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BACKGROUND: Across the last decade, healthcare emerged as a critical space for combatting modern slavery. Accurate and informative training of healthcare professionals is, therefore, essential. In the UK, the National Health...
Vascular smooth muscle cell phenotypic switching and plaque stability
Vascular smooth muscle cells (VSMCs) play important and varied roles in the development and progression of atherosclerosis. VSMCs form the medial layer of arteries where they maintain vessel tone via their contractile function....
Mechanisms of vascular smooth muscle cell investment and phenotypic diversification in vascular diseases.
In contrast with the heart, the adult mammalian vasculature retains significant remodelling capacity, dysregulation of which is implicated in disease development. In particular, vascular smooth muscle cells (VSMCs) play major...
cardiovascular disease Cell Plasticity Lineage tracing single cell RNA sequencing Vascular smooth muscle Animals Atherosclerosis Cell Lineage Cell Plasticity Cell Proliferation Gene Expression Gene Expression Regulation Humans Muscle Smooth Vascular Myocytes Smooth Muscle Phenotype Signal Transduction
Dairy consumption, systolic blood pressure, and risk of hypertension
Ming Ding, Tao Huang, Helle Km Bergholdt, Børge G Nordestgaard, Christina Ellervik, Lu Qi, CHARGE consortium
Jul 25, 2019
Objective To examine whether previous observed inverse associations of dairy intake with systolic blood pressure and risk of hypertension were causal.Design Mendelian randomization study using the single nucleotide polymorphism...
The Relationship between Health Literacy and Health Behaviour in People with Diabetes
New law puts Bolivian biodiversity hotspot on road to deforestation.
Álvaro Fernández-Llamazares, Joose Helle, Johanna Eklund, Andrew Balmford, R Mónica Moraes, Victoria Reyes-García, Mar Cabeza
Jan 23, 2018
In August 2017, the Bolivian government passed a contentious law downgrading the legal protection of the Isiboro-Sécure National Park and Indigenous Territory (TIPNIS, for its Spanish acronym), the ancestral homeland of four...
The impact of health behaviours on incident cardiovascular disease in Europeans and South Asians--a prospective analysis in the UK SABRE study.
Anne Eriksen, Therese Tillin, Laura O'Connor, Soren Brage, Alun Hughes, Jamil Mayet, Paul McKeigue, Peter Whincup, Nish Chaturvedi, Nita G Forouhi
May 18, 2015
Bone biodeterioration-The effect of marine and terrestrial depositional environments on early diagenesis and bone bacterial community.
Anne Marie Høier Eriksen, Tue Kjærgaard Nielsen, Henning Matthiesen, Christian Carøe, Lars Hestbjerg Hansen, David John Gregory, Gordon Turner-Walker, Matthew James Collins, M Thomas P Gilbert
Oct 29, 2021
Bacteria play an important role in the degradation of bone material. However, much remains to be learnt about the structure of their communities in degrading bone, and how the depositional environment influences their diversity...
REST selectively represses a subset of RE1-containing neuronal genes in mouse embryonic stem cells.
Helle F Jørgensen, Anna Terry, Chiara Beretta, C Filipe Pereira, Marion Leleu, Zhou-Feng Chen, Claire Kelly, Matthias Merkenschlager, Amanda G Fisher
May 04, 2018
REST is a transcriptional repressor that targets a group of neuronal genes in non-neuronal cells. In embryonic stem (ES) cells, REST has been implicated in controlling the expression of transcription factor genes that are...
Vascular smooth muscle cells in atherosclerosis.
Vascular smooth muscle cells (VSMCs) are a major cell type present at all stages of an atherosclerotic plaque. According to the 'response to injury' and 'vulnerable plaque' hypotheses, contractile VSMCs recruited from the media...
Embryonic stem cell-derived hemangioblasts remain epigenetically plastic and require PRC1 to prevent neural gene expression.
Luca Mazzarella, Helle F Jørgensen, Jorge Soza-Ried, Anna V Terry, Stella Pearson, Georges Lacaud, Valerie Kouskoff, Matthias Merkenschlager, Amanda G Fisher
Feb 12, 2019
Many lineage-specific developmental regulator genes are transcriptionally primed in embryonic stem (ES) cells; RNA Pol(II) is bound at their promoters but is prevented from productive elongation by the activity of polycomb...
