Search
Results: 507
The Small Things of Life and Death
GC Carr
Jul 10, 2017
Nazi Camps on British Soil
GC Carr
Jun 30, 2017
GC content shapes mRNA storage and decay in human cells.
Maïté Courel, Yves Clément, Clémentine Bossevain, Dominika Foretek, Olivia Vidal Cruchez, Zhou Yi, Marianne Bénard, Marie-Noëlle Benassy, Michel Kress, Caroline Vindry, Michèle Ernoult-Lange, Christophe Antoniewski, Antonin Morillon, Patrick Brest, Arnaud Hubstenberger, Hugues Roest Crollius, Nancy Standart, Dominique Weil
Mar 09, 2020
mRNA translation and decay appear often intimately linked although the rules of this interplay are poorly understood. In this study, we combined our recent P-body transcriptome with transcriptomes obtained following silencing of...
Marsupial chromosome DNA content and genome size assessed from flow karyotypes
Extensive chromosome homologies revealed by cross-species chromosome painting between marsupials have suggested a high level of genome conservation during evolution. Surprisingly, it has been reported that marsupial genome sizes...
GC content shapes mRNA storage and decay in human cells.
Maïté Courel, Yves Clément, Clémentine Bossevain, Dominika Foretek, Olivia Vidal Cruchez, Zhou Yi, Marianne Bénard, Marie-Noëlle Benassy, Michel Kress, Caroline Vindry, Michèle Ernoult-Lange, Christophe Antoniewski, Antonin Morillon, Patrick Brest, Arnaud Hubstenberger, Hugues Roest Crollius, Nancy Standart, Dominique Weil
Jan 27, 2020
mRNA translation and decay appear often intimately linked although the rules of this interplay are poorly understood. In this study, we combined our recent P-body transcriptome with transcriptomes obtained following silencing of...
Tetrad analysis in plants and fungi finds large differences in gene conversion rates but no GC bias
Haoxuan Liu, Ju Huang, Xiaoguang Sun, Jing Li, Yingwen Hu, Luyao Yu, Gianni Liti, Dacheng Tian, Laurence Hurst, Sihai Yang
Jan 01, 2018
GC-favouring gene conversion enables fixation of deleterious alleles, disturbs tests of natural selection and potentially explains both the evolution of recombination as well as the commonly reported intragenomic correlation...
Tetrad analysis in plants and fungi finds large differences in gene conversion rates but no GC bias
Haoxuan Liu, Ju Huang, Xiaoguang Sun, Jing Li, Yingwen Hu, Luyao Yu, Gianni Liti, Dacheng Tian, Laurence Hurst, Sihai Yang
Jan 01, 2018
GC-favouring gene conversion enables fixation of deleterious alleles, disturbs tests of natural selection and potentially explains both the evolution of recombination as well as the commonly reported intragenomic correlation...
Confirmation of the genetic association of CTLA4 and PTPN22 with ANCA-associated vasculitis.
Edward J Carr, Heather A Niederer, Julie Williams, Lorraine Harper, Richard A Watts, Paul A Lyons, Kenneth GC Smith
Jun 16, 2011
BACKGROUND: The genetic contribution to the aetiology of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is not well defined. Across different autoimmune diseases some genes with immunomodulatory roles...
Alleles Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis Antibodies Antineutrophil Cytoplasmic Antigens CD CTLA-4 Antigen Cohort Studies Gene Frequency Genetic Association Studies Genetic Predisposition to Disease Genotype Humans Polymorphism Single Nucleotide Protein Tyrosine Phosphatase Non-Receptor Type 22
Analysis of a wild mouse promoter variant reveals a novel role for FcγRIIb in the control of the germinal center and autoimmunity.
Marion Espéli, Menna R Clatworthy, Susanne Bökers, Kate E Lawlor, Antony J Cutler, Frank Köntgen, Paul A Lyons, Kenneth GC Smith
Nov 29, 2018
Genetic variants of the inhibitory Fc receptor FcγRIIb have been associated with systemic lupus erythematosus in humans and mice. The mechanism by which Fcgr2b variants contribute to the development of autoimmunity is unknown...
Animals Autoantibodies Autoimmunity B-Lymphocytes Chromatin Immunoprecipitation DNA Primers Enzyme-Linked Immunosorbent Assay Enzyme-Linked Immunospot Assay Flow Cytometry Gene Expression Regulation Gene Knock-In Techniques genetic variation Germinal Center Luciferases Mice Mice Inbred C57BL Mutagenesis Site-Directed Promoter Regions Genetic Receptors IgG Sequence Analysis DNA statistics Nonparametric Transcription Factor AP-1
A CD8+ NK cell transcriptomic signature associated with clinical outcome in relapsing remitting multiple sclerosis.
