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Results: 40
A new triggering receptor expressed on myeloid cells (Trem) family member, Trem-like 4, binds to dead cells and is a DNAX activation protein 12-linked marker for subsets of mouse macrophages and dendritic cells
Dendritic cells (DCs) are professional APCs that can control immune responses against self and altered self, typically foreign, determinants. DCs can be divided into several subsets, including CD8?+ and CD8?- DCs. These subsets...
Adaptor protein antigen presenting cell Cell Line dendritic cell macrophage experimental melanoma Spleen
Published by: Rockefeller University
An IFN-?-IL-18 signaling loop accelerates memory CD8+ T cell proliferation
Rapid proliferation is one of the important features of memory CD8+ T cells, ensuring rapid clearance of reinfection. Although several cytokines such as IL-15 and IL-7 regulate relatively slow homeostatic proliferation of memory...
Published by: Rockefeller University
Treml4, an Ig superfamily member, mediates presentation of several antigens to T cells in vivo, including protective immunity to HER2 protein
Members of the triggering expressed on myeloid cells (Trem) receptor family fine-tune inflammatory responses. We previously identified one of these receptors, called Treml4, expressed mainly in the spleen, as well as at high...
Published by: Rockefeller University
The modeling of Alzheimer's disease by the overexpression of mutant Presenilin 1 in human embryonic stem cells.
Makoto Honda, Itsunari Minami, Norie Tooi, Nobuhiro Morone, Hisae Nishioka, Kengo Uemura, Ayae Kinoshita, John E Heuser, Norio Nakatsuji, Kazuhiro Aiba
May 28, 2019
Cellular disease models are useful tools for Alzheimer's disease (AD) research. Pluripotent stem cells, including human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs), are promising materials for...
Learner Attitudes Towards Humanoid Robot Tutoring Systems
A novel framework for investigation of the learner attitude towards a humanoid robot tutoring system is proposed in the chapter. The theoretical approach attempts to understand both the cognitive motivation as well as the social...
Cybernetics Computer Science and Information Technology Network Architecture Physical Sciences and Engineering
Published by: IGI Global Scientific Publishing
Anterior cingulate cortex connectivity is associated with suppression of behavior in a rat model of chronic pain.
Laurel Morris, Christian Sprenger, Ken Koda, Daniela de la Mora, Tomomi Yamada, Hiroaki Mano, Yuto Kashiwagi, Yoshichika Yoshioka, Yasuhide Morioka, BJ Seymour
Sep 24, 2018
Pain Control by Co-adaptive Learning in a Brain-Machine Interface.
Suyi Zhang, Wako Yoshida, Hiroaki Mano, Takufumi Yanagisawa, Flavia Mancini, Kazuhisa Shibata, Mitsuo Kawato, Ben Seymour
Jul 28, 2020
Innovation in the field of brain-machine interfacing offers a new approach to managing human pain. In principle, it should be possible to use brain activity to directly control a therapeutic intervention in an interactive...
PAG adaptive control brain-machine interface endogenous pain modulation fMRI Insula Pain pgACC real-time decoding uncertainty Brain Mapping Brain-Computer Interfaces Cerebral Cortex Electroencephalography Gyrus Cinguli learning Magnetic Resonance Imaging Neural Pathways Neurofeedback Pain Pain Management Periaqueductal Gray
Insights into gene expression profiles induced by Socs3 depletion in keratinocytes.
Archana Bajpai, Takashi Ishii, Kosuke Miyauchi, Vipul Gupta, Yuka Nishio-Masaike, Yuki Shimizu-Yoshida, Masato Kubo, Hiroaki Kitano
Jul 11, 2019
Specific deletion of suppressor of cytokine signaling 3 (Socs3) in keratinocytes can cause severe skin inflammation with infiltration of immune cells. The molecular mechanisms and key regulatory pathways involved in these...
The control of tonic pain by active relief learning.
Suyi Zhang, Hiroaki Mano, Michael Lee, Wako Yoshida, Mitsuo Kawato, Trevor W Robbins, Ben Seymour
Apr 27, 2018
Tonic pain after injury characterises a behavioural state that prioritises recovery. Although generally suppressing cognition and attention, tonic pain needs to allow effective relief learning to reduce the cause of the pain....
Evaluating the Effectiveness of Bayesian Knowledge Tracing Model-Based Explainable Recommender
Explainable recommendation, which provides an explanation about why a quiz is recommended, helps to improve transparency, persuasiveness, and trustworthiness. However, little research examined the effectiveness of the...
Published by: IGI Global Scientific Publishing
Comparison of the Phenotype and Outcome of Granulomatosis with Polyangiitis Between UK and Japanese Cohorts.
