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Felson and Cohens` Routine Activity Theory and Waves of Kidnapping in Nigeria
Kidnapping is a global issue that affects every aspect of human endeavour. This violent crime is linked to wide spread unemployment, poor governance, border insecurity, illegal possession of arms and ammunitions. ...
abduction Criminality opportunities Organized crime security violence Sociology (Criminology and Security Studies)
Published by: Department of History, University of Karachi
Exosomes in Neuroblastoma Biology, Diagnosis, and Treatment.
Neuroblastoma is an extracranial solid tumour of the developing sympathetic nervous system accounting for circa 15% of deaths due to cancer in paediatric patients. The clinical course of this cancer may be variable, ranging from...
Dormancy in Breast Cancer, the Role of Autophagy, lncRNAs, miRNAs and Exosomes.
Breast cancer (BC) is the most frequently diagnosed cancer in women for which numerous diagnostic and therapeutic options have been developed. Namely, the targeted treatment of BC, for the most part, relies on the expression of...
Dormancy in Breast Cancer, the Role of Autophagy, lncRNAs, miRNAs and Exosomes.
Breast cancer (BC) is the most frequently diagnosed cancer in women for which numerous diagnostic and therapeutic options have been developed. Namely, the targeted treatment of BC, for the most part, relies on the expression of...
The Role of lncRNAs and miRNAs in Therapy-Induced Senescence in Neuroblastoma
Abstract
Purpose of Review
Neuroblastoma, a paediatric malignancy of the sympathoadrenal lineage with a variable clinical...
SARS-COV-2 antibody responses to AZD1222 vaccination in West Africa.
Adam Abdullahi, David Oladele, Michael Owusu, Steven A Kemp, James Ayorinde, Abideen Salako, Douglas Fink, Fehintola Ige, Isabella ATM Ferreira, Bo Meng, Augustina Angelina Sylverken, Chika Onwuamah, Kwame Ofori Boadu, Kazeem Osuolale, James Opoku Frimpong, Rufai Abubakar, Azuka Okuruawe, Haruna Wisso Abdullahi, Gideon Liboro, Lawrence Duah Agyemang, Nana Kwame Ayisi-Boateng, Oluwatosin Odubela, Gregory Ohihoin, Oliver Ezechi, Japhet Senyo Kamasah, Emmanuel Ameyaw, Joshua Arthur, Derrick Boakye Kyei, Dorcas Ohui Owusu, Olagoke Usman, Sunday Mogaji, Adedamola Dada, George Agyei, Soraya Ebrahimi, Lourdes Ceron Gutierrez, Sani H Aliyu, Rainer Doffinger, Rosemary Audu, Richard Adegbola, Petra Mlcochova, Richard Odame Phillips, Babatunde Lawal Solako, Ravindra K Gupta
Oct 17, 2022
Real-world data on vaccine-elicited neutralising antibody responses for two-dose AZD1222 in African populations are limited. We assessed baseline SARS-CoV-2 seroprevalence and levels of protective neutralizing antibodies prior...
The Contribution of Autophagy and LncRNAs to MYC-Driven Gene Regulatory Networks in Cancers
Leila Jahangiri, Perla Pucci, Tala Ishola, Ricky M. Trigg, John A. Williams, Joao Pereira, Megan L. Cavanagh, Suzanne D. Turner, Georgios V. Gkoutos, Loukia Tsaprouni
Aug 11, 2021
MYC is a target of the Wnt signalling pathway and governs numerous cellular and developmental programmes hijacked in cancers. The amplification of MYC is a frequently occurring genetic alteration in cancer genomes, and this...
SARS-COV-2 antibody responses to AZD1222 vaccination in West Africa.
