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A systematic review of antimicrobial resistance in Salmonella enterica serovar Typhi, the etiological agent of typhoid.
BACKGROUND: The temporal and spatial change in trends of antimicrobial resistance (AMR) in typhoid have not been systematically studied, and such information will be critical for defining intervention, as well as planning...
Constraints on lateral gene transfer in promoting fimbrial usher protein diversity and function.
Fimbriae are long, adhesive structures widespread throughout members of the family Enterobacteriaceae. They are multimeric extrusions, which are moved out of the bacterial cell through an integral outer membrane protein called...
Antibiotic Resistance and Typhoid.
Multiple drug (antibiotic) resistance (MDR) has become a major threat to the treatment of typhoid and other infectious diseases. Since the 1970s, this threat has increased in Salmonella enterica serovar Typhi, driven in part by...
Comparison of Salmonella enterica Serovars Typhi and Typhimurium Reveals Typhoidal Serovar-Specific Responses to Bile.
Rebecca Johnson, Matt Ravenhall, Derek Pickard, Gordon Dougan, Alexander Byrne, Gad Frankel
Jun 25, 2018
Salmonella enterica serovars Typhi and Typhimurium cause typhoid fever and gastroenteritis, respectively. A unique feature of typhoid infection is asymptomatic carriage within the gallbladder, which is linked with S Typhi...
T cell fate and clonality inference from single-cell transcriptomes.
Michael JT Stubbington, Tapio Lönnberg, Valentina Proserpio, Simon Clare, Anneliese O Speak, Gordon Dougan, Sarah A Teichmann
May 16, 2019
We developed TraCeR, a computational method to reconstruct full-length, paired T cell receptor (TCR) sequences from T lymphocyte single-cell RNA sequence data. TraCeR links T cell specificity with functional response by...
ATF7IP-Mediated Stabilization of the Histone Methyltransferase SETDB1 Is Essential for Heterochromatin Formation by the HUSH Complex.
ATF7IP H3K9me3 HUSH complex SETDB1 epigenetic silencing Heterochromatin histone methylation ubiquitin-mediated degradation Cell Nucleus Enzyme Stability Epigenesis Genetic Gene Deletion Gene Silencing HeLa Cells Heterochromatin Histone-Lysine N-Methyltransferase Histones Humans Lysine Methylation Multiprotein Complexes Proteasome Endopeptidase Complex Protein Binding Protein Methyltransferases Proteolysis Repressor Proteins Transcription Factors Transcriptome
Point-prevalence survey of carbapenemase-producing Enterobacteriaceae and vancomycin-resistant enterococci in adult inpatients in a university teaching hospital in the UK.
Infections with carbapenemase-producing Enterobacteriaceae (CPE) and vancomycin-resistant enterococci (VRE) are associated with increased morbidity and mortality, but the carriage rates of CRE and VRE among hospital inpatients...
CPE carriage prevalence SURVEILLANCE VRE Adolescent Adult Aged Aged 80 and over Carbapenem-Resistant Enterobacteriaceae Carrier State Enterobacteriaceae Infections Female Gram-Positive Bacterial Infections Hospitals University Humans Inpatients Male Middle Aged prevalence Surveys and Questionnaires United Kingdom Vancomycin-Resistant Enterococci Young Adult
Identification and characterization of the novel colonization factor CS30 based on whole genome sequencing in enterotoxigenic Escherichia coli (ETEC).
Astrid von Mentzer, Joshua Tobias, Gudrun Wiklund, Stefan Nordqvist, Martin Aslett, Gordon Dougan, Åsa Sjöling, Ann-Mari Svennerholm
Jun 25, 2018
The ability to colonize the small intestine is essential for enterotoxigenic Escherichia coli (ETEC) to cause diarrhea. Although 22 antigenically different colonization factors (CFs) have been identified and characterized in...
GENE SILENCING. Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells.
Iva A Tchasovnikarova, Richard T Timms, Nicholas J Matheson, Kim Wals, Robin Antrobus, Berthold Göttgens, Gordon Dougan, Mark A Dawson, Paul J Lehner
Jun 11, 2015
Animals Antigens Neoplasm Chromosomal Position Effects Conserved Sequence Drosophila melanogaster evolution Molecular Gene Silencing Genes Reporter Genetic Loci Green Fluorescent Proteins HeLa Cells Heterochromatin Histone-Lysine N-Methyltransferase Histones Humans Immunoprecipitation Multiprotein Complexes Nuclear Proteins Phosphoproteins Protein Methyltransferases
A novel therapeutic antibody screening method using bacterial high-content imaging reveals functional antibody binding phenotypes of Escherichia coli ST131
Mailis Maes, Zoe A. Dyson, Sarah E. Smith, David A. Goulding, Catherine Ludden, Stephen Baker, Paul Kellam, Stephen T. Reece, Gordon Dougan, Josefin Bartholdson Scott
Jul 24, 2020
The architecture and stabilisation of flagellotropic tailed bacteriophages.
Joshua M Hardy, Rhys A Dunstan, Rhys Grinter, Matthew J Belousoff, Jiawei Wang, Derek Pickard, Hariprasad Venugopal, Gordon Dougan, Trevor Lithgow, Fasséli Coulibaly
Sep 21, 2020
Flagellotropic bacteriophages engage flagella to reach the bacterial surface as an effective means to increase the capture radius for predation. Structural details of these viruses are of great interest given the substantial...
Population structure and antimicrobial resistance patterns of Salmonella Typhi isolates in urban Dhaka, Bangladesh from 2004 to 2016.