Shunsuke Furuta, Afzal N Chaudhry, Yoshihiro Arimura, Hiroaki Dobashi, Shouichi Fujimoto, Sakae Homma, Niels Rasmussen, David R Jayne
Feb 27, 2020
OBJECTIVE: There are differences in the frequencies of antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis subgroups between different geographic regions, and we have reported differences in the phenotype of...
ANTINEUTROPHIL CYTOPLASMIC ANTIBODY–ASSOCIATED VASCULITIS Europe Granulomatosis with polyangiitis Japan outcome Phenotype Adult Age of Onset Aged Antibodies Antineutrophil Cytoplasmic Disease-Free Survival Female Glucocorticoids Granulomatosis with polyangiitis Humans Japan Male Middle Aged Phenotype Prognosis Recurrence Retrospective Studies Survival Rate Treatment Outcome United Kingdom
Evaluation of Financial and Non-financial Conflicts of Interest and Quality of Evidence underlying Psoriatic Arthritis Clinical Practice Guidelines-Analysis of Personal Payments from Pharmaceutical Companies and Authors' Self-citation Rate in Japan and the United States
Hanano Mamada, Anju Murayama, Sae Kamamoto, Yudai Kaneda, Makoto Yoshida, Sota Sugiura, Erika Yamashita, Eiji Kusumi, Hiroaki Saito, Toyoaki Sawano, Tetsuya Tanimoto, Matt Vassar, Piotr Ozieranski, Akihiko Ozaki
Jun 30, 2023
OBJECTIVE: To assess financial conflict of interest (FCOI) and non-financial conflicts of interest (NFCOI) among psoriatic arthritis clinical practice guideline (PsACPG) authors in Japan and US, and to evaluate the quality of...
Selective rab11 transport and the intrinsic regenerative ability of CNS axons.
Hiroaki Koseki, Matteo Donegá, Brian YH Lam, Veselina Petrova, Susan van Erp, Giles SH Yeo, Jessica CF Kwok, Charles ffrench-Constant, Richard Eva, James W Fawcett
May 09, 2018
Neurons lose intrinsic axon regenerative ability with maturation, but the mechanism remains unclear. Using an in-vitro laser axotomy model, we show a progressive decline in the ability of cut CNS axons to form a new growth cone...
Epidemiology, clinical features, and impact of food habits on the risk of hepatocellular carcinoma
M Al-Amin Shawon, M Abul Khair Yousuf, Enayetur Raheem, Sium Ahmed, Tyeaba Tasnim Dipti, Mohammad Razuanul Hoque, Hiroaki Taniguchi, M Rezaul Karim
Apr 30, 2020
Hepatocellular carcinoma (HCC) is the sixth most common cancer and the third most common cause of cancer mortality worldwide. Infection with hepatitis B virus (HBV) and/or hepatitis C virus (HCV) is the most predominant cause of...
Breast cancer bone metastases are attenuated in a Tgif1-deficient bone microenvironment
Marie-Therese Haider, Hiroaki Saito, Jennifer Zarrer, Kevin Uzhunnumpuram, Sankari Nagarajan, Vijayalakshmi Kari, Michael Horn-Glander, Stefan Werner, Eric Hesse, Hanna Taipaleenmäki
Jun 06, 2020
Abstract: Background: Osteoclast activation is a hallmark of breast cancer-induced bone disease while little is known about the role of osteoblasts in this process. Recently, we identified the homeodomain protein TG-interacting...
Evaluation of Financial and Non-financial Conflicts of Interest and Quality of Evidence underlying Psoriatic Arthritis Clinical Practice Guidelines-Analysis of Personal Payments from Pharmaceutical Companies and Authors' Self-citation Rate in Japan and the United States
Hanano Mamada, Anju Murayama, Sae Kamamoto, Yudai Kaneda, Makoto Yoshida, Sota Sugiura, Erika Yamashita, Eiji Kusumi, Hiroaki Saito, Toyoaki Sawano, Tetsuya Tanimoto, Matt Vassar, Piotr Ozieranski, Akihiko Ozaki
Jun 30, 2023
OBJECTIVE: To assess financial conflict of interest (FCOI) and non-financial conflicts of interest (NFCOI) among psoriatic arthritis clinical practice guideline (PsACPG) authors in Japan and US, and to evaluate the quality of...
Breast cancer bone metastases are attenuated in a Tgif1-deficient bone microenvironment.
