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Results: 23
From single excipients to dual excipient platforms in dry powder inhaler products
Jagdeep Shur, Robert Price, David Lewis, Paul M. Young, Grahame Woollam, Dilraj Singh, Stephen Edge
Dec 05, 2016
Recent years have seen a marked diversification of excipient based formulation strategies used for the development and commercialisation of dry powder inhaler (DPI) products. These innovative approaches not only provide benefits...
From single excipients to dual excipient platforms in dry powder inhaler products
Jagdeep Shur, Robert Price, David Lewis, Paul M. Young, Grahame Woollam, Dilraj Singh, Stephen Edge
Dec 05, 2016
Recent years have seen a marked diversification of excipient based formulation strategies used for the development and commercialisation of dry powder inhaler (DPI) products. These innovative approaches not only provide benefits...
Feed-in Tariffs and Sustainable Energy: Why Different OECD Governments Support Sustainable Energy at Different Rates Through Feed-in Tariffs
Joshua M Grahame
Jan 01, 0001
Why is it that different governments in the OECD support sustainable energy at different rates? In the effort to explain this difference, Feed-in-Tariffs (FITs) will be closely examined to see if it can explain the significant...
feed-in tariffs OECD countries Renewable Energy sustainability policy tools investment Economics International Economics International Relations Oil, Gas, and Energy Political Economy Social and Behavioral Sciences sustainability
Published by: Ursinus College
The pharmaceutical solvent N-methyl-2-pyrollidone (NMP) attenuates inflammation through Krüppel-like factor 2 activation to reduce atherogenesis.
Marta Roche-Molina, Bryn Hardwick, Cristina Sanchez-Ramos, David Sanz-Rosa, Dirk Gewert, Francisco M Cruz, Andres Gonzalez-Guerra, Vicente Andres, Joaquin A Palma, Borja Ibanez, Grahame McKenzie, Juan A Bernal
Jul 28, 2021
N-methyl-2-pyrrolidone (NMP) is a versatile water-miscible polar aprotic solvent. It is used as a drug solubilizer and penetration enhancer in human and animal, yet its bioactivity properties remain elusive. Here, we report that...
Animals Anti-Inflammatory Agents Aorta Apoptosis Atherosclerosis Cell Adhesion Cell Line DNA Complementary Endothelial Cells Gene Expression Profiling Gene Library Human Umbilical Vein Endothelial Cells Humans Inflammation Kruppel-Like Transcription Factors Mice Mice Knockout ApoE Monocytes Pyrrolidinones RNA Small Interfering Solvents Tumor Necrosis Factor-alpha
The AuTOMATIC trial
Grace E Currie, James Totterdell, Grahame Bowland, Alan Leeb, Ian Peters, Chris C Blyth, Claire Waddington, Julie A Marsh, Thomas L Snelling
Feb 09, 2023
BACKGROUND: While most Australian children are vaccinated, delays in vaccination can put them at risk from preventable infections. Widespread mobile phone ownership in Australia could allow automated short message service (SMS)...
A cryptic hydrophobic pocket in the polo-box domain of the polo-like kinase PLK1 regulates substrate recognition and mitotic chromosome segregation.
Pooja Sharma, Robert Mahen, Maxim Rossmann, Jamie E Stokes, Bryn Hardwick, David J Huggins, Amy Emery, Dominique L Kunciw, Marko Hyvönen, David R Spring, Grahame J McKenzie, Ashok R Venkitaraman
Dec 06, 2019
The human polo-like kinase PLK1 coordinates mitotic chromosome segregation by phosphorylating multiple chromatin- and kinetochore-binding proteins. How PLK1 activity is directed to specific substrates via phosphopeptide...
The AuTOMATIC trial
Grace E Currie, James Totterdell, Grahame Bowland, Alan Leeb, Ian Peters, Chris C Blyth, Claire Waddington, Julie A Marsh, Thomas L Snelling
Mar 13, 2023
Background
While most Australian children are vaccinated, delays in vaccination can put them at risk from preventable infections. Widespread mobile phone ownership in Australia could allow automated short message service...
Vaccination Reminder Systems SMS mHealth Text Messaging Childhood immunisation Humans Bayes Theorem Child Australia Randomized Controlled Trials as Topic Vaccination Coverage Cell Phone
Published by: Trials
The pharmaceutical solvent N-methyl-2-pyrollidone (NMP) attenuates inflammation through Krüppel-like factor 2 activation to reduce atherogenesis
Marta Roche-Molina, Bryn Hardwick, Cristina Sanchez-Ramos, David Sanz-Rosa, Dirk Gewert, Francisco M. Cruz, Andres Gonzalez-Guerra, Vicente Andres, Joaquin A. Palma, Borja Ibanez, Grahame McKenzie, Juan A. Bernal
Jul 15, 2020
Abstract: N-methyl-2-pyrrolidone (NMP) is a versatile water-miscible polar aprotic solvent. It is used as a drug solubilizer and penetration enhancer in human and animal, yet its bioactivity properties remain elusive. Here, we...