Animals Blotting Western Cell Differentiation Cells Cultured Chromatin Chromatin Immunoprecipitation DNA-Binding Proteins Embryonic Stem Cells Epigenesis Genetic Fetal Proteins Green Fluorescent Proteins Hemangioblasts Histones Homeobox Protein Nkx-2.2 Homeodomain Proteins Integrases Mice Mice Knockout Polycomb Repressive Complex 1 Polycomb-Group Proteins RNA Messenger Repressor Proteins Reverse Transcriptase Polymerase Chain Reaction SOXB1 Transcription Factors T-Box Domain Proteins Transcription Factors Ubiquitin-Protein Ligases Vascular Endothelial Growth Factor Receptor-2 Zebrafish Proteins
Extensive Proliferation of a Subset of Differentiated, yet Plastic, Medial Vascular Smooth Muscle Cells Contributes to Neointimal Formation in Mouse Injury and Atherosclerosis Models.
Joel Chappell, Jennifer L Harman, Vagheesh M Narasimhan, Haixiang Yu, Kirsty Foote, Benjamin D Simons, Martin R Bennett, Helle F Jørgensen
Nov 22, 2016
Atherosclerosis lineage-tracing MACROPHAGES Neointima Phenotype vascular diseases vascular smooth muscle Animals Atherosclerosis Cell Proliferation Disease Models Animal Mice Mice Inbred BALB C Mice Inbred C57BL Mice Knockout Mice Transgenic Muscle Smooth Vascular Myocytes Smooth Muscle Neointima Vascular System Injuries
The double-stranded DNA-binding proteins TEBP-1 and TEBP-2 form a telomeric complex with POT-1.
Sabrina Dietz, Miguel Vasconcelos Almeida, Emily Nischwitz, Jan Schreier, Nikenza Viceconte, Albert Fradera-Sola, Christian Renz, Alejandro Ceron-Noriega, Helle D Ulrich, Dennis Kappei, René F Ketting, Falk Butter
Oct 25, 2021
Telomeres are bound by dedicated proteins, which protect them from DNA damage and regulate telomere length homeostasis. In the nematode Caenorhabditis elegans, a comprehensive understanding of the proteins interacting with the...
Efficacy and limitations of senolysis in atherosclerosis.
Abel Martin Garrido, Anuradha Kaistha, Anna K Uryga, Sebnem Oc, Kirsty Foote, Aarti Shah, Alison Finigan, Nichola Figg, Lina Dobnikar, Helle Jørgensen, Martin Bennett
Jun 07, 2021
AIMS: Traditional markers of cell senescence including p16, Lamin B1, and senescence-associated beta galactosidase (SAβG) suggest very high frequencies of senescent cells in atherosclerosis, while their removal via 'senolysis'...
Vascular Smooth Muscle Cell Plasticity and Autophagy in Dissecting Aortic Aneurysms.
Marc Clément, Joel Chappell, Juliette Raffort, Fabien Lareyre, Marie Vandestienne, Annabel L Taylor, Alison Finigan, James Harrison, Martin R Bennett, Patrick Bruneval, Soraya Taleb, Helle F Jørgensen, Ziad Mallat
Mar 29, 2019
Objective- Recent studies suggested the occurrence of phenotypic switching of vascular smooth muscle cells (VSMCs) during the development of aortic aneurysm (AA). However, lineage-tracing studies are still lacking, and the...
Angiotensin II Autophagy clones Endoplasmic Reticulum Inflammation Mice Smooth muscle cells Adult Aged aortic dissection Angiotensin II Animals Aorta Aortic Aneurysm Autophagy Autophagy-Related Protein 5 Cell Lineage Cell Plasticity Cells Cultured Disease Models Animal Endoribonucleases Female Humans Male Mice 129 Strain Mice Inbred C57BL Mice Knockout ApoE Middle Aged Muscle Smooth Vascular Myocytes Smooth Muscle Phenotype Protein Serine-Threonine Kinases Signal Transduction
The double-stranded DNA-binding proteins TEBP-1 and TEBP-2 form a telomeric complex with POT-1.
