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Results: 350
GC content shapes mRNA storage and decay in human cells.
Maïté Courel, Yves Clément, Clémentine Bossevain, Dominika Foretek, Olivia Vidal Cruchez, Zhou Yi, Marianne Bénard, Marie-Noëlle Benassy, Michel Kress, Caroline Vindry, Michèle Ernoult-Lange, Christophe Antoniewski, Antonin Morillon, Patrick Brest, Arnaud Hubstenberger, Hugues Roest Crollius, Nancy Standart, Dominique Weil
Mar 09, 2020
mRNA translation and decay appear often intimately linked although the rules of this interplay are poorly understood. In this study, we combined our recent P-body transcriptome with transcriptomes obtained following silencing of...
Marsupial chromosome DNA content and genome size assessed from flow karyotypes
Extensive chromosome homologies revealed by cross-species chromosome painting between marsupials have suggested a high level of genome conservation during evolution. Surprisingly, it has been reported that marsupial genome sizes...
GC content shapes mRNA storage and decay in human cells.
Maïté Courel, Yves Clément, Clémentine Bossevain, Dominika Foretek, Olivia Vidal Cruchez, Zhou Yi, Marianne Bénard, Marie-Noëlle Benassy, Michel Kress, Caroline Vindry, Michèle Ernoult-Lange, Christophe Antoniewski, Antonin Morillon, Patrick Brest, Arnaud Hubstenberger, Hugues Roest Crollius, Nancy Standart, Dominique Weil
Jan 27, 2020
mRNA translation and decay appear often intimately linked although the rules of this interplay are poorly understood. In this study, we combined our recent P-body transcriptome with transcriptomes obtained following silencing of...
Tetrad analysis in plants and fungi finds large differences in gene conversion rates but no GC bias
Haoxuan Liu, Ju Huang, Xiaoguang Sun, Jing Li, Yingwen Hu, Luyao Yu, Gianni Liti, Dacheng Tian, Laurence Hurst, Sihai Yang
Jan 01, 2018
GC-favouring gene conversion enables fixation of deleterious alleles, disturbs tests of natural selection and potentially explains both the evolution of recombination as well as the commonly reported intragenomic correlation...
Tetrad analysis in plants and fungi finds large differences in gene conversion rates but no GC bias
Haoxuan Liu, Ju Huang, Xiaoguang Sun, Jing Li, Yingwen Hu, Luyao Yu, Gianni Liti, Dacheng Tian, Laurence Hurst, Sihai Yang
Jan 01, 2018
GC-favouring gene conversion enables fixation of deleterious alleles, disturbs tests of natural selection and potentially explains both the evolution of recombination as well as the commonly reported intragenomic correlation...
Analysis of a wild mouse promoter variant reveals a novel role for FcγRIIb in the control of the germinal center and autoimmunity.
Marion Espéli, Menna R Clatworthy, Susanne Bökers, Kate E Lawlor, Antony J Cutler, Frank Köntgen, Paul A Lyons, Kenneth GC Smith
Nov 29, 2018
Genetic variants of the inhibitory Fc receptor FcγRIIb have been associated with systemic lupus erythematosus in humans and mice. The mechanism by which Fcgr2b variants contribute to the development of autoimmunity is unknown...
Animals Autoantibodies Autoimmunity B-Lymphocytes Chromatin Immunoprecipitation DNA Primers Enzyme-Linked Immunosorbent Assay Enzyme-Linked Immunospot Assay Flow Cytometry Gene Expression Regulation Gene Knock-In Techniques genetic variation Germinal Center Luciferases Mice Mice Inbred C57BL Mutagenesis Site-Directed Promoter Regions Genetic Receptors IgG Sequence Analysis DNA statistics Nonparametric Transcription Factor AP-1
False gene and chromosome losses in genome assemblies caused by GC content variation and repeats.
Juwan Kim, Chul Lee, Byung June Ko, Dong Ahn Yoo, Sohyoung Won, Adam M Phillippy, Olivier Fedrigo, Guojie Zhang, Kerstin Howe, Jonathan Wood, Richard Durbin, Giulio Formenti, Samara Brown, Lindsey Cantin, Claudio V Mello, Seoae Cho, Arang Rhie, Heebal Kim, Erich D Jarvis
Sep 28, 2022
BACKGROUND: Many short-read genome assemblies have been found to be incomplete and contain mis-assemblies. The Vertebrate Genomes Project has been producing new reference genome assemblies with an emphasis on being as complete...
Playing Mind Games: Neural Correlates of Personality, Cortical Activity and Suggestibility
Steven A Medeiros, Jr.
Jan 01, 0001
This study examined a potential relationship between extraversion-introversion and neuro-cortical activity measured through EEG, as well as the possibility that one's own implicit personality could be manipulated on a...
personality EEG suggestibility Extraversion implicit personality false beliefs Behavioral Neurobiology cognitive neuroscience Life Sciences Neuroscience and Neurobiology Other Neuroscience and Neurobiology
Published by: Ursinus College
Cardioprotection by ischemic postconditioning and cyclic guanosine monophosphate-elevating agents involves cardiomyocyte nitric oxide-sensitive guanylyl cyclase.
Sandra Frankenreiter, Dieter Groneberg, Anna Kuret, Thomas Krieg, Peter Ruth, Andreas Friebe, Robert Lukowski
Mar 13, 2018
AIMS: It has been suggested that the nitric oxide-sensitive guanylyl cyclase (NO-GC)/cyclic guanosine monophosphate (cGMP)-dependent signalling pathway affords protection against cardiac damage during acute myocardial infarction...