Interrogation of the protein-protein interactions between human BRCA2 BRC repeats and RAD51 reveals atomistic determinants of affinity.
Daniel J Cole, Eeson Rajendra, Meredith Roberts-Thomson, Bryn Hardwick, Grahame J McKenzie, Mike C Payne, Ashok R Venkitaraman, Chris-Kriton Skylaris
Aug 08, 2017
The breast cancer suppressor BRCA2 controls the recombinase RAD51 in the reactions that mediate homologous DNA recombination, an essential cellular process required for the error-free repair of DNA double-stranded breaks. The...
Amino Acid Motifs Amino Acid Sequence BRCA2 Protein Fluorescence Polarization Immunoassay Humans Models Molecular Molecular Sequence Data Mutation Protein Binding Protein Interaction Domains and Motifs Protein Interaction Mapping Protein Stability Rad51 Recombinase Repetitive Sequences Amino Acid Sequence Alignment Thermodynamics
A cryptic hydrophobic pocket in the polo-box domain of the polo-like kinase PLK1 regulates substrate recognition and mitotic chromosome segregation
Pooja Sharma, Robert Mahen, Maxim Rossmann, Jamie E. Stokes, Bryn Hardwick, David J. Huggins, Amy Emery, Dominique L. Kunciw, Marko Hyvönen, David R. Spring, Grahame J. McKenzie, Ashok R. Venkitaraman
Nov 03, 2020
Abstract: The human polo-like kinase PLK1 coordinates mitotic chromosome segregation by phosphorylating multiple chromatin- and kinetochore-binding proteins. How PLK1 activity is directed to specific substrates via...
Double Strain-Promoted Macrocyclization for the Rapid Selection of Cell-Active Stapled Peptides.
Yu Heng Lau, Yuteng Wu, Maxim Rossmann, Ban Xiong Tan, Peterson de Andrade, Yaw Sing Tan, Chandra Verma, Grahame J McKenzie, Ashok R Venkitaraman, Marko Hyvönen, David R Spring
Mar 27, 2018
Peptide stapling is a method for designing macrocyclic alpha-helical inhibitors of protein-protein interactions. However, obtaining a cell-active inhibitor can require significant optimization. We report a novel stapling...
A cryptic hydrophobic pocket in the polo-box domain of the polo-like kinase PLK1 regulates substrate recognition and mitotic chromosome segregation.
Pooja Sharma, Robert Mahen, Maxim Rossmann, Jamie E Stokes, Bryn Hardwick, David J Huggins, Amy Emery, Dominique L Kunciw, Marko Hyvönen, David R Spring, Grahame J McKenzie, Ashok R Venkitaraman
Aug 21, 2019
3' Untranslated Regions Cell Cycle Proteins Cell Survival Chromosome Segregation HeLa Cells Histones Humans Kinetochores Mitosis Mutagenesis Protein Binding Protein Domains Protein Kinase Inhibitors Protein Serine-Threonine Kinases Protein Structure Tertiary Proto-Oncogene Proteins RNA Interference RNA Small Interfering Substrate Specificity
Computationally-guided optimization of small-molecule inhibitors of the Aurora A kinase-TPX2 protein-protein interaction.
Daniel J Cole, Matej Janecek, Jamie E Stokes, Maxim Rossmann, John C Faver, Grahame J McKenzie, Ashok R Venkitaraman, Marko Hyvönen, David R Spring, David J Huggins, William L Jorgensen
Jun 15, 2018
Free energy perturbation theory, in combination with enhanced sampling of protein-ligand binding modes, is evaluated in the context of fragment-based drug design, and used to design two new small-molecule inhibitors of the...
Development of a Novel Cell-Permeable Protein-Protein Interaction Inhibitor for the Polo-box Domain of Polo-like Kinase 1.
David J Huggins, Bryn S Hardwick, Pooja Sharma, Amy Emery, Luca Laraia, Fengzhi Zhang, Ana J Narvaez, Meredith Roberts-Thomson, Alex T Crooks, Robert G Boyle, Richard Boyce, David W Walker, Natalia Mateu, Grahame J McKenzie, David R Spring, Ashok R Venkitaraman
Dec 16, 2019
Polo-like kinase 1 (PLK1) is a key regulator of mitosis and a recognized drug target for cancer therapy. Inhibiting the polo-box domain of PLK1 offers potential advantages of increased selectivity and subsequently reduced...
Development of a Novel Cell-Permeable Protein-Protein Interaction Inhibitor for the Polo-box Domain of Polo-like Kinase 1.
