Search
Results: 6
Functional reconstruction of a eukaryotic-like E1/E2/(RING) E3 ubiquitylation cascade from an uncultured archaeon.
Rory Hennell James, Eva F Caceres, Alex Escasinas, Haya Alhasan, Julie A Howard, Michael J Deery, Thijs JG Ettema, Nicholas P Robinson
Jan 24, 2018
The covalent modification of protein substrates by ubiquitin regulates a diverse range of critical biological functions. Although it has been established that ubiquitin-like modifiers evolved from prokaryotic sulphur transfer...
The effect of non-communicative eye movements on joint attention.
Nathan Caruana, Ayeh Alhasan, Kirilee Wagner, David M Kaplan, Alexandra Woolgar, Genevieve McArthur
Jul 16, 2020
Eye movements provide important signals for joint attention. However, those eye movements that indicate bids for joint attention often occur among non-communicative eye movements. This study investigated the influence of these...
Lesion site and therapy time predict responses to a therapy for anomia after stroke
Thomas MH Hope, Davide Nardo, Rachel Holland, Sasha Ondobaka, Haya Akkad, Cathy J Price, Alexander P Leff, Jenny Crinion
Sep 20, 2021
Stroke is a leading cause of disability, and language impairments (aphasia) after stroke are both common and particularly feared. Most stroke survivors with aphasia exhibit anomia (difficulties with naming common objects), but...
Dual binding motifs underpin the hierarchical association of perilipins1-3 with lipid droplets.
Dalila Ajjaji, Kalthoum Ben M'barek, Michael L Mimmack, Cheryl England, Haya Herscovitz, Liang Dong, Richard G Kay, Satish Patel, Vladimir Saudek, Donald M Small, David B Savage, Abdou Rachid Thiam
Feb 04, 2019
Lipid droplets (LDs) in all eukaryotic cells are coated with at least one of the perilipin (Plin) family of proteins. They all regulate key intracellular lipases but do so to significantly different extents. Where more than one...
Mutations in ELAC2 associated with hypertrophic cardiomyopathy impair mitochondrial tRNA 3'-end processing.
Makenzie Saoura, Christopher A Powell, Robert Kopajtich, Ahmad Alahmad, Haya H Al-Balool, Buthaina Albash, Majid Alfadhel, Charlotte L Alston, Enrico Bertini, Penelope E Bonnen, Drago Bratkovic, Rosalba Carrozzo, Maria A Donati, Michela Di Nottia, Daniele Ghezzi, Amy Goldstein, Eric Haan, Rita Horvath, Joanne Hughes, Federica Invernizzi, Eleonora Lamantea, Benjamin Lucas, Kyla-Gaye Pinnock, Maria Pujantell, Shamima Rahman, Pedro Rebelo-Guiomar, Saikat Santra, Daniela Verrigni, Robert McFarland, Holger Prokisch, Robert W Taylor, Louis Levinger, Michal Minczuk
May 31, 2019
Mitochondria RNA RNase Z Cardiomyopathy mitochondrial disease Alleles Amino Acid Substitution Biomarkers Cardiomyopathy Hypertrophic Cohort Studies Enzyme Activation Female Gene Expression Genes Mitochondrial Genetic Association Studies Genetic Predisposition to Disease Genotype Humans Infant Kinetics Male Mutation Neoplasm Proteins Phenotype Protein Conformation Protein Interaction Domains and Motifs RNA processing Post-Transcriptional RNA Transfer Structure-Activity Relationship Substrate Specificity