Sadia Isfat Ara Rahman, Zoe A Dyson, Elizabeth J Klemm, Farhana Khanam, Kathryn E Holt, Emran Kabir Chowdhury, Gordon Dougan, Firdausi Qadri
Mar 29, 2020
BACKGROUND:Multi-drug resistant typhoid fever remains an enormous public health threat in low and middle-income countries. However, we still lack a detailed understanding of the epidemiology and genomics of S. Typhi in many...
Published by: PLoS neglected tropical diseases
Identification of novel adenovirus genotype 90 in children from Bangladesh.
Charlotte J Houldcroft, Mathew A Beale, Md Abu Sayeed, Firdausi Qadri, Gordon Dougan, Ankur Mutreja
Nov 13, 2018
Field evaluation of a novel, rapid diagnostic assay, and molecular epidemiology of enterotoxigenic E. coli among Zambian children presenting with diarrhea.
Suwilanji Silwamba, Obvious N Chilyabanyama, Fraser Liswaniso, Caroline C Chisenga, Roma Chilengi, Gordon Dougan, Geoffrey Kwenda, Subhra Chakraborty, Michelo Simuyandi
Sep 04, 2022
BACKGROUND: Enterotoxigenic Escherichia coli (ETEC) is one of the top aetiologic agents of diarrhea in children under the age of 5 in low-middle income countries (LMICs). The lack of point of care diagnostic tools for routine...
Hyperactivation of HUSH complex function by Charcot-Marie-Tooth disease mutation in MORC2
IA Tchasovnikarova, RT Timms, CH Douse, RC Roberts, G Dougan, RE Kingston, Y Modis, PJ Lehner
Jul 13, 2017
Adenosine Triphosphatases CRISPR-Cas Systems Charcot-Marie-Tooth disease Chromatin Assembly and Disassembly Epigenetic Repression Gene Silencing HeLa Cells Heterochromatin Histone Code Histone-Lysine N-Methyltransferase Histones Humans Lysine Methylation Multiprotein Complexes Mutation Missense Neurons Protein Domains Protein Interaction Mapping Protein Methyltransferases Protein Processing Post-Translational Transcription Factors Transgenes
High-throughput clone library analysis of the mucosa-associated microbiota reveals dysbiosis and differences between inflamed and non-inflamed regions of the intestine in inflammatory bowel disease.
Alan W Walker, Jeremy D Sanderson, Carol Churcher, Gareth C Parkes, Barry N Hudspith, Neil Rayment, Jonathan Brostoff, Julian Parkhill, Gordon Dougan, Liljana Petrovska
Sep 06, 2019
BACKGROUND: The gut microbiota is thought to play a key role in the development of the inflammatory bowel diseases Crohn's disease (CD) and ulcerative colitis (UC). Shifts in the composition of resident bacteria have been...
Erratum: Antimicrobial resistance in human populations
[This corrects the article DOI: 10.1017/gheg.2017.4.].
Genetic dissection of mammalian ERAD through comparative haploid and CRISPR forward genetic screens.
Richard T Timms, Sam A Menzies, Iva A Tchasovnikarova, Lea C Christensen, James C Williamson, Robin Antrobus, Gordon Dougan, Lars Ellgaard, Paul J Lehner
Apr 07, 2016
Animals CRISPR-Cas Systems Endoplasmic Reticulum-Associated Degradation Fluorescent Dyes Genes Reporter Genetic Testing Glycoproteins HEK293 Cells Haploidy HeLa Cells Histocompatibility Antigens Class I Humans Mammals Oxidation-Reduction Protein Binding Protein Domains Thioredoxins alpha-Glucosidases
FBXO11 governs macrophage cell death and inflammation in response to bacterial toxins.
Yusun Jeon, Seong H Chow, Isabella Stuart, Ashley Weir, Amy TY Yeung, Christine Hale, Sushmita Sridhar, Gordon Dougan, James E Vince, Thomas Naderer
Apr 17, 2023
Staphylococcus aureus causes severe infections such as pneumonia and sepsis depending on the pore-forming toxin Panton-Valentine leukocidin (PVL). PVL kills and induces inflammation in macrophages and other myeloid cells by...
Genome-Wide Epigenetic and Transcriptomic Characterization of Human-Induced Pluripotent Stem Cell-Derived Intestinal Epithelial Organoids.
Judith Kraiczy, Alexander DB Ross, Jessica L Forbester, Gordon Dougan, Ludovic Vallier, Matthias Zilbauer
Jan 15, 2019
Five decades of genome evolution in the globally distributed, extensively antibiotic-resistant Acinetobacter baumannii global clone 1.
Kathryn Holt, Johanna J Kenyon, Mohammad Hamidian, Mark B Schultz, Derek J Pickard, Gordon Dougan, Ruth Hall
Jun 25, 2018
The majority of Acinetobacter baumannii isolates that are multiply, extensively and pan-antibiotic resistant belong to two globally disseminated clones, GC1 and GC2, that were first noticed in the 1970s. Here, we investigated...
Long-read-sequenced reference genomes of the seven major lineages of enterotoxigenic Escherichia coli (ETEC) circulating in modern time
Astrid von Mentzer, Grace A. Blackwell, Derek Pickard, Christine J. Boinett, Enrique Joffré, Andrew J. Page, Ann-Mari Svennerholm, Gordon Dougan, Åsa Sjöling
Apr 29, 2021
Abstract: Enterotoxigenic Escherichia coli (ETEC) is an enteric pathogen responsible for the majority of diarrheal cases worldwide. ETEC infections are estimated to cause 80,000 deaths annually, with the highest rates of burden...
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