Marie-Therese Haider, Hiroaki Saito, Jennifer Zarrer, Kevin Uzhunnumpuram, Sankari Nagarajan, Vijayalakshmi Kari, Michael Horn-Glander, Stefan Werner, Eric Hesse, Hanna Taipaleenmäki
Apr 09, 2021
BACKGROUND: Osteoclast activation is a hallmark of breast cancer-induced bone disease while little is known about the role of osteoblasts in this process. Recently, we identified the homeodomain protein TG-interacting factor-1...
bone metastases Breast Cancer Osteoblasts Tgif1 Animals Bone Neoplasms Bone and Bones Breast Neoplasms Cell Differentiation Cell Line Tumor Disease Models Animal Female Homeodomain Proteins Humans Mice Mice Inbred BALB C Mice Inbred C57BL Mice Knockout Osteoblasts Repressor Proteins Semaphorins Tumor Microenvironment
Heterometallic Benzenehexathiolato Coordination Nanosheets
Ryojun Toyoda, Naoya Fukui, Dionisius HL Tjhe, Ekaterina Selezneva, Hiroaki Maeda, Cédric Bourgès, Choon Meng Tan, Kenji Takada, Yuanhui Sun, Ian Jacobs, Kazuhide Kamiya, Hiroyasu Masunaga, Takao Mori, Sono Sasaki, Henning Sirringhaus, Hiroshi Nishihara
Feb 21, 2022
Exclusion of integrins from CNS axons is regulated by Arf6 activation and the AIS.
Elske HP Franssen, Rong-Rong Zhao, Hiroaki Koseki, Venkateswarlu Kanamarlapudi, Casper C Hoogenraad, Richard Eva, James W Fawcett
May 21, 2015
Unheard, unseen and unprotected
Tessa J Roseboom, Susan E Ozanne, Keith M Godfrey, Carmen R Isasi, Hiroaki Itoh, Rebecca Simmons, Amita Bansal, Mary Barker, Torsten Plosch, Deb M Sloboda, Stephen G Matthews, Caroline HD Fall, Lucilla Poston, Mark A Hanson
Dec 02, 2020
Discrimination of Dormant and Active Hematopoietic Stem Cells by G0 Marker Reveals Dormancy Regulation by Cytoplasmic Calcium.
Tsuyoshi Fukushima, Yosuke Tanaka, Fiona K Hamey, Chih-Hsiang Chang, Toshihiko Oki, Shuhei Asada, Yasutaka Hayashi, Takeshi Fujino, Taishi Yonezawa, Reina Takeda, Kimihito Cojin Kawabata, Tomofusa Fukuyama, Terumasa Umemoto, Keiyo Takubo, Hitoshi Takizawa, Susumu Goyama, Yasushi Ishihama, Hiroaki Honda, Berthold Göttgens, Toshio Kitamura
Dec 16, 2019
Quiescent hematopoietic stem cells (HSCs) are typically dormant, and only a few quiescent HSCs are active. The relationship between "dormant" and "active" HSCs remains unresolved. Here we generate a G0 marker (G0M) mouse line...
CDK G(0) phase HSC Calcium Cell Cycle dormancy Hematopoietic stem cell p27 Animals Biomarkers Calcium Cell Proliferation Cell Self Renewal Cytoplasm Female Gene Expression Profiling Gene Expression Regulation Gene Regulatory Networks Hematopoietic Stem Cells Male Mice Mice Inbred C57BL Resting Phase Cell Cycle Single-Cell Analysis
HIF-1α-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity.
Hiroaki Semba, Norihiko Takeda, Takayuki Isagawa, Yuki Sugiura, Kurara Honda, Masaki Wake, Hidenobu Miyazawa, Yoshifumi Yamaguchi, Masayuki Miura, Dana MR Jenkins, Hyunsung Choi, Jung-Whan Kim, Masataka Asagiri, Andrew S Cowburn, Hajime Abe, Katsura Soma, Katsuhiro Koyama, Manami Katoh, Keimon Sayama, Nobuhito Goda, Randall S Johnson, Ichiro Manabe, Ryozo Nagai, Issei Komuro
May 04, 2018
In severely hypoxic condition, HIF-1α-mediated induction of Pdk1 was found to regulate glucose oxidation by preventing the entry of pyruvate into the tricarboxylic cycle. Monocyte-derived macrophages, however, encounter a...
Methods for biogeochemical studies of sea ice
LA Miller, F Fripiat, BGT Else, JS Bowman, KA Brown, RE Collins, M Ewert, A Fransson, M Gosselin, D Lannuzel, KM Meiners, C Michel, J Nishioka, D Nomura, S Papadimitriou, LM Russell, LL Sørensen, DN Thomas, JL Tison, MA Van Leeuwe, M Vancoppenolle, EW Wolff, J Zhou
Mar 19, 2015
Sterile protection and transmission blockade by a multistage anti-malarial vaccine in the pre-clinical study.
Mitsuhiro Iyori, Andrew M Blagborough, Tetsushi Mizuno, Yu-Ichi Abe, Mio Nagaoka, Naoto Hori, Iroha Yamagoshi, Dari F Da, William F Gregory, Ammar A Hasyim, Yutaro Yamamoto, Akihiko Sakamoto, Kunitaka Yoshida, Hiroaki Mizukami, Hisatoshi Shida, Shigeto Yoshida
Oct 13, 2022
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