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G-Quadruplexes
Guanine (G)-rich sequences in nucleic acids can assemble into G-quadruplex structures that involve G-quartets linked by loop nucleotides. The structural and topological diversity of G-quadruplexes have attracted great attention...
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“I think we need to empower people to manage it better themselves”:

Objectives: To elicit healthcare practitioners’ views on treatment following sport-related knee injury in young adults (18–35) and the potential for individuals to self-manage joint health. Design: Semi-structured interviews...

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Why young people stop taking their attention deficit hyperactivity disorder medication
BACKGROUND: Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder that can persist into adulthood. Young people often stop taking ADHD medication during adolescence despite evidence that...
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Remote stereocontrol in [3,3]-sigmatropic rearrangements
The Ireland - Claisen [3,3]-sigmatropic rearrangement has been used to access biologically important β,β′-dihydroxy α-amino acids. The rearrangement reported is highly stereoselective and offers excellent levels of remote...
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“I think we need to empower people to manage it better themselves”:

Objectives: To elicit healthcare practitioners’ views on treatment following sport-related knee injury in young adults (18–35) and the potential for individuals to self-manage joint health. Design: Semi-structured interviews...

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RNA promotes phase separation of glycolysis enzymes into yeast G bodies in hypoxia.
In hypoxic stress conditions, glycolysis enzymes assemble into singular cytoplasmic granules called glycolytic (G) bodies. G body formation in yeast correlates with increased glucose consumption and cell survival. However, the...
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Remote stereocontrol in [3,3]-sigmatropic rearrangements
The Ireland - Claisen [3,3]-sigmatropic rearrangement has been used to access biologically important β,β′-dihydroxy α-amino acids. The rearrangement reported is highly stereoselective and offers excellent levels of remote...
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Modelling and simulation of biased agonism dynamics at a G protein-coupled receptor.
Theoretical models of G protein-coupled receptor (GPCR) concentration-response relationships often assume an agonist producing a single functional response via a single active state of the receptor. These models have largely...
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Physiological Response of the Freshwater Mussel Unio douglasiae in Microcystis aeruginosa Bloom Waters.
In the present study, we evaluated the effects of different environments on the filtering rate (FR), mortality, and biodeposition (BD) of the freshwater mussel Unio douglasiae in bloom waters containing the toxic cyanobacterium...
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Amino-Acid-Derived Naphthalenediimides as Versatile G-Quadruplex Binders

The design and synthesis of water soluble, amino-acid-functionalised naphthalenediimides (NDIs) as potential ligands of native G-quadruplexes is reported. The NDIs were tested on a panel of oncogene promoters, on the human...

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Amino-Acid-Derived Naphthalenediimides as Versatile G-Quadruplex Binders

The design and synthesis of water soluble, amino-acid-functionalised naphthalenediimides (NDIs) as potential ligands of native G-quadruplexes is reported. The NDIs were tested on a panel of oncogene promoters, on the human...

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GPs role identifying young people who self-harm
Background: Self-harm is common among young people and is evident in increasingly younger age groups. Many young people who self-harm do visit their General Practitioner (GP) but do not access specialist support. GP’s can find...
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Preventing Smoking in Young People
Aims: To examine existing evidence on the effectiveness of interventions that are designed to prevent the illegal sale of tobacco to young people. The review considers specific sub-questions related to the factors that might...
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Locating young refugees historically
Jason Hart
Apr 10, 2014
Nowadays humanitarian organisations are often keen to engage young displaced people in programmatic efforts. In such efforts attention is commonly paid to the impact of the social dynamics of gender. However, similar...
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Locating young refugees historically
Jason Hart
Apr 10, 2014
Nowadays humanitarian organisations are often keen to engage young displaced people in programmatic efforts. In such efforts attention is commonly paid to the impact of the social dynamics of gender. However, similar...
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Dendritic cells stimulate primary human cytolytic lymphocyte responses in the absence of CD4+ helper T cells
Young, J.W., and Steinman, R.M. Dendritic cells stimulate primary human cytolytic lymphocyte responses in the absence of CD4+ helper T cells. J. Exp. Med. 171: 1315-1332, 1990

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