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Vasohibin-1 is identified as a master-regulator of endothelial cell apoptosis using gene network analysis.
Muna Affara, Debbie Sanders, Hiromitsu Araki, Yoshinori Tamada, Benjamin J Dunmore, Sally Humphreys, Seiya Imoto, Christopher Savoie, Satoru Miyano, Satoru Kuhara, David Jeffries, Cristin Print, D Stephen Charnock-Jones
Apr 06, 2020
BACKGROUND: Apoptosis is a critical process in endothelial cell (EC) biology and pathology, which has been extensively studied at protein level. Numerous gene expression studies of EC apoptosis have also been performed, however...
Gene network inference and visualization tools for biologists
Daniel Hurley, Hiromitsu Araki, Yoshinori Tamada, Ben Dunmore, Deborah Sanders, Sally Humphreys, Muna Affara, Seiya Imoto, Kaori Yasuda, Yuki Tomiyasu, Kosuke Tashiro, Christopher Savoie, Vicky Cho, Stephen Smith, Satoru Kuhara, Satoru Miyano, D Stephen Charnock-Jones, Edmund J Crampin, Cristin G Print
Jan 23, 2018
Gene regulatory networks inferred from RNA abundance data have generated significant interest, but despite this, gene network approaches are used infrequently and often require input from bioinformaticians. We have assembled a...
Replaying Life's Tape With Intraclonal Germinal Center Evolution
Tatsuya Araki
Jan 01, 0001
Because high-affinity antibodies produced by germinal centers (GCs) are critical in protecting against the ever-increasing array of pathogens, understanding how GC response allows our immune system to recognize a variety of...
Published by: Rockefeller University
Data processing for the sandwiched Rényi divergence
The α-sandwiched Rényi divergence satisfies the data processing inequality, i.e. monotonicity under quantum operations, for α≥ 1 / 2. In this article, we derive a necessary and sufficient algebraic condition for equality in the...
HOT1 is a mammalian direct telomere repeat-binding protein contributing to telomerase recruitment.
Dennis Kappei, Falk Butter, Christian Benda, Marion Scheibe, Irena Draškovič, Michelle Stevense, Clara Lopes Novo, Claire Basquin, Masatake Araki, Kimi Araki, Dragomir Blazhev Krastev, Ralf Kittler, Rolf Jessberger, J Arturo Londoño-Vallejo, Matthias Mann, Frank Buchholz
Jun 28, 2019
Telomeres are repetitive DNA structures that, together with the shelterin and the CST complex, protect the ends of chromosomes. Telomere shortening is mitigated in stem and cancer cells through the de novo addition of telomeric...
Generating polyketide diversity in Dictyostelium
Tamao Saito, Tomoyuki Iijima, Kohei Koyama, Tomonori Shinagawa, Ayaka Yamanaka, Tsuyoshi Araki, Noriyuki Suzuki, Toyonobu Usuki, Robert R. Kay
Oct 24, 2022
Development and physiology RESEARCH ARTICLES Dictyostelium discoideum polyketide synthase dibenzofuran differentiation-inducing factor (DIF) antibacterial compound
Published by: The Royal Society
Generating polyketide diversity in Dictyostelium
Tamao Saito, Tomoyuki Iijima, Kohei Koyama, Tomonori Shinagawa, Ayaka Yamanaka, Tsuyoshi Araki, Noriyuki Suzuki, Toyonobu Usuki, Robert R Kay
Sep 21, 2022
Generation of Vascular Endothelial Cells and Hematopoietic Cells by Blastocyst Complementation.
