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Patient Reported Experiences and Delays During the Diagnostic Pathway for Pulmonary Fibrosis
Iris G van der Sar, Steve Jones, Deborah L Clarke, Francesco Bonella, Jean Michel Fourrier, Katarzyna Lewandowska, Guadalupe Bermudo, Alexander Simidchiev, Irina R Strambu, Marlies S Wijsenbeek, Helen Parfrey
Aug 18, 2021
Introduction: Pulmonary fibrosis includes a spectrum of diseases and is incurable. There is a variation in disease course, but it is often progressive leading to increased breathlessness, impaired quality of life, and decreased...
Group-contribution coarse-grained molecular simulations of polystyrene melts and polystyrene solutions in alkanes using the SAFT-γ force field
Guadalupe Jiménez-Serratos, Carmelo Herdes, Andrew J. Haslam, George Jackson, Erich A. Müller
Jun 27, 2017
A coarse-grained (CG) model for atactic polystyrene is presented and studied via classical molecular dynamics simulations. The interactions between the CG segments are described by Mie potentials, with parameters obtained from a...
The conserved transmembrane proteoglycan Perdido/Kon-tiki is essential for myofibrillogenesis and sarcomeric structure in Drosophila.
Muscle differentiation requires the assembly of high-order structures called myofibrils, composed of sarcomeres. Even though the molecular organization of sarcomeres is well known, the mechanisms underlying myofibrillogenesis...
LanB1 Cooperates With Kon-Tiki During Embryonic Muscle Migration in Drosophila.
Juan José Pérez-Moreno, Carmen Santa-Cruz Mateos, María Dolores Martín-Bermudo, Beatriz Estrada
Feb 20, 2022
Muscle development is a multistep process that involves cell specification, myoblast fusion, myotube migration, and attachment to the tendons. In spite of great efforts trying to understand the basis of these events, little is...
Group-contribution coarse-grained molecular simulations of polystyrene melts and polystyrene solutions in alkanes using the SAFT-γ force field
Guadalupe Jiménez-Serratos, Carmelo Herdes, Andrew J. Haslam, George Jackson, Erich A. Müller
Jun 27, 2017
A coarse-grained (CG) model for atactic polystyrene is presented and studied via classical molecular dynamics simulations. The interactions between the CG segments are described by Mie potentials, with parameters obtained from a...
Integrins regulate epithelial cell shape by controlling the architecture and mechanical properties of basal actomyosin networks.
Carmen Santa-Cruz Mateos, Andrea Valencia-Expósito, Isabel M Palacios, María D Martín-Bermudo
Dec 07, 2020
Forces generated by the actomyosin cytoskeleton are key contributors to many morphogenetic processes. The actomyosin cytoskeleton organises in different types of networks depending on intracellular signals and on cell-cell and...
Hadoop Paradigm for Satellite Environmental Big Data Processing
The important growth of industrial, transport, and agriculture activities, has not led only to the air quality and climate changes issues, but also to the increase of the potential natural disasters. The emission of harmful...
Published by: IGI Global Scientific Publishing
Intrinsically disordered protein biosensor tracks the physical-chemical effects of osmotic stress on cells.
Cesar L Cuevas-Velazquez, Tamara Vellosillo, Karina Guadalupe, Hermann Broder Schmidt, Feng Yu, David Moses, Jennifer AN Brophy, Dante Cosio-Acosta, Alakananda Das, Lingxin Wang, Alexander M Jones, Alejandra A Covarrubias, Shahar Sukenik, José R Dinneny
Nov 22, 2021
Cell homeostasis is perturbed when dramatic shifts in the external environment cause the physical-chemical properties inside the cell to change. Experimental approaches for dynamically monitoring these intracellular effects are...
Arabidopsis Arabidopsis Proteins Binding Sites Biosensing Techniques Cell Line Tumor Escherichia coli Fluorescence Resonance Energy Transfer Gene Expression Humans Intrinsically Disordered Proteins Kinetics Models Molecular Molecular Chaperones Osmolar Concentration Osmotic Pressure Osteoblasts Protein Binding Protein Conformation Protein Interaction Domains and Motifs Recombinant Proteins Saccharomyces cerevisiae Thermodynamics water
α-Spectrin and integrins act together to regulate actomyosin and columnarization, and to maintain a monolayered follicular epithelium.
Bing Fu Ng, Gokul Kannan Selvaraj, Carmen Santa-Cruz Mateos, Inna Grosheva, Ines Alvarez-Garcia, María Dolores Martín-Bermudo, Isabel M Palacios
Feb 25, 2016
Intrinsically disordered protein biosensor tracks the physical-chemical effects of osmotic stress on cells
Cesar L. Cuevas-Velazquez, Tamara Vellosillo, Karina Guadalupe, Hermann Broder Schmidt, Feng Yu, David Moses, Jennifer A. N. Brophy, Dante Cosio-Acosta, Alakananda Das, Lingxin Wang, Alexander M. Jones, Alejandra A. Covarrubias, Shahar Sukenik, José R. Dinneny
Sep 14, 2021
The careful control of Polo kinase by APC/C-Ube2C ensures the intercellular transport of germline centrosomes during Drosophila oogenesis.