Eoin F McKinney, Iona Cuthbertson, Kristina M Harris, Dawn E Smilek, Christopher Connor, Giulia Manferrari, Edward J Carr, Scott S Zamvil, Kenneth GC Smith
Nov 25, 2020
False gene and chromosome losses in genome assemblies caused by GC content variation and repeats.
Juwan Kim, Chul Lee, Byung June Ko, Dong Ahn Yoo, Sohyoung Won, Adam M Phillippy, Olivier Fedrigo, Guojie Zhang, Kerstin Howe, Jonathan Wood, Richard Durbin, Giulio Formenti, Samara Brown, Lindsey Cantin, Claudio V Mello, Seoae Cho, Arang Rhie, Heebal Kim, Erich D Jarvis
Sep 28, 2022
BACKGROUND: Many short-read genome assemblies have been found to be incomplete and contain mis-assemblies. The Vertebrate Genomes Project has been producing new reference genome assemblies with an emphasis on being as complete...
Three Aphid-Transmitted Viruses Encourage Vector Migration From Infected Common Bean ( Phaseolus vulgaris ) Plants Through a Combination of Volatile and Surface Cues
Francis O. Wamonje, Trisna D. Tungadi, Alex M. Murphy, Adrienne E. Pate, Christine Woodcock, John C. Caulfield, J. Musembi Mutuku, Nik J. Cunniffe, Toby J. A. Bruce, Christopher A. Gilligan, John A. Pickett, John P. Carr
Dec 28, 2020
Bean common mosaic virus (BCMV), bean common mosaic necrosis virus (BCMNV), and cucumber mosaic virus (CMV) are important pathogens of common bean (Phaseolus vulgaris), a crop vital for food security in sub-Saharan Africa. These...
Contrasting genetic association of IL2RA with SLE and ANCA-associated vasculitis.
Edward J Carr, Menna R Clatworthy, Christopher E Lowe, John A Todd, Andrew Wong, Timothy J Vyse, Lavanya Kamesh, Richard A Watts, Paul A Lyons, Kenneth GC Smith
Jun 16, 2011
BACKGROUND: Autoimmune diseases are complex and have genetic and environmental susceptibility factors. The objective was to test the genetic association of systemic lupus erythematosus (SLE) and anti-neutrophil cytoplasmic...
Rejuvenating conventional dendritic cells and T follicular helper cell formation after vaccination.
Marisa Stebegg, Alexandre Bignon, Danika Lea Hill, Alyssa Silva-Cayetano, Christel Krueger, Ine Vanderleyden, Silvia Innocentin, Louis Boon, Jiong Wang, Martin S Zand, James Dooley, Jonathan Clark, Adrian Liston, Edward Carr, Michelle A Linterman
Jun 05, 2020
Germinal centres (GCs) are T follicular helper cell (Tfh)-dependent structures that form in response to vaccination, producing long-lived antibody secreting plasma cells and memory B cells that protect against subsequent...
Ageing Dendritic Cells germinal centre response human immunology Inflammation MOUSE T follicular helper cells Adolescent Adoptive Transfer Adult Aged aging Animals B-Lymphocytes Bone Marrow Cells CD11 Antigens Chimera Female Germinal Center Humans Immunity Humoral Immunologic Memory Influenza Vaccines Influenza Human Male Mice Mice Knockout Middle Aged Orthomyxoviridae Infections Receptor Interferon alpha-beta T follicular helper cells T-Lymphocytes Helper-Inducer Vaccination Young Adult
A CD8+ T cell transcription signature predicts prognosis in autoimmune disease.
Eoin F McKinney, Paul A Lyons, Edward J Carr, Jane L Hollis, David RW Jayne, Lisa C Willcocks, Maria Koukoulaki, Alvis Brazma, Vojislav Jovanovic, D Michael Kemeny, Andrew J Pollard, Paul A Macary, Afzal N Chaudhry, Kenneth GC Smith
Nov 24, 2020
Autoimmune diseases are common and debilitating, but their severe manifestations could be reduced if biomarkers were available to allow individual tailoring of potentially toxic immunosuppressive therapy. Gene expression-based...
Antibodies Antineutrophil Cytoplasmic Autoimmune Diseases Autoimmunity CD8-Positive T-Lymphocytes Cohort Studies Dose-Response Relationship Drug Gene Expression Humans Immunosuppressive Agents Inflammation Interleukin-7 Lupus Erythematosus Systemic Prognosis Receptors Antigen T-Cell Signal Transduction T-Lymphocytes Vasculitis
Cardioprotection by ischemic postconditioning and cyclic guanosine monophosphate-elevating agents involves cardiomyocyte nitric oxide-sensitive guanylyl cyclase.