Sanae Hamanaka, Ayumi Umino, Hideyuki Sato, Tomonari Hayama, Ayaka Yanagida, Naoaki Mizuno, Toshihiro Kobayashi, Mariko Kasai, Fabian Patrik Suchy, Satoshi Yamazaki, Hideki Masaki, Tomoyuki Yamaguchi, Hiromitsu Nakauchi
Dec 13, 2018
In the case of organ transplantation accompanied by vascular anastomosis, major histocompatibility complex mismatched vascular endothelial cells become a target for graft rejection. Production of a rejection-free, transplantable...
blastocyst complementation hematopoietic cells Pluripotent Stem Cells tissue regeneration vascular endothelial cells aging Animals Blastocyst Chimera Endothelial Cells Hematopoietic Stem Cells Induced Pluripotent Stem Cells Mice Inbred C57BL Mice Knockout Neovascularization Physiologic Pericytes Phenotype Platelet Endothelial Cell Adhesion Molecule-1 Vascular Endothelial Growth Factor Receptor-2
Blastocyst complementation using Prdm14 -deficient rats enables efficient germline transmission and generation of functional mouse spermatids in rats
Toshihiro Kobayashi, Teppei Goto, Mami Oikawa, Makoto Sanbo, Fumika Yoshida, Reiko Terada, Naoko Niizeki, Naoyo Kajitani, Kanako Kazuki, Yasuhiro Kazuki, Shinichi Hochi, Hiromitsu Nakauchi, M. Azim Surani, Masumi Hirabayashi
Feb 26, 2021
Abstract: Murine animal models from genetically modified pluripotent stem cells (PSCs) are essential for functional genomics and biomedical research, which require germline transmission for the establishment of colonies....
Generating polyketide diversity in
<i>Dictyostelium</i>
Tamao Saito, Tomoyuki Iijima, Kohei Koyama, Tomonori Shinagawa, Ayaka Yamanaka, Tsuyoshi Araki, Noriyuki Suzuki, Toyonobu Usuki, Robert R Kay
Sep 20, 2022
Generating polyketide diversity in Dictyostelium
Tamao Saito, Tomoyuki Iijima, Kohei Koyama, Tomonori Shinagawa, Ayaka Yamanaka, Tsuyoshi Araki, Noriyuki Suzuki, Toyonobu Usuki, Robert R Kay
Dec 12, 2022
Blastocyst complementation using Prdm14-deficient rats enables efficient germline transmission and generation of functional mouse spermatids in rats.
Toshihiro Kobayashi, Teppei Goto, Mami Oikawa, Makoto Sanbo, Fumika Yoshida, Reiko Terada, Naoko Niizeki, Naoyo Kajitani, Kanako Kazuki, Yasuhiro Kazuki, Shinichi Hochi, Hiromitsu Nakauchi, M Azim Surani, Masumi Hirabayashi
Apr 16, 2021
Murine animal models from genetically modified pluripotent stem cells (PSCs) are essential for functional genomics and biomedical research, which require germline transmission for the establishment of colonies. However, the...
Human iPS derived progenitors bioengineered into liver organoids using an inverted colloidal crystal poly (ethylene glycol) scaffold.
Soon Seng Ng, Kourosh Saeb-Parsy, Samuel JI Blackford, Joe M Segal, Maria Paola Serra, Marta Horcas-Lopez, Da Yoon No, Sotiris Mastoridis, Wayel Jassem, Curtis W Frank, Nam Joon Cho, Hiromitsu Nakauchi, Jeffrey S Glenn, S Tamir Rashid
Dec 17, 2018
Generation of human organoids from induced pluripotent stem cells (iPSCs) offers exciting possibilities for developmental biology, disease modelling and cell therapy. Significant advances towards those goals have been hampered...
Imaging-Based Screen Identifies Laminin 411 as a Physiologically Relevant Niche Factor with Importance for i-Hep Applications.
John Ong, Maria Paola Serra, Joe Segal, Ana-Maria Cujba, Soon Seng Ng, Richard Butler, Val Millar, Stephanie Hatch, Salman Zimri, Hiroyuki Koike, Karen Chan, Andrew Bonham, Michelle Walk, Ty Voss, Nigel Heaton, Ragai Mitry, Anil Dhawan, Daniel Ebner, Davide Danovi, Hiromitsu Nakauchi, S Tamir Rashid
Mar 17, 2020
Use of hepatocytes derived from induced pluripotent stem cells (i-Heps) is limited by their functional differences in comparison with primary cells. Extracellular niche factors likely play a critical role in bridging this gap....