Adam Abdullahi, David Oladele, Michael Owusu, Steven A Kemp, James Ayorinde, Abideen Salako, Douglas Fink, Fehintola Ige, Isabella ATM Ferreira, Bo Meng, Augustina Angelina Sylverken, Chika Onwuamah, Kwame Ofori Boadu, Kazeem Osuolale, James Opoku Frimpong, Rufai Abubakar, Azuka Okuruawe, Haruna Wisso Abdullahi, Gideon Liboro, Lawrence Duah Agyemang, Nana Kwame Ayisi-Boateng, Oluwatosin Odubela, Gregory Ohihoin, Oliver Ezechi, Japhet Senyo Kamasah, Emmanuel Ameyaw, Joshua Arthur, Derrick Boakye Kyei, Dorcas Ohui Owusu, Olagoke Usman, Sunday Mogaji, Adedamola Dada, George Agyei, Soraya Ebrahimi, Lourdes Ceron Gutierrez, Sani H Aliyu, Rainer Doffinger, Rosemary Audu, Richard Adegbola, Petra Mlcochova, Richard Odame Phillips, Babatunde Lawal Solako, Ravindra K Gupta
Nov 17, 2022
Real-world data on vaccine-elicited neutralising antibody responses for two-dose AZD1222 in African populations are limited. We assessed baseline SARS-CoV-2 seroprevalence and levels of protective neutralizing antibodies prior...
The Contribution of Autophagy and LncRNAs to MYC-Driven Gene Regulatory Networks in Cancers.
Leila Jahangiri, Perla Pucci, Tala Ishola, Ricky M Trigg, John A Williams, Joao Pereira, Megan L Cavanagh, Suzanne D Turner, Georgios V Gkoutos, Loukia Tsaprouni
Aug 06, 2021
MYC is a target of the Wnt signalling pathway and governs numerous cellular and developmental programmes hijacked in cancers. The amplification of MYC is a frequently occurring genetic alteration in cancer genomes, and this...
Pilot randomized crossover study comparing the efficacy of transnasal disposable endosheath with standard endoscopy to detect Barrett's esophagus.
Mohammed K Shariff, Sibu Varghese, Maria O'Donovan, Zarah Abdullahi, Xinxue Liu, Rebecca C Fitzgerald, Massimiliano di Pietro
Feb 18, 2016
Deep analysis of neuroblastoma core regulatory circuitries using online databases and integrated bioinformatics shows their pan-cancer roles as prognostic predictors.
Leila Jahangiri, Perla Pucci, Tala Ishola, Joao Pereira, Megan L Cavanagh, Suzanne D Turner
Dec 15, 2021
AIM: Neuroblastoma is a heterogeneous childhood cancer derived from the neural crest. The dual cell identities of neuroblastoma include Mesenchymal (MES) and Adrenergic (ADRN). These identities are conferred by a small set of...
Preferential MGMT hypermethylation in SDH-deficient wild-type GIST.
Olivier T Giger, Rogier Ten Hoopen, David Shorthouse, Shukri Abdullahi, Venkata Ramesh Bulusu, Saili Jadhav, Eamonn R Maher, Ruth T Casey
Nov 03, 2022
The Role of Autophagy and lncRNAs in the Maintenance of Cancer Stem Cells
Leila Jahangiri, Tala Ishola, Perla Pucci, Ricky M. Trigg, Joao Pereira, John A. Williams, Megan L. Cavanagh, Georgios V. Gkoutos, Loukia Tsaprouni, Suzanne D. Turner
Mar 12, 2021
Cancer stem cells (CSCs) possess properties such as self-renewal, resistance to apoptotic cues, quiescence, and DNA-damage repair capacity. Moreover, CSCs strongly influence the tumour microenvironment (TME) and may account for...
Reversible Data Hiding with Multiple Data for Multiple Users in an Encrypted Image
This article presents a new method which embeds multiple data from multiple users in an encrypted image. Here, the data from several users is embedded into an encrypted image. Initially, the image is encrypted by the owner...
Published by: IGI Global Scientific Publishing
Ultra Violet (UV) Light Irradiation Device for Hospital Disinfection
Jazuli Kazaure, Khalid Haruna, Ugochukwu Matthew, Andrew Nwanakwaugwu, Ubochi Nwamouh, Nwamaka Okafor, Oluwafemi Olawoyin
Jan 01, 2022
The biomedical technology application of ultraviolet light device was reviewed in the current research in a manner to improve public healthcare safety. The research adopted ultraviolet light irradiation to enable elimination of...
