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Modeling Parkinson's Disease Neuropathology and Symptoms by Intranigral Inoculation of Preformed Human α-Synuclein Oligomers.
Laura Boi, Augusta Pisanu, Maria Francesca Palmas, Giuliana Fusco, Ezio Carboni, Maria Antonietta Casu, Valentina Satta, Maria Scherma, Elzbieta Janda, Ignazia Mocci, Giovanna Mulas, Anna Ena, Saturnino Spiga, Paola Fadda, Alfonso De Simone, Anna R Carta
Nov 13, 2020
The accumulation of aggregated α-synuclein (αSyn) is a hallmark of Parkinson's disease (PD). Current evidence indicates that small soluble αSyn oligomers (αSynOs) are the most toxic species among the forms of αSyn aggregates...
Parkinson Disease COGNITIVE IMPAIRMENT Microglia motor deficits neurodegeneration Neuroinflammation α-synuclein oligomers Animals Cytokines Disease Models Animal Dopamine Dopaminergic Neurons Humans Inflammation Male Microglia Neurons Parkinson Disease Phagocytosis Phosphorylation Rats Rats Sprague-Dawley Recombinant Proteins Substantia Nigra ALPHA-SYNUCLEIN
The Intranigral Infusion of Human-Alpha Synuclein Oligomers Induces a Cognitive Impairment in Rats Associated with Changes in Neuronal Firing and Neuroinflammation in the Anterior Cingulate Cortex.
Maria Francesca Palmas, Michela Etzi, Augusta Pisanu, Chiara Camoglio, Claudia Sagheddu, Michele Santoni, Maria Francesca Manchinu, Mauro Pala, Giuliana Fusco, Alfonso De Simone, Luca Picci, Giovanna Mulas, Saturnino Spiga, Maria Scherma, Paola Fadda, Marco Pistis, Nicola Simola, Ezio Carboni, Anna R Carta
Oct 10, 2022
Parkinson's disease (PD) is a complex pathology causing a plethora of non-motor symptoms besides classical motor impairments, including cognitive disturbances. Recent studies in the PD human brain have reported microgliosis in...
Negative feedback via RSK modulates Erk-dependent progression from naïve pluripotency.
RSK Embryonic Stem Cells mitogen‐activated protein kinase Pluripotency signalling feedback Animals Cell Differentiation Cell Lineage Embryonic Stem Cells Extracellular Signal-Regulated MAP Kinases Feedback Physiological Humans Mutation Phosphoproteins Phosphorylation Pluripotent Stem Cells Proteome Ribosomal Protein S6 Kinases 90-kDa Small Molecule Libraries
Defined conditions for propagation and manipulation of mouse embryonic stem cells.
Carla Mulas, Tüzer Kalkan, Ferdinand von Meyenn, Harry G Leitch, Jennifer Nichols, Austin Smith
Feb 23, 2019
DIFFERENTIATION Embryonic Stem Cells Pluripotency self-renewal Animals CRISPR-Cas Systems Cell Culture Techniques Cell Cycle Cell Differentiation Coculture Techniques Culture Media Embryo Mammalian Embryonic Stem Cells Humans Karyotyping Mice Mice Inbred C57BL Mouse embryonic stem cells Neurons RNA Small Interfering Signal Transduction
Microfluidic platform for 3D cell culture with live imaging and clone retrieval.
Carla Mulas, Andrew C Hodgson, Timo N Kohler, Chibeza C Agley, Peter Humphreys, Hans Kleine-Brüggeney, Florian Hollfelder, Austin Smith, Kevin J Chalut
Jun 26, 2020
Combining live imaging with the ability to retrieve individual cells of interest remains a technical challenge. Combining imaging with precise cell retrieval is of particular interest when studying highly dynamic or transient...
Complementary Activity of ETV5, RBPJ, and TCF3 Drives Formative Transition from Naive Pluripotency.
Tüzer Kalkan, Susanne Bornelöv, Carla Mulas, Evangelia Diamanti, Tim Lohoff, Meryem Ralser, Sjors Middelkamp, Patrick Lombard, Jennifer Nichols, Austin Smith
Apr 10, 2019
ETS factors RBPJ Commitment DIFFERENTIATION Embryonic Stem Cell Epiblast gene regulatory network Pluripotency self-renewal Animals Basic Helix-Loop-Helix Transcription Factors Cell Differentiation Cell Line Cell Lineage Cell Self Renewal DNA-Binding Proteins Gene Knockout Techniques Gene Regulatory Networks Immunoglobulin J Recombination Signal Sequence-Binding Protein Mice Mice Inbred C57BL Mice Inbred CBA Nanog Homeobox Protein Neurons Pluripotent Stem Cells RNA Small Interfering T-Box Domain Proteins Transcription Factors
Convergence of interaction-driven evolutions of dislocations with Wasserstein dissipation and slip-plane confinement
We consider systems of n parallel edge dislocations in a single slip system, represented by points in a two-dimensional domain; the elastic medium is modelled as a continuum. We formulate the energy of this system in terms of...