Sandra Frankenreiter, Dieter Groneberg, Anna Kuret, Thomas Krieg, Peter Ruth, Andreas Friebe, Robert Lukowski
Mar 13, 2018
AIMS: It has been suggested that the nitric oxide-sensitive guanylyl cyclase (NO-GC)/cyclic guanosine monophosphate (cGMP)-dependent signalling pathway affords protection against cardiac damage during acute myocardial infarction...
Animals Benzoates Cyclic GMP Disease Models Animal Enzyme Activators Female Ischemic Postconditioning Large-Conductance Calcium-Activated Potassium Channels Male Mice Knockout Myocardial Infarction Myocardial Reperfusion Injury Myocytes Cardiac Nitric oxide Phosphodiesterase 5 Inhibitors Signal Transduction Sildenafil Citrate Soluble Guanylyl Cyclase Tadalafil Tetrazoles Thiourea Time Factors Up-Regulation
Rejuvenating conventional dendritic cells and T follicular helper cell formation after vaccination
Marisa Stebegg, Alexandre Bignon, Danika Lea Hill, Alyssa Silva-Cayetano, Christel Krueger, Ine Vanderleyden, Silvia Innocentin, Louis Boon, Jiong Wang, Martin S Zand, James Dooley, Jonathan Clark, Adrian Liston, Edward Carr, Michelle A Linterman
Mar 25, 2020
Germinal centres (GCs) are T follicular helper cell (Tfh)-dependent structures that form in response to vaccination, producing long-lived antibody secreting plasma cells and memory B cells that protect against subsequent...
Gene expression profiling of CD8+ T cells predicts prognosis in patients with Crohn disease and ulcerative colitis.
James C Lee, Paul A Lyons, Eoin F McKinney, John M Sowerby, Edward J Carr, Francesca Bredin, Hannah M Rickman, Huzefa Ratlamwala, Alexander Hatton, Tim F Rayner, Miles Parkes, Kenneth GC Smith
Nov 29, 2018
Crohn disease (CD) and ulcerative colitis (UC) are increasingly common, chronic forms of inflammatory bowel disease. The behavior of these diseases varies unpredictably among patients. Identification of reliable prognostic...
Determination of the Synthetic Cannabinoids JWH-122, JWH-210, UR-144 in Oral Fluid of Consumers by GC-MS and Quantification of Parent Compounds and Metabolites by UHPLC-MS/MS.
Nunzia La Maida, Manuela Pellegrini, Esther Papaseit, Clara Pérez-Mañá, Lourdes Poyatos, Mireia Ventura, Liliana Galindo, Francesco Paolo Busardò, Simona Pichini, Magí Farré, Emilia Marchei
Dec 11, 2020
The consumption of synthetic cannabinoids (SCs) has significantly increased in the last decade and the analysis of SCs and their metabolites in human specimens is gaining interest in clinical and forensic toxicology. A pilot...
Tumors Widely Express Hundreds of Embryonic Germline Genes.
Jan Willem Bruggeman, Naoko Irie, Paul Lodder, Ans MM van Pelt, Jan Koster, Geert Hamer
Dec 22, 2020
We have recently described a class of 756 genes that are widely expressed in cancers, but are normally restricted to adult germ cells, referred to as germ cell cancer genes (GC genes). We hypothesized that carcinogenesis...
Can follicular helper T cells be targeted to improve vaccine efficacy?
The success of most vaccines relies on the generation of antibodies to provide protection against subsequent infection; this in turn depends on a robust germinal centre (GC) response that culminates in the production of...
A bioactive phlebovirus-like envelope protein in a hookworm endogenous virus
Monique Merchant, carlos Perez Mata, yangci Liu, haomin Zhai, Anna Protasio, Yorgo Modis
Jun 11, 2022
Endogenous viral elements (EVEs), accounting for 15% of our genome, serve as a genetic reservoir from which new genes can emerge. Nematode EVEs are particularly diverse and informative of virus evolution. We identify Atlas virus...
Regulation of the Germinal Center Response.
Marisa Stebegg, Saumya D Kumar, Alyssa Silva-Cayetano, Valter R Fonseca, Michelle A Linterman, Luis Graca
Jun 24, 2019
The germinal center (GC) is a specialized microstructure that forms in secondary lymphoid tissues, producing long-lived antibody secreting plasma cells and memory B cells, which can provide protection against reinfection. Within...
Computational Studies of the Mechanical Stability for Single-Strand Break DNA.
The stability of DNA is crucial for the existence of most living organisms. Even a single DNA break can lead to serious problems, including cell death. In this work the position specificity of single strand breaks (SSB) and the...
|
|< |
< |
1 |