Published by: IGI Global Scientific Publishing
EBOVAC-Salone
Thomas Mooney, Elizabeth Smout, Bailah Leigh, Brian Greenwood, Luisa Enria, David Ishola, Daniela Manno, Mohamed Samai, Macaya Douoguih, Deborah Watson-Jones
Oct 01, 2018
Background/aims: During the 2014–2016 West African Ebola epidemic, clinical trials were fast-tracked in order to identify prophylactic vaccines and experimental treatments that might be useful in preventing or treating Ebola....
EBOVAC-Salone
Thomas Mooney, Elizabeth Smout, Bailah Leigh, Brian Greenwood, Luisa Enria, David Ishola, Daniela Manno, Mohamed Samai, Macaya Douoguih, Deborah Watson-Jones
Oct 01, 2018
Background/aims: During the 2014–2016 West African Ebola epidemic, clinical trials were fast-tracked in order to identify prophylactic vaccines and experimental treatments that might be useful in preventing or treating Ebola....
Liver steatosis and fibrosis in people with human immunodeficiency virus in West Africa and the relationship with hepatitis B virus coinfection.
Giovanni Villa, Dorcas Owusu, Colette Smith, Marilyn Azumah, Adam Abdullahi, Suzannah Phillips, Laila Sayeed, Harrison Austin, David Chadwick, Richard Odame Phillips, Anna Maria Geretti
Sep 14, 2022
Increased risk of A(H1N1)pdm09 influenza infection in UK pig industry workers compared to a general population cohort.
Ellen Fragaszy, David A Ishola, Ian H Brown, Joanne Enstone, Jonathan S Nguyen-Van-Tam, Robin Simons, Alexander W Tucker, Barbara Wieland, Susanna M Williamson, Andrew C Hayward, Flu Watch Group, James LN Wood, Combating Swine Influenza (COSI) Consortium
Feb 12, 2016
Age-related immune response heterogeneity to SARS-CoV-2 vaccine BNT162b2.
Dami A Collier, Isabella ATM Ferreira, Prasanti Kotagiri, Rawlings P Datir, Eleanor Y Lim, Emma Touizer, Bo Meng, Adam Abdullahi, CITIID-NIHR BioResource COVID-19 Collaboration, Anne Elmer, Nathalie Kingston, Barbara Graves, Emma Le Gresley, Daniela Caputo, Laura Bergamaschi, Kenneth GC Smith, John R Bradley, Lourdes Ceron-Gutierrez, Paulina Cortes-Acevedo, Gabriela Barcenas-Morales, Michelle A Linterman, Laura E McCoy, Chris Davis, Emma Thomson, Paul A Lyons, Eoin McKinney, Rainer Doffinger, Mark Wills, Ravindra K Gupta
Sep 10, 2021
Although two-dose mRNA vaccination provides excellent protection against SARS-CoV-2, there is little information about vaccine efficacy against variants of concern (VOC) in individuals above eighty years of age1. Here we...
Adult Aged Aged 80 and over aging Antibodies Neutralizing Antibodies Viral Autoantibodies B-Lymphocytes BNT162 Vaccine COVID-19 Vaccines Female Health Personnel Humans Immunity Immunization Secondary Immunoglobulin A Immunoglobulin Class Switching Immunoglobulin G Immunologic Memory Inflammation Interferon-gamma Interleukin-2 Male Middle Aged SARS-CoV-2 Somatic Hypermutation Immunoglobulin Spike Glycoprotein Coronavirus T-Lymphocytes Vaccination vaccines Synthetic
SARS-CoV-2 B.1.617 Mutations L452R and E484Q Are Not Synergistic for Antibody Evasion.
Isabella ATM Ferreira, Steven A Kemp, Rawlings Datir, Akatsuki Saito, Bo Meng, Partha Rakshit, Akifumi Takaori-Kondo, Yusuke Kosugi, Keiya Uriu, Izumi Kimura, Kotaro Shirakawa, Adam Abdullahi, Anurag Agarwal, Seiya Ozono, Kenzo Tokunaga, Kei Sato, Ravindra K Gupta, Indian SARS-CoV-2 Genomics Consortium CITIID-NIHR BioResource COVID-19 Collaboration, Genotype to Phenotype Japan (G2P-Japan) Consortium
Jul 29, 2021
The SARS-CoV-2 B.1.617 variant emerged in the Indian state of Maharashtra in late 2020. There have been fears that 2 key mutations seen in the receptor-binding domain, L452R and E484Q, would have additive effects on evasion of...