Alexis Leah Braun, Francesco Meghini, Gema Villa-Fombuena, Morgane Guermont, Elisa Fernandez-Martinez, Zhang Qian, Maria Dolores Martín-Bermudo, Acaimo González-Reyes, David Moore Glover, Yuu Kimata
Jun 29, 2021
A feature of metazoan reproduction is the elimination of maternal centrosomes from the oocyte. In animals that form syncytial cysts during oogenesis, including Drosophila and human, all centrosomes within the cyst migrate to the...
Intrinsically disordered protein biosensor tracks the physical-chemical effects of osmotic stress on cells.
Cesar L Cuevas-Velazquez, Tamara Vellosillo, Karina Guadalupe, Hermann Broder Schmidt, Feng Yu, David Moses, Jennifer A N Brophy, Dante Cosio-Acosta, Alakananda Das, Lingxin Wang, Alexander M Jones, Alejandra A Covarrubias, Shahar Sukenik, José R Dinneny
Oct 18, 2021
Cell Line Tumor Osteoblasts Humans Escherichia coli Saccharomyces cerevisiae Arabidopsis water Molecular Chaperones Arabidopsis Proteins Recombinant Proteins Fluorescence Resonance Energy Transfer Biosensing Techniques Gene Expression Binding Sites Protein Conformation Protein Binding Kinetics Osmolar Concentration Osmotic Pressure Thermodynamics Models Molecular Protein Interaction Domains and Motifs Intrinsically Disordered Proteins
Published by: Nature Communications
Laminin Levels Regulate Tissue Migration and Anterior-Posterior Polarity during Egg Morphogenesis in Drosophila.
María C Díaz de la Loza, Alfonsa Díaz-Torres, Federico Zurita, Alicia E Rosales-Nieves, Emad Moeendarbary, Kristian Franze, María D Martín-Bermudo, Acaimo González-Reyes
Mar 28, 2018
Basement membranes (BMs) are specialized extracellular matrices required for tissue organization and organ formation. We study the role of laminin and its integrin receptor in the regulation of tissue migration during Drosophila...
The careful control of Polo kinase by APC/C-Ube2C ensures the intercellular transport of germline centrosomes during Drosophila oogenesis.
Alexis Leah Braun, Francesco Meghini, Gema Villa-Fombuena, Morgane Guermont, Elisa Fernandez-Martinez, Zhang Qian, Maria Dolores Martín-Bermudo, Acaimo González-Reyes, David Moore Glover, Yuu Kimata
Dec 08, 2022
APC/C Drosophila polo kinase centrosomes Fertility GERMLINE Alleles Anaphase-Promoting Complex-Cyclosome Animals Base Sequence Biological Transport Biomarkers Centrosome Drosophila Drosophila Proteins Gene Expression Regulation Genotype Oocytes Oogenesis Protein Serine-Threonine Kinases Protein Stability Proteolysis Sequence Deletion Ubiquitin-Conjugating Enzymes
ECM-Regulator timp Is Required for Stem Cell Niche Organization and Cyst Production in the Drosophila Ovary.
John R Pearson, Federico Zurita, Laura Tomás-Gallardo, Alfonsa Díaz-Torres, María Del Carmen Díaz de la Loza, Kristian Franze, María D Martín-Bermudo, Acaimo González-Reyes
Feb 29, 2016
Low Birth Weight Intensifies Changes in Markers of Hepatocarcinogenesis Induced by Fructose Consumption in Rats.
Lorena de Souza Almeida, Caio Jordão Teixeira, Carolina Vieira Campos, Laís Guadalupe Casaloti, Frhancielly Shirley Sodré, Vinícius Cooper Capetini, Andressa Godoy Amaral, Tanyara Baliani Payolla, Lucas Carminatti Pantaleão, Gabriel Forato Anhê, Silvana Bordin
Oct 06, 2022
p53 in AgRP neurons is required for protection against diet-induced obesity via JNK1.
Mar Quiñones, Omar Al-Massadi, Cintia Folgueira, Stephan Bremser, Rosalía Gallego, Leonardo Torres-Leal, Roberta Haddad-Tóvolli, Cristina García-Caceres, Rene Hernandez-Bautista, Brian YH Lam, Daniel Beiroa, Estrella Sanchez-Rebordelo, Ana Senra, Jose A Malagon, Patricia Valerio, Marcos F Fondevila, Johan Fernø, Maria M Malagon, Raian Contreras, Paul Pfluger, Jens C Brüning, Giles Yeo, Matthias Tschöp, Carlos Diéguez, Miguel López, Marc Claret, Peter Kloppenburg, Guadalupe Sabio, Ruben Nogueiras
Sep 10, 2018
p53 is a well-known tumor suppressor that has emerged as an important player in energy balance. However, its metabolic role in the hypothalamus remains unknown. Herein, we show that mice lacking p53 in agouti-related peptide...