Convergence of interaction-driven evolutions of dislocations with Wasserstein dissipation and slip-plane confinement
We consider systems of n parallel edge dislocations in a single slip system, represented by points in a two-dimensional domain; the elastic medium is modelled as a continuum. We formulate the energy of this system in terms of...
The unfolded protein response in neurodegenerative disorders - therapeutic modulation of the PERK pathway.
The unfolded protein response (UPR) is a highly conserved protein quality control mechanism, activated in response to Endoplasmic Reticulum (ER) stress. Signalling is mediated through three branches, PERK, IRE1, and ATF6...
Tool wear classification using time series imaging and deep learning
Abstract: Tool condition monitoring (TCM) has become essential to achieve high-quality machining as well as cost-effective production. Identification of the cutting tool state during machining before it reaches its failure stage...
Tensile Strength of Artificially Cemented Sandstone Generated via Microbially Induced Carbonate Precipitation
Artificially bio-cemented sands treated with microbially induced calcite precipitation are weakly cemented rocks representing intermediate materials between locked and carbonate sands. Variations in cementation significantly...
The equilibrium measure for a nonlocal dislocation energy
In this paper we characterize the equilibrium measure for a nonlocal and anisotropic weighted energy describing the interaction of positive dislocations in the plane. We prove that the minimum value of the energy is attained...
Early downregulation of hsa-miR-144-3p in serum from drug-naïve Parkinson's disease patients.
Elisa Zago, Alessandra Dal Molin, Giovanna Maria Dimitri, Luciano Xumerle, Chiara Pirazzini, Maria Giulia Bacalini, Maria Giovanna Maturo, Tiago Azevedo, Simeon Spasov, Pilar Gómez-Garre, María Teresa Periñán, Silvia Jesús, Luca Baldelli, Luisa Sambati, Giovanna Calandra-Buonaura, Paolo Garagnani, Federica Provini, Pietro Cortelli, Pablo Mir, Claudia Trenkwalder, Brit Mollenhauer, Claudio Franceschi, Pietro Liò, Christine Nardini, PROPAG-AGEING consortium
Jan 28, 2022
Advanced age represents one of the major risk factors for Parkinson's Disease. Recent biomedical studies posit a role for microRNAs, also known to be remodelled during ageing. However, the relationship between microRNA...
Prions
Neurodegenerative diseases are characterized by the aggregation of misfolded proteins in the brain. Among these disorders are the prion diseases, which are transmissible, and in which the misfolded proteins ("prions") are also...
Alzheimer Disease Alzheimer's gene therapy neurodegeneration Neuroprotection Prion Unfolded Protein Response (UPR) adenine Alzheimer Disease Amyloid beta-Peptides Animals Humans Indoles Neurodegenerative Diseases Parkinson Disease Prion Diseases Prions Protein Conformation Protein Kinase Inhibitors Tauopathies Unfolded Protein Response ALPHA-SYNUCLEIN eIF-2 Kinase tau Proteins
Tool wear classification using time series imaging and deep learning
Tool condition monitoring (TCM) has become essential to achieve high-quality machining as well as cost-effective production. Identification of the cutting tool state during machining before it reaches its failure stage is...
Developing Therapies for Neurodegenerative Disorders
Reply: Trazodone to change the risk of neurodegeneration
We were interested to read the authors’ comments our recent paper in Brain (Halliday et al., 2017). We agree that carefully designed phase II and phase III trials would be needed to test the efficacy of trazodone as a treatment...
StemBond hydrogels control the mechanical microenvironment for pluripotent stem cells
Céline Labouesse, Bao Xiu Tan, Chibeza C. Agley, Moritz Hofer, Alexander K. Winkel, Giuliano G. Stirparo, Hannah T. Stuart, Christophe M. Verstreken, Carla Mulas, William Mansfield, Paul Bertone, Kristian Franze, José C. R. Silva, Kevin J. Chalut
Oct 21, 2021
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