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Gene Ontology Consortium
Gene Ontology Consortium
May 06, 2020
The Gene Ontology (GO; http://www.geneontology.org) is a community-based bioinformatics resource that supplies information about gene product function using ontologies to represent biological knowledge. Here we describe...
The Gene Ontology resource
Gene Ontology Consortium
Feb 08, 2021
The Gene Ontology Consortium (GOC) provides the most comprehensive resource currently available for computable knowledge regarding the functions of genes and gene products. Here, we report the advances of the consortium over the...
The Gene Ontology Resource
The Gene Ontology Consortium
Feb 11, 2019
The Gene Ontology resource (GO; http://geneontology.org) provides structured, computable knowledge regarding the functions of genes and gene products. Founded in 1998, GO has become widely adopted in the life sciences, and its...
The Gene Ontology
Gene Ontology Consortium
May 06, 2020
The Gene Ontology (GO) (http://www.geneontology.org) is a community bioinformatics resource that represents gene product function through the use of structured, controlled vocabularies. The number of GO annotations of gene...
The Gene Ontology in 2010
Gene Ontology Consortium
May 06, 2020
The Gene Ontology (GO) Consortium (http://www.geneontology.org) (GOC) continues to develop, maintain and use a set of structured, controlled vocabularies for the annotation of genes, gene products and sequences. The GO...
The Gene Ontology project in 2008.
Gene Ontology Consortium
May 06, 2020
The Gene Ontology (GO) project (http://www.geneontology.org/) provides a set of structured, controlled vocabularies for community use in annotating genes, gene products and sequences (also see http://www.sequenceontology.org/)....
The Gene Ontology (GO) project in 2006.
Gene Ontology Consortium
May 06, 2020
The Gene Ontology (GO) project (http://www.geneontology.org) develops and uses a set of structured, controlled vocabularies for community use in annotating genes, gene products and sequences (also see...
The Gene Ontology's Reference Genome Project
The Gene Ontology (GO) is a collaborative effort that provides structured vocabularies for annotating the molecular function, biological role, and cellular location of gene products in a highly systematic way and in a...
Effector gene birth in plant parasitic nematodes
Catherine J Lilley, Abbas Maqbool, Duqing Wu, Hazijah B Yusup, Laura M Jones, Paul RJ Birch, Mark J Banfield, Peter E Urwin, Sebastian Eves-van den Akker
Oct 10, 2018
Plant pathogens and parasites are a major threat to global food security. Plant parasitism has arisen four times independently within the phylum Nematoda, resulting in at least one parasite of every major food crop in the world....
Protection of CpG islands from DNA methylation is DNA-encoded and evolutionarily conserved.
DNA methylation is a repressive epigenetic modification that covers vertebrate genomes. Regions known as CpG islands (CGIs), which are refractory to DNA methylation, are often associated with gene promoters and play central...
Animals Cell Line Chromosomes Human Pair 21 Conserved Sequence CpG Islands DNA DNA Methylation evolution Molecular Female Gene Expression Regulation Humans Male Mice Inbred C57BL Mice Transgenic Promoter Regions Genetic Protein Binding Repetitive Sequences Nucleic Acid Species Specificity Transcription Factors Vertebrates
Comment on Herring et al. The Use of "Retardation" in FRAXA, FMRP, FMR1 and Other Designations. Cells 2022, 11, 1044.
This commentary is written in response to the recent article from Herring et al., discussing the eradication of the offensive term "retardation" from gene nomenclature. We discuss the work of the HUGO (Human Genome Organisation)...
Transcriptional coupling of neighboring genes and gene expression noise
How is noise in gene expression modulated? Do mechanisms of noise control impact genome organization? In yeast, the expression of one gene can affect that of a very close neighbor. As the effect is highly regionalized, we...
Annotation of gene product function from high-throughput studies using the Gene Ontology.
Helen Attrill, Pascale Gaudet, Rachael P Huntley, Ruth C Lovering, Stacia R Engel, Sylvain Poux, Kimberly M Van Auken, George Georghiou, Marcus C Chibucos, Tanya Z Berardini, Valerie Wood, Harold Drabkin, Petra Fey, Penelope Garmiri, Midori A Harris, Tony Sawford, Leonore Reiser, Rebecca Tauber, Sabrina Toro, Gene Ontology Consortium
Feb 14, 2019
High-throughput studies constitute an essential and valued source of information for researchers. However, high-throughput experimental workflows are often complex, with multiple data sets that may contain large numbers of false...
Transcriptional coupling of neighboring genes and gene expression noise
How is noise in gene expression modulated? Do mechanisms of noise control impact genome organization? In yeast, the expression of one gene can affect that of a very close neighbor. As the effect is highly regionalized, we...
