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Interview with Gloria Mobley Brown - OH 780
This interview was conducted by Martin Jackson with Gloria Mobley Brown as part of Project 2020: A Collaborative Oral History. Mrs. Brown, 89, discusses her experiences as a Black student and educator, particularly during the...
2020 Black women Civil Rights Movement race Race Relations Black Lives Matter Education Rock Hill law
Published by: Winthrop University
Interview with Booker T. Brown - OH 689
This interview was conducted by Dr. George Garrison with Booker T. Brown with a focus on the History of Emmett Scott High School. Emmett Scott was the segregated high school for African-Americans, which was named after Emmett...
Published by: Winthrop University
Neuronal Loss after Stroke Due to Microglial Phagocytosis of Stressed Neurons.
Guy C Brown
Jan 05, 2022
After stroke, there is a rapid necrosis of all cells in the infarct, followed by a delayed loss of neurons both in brain areas surrounding the infarct, known as 'selective neuronal loss', and in brain areas remote from, but...
The endotoxin hypothesis of neurodegeneration
Guy C. Brown
Sep 12, 2020
Abstract: The endotoxin hypothesis of neurodegeneration is the hypothesis that endotoxin causes or contributes to neurodegeneration. Endotoxin is a lipopolysaccharide (LPS), constituting much of the outer membrane of...
Brown and beige fat
Stefania Carobbio, Anne-Claire Guénantin, Isabella Samuelson, Myriam Bahri, Antonio Vidal-Puig
Nov 18, 2020
The adipose organ portrays adipocytes of diverse tones: white, brown and beige, each type with distinct functions. Adipocytes orchestrate their adaptation and expansion to provide storage to excess nutrients, the quick...
Nitric oxide protects the heart from ischemia-induced apoptosis and mitochondrial damage via protein kinase G mediated blockage of permeability transition and cytochrome c release.
The Ursinus Weekly, February 3, 1919
Practice teaching and the small college Gettysburg quintette too speedy for Ursinus Opening session of the H.-P. group Ursinus trounces Washington Brotherhood of St. Paul holds meeting Campus democracy Junior girls sell...
Ursinus College Collegeville Pennsylvania newspaper Basketball YMCA YWCA Zwinglian literary society Schaff literary society cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
Neu1 Is Released From Activated Microglia, Stimulating Microglial Phagocytosis and Sensitizing Neurons to Glutamate
Neuraminidase 1 (Neu1) hydrolyses terminal sialic acid residues from glycoproteins and glycolipids, and is normally located in lysosomes, but can be released onto the surface of activated myeloid cells and microglia. We report...
Studying Brown Adipose Tissue in a Human in vitro Context.
New treatments for obesity and associated metabolic disease are increasingly warranted with the growth of the obesity pandemic. Brown adipose tissue (BAT) may represent a promising therapeutic target to treat obesity, as this...
Does Soluble TREM2 Protect Against Alzheimer's Disease?
Triggering Receptor Expressed in Myeloid Cells 2 (TREM2) is a pattern recognition receptor on myeloid cells, and is upregulated on microglia surrounding amyloid plaques in Alzheimer's disease (AD). Rare, heterozygous...
Amyloid β induces microglia to phagocytose neurons via activation of protein kinase Cs and NADPH oxidase.
Jean Carson Brown of Charlotte NC Jan. 14, 1947
Winthrop News Service
Jan 01, 0001
Jean Carson Brown of Charlotte, NC was named for Who's Who at Winthrop College. Miss Brown is a senior and editor of The Journal, Winthrop College's student literary publication.
Published by: Winthrop University
Knockout of the P2Y6 Receptor Prevents Peri-Infarct Neuronal Loss after Transient, Focal Ischemia in Mouse Brain.
After stroke, there is a delayed neuronal loss in brain areas surrounding the infarct, which may in part be mediated by microglial phagocytosis of stressed neurons. Microglial phagocytosis of stressed or damaged neurons can be...
Jean Carson Brown of Charlotte NC Jan. 8, 1947
Winthrop News Service
Jan 01, 0001
Jean Carson Brown, senior at Winthrop College, was selected for Who's Who among students in American colleges and universities. Miss Brown was active in campus affairs, serving as president of the campus poetry club, president...
Published by: Winthrop University
Cold Exposure Drives Weight Gain and Adiposity following Chronic Suppression of Brown Adipose Tissue.
Peter Aldiss, Jo E Lewis, Irene Lupini, Ian Bloor, Ramyar Chavoshinejad, David J Boocock, Amanda K Miles, Francis JP Ebling, Helen Budge, Michael E Symonds
Feb 09, 2022
Therapeutic activation of thermogenic brown adipose tissue (BAT) may be feasible to prevent, or treat, cardiometabolic disease. However, rodents are commonly housed below thermoneutrality (~20 °C) which can modulate their...
brown adipose tissue healthy expansion of adipose tissue Proteomics thermoneutrality Acetanilides Adipose Tissue Brown Animals Cold Temperature Disease Models Animal Gene Expression Profiling Gene Expression Regulation Male Proteomics Rats Subcutaneous Fat Thermogenesis Thiazoles Uncoupling Protein 1 Weight Gain
Calreticulin and Galectin-3 Opsonise Bacteria for Phagocytosis by Microglia.
Opsonins are soluble, extracellular proteins, released by activated immune cells, and when bound to a target cell, can induce phagocytes to phagocytose the target cell. There are three known classes of opsonin: antibodies...
Sialylation and Galectin-3 in Microglia-Mediated Neuroinflammation and Neurodegeneration
Microglia are brain macrophages that mediate neuroinflammation and contribute to and protect against neurodegeneration. The terminal sugar residue of all glycoproteins and glycolipids on the surface of mammalian cells is...
c-jun is essential for sympathetic neuronal death induced by NGF withdrawal but not by p75 activation.
Sympathetic neurons depend on NGF binding to TrkA for their survival during vertebrate development. NGF deprivation initiates a transcription-dependent apoptotic response, which is suggested to require activation of the...
Animals Apoptosis Base Sequence Brain-Derived Neurotrophic Factor Cells Cultured Cycloheximide Gene Expression Regulation Developmental Genetic Vectors Green Fluorescent Proteins Immunohistochemistry Indicators and Reagents Integrases Luminescent Proteins Mice Mice Knockout Mutation Nerve Growth Factor Neurons Protein Synthesis Inhibitors Proto-Oncogene Proteins c-jun Receptor Nerve Growth Factor Superior Cervical Ganglion Transfection Viral Proteins
Sialylation acts as a checkpoint for innate immune responses in the central nervous system.
Sialic acids are monosaccharides that normally terminate the glycan chains of cell surface glyco-proteins and -lipids in mammals, and are highly enriched in the central nervous tissue. Sialic acids are conjugated to proteins and...
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