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A drug-discovery-oriented non-invasive protocol for protein crystal cryoprotection by dehydration, with application for crystallization screening.
Dom Bellini
Apr 02, 2022
In X-ray macromolecular crystallography, cryoprotection of crystals mounted on harvesting loops is achieved when the water in the sample solvent transitions to vitreous ice before crystalline ice forms. This is achieved by rapid...
General Relativity, Mental Causation, and Energy Conservation.
J Brian Pitts
Jul 20, 2022
The conservation of energy and momentum have been viewed as undermining Cartesian mental causation since the 1690s. Modern discussions of the topic tend to use mid-nineteenth century physics, neglecting both locality and...
Identifying a large number of high-yield genes in rice by pedigree analysis, whole genome sequencing and CRISPR-Cas9 gene knockout
Ju Huang, Jing Li, Jun Zhou, Long Wang, Sihai Yang, Laurence Hurst, Wen-Hsiung Li, Dacheng Tian
Aug 07, 2018
Repeated artificial selection of a complex trait facilitates the identification of genes underlying the trait, especially if multiple selected descendant lines are available. Here we developed a pedigree-based approach to...
Low defect and high electrical conductivity of graphene through plasma graphene healing treatment monitored with in situ optical emission spectroscopy.
Mohammad Salehi, Parnia Bastani, Loghman Jamilpanah, Abbas Madani, Seyed Majid Mohseni, Babak Shokri
Oct 13, 2021
Fundamental studies on graphene (Gr) and its real device applications have been affected by unavoidable defects and impurities which are usually present in synthesized Gr. Therefore, post treatment methods on Gr have been an...
Identifying a large number of high-yield genes in rice by pedigree analysis, whole genome sequencing and CRISPR-Cas9 gene knockout
Ju Huang, Jing Li, Jun Zhou, Long Wang, Sihai Yang, Laurence Hurst, Wen-Hsiung Li, Dacheng Tian
Aug 07, 2018
Repeated artificial selection of a complex trait facilitates the identification of genes underlying the trait, especially if multiple selected descendant lines are available. Here we developed a pedigree-based approach to...
A new transform method II
A new method for solving boundary-value problems (BVPs) for linear and certain nonlinear PDEs was introduced by one of the authors in the late 1990s. For linear PDEs, this method constructs novel integral representations (IRs)...
Glucocorticoid Receptor Binding Induces Rapid and Prolonged Large-Scale Chromatin Decompaction at Multiple Target Loci.
Glucocorticoids act by binding to the glucocorticoid receptor (GR), which binds to specific motifs within enhancers of target genes to activate transcription. Previous studies have suggested that GRs can promote interactions...
chromatin remodeling ENHANCER fluorescence in situ hybridization glucocorticoid receptor macrophage Animals Binding Sites Chromatin Chromatin Assembly and Disassembly DNA-Binding Proteins Dexamethasone Gene Expression Regulation Humans In Situ Hybridization Fluorescence Kinetics Kruppel-Like Factor 4 Kruppel-Like Transcription Factors MACROPHAGES Male Mice Mice Inbred C57BL Nuclear Receptor Coactivators Primary Cell Culture Promoter Regions Genetic Protein Binding Proto-Oncogene Proteins c-fos Receptors Glucocorticoid Signal Transduction Transcription Factors
Resilient High Catalytic Performance of Platinum Nanocatalysts with Porous Graphene Envelope.
Despite the innumerable developments of nanosized and well dispersed noble metal catalysts, the degradation of metal nanoparticle catalysts has proven to be a significant obstacle for the commercialization of the hydrogen fuel...
Control of Geminate Recombination by the Material Composition and Processing Conditions in Novel Polymer
Jiangbin Zhang, Qinying Gu, Thu Trang Do, Kira Rundel, Prashant Sonar, Richard H Friend, Christopher R McNeill, Artem A Bakulin
Mar 16, 2018
Herein, we report on the charge dynamics of photovoltaic devices based on two novel small-molecule nonfullerene acceptors featuring a central ketone unit. Using ultrafast near-infrared spectroscopy with optical and photocurrent...
The FUSION protein crystallization screen.
The success and speed of atomic structure determination of biological macromolecules by X-ray crystallography depends critically on the availability of diffraction-quality crystals. However, the process of screening...
Martin Peerson and Greville’s Caelica’
GR Alexander
Mar 27, 2017
This article assesses the relations between Martin Peerson’s Mottects or Grave Chamber Musique (1630) and Fulke Greville’s lyric sequence Caelica.1 It focuses on two particular questions: what kind of an interpretation or...
Restricted Proliferation During Neurogenesis Contributes to Regionalisation of the Amphioxus Nervous System.
The central nervous system of the cephalochordate amphioxus consists of a dorsal neural tube with an anterior brain. Two decades of gene expression analyses in developing amphioxus embryos have shown that, despite apparent...
Elevated Hypothalamic Glucocorticoid Levels Are Associated With Obesity and Hyperphagia in Male Mice.
Charlotte Sefton, Erika Harno, Alison Davies, Helen Small, Tiffany-Jayne Allen, Jonathan R Wray, Catherine B Lawrence, Anthony P Coll, Anne White
Nov 29, 2016
Glucocorticoid (Gc) excess, from endogenous overproduction in disorders of the hypothalamic-pituitary-adrenal axis or exogenous medical therapy, is recognized to cause adverse metabolic side effects. The Gc receptor (GR) is...
An entrainment model for lazy turbulent plumes
An entrainment model for lazy turbulent plumes is proposed, the resulting solutions of the plume conservation equations are developed and the implications for plume behaviour are considered and compared with the available...
Resilience to Plasma and Cerebrospinal Fluid Amyloid-β in Cognitively Normal Individuals
Objective: To define resilience metrics for cognitive decline based on plasma and cerebrospinal fluid (CSF) amyloid-β (Aβ) and examine the demographic, genetic, and neuroimaging factors associated with interindividual...
A trust region subproblem for 3D electrical impedance tomography inverse problem using experimental data
Image reconstruction in electrical impedance tomography (EIT) is an ill-posed nonlinear inverse problem. Regularization methods are needed to solve this problem. The results of the ill-posed EIT problem strongly depends on noise...
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