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Dynamic structure mediates halophilic adaptation of a DNA polymerase from the deep-sea brines of the Red Sea.
Masateru Takahashi, Etsuko Takahashi, Luay I Joudeh, Monica Marini, Gobind Das, Mohamed M Elshenawy, Anastassja Akal, Kosuke Sakashita, Intikhab Alam, Muhammad Tehseen, Mohamed A Sobhy, Ulrich Stingl, Jasmeen S Merzaban, Enzo Di Fabrizio, Samir M Hamdan
Nov 05, 2018
The deep-sea brines of the Red Sea are remote and unexplored environments characterized by high temperatures, anoxic water, and elevated concentrations of salt and heavy metals. This environment provides a rare system to study...
PHA-680626 Is an Effective Inhibitor of the Interaction between Aurora-A and N-Myc.
Dalila Boi, Fani Souvalidou, Davide Capelli, Federica Polverino, Grazia Marini, Roberta Montanari, Giorgio Pochetti, Angela Tramonti, Roberto Contestabile, Daniela Trisciuoglio, Patrizia Carpinelli, Camilla Ascanelli, Catherine Lindon, Alessandro De Leo, Michele Saviano, Roberto Di Santo, Roberta Costi, Giulia Guarguaglini, Alessandro Paiardini
Dec 22, 2021
Neuroblastoma is a severe childhood disease, accounting for ~10% of all infant cancers. The amplification of the MYCN gene, coding for the N-Myc transcription factor, is an essential marker correlated with tumor progression and...
Aurora-A N-Myc PHA-680626 amphosteric inhibitors Neuroblastoma Adenosine Triphosphate Antineoplastic Agents Aurora Kinase A Azepines Benzazepines Binding Sites Binding Competitive Cell Line Drug Evaluation Preclinical Humans N-Myc Proto-Oncogene Protein Neuroblastoma Protein Conformation Protein Kinase Inhibitors Pyrazoles Pyrimidines Pyrroles Surface Plasmon Resonance
Analysis of a scaled stone masonry facade subjected to differential settlements
Historical masonry structures are vulnerable to differential settlements of the ground. This vulnerability is potentially higher for historic buildings on wooden pile foundations, which can have their bearing capacity reduced by...
Cracking damage assessment differential settlements experimental testing Masonry numerical modelling physical modelling /dk/atira/pure/subjectarea/asjc/1200/1206 name=Conservation /dk/atira/pure/subjectarea/asjc/2200/2216 name=Architecture /dk/atira/pure/subjectarea/asjc/1200/1213 name=Visual Arts and Performing Arts
Surface-induced nonlinearity enhancement in subwavelength rod waveguides
We develop a perturbative theory to describe optical propagation in subwavelength rod waveguides. In this approach, we account for loss and nonlinearity in the boundary conditions. A comparison to the traditional perturbative...
Surface-induced nonlinearity enhancement of TM modes in planar subwavelength waveguides
Using an asymptotic expansion of Maxwell equations and boundary conditions, we derive an amplitude equation for nonlinear TM modes in planar metal and dielectric waveguides. Our approach reveals that the physics of the...
Digital Participatory Platforms for Urban Regeneration
Despite the increase in the globally connected population, there is still a high percentage of European citizens who do not have basic digital skills. In the era of smart cities, the Digital Divide affects the possibility for...
Published by: IGI Global Scientific Publishing
Surface-induced nonlinearity enhancement of TM modes in planar subwavelength waveguides
Using an asymptotic expansion of Maxwell equations and boundary conditions, we derive an amplitude equation for nonlinear TM modes in planar metal and dielectric waveguides. Our approach reveals that the physics of the...
Minimum cost network design in strategic alliances
Strategic alliances are established between firms to improve their competitiveness in markets and generally appear in the form of joint ventures. Such collaborative efforts require centralized planning, and the survival of...
Centralized planning collaboration Network design Strategic alliances transaction costs /dk/atira/pure/subjectarea/asjc/1400/1408 name=Strategy and Management /dk/atira/pure/subjectarea/asjc/1800/1803 name=Management Science and Operations Research /dk/atira/pure/subjectarea/asjc/1800/1802 name=Information Systems and Management
Surface-induced nonlinearity enhancement in subwavelength rod waveguides
We develop a perturbative theory to describe optical propagation in subwavelength rod waveguides. In this approach, we account for loss and nonlinearity in the boundary conditions. A comparison to the traditional perturbative...
Minimum cost network design in strategic alliances
Strategic alliances are established between firms to improve their competitiveness in markets and generally appear in the form of joint ventures. Such collaborative efforts require centralized planning, and the survival of...
