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IPR Policy Brief - What a drag
Research conducted in 2012 by Professors Paul Gregg (University of Bath) and Stephen Machin (University College London) on behalf of the Resolution Foundation, has found that the stagnation in real wage growth in the UK labour...
/dk/atira/pure/sustainabledevelopmentgoals/decent_work_and_economic_growth name=SDG 8 - Decent Work and Economic Growth
Published by: University of Bath
IPR Policy Brief - What a drag
Research conducted in 2012 by Professors Paul Gregg (University of Bath) and Stephen Machin (University College London) on behalf of the Resolution Foundation, has found that the stagnation in real wage growth in the UK labour...
/dk/atira/pure/sustainabledevelopmentgoals/decent_work_and_economic_growth name=SDG 8 - Decent Work and Economic Growth
Published by: University of Bath
IPR Policy Brief - Youth employment - still waiting for the upturn
Paul Gregg
Mar 01, 2014
Recessions always hit young people hard. Firms’ first response to declining orders is to stop hiring new recruits rather than sacking experienced staff.
Young people disproportionately rely on new hiring to secure...
Young people disproportionately rely on new hiring to secure...
/dk/atira/pure/sustainabledevelopmentgoals/decent_work_and_economic_growth name=SDG 8 - Decent Work and Economic Growth
Published by: University of Bath
IPR Policy Brief - What are the prospects for a wage recovery in the UK
Between 1978 and 2008 real wages grew at nearly 2% per year.
Although, during past recessions real wages fell short of this trend, as unemployment fell the wage recovery not only re-ignited wage growth, but made up the...
Although, during past recessions real wages fell short of this trend, as unemployment fell the wage recovery not only re-ignited wage growth, but made up the...
/dk/atira/pure/sustainabledevelopmentgoals/decent_work_and_economic_growth name=SDG 8 - Decent Work and Economic Growth
Published by: University of Bath
IPR Policy Brief - The 2013 Comprehensive Spending Review and the implications for making work pay and family poverty
To cut the deficit, the UK government has increasingly turned to cuts in working age welfare.
To date, it has operated a ‘salami slicing’ approach: cutting or capping out of work benefit entitlements, in-work tax...
To date, it has operated a ‘salami slicing’ approach: cutting or capping out of work benefit entitlements, in-work tax...
Published by: University of Bath
IPR Policy Brief - Youth employment - still waiting for the upturn
Paul Gregg
Mar 01, 2014
Recessions always hit young people hard. Firms’ first response to declining orders is to stop hiring new recruits rather than sacking experienced staff.
Young people disproportionately rely on new hiring to secure...
Young people disproportionately rely on new hiring to secure...
/dk/atira/pure/sustainabledevelopmentgoals/decent_work_and_economic_growth name=SDG 8 - Decent Work and Economic Growth
Published by: University of Bath
IPR Policy Brief - The 2013 Comprehensive Spending Review and the implications for making work pay and family poverty
To cut the deficit, the UK government has increasingly turned to cuts in working age welfare.
To date, it has operated a ‘salami slicing’ approach: cutting or capping out of work benefit entitlements, in-work tax...
To date, it has operated a ‘salami slicing’ approach: cutting or capping out of work benefit entitlements, in-work tax...
Published by: University of Bath
B-hadron production in NNLO QCD
We calculate, for the first time, the NNLO QCD corrections to identified
heavy hadron production at hadron colliders. The calculation is based on a
flexible numeric framework which allows the calculation of any distribution of
a...
IPR Policy Brief - What are the prospects for a wage recovery in the UK
Between 1978 and 2008 real wages grew at nearly 2% per year.
Although, during past recessions real wages fell short of this trend, as unemployment fell the wage recovery not only re-ignited wage growth, but made up the...
Although, during past recessions real wages fell short of this trend, as unemployment fell the wage recovery not only re-ignited wage growth, but made up the...
/dk/atira/pure/sustainabledevelopmentgoals/decent_work_and_economic_growth name=SDG 8 - Decent Work and Economic Growth
Published by: University of Bath
Restriction endonuclease TseI cleaves A:A and T
Long Ma, Kai Chen, David J Clarke, Christopher P Nortcliffe, Geoffrey G Wilson, J Michael Edwardson, A Jennifer Morton, Anita C Jones, David TF Dryden
Feb 13, 2020
The type II restriction endonuclease TseI recognizes the DNA target sequence 5'-G^CWGC-3' (where W = A or T) and cleaves after the first G to produce fragments with three-base 5'-overhangs. We have determined that it is a...
