Search
Results: 65
Capture Hi-C reveals novel candidate genes and complex long-range interactions with related autoimmune risk loci.
Paul Martin, Amanda McGovern, Gisela Orozco, Kate Duffus, Annie Yarwood, Stefan Schoenfelder, Nicholas J Cooper, Anne Barton, Chris Wallace, Peter Fraser, Jane Worthington, Steve Eyre
Dec 22, 2015
Capture Hi-C reveals novel candidate genes and complex long-range interactions with related autoimmune risk loci
Paul Martin, Amanda McGovern, Gisela Orozco, Kate Duffus, Annie Yarwood, Stefan Schoenfelder, Nicholas J Cooper, Anne Barton, Chris Wallace, Peter Fraser, Jane Worthington, Steve Eyre
Aug 09, 2017
This is the final version of the article. It first appeared from Nature Publishing Group via http://dx.doi.org/10.1038/ncomms10069
Published by: Nature Communications
Identifying Causal Genes at the Multiple Sclerosis Associated Region 6q23 Using Capture Hi-C.
Paul Martin, Amanda McGovern, Jonathan Massey, Stefan Schoenfelder, Kate Duffus, Annie Yarwood, Anne Barton, Jane Worthington, Peter Fraser, Stephen Eyre, Gisela Orozco
Jul 15, 2019
BACKGROUND: The chromosomal region 6q23 has been found to be associated with multiple sclerosis (MS) predisposition through genome wide association studies (GWAS). There are four independent single nucleotide polymorphisms...
Capture Hi-C identifies a novel causal gene, IL20RA, in the pan-autoimmune genetic susceptibility region 6q23.
Amanda McGovern, Stefan Schoenfelder, Paul Martin, Jonathan Massey, Kate Duffus, Darren Plant, Annie Yarwood, Arthur G Pratt, Amy E Anderson, John D Isaacs, Julie Diboll, Nishanthi Thalayasingam, Caroline Ospelt, Anne Barton, Jane Worthington, Peter Fraser, Stephen Eyre, Gisela Orozco
Jul 15, 2019
BACKGROUND: The identification of causal genes from genome-wide association studies (GWAS) is the next important step for the translation of genetic findings into biologically meaningful mechanisms of disease and potential...
Autoimmunity Capture Hi-C Causal genes Functional genomics Genome-wide association studies (GWAS) Single nucleotide polymorphisms (SNP) Arthritis Rheumatoid B-Lymphocytes Chromatin Chromosomes Human Pair 6 Genetic Predisposition to Disease Genome Human Genome-Wide Association Study Humans Polymorphism Single Nucleotide psoriasis Receptors Interleukin T-Lymphocytes
A Case Study of Clozapine and Cognition
George Savulich, Gisela Mezquida, Samuel Atkinson, Miguel bernardo, Emilio Fernandez-Egea
Mar 27, 2018
Cognitive dysfunction is a hallmark feature of schizophrenia, often presenting in patients with psychotic disorders since the first episode (1) or earlier (2). Antipsychotic medication is effective for treating the positive...
Protein disorder-to-order transition enhances the nucleosome-binding affinity of H1.
Intrinsically disordered proteins are crucial elements of chromatin heterogenous organization. While disorder in the histone tails enables a large variation of inter-nucleosome arrangements, disorder within the chromatin-binding...
Passivity analysis and control of nonlinear systems modelled by bond graphs
Recent results on the passivity analysis and control of physical systems, based on the balance of dissipated and internally generated energy, are generalised to nonlinear systems represented by bond graphs. For linear systems...
Passivity analysis and control of nonlinear systems modelled by bond graphs
Recent results on the passivity analysis and control of physical systems, based on the balance of dissipated and internally generated energy, are generalised to nonlinear systems represented by bond graphs. For linear systems...
All-in-one disulfide bridging enables the generation of antibody conjugates with modular cargo loading.
Friederike M Dannheim, Stephen J Walsh, Carolina T Orozco, Anders Højgaard Hansen, Jonathan D Bargh, Sophie E Jackson, Nicholas J Bond, Jeremy S Parker, Jason S Carroll, David R Spring
Sep 16, 2022
Antibody-drug conjugates (ADCs) are valuable therapeutic entities which leverage the specificity of antibodies to selectively deliver cytotoxins to antigen-expressing targets such as cancer cells. However, current methods for...
NAFlex
Adam Hospital, Ignacio Faustino, Rosana Collepardo-Guevara, Carlos González, Josep Lluis Gelpí, Modesto Orozco
Mar 25, 2021
We present NAFlex, a new web tool to study the flexibility of nucleic acids, either isolated or bound to other molecules. The server allows the user to incorporate structures from protein data banks, completing gaps and removing...