Animals Benzoates Cyclic GMP Disease Models Animal Enzyme Activators Female Ischemic Postconditioning Large-Conductance Calcium-Activated Potassium Channels Male Mice Knockout Myocardial Infarction Myocardial Reperfusion Injury Myocytes Cardiac Nitric oxide Phosphodiesterase 5 Inhibitors Signal Transduction Sildenafil Citrate Soluble Guanylyl Cyclase Tadalafil Tetrazoles Thiourea Time Factors Up-Regulation
Determination of the Synthetic Cannabinoids JWH-122, JWH-210, UR-144 in Oral Fluid of Consumers by GC-MS and Quantification of Parent Compounds and Metabolites by UHPLC-MS/MS.
Nunzia La Maida, Manuela Pellegrini, Esther Papaseit, Clara Pérez-Mañá, Lourdes Poyatos, Mireia Ventura, Liliana Galindo, Francesco Paolo Busardò, Simona Pichini, Magí Farré, Emilia Marchei
Dec 11, 2020
The consumption of synthetic cannabinoids (SCs) has significantly increased in the last decade and the analysis of SCs and their metabolites in human specimens is gaining interest in clinical and forensic toxicology. A pilot...
Tumors Widely Express Hundreds of Embryonic Germline Genes.
Jan Willem Bruggeman, Naoko Irie, Paul Lodder, Ans MM van Pelt, Jan Koster, Geert Hamer
Dec 22, 2020
We have recently described a class of 756 genes that are widely expressed in cancers, but are normally restricted to adult germ cells, referred to as germ cell cancer genes (GC genes). We hypothesized that carcinogenesis...
Can follicular helper T cells be targeted to improve vaccine efficacy?
The success of most vaccines relies on the generation of antibodies to provide protection against subsequent infection; this in turn depends on a robust germinal centre (GC) response that culminates in the production of...
A bioactive phlebovirus-like envelope protein in a hookworm endogenous virus
Monique Merchant, carlos Perez Mata, yangci Liu, haomin Zhai, Anna Protasio, Yorgo Modis
Jun 11, 2022
Endogenous viral elements (EVEs), accounting for 15% of our genome, serve as a genetic reservoir from which new genes can emerge. Nematode EVEs are particularly diverse and informative of virus evolution. We identify Atlas virus...
Regulation of the Germinal Center Response.
Marisa Stebegg, Saumya D Kumar, Alyssa Silva-Cayetano, Valter R Fonseca, Michelle A Linterman, Luis Graca
Jun 24, 2019
The germinal center (GC) is a specialized microstructure that forms in secondary lymphoid tissues, producing long-lived antibody secreting plasma cells and memory B cells, which can provide protection against reinfection. Within...
Anxiety, Gambling Activity, and Neurocognition
Gustavo C Medeiros, Daniela G Sampaio, Eric W Leppink, Samuel R Chamberlain, Jon E Grant
Jul 11, 2016
Computational Studies of the Mechanical Stability for Single-Strand Break DNA.
The stability of DNA is crucial for the existence of most living organisms. Even a single DNA break can lead to serious problems, including cell death. In this work the position specificity of single strand breaks (SSB) and the...
Immunophenotype of Gastric Tumors Unveils a Pleiotropic Role of Regulatory T Cells in Tumor Development.
Sara Rocha, Afonso P Basto, Marieke E Ijsselsteijn, Sara P Teles, Maria M Azevedo, Gilza Gonçalves, Irene Gullo, Gabriela M Almeida, Joaquín J Maqueda, Marta I Oliveira, Fátima Carneiro, João T Barata, Luís Graça, Noel FCC de Miranda, Joana Carvalho, Carla Oliveira
Jan 24, 2021
Gastric cancer (GC) patients display increased regulatory T cell (Tregs) numbers in peripheral blood and among tumor-infiltrating lymphocytes. Nevertheless, the role of Tregs in GC progression remains controversial. Here, we...
Are brief interventions to increase physical activity cost-effective? A systematic review.
Vijay GC, Edward Cf Wilson, Marc Suhrcke, Wendy Hardeman, Stephen Sutton, VBI Programme Team
Jul 28, 2015
Comparison of Latanoprostene Bunod 0.024% and Timolol Maleate 0.5% in Open-Angle Glaucoma or Ocular Hypertension
Felipe A Medeiros, Keith R Martin, James Peace, Baldo Scassellati Sforzolini, Jason L Vittitow, Robert N Weinreb
Sep 03, 2019
PURPOSE: To compare the intraocular pressure (IOP)-lowering effect of latanoprostene bunod (LBN) 0.024% with timolol maleate 0.5% in subjects with open-angle glaucoma (OAG) or ocular hypertension (OHT). DESIGN: Prospective...
Functional constraints on SoxE proteins in neural crest development
Eric M. Lee, Tian Yuan, Reyna D. Ballim, Kristy Nguyen, Robert N. Kelsh, Daniel M. Medeiros, David W. McCauley
Oct 01, 2016
Vertebrate SoxE genes (Sox8, 9, and 10) are key regulators of neural crest cell (NCC) development. These genes arose by duplication from a single SoxE gene in the vertebrate ancestor. Although SoxE paralogs are coexpressed early...
The Small Things of Life and Death
GC Carr
Jul 10, 2017
Growth pattern trajectories in boys with Duchenne muscular dystrophy.
Georgia Stimpson, Sarah Raquq, Mary Chesshyre, Mary Fewtrell, Deborah Ridout, Anna Sarkozy, Adnan Manzur, Vandana Ayyar Gupta, Ramona De Amicis, Francesco Muntoni, Giovanni Baranello, NorthStar Network
Jan 28, 2022
OBJECTIVES: The objective of this study is to analyse retrospective, observational, longitudinal growth (weight, height and BMI) data in ambulatory boys aged 5-12 years with Duchenne muscular dystrophy (DMD). BACKGROUND: We...
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