Revisiting Gregg v. Georgia: Racial Bias and the Legality of the Death Penalty
Joseph Heasley
Jan 01, 0001
In Furman v. Georgia (1972), the U.S. Supreme Court struck down the capital convictions of Jackson Furman and other African American inmates sentenced to death, holding that the death penalty could not be applied lawfully given...
death penalty race racial bias Furman v. Georgia Gregg v. Georgia American Studies Arts and Humanities Civil Rights and Discrimination law Law and Race Law and Society
Published by: Ursinus College
Lignocellulose degradation mechanisms across the Tree of Life.
Interview with Booker T. Brown - OH 689
This interview was conducted by Dr. George Garrison with Booker T. Brown with a focus on the History of Emmett Scott High School. Emmett Scott was the segregated high school for African-Americans, which was named after Emmett...
Published by: Winthrop University
English Department Chair Gregg Hecimovich to Speak on N.C. Slave Narrative at Winthrop
Winthrop University
Jan 01, 0001
The origins of Gregg Hecimovich's book date back to 2001 when Henry Louis Gates Jr. of Harvard University purchased a 19th-century African-American manuscript at auction titled "The Bondwoman's Narrative." Hecimovich, who is...
Published by: Winthrop University
PI3Kδ Forms Distinct Multiprotein Complexes at the TCR Signalosome in Naïve and Differentiated CD4 + T Cells
Daisy H. Luff, Katarzyna Wojdyla, David Oxley, Tamara Chessa, Kevin Hudson, Phillip T. Hawkins, Len R. Stephens, Simon T. Barry, Klaus Okkenhaug
Mar 22, 2021
Phosphoinositide 3-kinases (PI3Ks) play a central role in adaptive immunity by transducing signals from the T cell antigen receptor (TCR) via production of PIP3. PI3Kδ is a heterodimer composed of a p110δ catalytic subunit...
PI3Kδ Forms Distinct Multiprotein Complexes at the TCR Signalosome in Naïve and Differentiated CD4+ T Cells.
Daisy H Luff, Katarzyna Wojdyla, David Oxley, Tamara Chessa, Kevin Hudson, Phillip T Hawkins, Len R Stephens, Simon T Barry, Klaus Okkenhaug
Feb 03, 2021
Phosphoinositide 3-kinases (PI3Ks) play a central role in adaptive immunity by transducing signals from the T cell antigen receptor (TCR) via production of PIP3. PI3Kδ is a heterodimer composed of a p110δ catalytic subunit...
CD4-Positive T-Lymphocytes Animals Mice Inbred C57BL Mice Multiprotein Complexes Receptors Antigen T-Cell Interleukin-2 Lymphocyte Activation Specific Pathogen-Free Organisms Signal Transduction Cell Differentiation Gene Knockout Techniques Class I Phosphatidylinositol 3-Kinases CRISPR-Cas Systems Gene Editing
Extracellular Lactate
James T Grist, Lorna B Jarvis, Zoya Georgieva, Sara Thompson, Harpreet Kaur Sandhu, Keith Burling, Ashley Clarke, Sarah Jackson, Mark Wills, Ferdia A Gallagher, Joanne L Jones
Feb 23, 2018
Following activation, T cells rapidly divide and acquire effector functions. This energetically demanding process depends upon the ability of T cells to undergo metabolic remodeling from oxidative phosphorylation to aerobic...
T Lymphocytes in Histiocytic Sarcomas of Flat-Coated Retriever Dogs.
Flat-Coated Retriever dogs are predisposed to the development of histiocytic sarcoma (HS), a poorly differentiated, highly malignant neoplasm. The authors have previously documented a significant lymphocytic infiltrate in such...
High fidelity analysis to predict failure in T-joints
Composite T-joints and similar skin-stiffener joints have a central role in aerospace structures. However, their accurate numerical analysis is still a great challenge due to their complex geometry and stress state during...
The microRNA miR-155 controls CD8(+) T cell responses by regulating interferon signaling.
Donald T Gracias, Erietta Stelekati, Jennifer L Hope, Alina C Boesteanu, Travis A Doering, Jillian Norton, Yvonne M Mueller, Joseph A Fraietta, E John Wherry, Martin Turner, Peter D Katsikis
Aug 14, 2019
We found upregulation of expression of the microRNA miR-155 in primary effector and effector memory CD8(+) T cells, but low miR-155 expression in naive and central memory cells. Antiviral CD8(+) T cell responses and viral...