How accurate are accurate force-fields for B-DNA?
Pablo D Dans, Ivan Ivani, Adam Hospital, Guillem Portella, Carlos González, Modesto Orozco
Nov 13, 2017
Last generation of force-fields are raising expectations on the quality of molecular dynamics (MD) simulations of DNA, as well as to the belief that theoretical models can substitute experimental ones in several cases. However...
The (in)dependence of alternative splicing and gene duplication.
Alternative splicing (AS) and gene duplication (GD) both are processes that diversify the protein repertoire. Recent examples have shown that sequence changes introduced by AS may be comparable to those introduced by GD. In...
Online Interval Type-2 Fuzzy Extreme Learning Machine Applied to 3D Path Following for Remotely Operated Underwater Vehicles
Adrian Rubio-Solis, Uriel Martinez Hernandez, Luciano Nava-Balanzar, Luis Garcia-Valdovinos, Noe Rodriguez-Olivares, Juan Orozco-Muniz, Tomas Salgado-Jimenez
Jan 31, 2022
In marine missions that involve 3D path following tasks, the overall goal of Underwater Vehicles (UVs) is the successful completion of a path previously specified by the operator. This implies that the path must be followed...
Computational Linguistic and SNA to Classify and Prevent Systemic Risk in the Colombian Banking Industry
The banking sector has been one of the first to identify the importance of social media analysis to understand customers' needs to offer new services, segment the market, build customer loyalty, or understand their requests....
Published by: IGI Global Scientific Publishing
Influence of secondary sources in the Brief Negative Symptom Scale.
Devi Treen, George Savulich, Gisela Mezquida, Maria Paz García-Portilla, Alba Toll, Clemente García-Rizo, Leticia García-Álvarez, Daniel Bergé, Julio Bobes, Miguel bernardo, Emilio Fernandez-Egea, Anna Mané
Nov 23, 2018
Are animals autistic savants.
Giorgio Vallortigara, Allan Snyder, Gisela Kaplan, Patrick Bateson, Nicola S Clayton, Lesley J Rogers
Mar 02, 2020
Do animals have privileged access to lower level sensory information before it is packaged into concepts, as it has been argued for autistic savants?
The influence of intercalated oxygen on the properties of graphene on polycrystalline Cu under various environmental conditions.
Obstetric Phenotypes in the Heterogeneity of Schizophrenia.
Gisela Mezquida, Emilio Fernandez-Egea, Devi Treen, Anna Mané, Daniel Bergé, George Savulich, Leticia Garcia-Alvarez, Paz García-Portilla, Julio Bobes, Miguel bernardo, Clemente Garcia-Rizo
Dec 03, 2018
Interconversion of Unexpected Thiol States Affects the Stability, Structure, and Dynamics of Antibody Engineered for Site-Specific Conjugation.
Carolina T Orozco, Matthew J Edgeworth, Paul WA Devine, Alistair R Hines, Owen Cornwell, Christopher Thompson, Xiangyang Wang, Jonathan J Phillips, Peter Ravn, Sophie E Jackson, Nicholas J Bond
Nov 10, 2021
Photoelectron Spectroscopy at the Graphene-Liquid Interface Reveals the Electronic Structure of an Electrodeposited Cobalt/Graphene Electrocatalyst.
Juan J Velasco-Velez, Verena Pfeifer, Michael Hävecker, Robert S Weatherup, Rosa Arrigo, Cheng-Hao Chuang, Eugen Stotz, Gisela Weinberg, Miquel Salmeron, Robert Schlögl, Axel Knop-Gericke
Sep 18, 2015
Interactions of a Bacterial RND Transporter with a Transmembrane Small Protein in a Lipid Environment.
Dijun Du, Arthur Neuberger, Mona Wu Orr, Catherine E Newman, Pin-Chia Hsu, Firdaus Samsudin, Andrzej Szewczak-Harris, Leana M Ramos, Mekdes Debela, Syma Khalid, Gisela Storz, Ben F Luisi
Mar 31, 2020
allostery antibiotic cryoEM drug efflux Molecular dynamics small protein structural model transmembrane transport Allosteric Regulation Binding Sites Cardiolipins Carrier Proteins Chloramphenicol Cryoelectron Microscopy Crystallography X-Ray Drug Resistance Bacterial Escherichia coli Escherichia coli Proteins Models Molecular Multidrug Resistance-Associated Proteins Multiprotein Complexes Protein Binding Protein Conformation Substrate Specificity
|
|< |
< |
1 |