Transcription-coupled repair and mismatch repair contribute towards preserving genome integrity at mononucleotide repeat tracts
Ilias Georgakopoulos-Soares, Gene Koh, Sophie E. Momen, Josef Jiricny, Martin Hemberg, Serena Nik-Zainal
Apr 24, 2021
Abstract: The mechanisms that underpin how insertions or deletions (indels) become fixed in DNA have primarily been ascribed to replication-related and/or double-strand break (DSB)-related processes. Here, we introduce a method...
Gene-gene and gene-environment interactions in lipodystrophy
Monogenic lipodystrophies are a heterogeneous group of rare disorders characterized by a lack of adipose tissue (AT), all of which predispose patients to the development of insulin resistance and its related metabolic sequelae....
What drives success in English medium taught courses? The interplay between language proficiency, academic skills, and motivation.
This article explores the relationship between course performance, English
language proficiency, motivation, and academic language skills in an English
medium instruction (EMI) university context. It analyses test and...
language proficiency, motivation, and academic language skills in an English
medium instruction (EMI) university context. It analyses test and...
Human germline gene editing needs global regulation
Ryan Prestil
Apr 23, 2020
The first gene-edited human babies were born in China in late 2018, but no new legislation has been enacted despite widespread outrage. There is a pressing societal need to address the moral and ethical issues associated with...
Examining the epigenetic mechanisms of childhood adversity and sensitive periods
Yiwen Zhu, Alexandre A. Lussier, Andrew D.A.C. Smith, Andrew J. Simpkin, Matthew J. Suderman, Esther Walton, Caroline L. Relton, Erin C. Dunn
Oct 31, 2022
Background: Sensitive periods are developmental stages of heightened plasticity when life experiences, including exposure to childhood adversity, have the potential to exert more lasting impacts. Epigenetic mechanisms...
ALSPAC childhood adversity epigenetics plasticity sensitive periods /dk/atira/pure/subjectarea/asjc/2700/2712 name=Endocrinology, Diabetes and Metabolism /dk/atira/pure/subjectarea/asjc/1300/1310 name=Endocrinology /dk/atira/pure/subjectarea/asjc/2800/2807 name=Endocrine and Autonomic Systems /dk/atira/pure/subjectarea/asjc/2700/2738 name=Psychiatry and Mental health /dk/atira/pure/subjectarea/asjc/2800/2803 name=Biological Psychiatry /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
FROM GENE TO ORGANISM
The Rockefeller University
Jan 01, 0001
Centennial Symposium
From Gene to Organism: Insights from Cell, Developmental and Molecular Biology
Published by: The Rockefeller University
The mammalian gene function resource
Allan Bradley, Konstantinos Anastassiadis, Abdelkader Ayadi, James F Battey, Cindy Bell, Marie-Christine Birling, Joanna Bottomley, Steve D Brown, Antje Bürger, Carol J Bult, Wendy Bushell, Francis S Collins, Christian Desaintes, Brendan Doe, Aris Economides, Janan T Eppig, Richard H Finnell, Colin Fletcher, Martin Fray, David Frendewey, Roland H Friedel, Frank G Grosveld, Jens Hansen, Yann Hérault, Geoffrey Hicks, Andreas Hörlein, Richard Houghton, Martin Hrabé de Angelis, Danny Huylebroeck, Vivek Iyer, Pieter J de Jong, James A Kadin, Cornelia Kaloff, Karen Kennedy, Manousos Koutsourakis, KC Kent Lloyd, Susan Marschall, Jeremy Mason, Colin McKerlie, Michael P McLeod, Harald von Melchner, Mark Moore, Alejandro O Mujica, Andras Nagy, Mikhail Nefedov, Lauryl M Nutter, Guillaume Pavlovic, Jane L Peterson, Jonathan Pollock, Ramiro Ramirez-Solis, Derrick E Rancourt, Marcello Raspa, Jacques E Remacle, Martin Ringwald, Barry Rosen, Nadia Rosenthal, Janet Rossant, Patricia Ruiz Noppinger, Ed Ryder, Joel Zupicich Schick, Frank Schnütgen, Paul Schofield, Claudia Seisenberger, Mohammed Selloum, Elizabeth M Simpson, William C Skarnes, Damian Smedley, William L Stanford, A Francis Stewart, Kevin Stone, Kate Swan, Hamsa Tadepally, Lydia Teboul, Glauco P Tocchini-Valentini, David Valenzuela, Anthony P West, Ken-ichi Yamamura, Yuko Yoshinaga, Wolfgang Wurst
Oct 14, 2020
In 2007, the International Knockout Mouse Consortium (IKMC) made the ambitious promise to generate mutations in virtually every protein-coding gene of the mouse genome in a concerted worldwide action. Now, 5 years later, the...
Exploring the role of self-efficacy beliefs and learner success in English Medium Instruction
English medium instruction (EMI) is a growing phenomenon in higher education contexts across the globe, and EMI programs are expanding rapidly in Japan as part of their internationalization efforts. This paper explores the...
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