Animals CD8-Positive T-Lymphocytes Cell Proliferation Flow Cytometry Gene Expression Profiling Gene Regulatory Networks Immunoblotting Immunologic Memory Interferon Regulatory Factor-7 Interferons Mice Mice Inbred C57BL Mice Knockout MicroRNAs Oligonucleotide Array Sequence Analysis Orthomyxoviridae Orthomyxoviridae Infections RNA Interference Reverse Transcriptase Polymerase Chain Reaction STAT1 Transcription Factor Signal Transduction Suppressor of Cytokine Signaling 1 Protein Suppressor of Cytokine Signaling Proteins
High fidelity analysis to predict failure in T-joints
Composite T-joints and similar skin-stiffener joints have a central role in aerospace structures. However, their accurate numerical analysis is still a great challenge due to their complex geometry and stress state during...
An HIF-1α/VEGF-A Axis in Cytotoxic T Cells Regulates Tumor Progression.
Asis Palazon, Petros A Tyrakis, David Macias, Pedro Veliça, Helene Rundqvist, Susan Fitzpatrick, Nikola Vojnovic, Anthony T Phan, Niklas Loman, Ingrid Hedenfalk, Thomas Hatschek, John Lövrot, Theodoros Foukakis, Ananda W Goldrath, Jonas Bergh, Randall S Johnson
May 31, 2018
Cytotoxic T cells infiltrating tumors are thought to utilize HIF transcription factors during adaptation to the hypoxic tumor microenvironment. Deletion analyses of the two key HIF isoforms found that HIF-1α, but not HIF-2α, was...
HIF transcription factors VEGF angiogenesis cytotoxic T cells Hypoxia Immunotherapy Animals Breast Neoplasms CD8-Positive T-Lymphocytes Cell Line Tumor Cells Cultured Disease Progression Female Gene Expression Profiling Gene Expression Regulation Neoplastic Humans Hypoxia-Inducible Factor 1 alpha Subunit Mice Inbred C57BL Mice Knockout Neoplasms Experimental Neovascularization Pathologic T-Lymphocytes Cytotoxic Vascular Endothelial Growth Factor A
Carcinomas assemble a filamentous CXCL12-keratin-19 coating that suppresses T cell-mediated immune attack.
Zhikai Wang, Philip Moresco, Ran Yan, Jiayun Li, Ya Gao, Daniele Biasci, Min Yao, Jordan Pearson, Jaclyn F Hechtman, Tobias Janowitz, Raza M Zaidi, Matthew J Weiss, Douglas T Fearon
Feb 20, 2022
Cancer immunotherapy frequently fails because most carcinomas have few T cells, suggesting that cancers can suppress T cell infiltration. Here, we show that cancer cells of human pancreatic ductal adenocarcinoma (PDA)...
Does the PI3K pathway promote or antagonize regulatory T cell development and function?
Regulatory T cells (Tregs) prevent autoimmunity and inflammation by suppressing the activation of other T cells and antigen presenting cells. The role of phosphoinositide 3-kinase (PI3K) signaling in Treg is controversial. Some...
S-2-hydroxyglutarate regulates CD8+ T-lymphocyte fate.
Petros A Tyrakis, Asis Palazon, David Macias, Kian L Lee, Anthony T Phan, Pedro Veliça, Jia You, Grace S Chia, Jingwei Sim, Andrew Doedens, Alice Abelanet, Colin E Evans, John R Griffiths, Lorenz Poellinger, Ananda W Goldrath, Randall S Johnson
Dec 14, 2016
R-2-hydroxyglutarate accumulates to millimolar levels in cancer cells with gain-of-function isocitrate dehydrogenase 1/2 mutations. These levels of R-2-hydroxyglutarate affect 2-oxoglutarate-dependent dioxygenases. Both...
Animals CD8-Positive T-Lymphocytes Cell Differentiation DNA DNA Methylation Dioxygenases Glutarates Histones Homeostasis Hypoxia Hypoxia-Inducible Factor 1 alpha Subunit Ketoglutaric Acids Lymphocyte Activation Lysine Mice Oxygen Protein Stability Receptors Antigen T-Cell Von Hippel-Lindau Tumor Suppressor Protein
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