Identification and characterization of in vitro expanded hematopoietic stem cells.
James LC Che, Daniel Bode, Iwo Kucinski, Alyssa H Cull, Fiona Bain, Hans J Becker, Maria Jassinskaja, Melania Barile, Grace Boyd, Miriam Belmonte, Andy GX Zeng, Kyomi J Igarashi, Juan Rubio-Lara, Mairi S Shepherd, Anna Clay, John E Dick, Adam C Wilkinson, Hiromitsu Nakauchi, Satoshi Yamazaki, Berthold Göttgens, David G Kent
Aug 16, 2022
The Naming of Names
John L Bowman, Takashi Araki, Mario A Arteaga-Vazquez, Frederic Berger, Liam Dolan, Jim Haseloff, Kimitsune Ishizaki, Junko Kyozuka, Shih-Shun Lin, Hideki Nagasaki, Hirofumi Nakagami, Keiji Nakajima, Yasukazu Nakamura, Kyoko Ohashi-Ito, Shinichiro Sawa, Masaki Shimamura, Roberto Solano, Hirokazu Tsukaya, Takashi Ueda, Yuichiro Watanabe, Katsuyuki T Yamato, Sabine Zachgo, Takayuki Kohchi
Sep 15, 2021
While Marchantia polymorpha has been utilized as a model system to investigate fundamental biological questions for over almost two centuries, there is renewed interest in M. polymorpha as a model genetic organism in the...
ISSCR Guidelines for Stem Cell Research and Clinical Translation
Robin Lovell-Badge, Eric Anthony, Roger A Barker, Tania Bubela, Ali H Brivanlou, Melissa Carpenter, R Alta Charo, Amander Clark, Ellen Clayton, Yali Cong, George Q Daley, Jianping Fu, Misao Fujita, Andy Greenfield, Steve A Goldman, Lori Hill, Insoo Hyun, Rosario Isasi, Jeffrey Kahn, Kazuto Kato, Jin-Soo Kim, Jonathan Kimmelman, Jürgen A Knoblich, Debra Mathews, Nuria Montserrat, Jack Mosher, Megan Munsie, Hiromitsu Nakauchi, Luigi Naldini, Gail Naughton, Kathy Niakan, Ubaka Ogbogu, Roger Pedersen, Nicolas Rivron, Heather Rooke, Janet Rossant, Jeff Round, Mitinori Saitou, Douglas Sipp, Julie Steffann, Jeremy Sugarman, Azim Surani, Jun Takahashi, Fuchou Tang, Leigh Turner, Patricia J Zettler, Xiaomei Zhai
May 28, 2021
The International Society for Stem Cell Research has updated its Guidelines for Stem Cell Research and Clinical Translation in order to address advances in stem cell science and other relevant fields, together with the...
ISSCR Guidelines for Stem Cell Research and Clinical Translation
Robin Lovell-Badge, Eric Anthony, Roger A Barker, Tania Bubela, Ali H Brivanlou, Melissa Carpenter, R Alta Charo, Amander Clark, Ellen Clayton, Yali Cong, George Q Daley, Jianping Fu, Misao Fujita, Andy Greenfield, Steve A Goldman, Lori Hill, Insoo Hyun, Rosario Isasi, Jeffrey Kahn, Kazuto Kato, Jin-Soo Kim, Jonathan Kimmelman, Jürgen A Knoblich, Debra Mathews, Nuria Montserrat, Jack Mosher, Megan Munsie, Hiromitsu Nakauchi, Luigi Naldini, Gail Naughton, Kathy Niakan, Ubaka Ogbogu, Roger Pedersen, Nicolas Rivron, Heather Rooke, Janet Rossant, Jeff Round, Mitinori Saitou, Douglas Sipp, Julie Steffann, Jeremy Sugarman, Azim Surani, Jun Takahashi, Fuchou Tang, Leigh Turner, Patricia J Zettler, Xiaomei Zhai
Jun 28, 2021
The International Society for Stem Cell Research has updated its Guidelines for Stem Cell Research and Clinical Translation in order to address advances in stem cell science and other relevant fields, together with the...