Centralized planning collaboration Network design Strategic alliances transaction costs /dk/atira/pure/subjectarea/asjc/1400/1408 name=Strategy and Management /dk/atira/pure/subjectarea/asjc/1800/1803 name=Management Science and Operations Research /dk/atira/pure/subjectarea/asjc/1800/1802 name=Information Systems and Management
Graphene-clad tapered fiber
We derive a pulse propagation equation for a graphene-clad optical fiber, treating the optical response of the graphene and nonlinearity of the dielectric fiber core as perturbations in asymptotic expansion of Maxwell equations....
Graphene-clad tapered fiber
We derive a pulse propagation equation for a graphene-clad optical fiber, treating the optical response of the graphene and nonlinearity of the dielectric fiber core as perturbations in asymptotic expansion of Maxwell equations....
Analysis of a scaled stone masonry facade subjected to differential settlements
Historical masonry structures are vulnerable to differential settlements of the ground. This vulnerability is potentially higher for historic buildings on wooden pile foundations, which can have their bearing capacity reduced by...
Cracking damage assessment differential settlements experimental testing Masonry numerical modelling physical modelling /dk/atira/pure/subjectarea/asjc/1200/1206 name=Conservation /dk/atira/pure/subjectarea/asjc/2200/2216 name=Architecture /dk/atira/pure/subjectarea/asjc/1200/1213 name=Visual Arts and Performing Arts
Progressive tauopathy in P301S tau transgenic mice is associated with a functional deficit of the olfactory system.
MSI and EBV Positive Gastric Cancer's Subgroups and Their Link With Novel Immunotherapy
Maria Grazia Rodriquenz, Giandomenico Roviello, Alberto D'Angelo, Daniele Lavacchi, Franco Roviello, Karol Polom
May 11, 2020
Gastric cancers have been historically classified based on histomorphologic features. The Cancer Genome Atlas network reported the comprehensive identification of genetic alterations associated with gastric cancer...
Tau aggregation and its relation to selected forms of neuronal cell death.
How neurons die in neurodegenerative diseases is still unknown. The distinction between apoptosis as a genetically controlled mechanism, and necrosis, which was viewed as an unregulated process, has blurred with the...
Propagation of Tau aggregates.
Since 2009, evidence has accumulated to suggest that Tau aggregates form first in a small number of brain cells, from where they propagate to other regions, resulting in neurodegeneration and disease. Propagation of Tau...
MSI and EBV Positive Gastric Cancer's Subgroups and Their Link With Novel Immunotherapy
Maria Grazia Rodriquenz, Giandomenico Roviello, Alberto D'Angelo, Daniele Lavacchi, Franco Roviello, Karol Polom
May 11, 2020
Gastric cancers have been historically classified based on histomorphologic features. The Cancer Genome Atlas network reported the comprehensive identification of genetic alterations associated with gastric cancer...
ZNF281 is recruited on DNA breaks to facilitate DNA repair by non-homologous end joining.
Sara Nicolai, Robert Mahen, Giuseppe Raschellà, Alberto Marini, Marco Pieraccioli, Michal Malewicz, Ashok R Venkitaraman, Gerry Melino
Feb 12, 2020
Living in Promiscuity
Alpha-synuclein (α-syn) is a small protein that, in neurons, localizes predominantly to presynaptic terminals. Due to elevated conformational plasticity, which can be affected by environmental factors, in addition to undergoing...
Identification of GOLPH3 Partners in Drosophila Unveils Potential Novel Roles in Tumorigenesis and Neural Disorders.
Stefano Sechi, Angela Karimpour-Ghahnavieh, Anna Frappaolo, Laura Di Francesco, Roberto Piergentili, Eugenia Schininà, Pier Paolo D'Avino, Maria Grazia Giansanti
Nov 25, 2021
Golgi phosphoprotein 3 (GOLPH3) is a highly conserved peripheral membrane protein localized to the Golgi apparatus and the cytosol. GOLPH3 binding to Golgi membranes depends on phosphatidylinositol 4-phosphate [PI(4)P] and...
Drosophila FMRP GOLPH3 Golgi Cell Cycle male meiosis Spermatogenesis Animals Carcinogenesis Cell Proliferation Cytokinesis Cytoskeleton Drosophila Drosophila Proteins Golgi Apparatus Membrane Proteins Nervous System Nervous System Diseases Oncogene Proteins Phosphatidylinositol Phosphates Protein Interaction Maps Protein Transport
Super-resolution imaging reveals α-synuclein seeded aggregation in SH-SY5Y cells.
Jason C Sang, Eric Hidari, Georg Meisl, Rohan T Ranasinghe, Maria Grazia Spillantini, David Klenerman
Jun 22, 2021
Aggregation of α-synuclein (α-syn) is closely linked to Parkinson's disease (PD) and the related synucleinopathies. Aggregates spread through the brain during the progression of PD, but the mechanism by which this occurs is...
Published by: Communications biology
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