B.1.617 covid-19 Indian variant SARS-CoV-2 Antibody Escape evasion FITNESS infectivity neutralizing antibodies resistance spike mutation Angiotensin-Converting Enzyme 2 Animals Antibodies Neutralizing Antibodies Viral BNT162 Vaccine covid-19 COVID-19 Vaccines Chlorocebus aethiops HEK293 Cells Humans Immune Evasion india Mutation Protein Binding SARS-CoV-2 Serine Endopeptidases Spike Glycoprotein Coronavirus Vero Cells
SARS-CoV-2 B.1.617.2 Delta variant replication and immune evasion.
Petra Mlcochova, Steven A Kemp, Mahesh Shanker Dhar, Guido Papa, Bo Meng, Isabella ATM Ferreira, Rawlings Datir, Dami A Collier, Anna Albecka, Sujeet Singh, Rajesh Pandey, Jonathan Brown, Jie Zhou, Niluka Goonawardane, Swapnil Mishra, Charles Whittaker, Thomas Mellan, Robin Marwal, Meena Datta, Shantanu Sengupta, Kalaiarasan Ponnusamy, Venkatraman Srinivasan Radhakrishnan, Adam Abdullahi, Oscar Charles, Partha Chattopadhyay, Priti Devi, Daniela Caputo, Tom Peacock, Chand Wattal, Neeraj Goel, Ambrish Satwik, Raju Vaishya, Meenakshi Agarwal, Indian SARS-CoV-2 Genomics Consortium (INSACOG), Genotype to Phenotype Japan (G2P-Japan) Consortium, CITIID-NIHR BioResource COVID-19 Collaboration, Antranik Mavousian, Joo Hyeon Lee, Jessica Bassi, Chiara Silacci-Fegni, Christian Saliba, Dora Pinto, Takashi Irie, Isao Yoshida, William L Hamilton, Kei Sato, Samir Bhatt, Seth Flaxman, Leo C James, Davide Corti, Luca Piccoli, Wendy S Barclay, Partha Rakshit, Anurag Agrawal, Ravindra K Gupta
Sep 10, 2021
The B.1.617.2 (Delta) variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first identified in the state of Maharashtra in late 2020 and spread throughout India, outcompeting pre-existing lineages...
Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts infectivity and fusogenicity.
Bo Meng, Adam Abdullahi, Isabella ATM Ferreira, Niluka Goonawardane, Akatsuki Saito, Izumi Kimura, Daichi Yamasoba, Pehuén Pereyra Gerber, Saman Fatihi, Surabhi Rathore, Samantha K Zepeda, Guido Papa, Steven A Kemp, Terumasa Ikeda, Mako Toyoda, Toong Seng Tan, Jin Kuramochi, Shigeki Mitsunaga, Takamasa Ueno, Kotaro Shirakawa, Akifumi Takaori-Kondo, Teresa Brevini, Donna L Mallery, Oscar J Charles, CITIID-NIHR BioResource COVID-19 Collaboration, Genotype to Phenotype Japan (G2P-Japan) Consortium, Ecuador-COVID19 Consortium, John E Bowen, Anshu Joshi, Alexandra C Walls, Laurelle Jackson, Darren Martin, Kenneth GC Smith, John Bradley, John AG Briggs, Jinwook Choi, Elo Madissoon, Kerstin B Meyer, Petra Mlcochova, Lourdes Ceron-Gutierrez, Rainer Doffinger, Sarah A Teichmann, Andrew J Fisher, Matteo S Pizzuto, Anna de Marco, Davide Corti, Myra Hosmillo, Joo Hyeon Lee, Leo C James, Lipi Thukral, David Veesler, Alex Sigal, Fotios Sampaziotis, Ian G Goodfellow, Nicholas J Matheson, Kei Sato, Ravindra K Gupta
Mar 31, 2022
The SARS-CoV-2 Omicron BA.1 variant emerged in 20211 and has multiple mutations in its spike protein2. Here we show that the spike protein of Omicron has a higher affinity for ACE2 compared with Delta, and a marked change in its...