Sabrina Dietz, Miguel Vasconcelos Almeida, Emily Nischwitz, Jan Schreier, Nikenza Viceconte, Albert Fradera-Sola, Christian Renz, Alejandro Ceron-Noriega, Helle D Ulrich, Dennis Kappei, René F Ketting, Falk Butter
Jun 12, 2021
Telomeres are bound by dedicated proteins, which protect them from DNA damage and regulate telomere length homeostasis. In the nematode Caenorhabditis elegans, a comprehensive understanding of the proteins interacting with the...
Germ Cells Telomere Animals Animals Genetically Modified Caenorhabditis elegans Multiprotein Complexes DNA-Binding Proteins Telomere-Binding Proteins Caenorhabditis elegans Proteins Protein Isoforms DNA Microscopy Fluorescence Phylogeny Binding Sites Base Sequence Protein Binding Mutation
Published by: Nature Communications
The Provenance, Use and Circulation of Metals in the European Bronze Age
M Radivojevic, Benjamin Roberts, Ernst Pernicka, Zofia Stos-Gale, Marcos Martinon-Torres, Thilo Rehren, Peter Bray, Dirk Brandherm, Johan Ling, Jianjun Mei, Helle Vandkilde, Kristian Kristiansen, Stephen Shennan, Cyprian Broodbank
Jul 06, 2018
Disease-relevant transcriptional signatures identified in individual smooth muscle cells from healthy mouse vessels.
Lina Dobnikar, Annabel L Taylor, Joel Chappell, Phoebe Oldach, Jennifer L Harman, Erin Oerton, Elaine Dzierzak, Martin R Bennett, Mikhail Spivakov, Helle F Jørgensen
Dec 10, 2018
The double-stranded DNA-binding proteins TEBP-1 and TEBP-2 form a telomeric complex with POT-1
Sabrina Dietz, Miguel Vasconcelos Almeida, Emily Nischwitz, Jan Schreier, Nikenza Viceconte, Albert Fradera-Sola, Christian Renz, Alejandro Ceron-Noriega, Helle D. Ulrich, Dennis Kappei, René F. Ketting, Falk Butter
May 11, 2021
Abstract: Telomeres are bound by dedicated proteins, which protect them from DNA damage and regulate telomere length homeostasis. In the nematode Caenorhabditis elegans, a comprehensive understanding of the proteins interacting...
Telomere damage promotes vascular smooth muscle cell senescence and immune cell recruitment after vessel injury.
Anna K Uryga, Mandy OJ Grootaert, Abel M Garrido, Sebnem Oc, Kirsty Foote, Joel Chappell, Alison Finigan, Francesca Rossiello, Fabrizio d'Adda di Fagagna, Dimitra Aravani, Helle F Jorgensen, Martin R Bennett
Apr 15, 2021
Accumulation of vascular smooth muscle cells (VSMCs) is a hallmark of multiple vascular pathologies, including following neointimal formation after injury and atherosclerosis. However, human VSMCs in advanced atherosclerotic...
Animals Atherosclerosis Cell Proliferation Cells Cultured Cellular Senescence DNA Damage Disease Models Animal Humans Inflammation Male Mice Mice Inbred C57BL Mice Knockout Microfilament Proteins Muscle Proteins Muscle Smooth Vascular Myocytes Smooth Muscle Neointima Telomere Telomeric Repeat Binding Protein 2
Telomere damage promotes vascular smooth muscle cell senescence and immune cell recruitment after vessel injury.
Anna K Uryga, Mandy O J Grootaert, Abel M Garrido, Sebnem Oc, Kirsty Foote, Joel Chappell, Alison Finigan, Francesca Rossiello, Fabrizio d'Adda di Fagagna, Dimitra Aravani, Helle F Jorgensen, Martin R Bennett
Jun 22, 2021
Accumulation of vascular smooth muscle cells (VSMCs) is a hallmark of multiple vascular pathologies, including following neointimal formation after injury and atherosclerosis. However, human VSMCs in advanced atherosclerotic...
Published by: Communications biology
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