupled receptors, the target of so many...
Obsessive-compulsive disorder in adults with high-functioning autism spectrum disorder
Background: Little is known about the symptom profile of obsessive-compulsive disorder (OCD) in individuals who have autism spectrum disorders (ASD). It is also unknown whether self-report questionnaires are useful in measuring...
Genetic association study of childhood aggression across raters, instruments, and age.
Hill F Ip, Camiel M van der Laan, Eva M L Krapohl, Isabell Brikell, Cristina Sánchez-Mora, Ilja M Nolte, Beate St Pourcain, Koen Bolhuis, Teemu Palviainen, Hadi Zafarmand, Lucía Colodro-Conde, Scott Gordon, Tetyana Zayats, Fazil Aliev, Chang Jiang, Carol A Wang, Gretchen Saunders, Ville Karhunen, Anke R Hammerschlag, Daniel E Adkins, Richard Border, Roseann E Peterson, Joseph A Prinz, Elisabeth Thiering, Ilkka Seppälä, Natàlia Vilor-Tejedor, Tarunveer S Ahluwalia, Felix R Day, Jouke-Jan Hottenga, Andrea G Allegrini, Kaili Rimfeld, Qi Chen, Yi Lu, Joanna Martin, María Soler Artigas, Paula Rovira, Rosa Bosch, Gemma Español, Josep Antoni Ramos Quiroga, Alexander Neumann, Judith Ensink, Katrina Grasby, José J Morosoli, Xiaoran Tong, Shelby Marrington, Christel Middeldorp, James G Scott, Anna Vinkhuyzen, Andrey A Shabalin, Robin Corley, Luke M Evans, Karen Sugden, Silvia Alemany, Lærke Sass, Rebecca Vinding, Kate Ruth, Jess Tyrrell, Gareth E Davies, Erik A Ehli, Fiona A Hagenbeek, Eveline De Zeeuw, Toos C E M Van Beijsterveldt, Henrik Larsson, Harold Snieder, Frank C Verhulst, Najaf Amin, Alyce M Whipp, Tellervo Korhonen, Eero Vuoksimaa, Richard J Rose, André G Uitterlinden, Andrew C Heath, Pamela Madden, Jan Haavik, Jennifer R Harris, Øyvind Helgeland, Stefan Johansson, Gun Peggy S Knudsen, Pal Rasmus Njolstad, Qing Lu, Alina Rodriguez, Anjali K Henders, Abdullah Mamun, Jackob M Najman, Sandy Brown, Christian Hopfer, Kenneth Krauter, Chandra Reynolds, Andrew Smolen, Michael Stallings, Sally Wadsworth, Tamara L Wall, Judy L Silberg, Allison Miller, Liisa Keltikangas-Järvinen, Christian Hakulinen, Laura Pulkki-Råback, Alexandra Havdahl, Per Magnus, Olli T Raitakari, John R B Perry, Sabrina Llop, Maria-Jose Lopez-Espinosa, Klaus Bønnelykke, Hans Bisgaard, Jordi Sunyer, Terho Lehtimäki, Louise Arseneault, Marie Standl, Joachim Heinrich, Joseph Boden, John Pearson, L John Horwood, Martin Kennedy, Richie Poulton, Lindon J Eaves, Hermine H Maes, John Hewitt, William E Copeland, Elizabeth J Costello, Gail M Williams, Naomi Wray, Marjo-Riitta Järvelin, Matt McGue, William Iacono, Avshalom Caspi, Terrie E Moffitt, Andrew Whitehouse, Craig E Pennell, Kelly L Klump, S Alexandra Burt, Danielle M Dick, Ted Reichborn-Kjennerud, Nicholas G Martin, Sarah E Medland, Tanja Vrijkotte, Jaakko Kaprio, Henning Tiemeier, George Davey Smith, Catharina A Hartman, Albertine J Oldehinkel, Miquel Casas, Marta Ribasés, Paul Lichtenstein, Sebastian Lundström, Robert Plomin, Meike Bartels, Michel G Nivard, Dorret I Boomsma
Aug 31, 2021
Childhood aggressive behavior (AGG) has a substantial heritability of around 50%. Here we present a genome-wide association meta-analysis (GWAMA) of childhood AGG, in which all phenotype measures across childhood ages from...
Humans Retrospective Studies Aggression Mental Disorders Adolescent Child Child Preschool Infant Female Genome-Wide Association Study Genetic Association Studies
Published by: Translational psychiatry
Receptor Quaternary Organization Explains G Protein-Coupled Receptor Family Structure.
James H Felce, Sarah L Latty, Rachel G Knox, Susan R Mattick, Yuan Lui, Steven F Lee, David Klenerman, Simon J Davis
May 10, 2018
The organization of Rhodopsin-family G protein-coupled receptors (GPCRs) at the cell surface is controversial. Support both for and against the existence of dimers has been obtained in studies of mostly individual receptors....
The Expansion of Approximant /r/ in Dutch
Renée Van Bezooijen
Sep 30, 2014
In present-day Standard Dutch as spoken in the Netherlands, three main categories of pronunciation variants of Irl can be distinguished, namely alveolar /r/, uvular /r/, and approximant /r/. Approximant /r/, the focus of this...
Published by: Atlantic Provinces Linguistic Association
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