David J Huggins, Bryn S Hardwick, Pooja Sharma, Amy Emery, Luca Laraia, Fengzhi Zhang, Ana J Narvaez, Meredith Roberts-Thomson, Alex T Crooks, Robert G Boyle, Richard Boyce, David W Walker, Natalia Mateu, Grahame J McKenzie, David R Spring, Ashok R Venkitaraman
Feb 19, 2020
Polo-like kinase 1 (PLK1) is a key regulator of mitosis and a recognized drug target for cancer therapy. Inhibiting the polo-box domain of PLK1 offers potential advantages of increased selectivity and subsequently reduced...
Published by: ACS omega
Allosteric modulation of AURKA kinase activity by a small-molecule inhibitor of its protein-protein interaction with TPX2.
Matej Janeček, Maxim Rossmann, Pooja Sharma, Amy Emery, David J Huggins, Simon R Stockwell, Jamie E Stokes, Yaw S Tan, Estrella Guarino Almeida, Bryn Hardwick, Ana J Narvaez, Marko Hyvönen, David R Spring, Grahame J McKenzie, Ashok R Venkitaraman
Jul 01, 2016
A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death.
Duncan E Scott, Nicola J Francis-Newton, May E Marsh, Anthony G Coyne, Gerhard Fischer, Tommaso Moschetti, Andrew R Bayly, Timothy D Sharpe, Kalina T Haas, Lorraine Barber, Chiara R Valenzano, Rajavel Srinivasan, David J Huggins, MiYoung Lee, Amy Emery, Bryn Hardwick, Matthias Ehebauer, Claudio Dagostin, Alessandro Esposito, Luca Pellegrini, Trevor Perrior, Grahame McKenzie, Tom L Blundell, Marko Hyvönen, John Skidmore, Ashok R Venkitaraman, Chris Abell
Feb 08, 2021
LGR5 Activates Noncanonical Wnt Signaling and Inhibits Aldosterone Production in the Human Adrenal.
Lalarukh Haris Shaikh, Junhua Zhou, Ada ED Teo, Sumedha Garg, Sudeshna Guha Neogi, Nichola Figg, Giles S Yeo, Haixiang Yu, Janet J Maguire, Wanfeng Zhao, Martin R Bennett, Elena AB Azizan, Anthony P Davenport, Grahame McKenzie, Morris J Brown
Jun 05, 2015
AMPK-dependent phosphorylation of MTFR1L regulates mitochondrial morphology.
Lisa Tilokani, Fiona M Russell, Stevie Hamilton, Daniel M Virga, Mayuko Segawa, Vincent Paupe, Anja V Gruszczyk, Margherita Protasoni, Luis-Carlos Tabara, Mark Johnson, Hanish Anand, Michael P Murphy, D Grahame Hardie, Franck Polleux, Julien Prudent
Dec 12, 2022
Mitochondria are dynamic organelles that undergo membrane remodeling events in response to metabolic alterations to generate an adequate mitochondrial network. Here, we investigated the function of mitochondrial fission...
The road to recovery
Lindsay F Banin, Elizabeth H Raine, Lucy M Rowland, Robin L Chazdon, Stuart W Smith, Nur Estya Binte Rahman, Adam Butler, Christopher Philipson, Grahame G Applegate, E Petter Axelsson, Sugeng Budiharta, Siew Chin Chua, Mark EJ Cutler, Stephen Elliott, Elva Gemita, Elia Godoong, Laura LB Graham, Robin M Hayward, Andy Hector, Ulrik Ilstedt, Joel Jensen, Srinivasan Kasinathan, Christopher J Kettle, Daniel Lussetti, Benjapan Manohan, Colin Maycock, Kang Min Ngo, Michael J O'Brien, Anand M Osuri, Glen Reynolds, Yap Sauwai, Stefan Scheu, Mangarah Silalahi, Eleanor M Slade, Tom Swinfield, David A Wardle, Charlotte Wheeler, Kok Loong Yeong, David FRP Burslem
Dec 15, 2022
Current policy is driving renewed impetus to restore forests to return ecological function, protect species, sequester carbon and secure livelihoods. Here we assess the contribution of tree planting to ecosystem restoration in...
The road to recovery
Lindsay F Banin, Elizabeth H Raine, Lucy M Rowland, Robin L Chazdon, Stuart W Smith, Nur Estya Binte Rahman, Adam Butler, Christopher Philipson, Grahame G Applegate, E Petter Axelsson, Sugeng Budiharta, Siew Chin Chua, Mark EJ Cutler, Stephen Elliott, Elva Gemita, Elia Godoong, Laura LB Graham, Robin M Hayward, Andy Hector, Ulrik Ilstedt, Joel Jensen, Srinivasan Kasinathan, Christopher J Kettle, Daniel Lussetti, Benjapan Manohan, Colin Maycock, Kang Min Ngo, Michael J O'Brien, Anand M Osuri, Glen Reynolds, Yap Sauwai, Stefan Scheu, Mangarah Silalahi, Eleanor M Slade, Tom Swinfield, David A Wardle, Charlotte Wheeler, Kok Loong Yeong, David FRP Burslem
Nov 15, 2022