Adult Aged Aged 80 and over Angiotensin-Converting Enzyme 2 Animals Antibodies Neutralizing Antibodies Viral covid-19 COVID-19 Vaccines Cell Line Cell Membrane Chlorocebus aethiops Convalescence Female Humans Immune Sera Intestines Lung Male Membrane Fusion Middle Aged Mutation Nasal Mucosa SARS-CoV-2 Serine Endopeptidases Spike Glycoprotein Coronavirus Tissue Culture Techniques Virulence Virus Internalization Virus Replication
Age-related immune response heterogeneity to SARS-CoV-2 vaccine BNT162b2
Dami A. Collier, Isabella A. T. M. Ferreira, Prasanti Kotagiri, Rawlings P. Datir, Eleanor Y. Lim, Emma Touizer, Bo Meng, Adam Abdullahi, Anne Elmer, Nathalie Kingston, Barbara Graves, Emma Le Gresley, Daniela Caputo, Laura Bergamaschi, Kenneth G. C. Smith, John R. Bradley, Lourdes Ceron-Gutierrez, Paulina Cortes-Acevedo, Gabriela Barcenas-Morales, Michelle A. Linterman, Laura E. McCoy, Chris Davis, Emma Thomson, Eoin McKinney, Rainer Doffinger, Mark Wills, Ravindra K. Gupta, Stephen Baker, Gordon Dougan, Christoph Hess, Paul J. Lehner, Paul A. Lyons, Nicholas J. Matheson, Willem H. Owehand, Caroline Saunders, Charlotte Summers, James E. D. Thaventhiran, Mark Toshner, Michael P. Weekes, Patrick Maxwell, Ashley Shaw, Ashlea Bucke, Jo Calder, Laura Canna, Jason Domingo, Stewart Fuller, Julie Harris, Sarah Hewitt, Jane Kennet, Sherly Jose, Jenny Kourampa, Anne Meadows, Criona O’Brien, Jane Price, Cherry Publico, Rebecca Rastall, Carla Ribeiro, Jane Rowlands, Valentina Ruffolo, Hugo Tordesillas, Ben Bullman, Benjamin J. Dunmore, Stuart Fawke, Stefan Gräf, Josh Hodgson, Christopher Huang, Kelvin Hunter, Emma Jones, Ekaterina Legchenko, Cecilia Matara, Jennifer Martin, Federica Mescia, Ciara O’Donnell, Linda Pointon, Nicole Pond, Joy Shih, Rachel Sutcliffe, Tobias Tilly, Carmen Treacy, Zhen Tong, Jennifer Wood, Marta Wylot, Ariana Betancourt, Georgie Bower, Chiara Cossetti, Aloka De Sa, Madeline Epping, Nick Gleadall, Richard Grenfell, Andrew Hinch, Oisin Huhn, Sarah Jackson, Isobel Jarvis, Ben Krishna, Daniel Lewis, Joe Marsden, Francesca Nice, Georgina Okecha, Ommar Omarjee, Marianne Perera, Martin Potts, Nathan Richoz, Veronika Romashova, Natalia Savinykh Yarkoni, Rahul Sharma, Luca Stefanucci, Jonathan Stephens, Mateusz Strezlecki, Lori Turner, Eckart M. D. D. De Bie, Katherine Bunclark, Masa Josipovic, Michael Mackay, Alice Michael, Sabrina Rossi, Mayurun Selvan, Sarah Spencer, Cissy Yong, Ali Ansaripour, Lucy Mwaura, Caroline Patterson, Gary Polwarth, Petra Polgarova, Giovanni di Stefano, Codie Fahey, Rachel Michel, Sze-How Bong, Jerome D. Coudert, Elaine Holmes, John Allison, Helen Butcher, Debbie Clapham-Riley, Eleanor Dewhurst, Anita Furlong, Jennifer Gray, Tasmin Ivers, Mary Kasanicki, Rachel Linger, Sarah Meloy, Francesca Muldoon, Nigel Ovington, Sofia Papadia, Isabel Phelan, Hannah Stark, Kathleen E. Stirrups, Paul Townsend, Neil Walker, Jennifer Webster
Aug 18, 2021
Abstract: Although two-dose mRNA vaccination provides excellent protection against SARS-CoV-2, there is little information about vaccine efficacy against variants of concern (VOC) in individuals above eighty years of age1. Here...
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