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A Bone Morphogenetic Protein (BMP)-derived Peptide Based on the Type I Receptor-binding Site Modifies Cell-type Dependent BMP Signalling.
A Bone Morphogenetic Protein (BMP)-derived Peptide Based on the Type I Receptor-binding Site Modifies Cell-type Dependent BMP Signalling
Abstract: Bone morphogenetic proteins (BMPs) are multifunctional cytokines of the transforming growth factor β (TGFβ) superfamily with potential therapeutic applications due to their broad biological functionality. Designing BMP...
Letter by Morrell et al Regarding Article, "Selective BMP-9 Inhibition Partially Protects Against Experimental Pulmonary Hypertension".
We read with interest the article by Tu et al1 demonstrating that genetic loss of Bmp9 (bone morphogenetic protein 9) protects mice from hypoxia-induced pulmonary hypertension and that inhibition of BMP9 with anti-BMP9 or the...
Elabela/Toddler is an Endogenous Agonist of the Apelin APJ Receptor in the Adult Cardiovascular System, and Exogenous Administration of the Peptide Compensates for the Downregulation of its Expression in Pulmonary Arterial Hypertension
P Yang, C Read, RE Kuc, G Buonincontri, M Southwood, R Torella, PD Upton, A Crosby, SJ Sawiak, TA Carpenter, RC Glen, NW Morrell, JJ Maguire, AP Davenport
Mar 10, 2017
A novel cyclic biased agonist of the apelin receptor, MM07, is disease modifying in the rat monocrotaline model of pulmonary arterial hypertension.
Peiran Yang, Cai Read, Rhoda E Kuc, Duuamene Nyimanu, Thomas L Williams, Alexi Crosby, Guido Buonincontri, Mark Southwood, Stephen J Sawiak, Robert C Glen, Nicholas W Morrell, Anthony P Davenport, Janet J Maguire
Feb 08, 2019
Police Chief Receives Award for Come-See-Me Festival Support
Winthrop University
Jan 01, 0001
Winthrop Chief of Police Frank Zebedis has received the Come-See-Me Festival's Beyond the Call of Glen Award for his support. Zebedis was appointed chief of police in 1998.
Published by: Winthrop University
Mars Science Laboratory CheMin Data From the Glen Torridon Region and the Significance of Lake-Groundwater Interactions in Interpreting Mineralogy and Sedimentary History
MT Thorpe, TF Bristow, EB Rampe, NJ Tosca, JP Grotzinger, KA Bennett, CN Achilles, DF Blake, SJ Chipera, G Downs, RT Downs, SM Morrison, V Tu, N Castle, P Craig, DJD Marais, RM Hazen, DW Ming, RV Morris, AH Treiman, DT Vaniman, AS Yen, AR Vasavada, E Dehouck, JC Bridges, J Berger, A McAdam, T Peretyazhko, KL Siebach, AB Bryk, VK Fox, CM Fedo
Nov 03, 2022
The Glen Torridon (GT) region in Gale crater, Mars is a region with strong clay mineral signatures inferred from orbital spectroscopy. The CheMin X‐ray diffraction (XRD) instrument onboard the Mars Science Laboratory rover...
Thermal compensation using the hybrid metrology approach compared to traditional scaling
Control of temperature in large-scale manufacturing environments is not always practical or economical, introducing thermal effects including variation in ambient refractive index and thermal expansion. Thermal expansion is one...
Constraint-based simulation of carton folding operations
Cartons are a common means for packaging a variety of items. These are usually “erected” by dedicated machines which fold the carton into shape from a flat net. When there is a need to use new forms of cartons, dedicated...
Visually decomposing vehicle images
This paper presents a technique to investigate the influence of aesthetic features and brand recognition of vehicles. Appearance has been shown to impact greatly on consumer perception of products and their branding, yet there...
A constraint-net approach to the resolution of conflicts in a product with multi-technology requirements
Whilst many procedures exist to support the systematic development of a product, it is often difficult to create an environment in which the early stages of the design are resolved. This can particularly happen when the product...
Validating the validation
Abstract: Machine learning methods may have the potential to significantly accelerate drug discovery. However, the increasing rate of new methodological approaches being published in the literature raises the fundamental...
Validating the validation
Machine learning methods may have the potential to significantly accelerate drug discovery. However, the increasing rate of new methodological approaches being published in the literature raises the fundamental question of how...
IonFlow
INTRODUCTION: Inductively coupled plasma mass spectrometry (ICP-MS) experiments generate complex multi-dimensional data sets that require specialist data analysis tools. OBJECTIVE: Here we describe tools to facilitate analysis...
Atlas of spherical four-bar mechanisms
Glen Mullineux
Nov 01, 2011
An atlas or catalogue of mechanisms provides a useful aid in the synthesis of mechanisms for new applications. The atlas stores mechanisms together with their coupler paths. Fourier techniques can be used as a convenient means...
Atlas of spherical four-bar mechanisms
Glen Mullineux
Nov 01, 2011
An atlas or catalogue of mechanisms provides a useful aid in the synthesis of mechanisms for new applications. The atlas stores mechanisms together with their coupler paths. Fourier techniques can be used as a convenient means...
NucliTrack
Summary: Live imaging studies give unparalleled insight into dynamic single cell behaviours and fate decisions. However, the challenge of reliably tracking single cells over long periods of time limits both the throughput and...
IonFlow
Abstract: Introduction: Inductively coupled plasma mass spectrometry (ICP-MS) experiments generate complex multi-dimensional data sets that require specialist data analysis tools. Objective: Here we describe tools to facilitate...
Validating the validation
Abstract: Machine learning methods may have the potential to significantly accelerate drug discovery. However, the increasing rate of new methodological approaches being published in the literature raises the fundamental...
A method for exploring similarities and visual references to brand in the appearance of mature mass-market products
Product appearance and in particular its association with branding has been shown to play an increasingly important role in the commercial success of mature mass-market products. This paper presents a novel approach to analyse...
A method for exploring similarities and visual references to brand in the appearance of mature mass-market products
Product appearance and in particular its association with branding has been shown to play an increasingly important role in the commercial success of mature mass-market products. This paper presents a novel approach to analyse...
The Ursinus Weekly, May 3, 1943
WSGA has dinner for Ursinus women to install officers Combined Y's present illustrated lecture at vespers Sunday night May Day celebration features coronation ceremony, plays 60 students sign to donate blood United aircraft...
Ursinus College Collegeville Pennsylvania newspaper Fred Swift student government YMCA YWCA Jean Steck May Day pageant Alpha Psi Omega Elizabeth White J. L. T. Appleton baseball softball tennis Women's Athletic Association Curtain Club cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
Using constraints at the conceptual stage of the design of carton erection
Cartons are a common way to package many consumer goods. If new designs are used it is necessary to simulate their erection to ensure that this works correctly, particularly at high speed. In this paper, constraint-based...
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