Published by: Stem Cell Reports
Narrowband Searches for Continuous and Long-duration Transient Gravitational Waves from Known Pulsars in the LIGO-Virgo Third Observing Run
R Abbott, TD Abbott, F Acernese, K Ackley, C Adams, N Adhikari, RX Adhikari, VB Adya, C Affeldt, D Agarwal, M Agathos, K Agatsuma, N Aggarwal, OD Aguiar, L Aiello, A Ain, P Ajith, T Akutsu, S Albanesi, A Allocca, PA Altin, A Amato, C Anand, S Anand, A Ananyeva, SB Anderson, WG Anderson, M Ando, T Andrade, N Andres, T Andrić, SV Angelova, S Ansoldi, JM Antelis, S Antier, S Appert, K Arai, K Arai, Y Arai, S Araki, A Araya, MC Araya, JS Areeda, M Arène, N Aritomi, N Arnaud, SM Aronson, KG Arun, H Asada, Y Asali, G Ashton, Y Aso, M Assiduo, SM Aston, P Astone, F Aubin, C Austin, S Babak, F Badaracco, MKM Bader, C Badger, S Bae, Y Bae, AM Baer, S Bagnasco, Y Bai, M Bailes, L Baiotti, J Baird, R Bajpai, M Ball, G Ballardin, SW Ballmer, A Balsamo, G Baltus, S Banagiri, D Bankar, JC Barayoga, C Barbieri, BC Barish, D Barker, P Barneo, F Barone, B Barr, L Barsotti, M Barsuglia, D Barta, J Bartlett, MA Barton, I Bartos, R Bassiri, A Basti, M Bawaj, JC Bayley, AC Baylor, M Bazzan, B Bécsy, VM Bedakihale, M Bejger, I Belahcene
Jun 29, 2022
Isolated neutron stars that are asymmetric with respect to their spin axis
are possible sources of detectable continuous gravitational waves. This paper
presents a fully-coherent search for such signals from eighteen pulsars in...
Observation of Gravitational Waves from Two Neutron Star-Black Hole Coalescences
R Abbott, TD Abbott, S Abraham, F Acernese, K Ackley, A Adams, C Adams, RX Adhikari, VB Adya, C Affeldt, D Agarwal, M Agathos, K Agatsuma, N Aggarwal, OD Aguiar, L Aiello, A Ain, P Ajith, T Akutsu, KM Aleman, G Allen, A Allocca, PA Altin, A Amato, S Anand, A Ananyeva, SB Anderson, WG Anderson, M Ando, SV Angelova, S Ansoldi, JM Antelis, S Antier, S Appert, K Arai, K Arai, Y Arai, S Araki, A Araya, MC Araya, JS Areeda, M Arène, N Aritomi, N Arnaud, SM Aronson, KG Arun, H Asada, Y Asali, G Ashton, Y Aso, SM Aston, P Astone, F Aubin, P Aufmuth, K AultONeal, C Austin, S Babak, F Badaracco, MKM Bader, S Bae, Y Bae, AM Baer, S Bagnasco, Y Bai, L Baiotti, J Baird, R Bajpai, M Ball, G Ballardin, SW Ballmer, M Bals, A Balsamo, G Baltus, S Banagiri, D Bankar, RS Bankar, JC Barayoga, C Barbieri, BC Barish, D Barker, P Barneo, F Barone, B Barr, L Barsotti, M Barsuglia, D Barta, J Bartlett, MA Barton, I Bartos, R Bassiri, A Basti, M Bawaj, JC Bayley, AC Baylor, M Bazzan, B Bécsy, VM Bedakihale, M Bejger, I Belahcene, V Benedetto
Jul 07, 2021
We report the observation of gravitational waves from two compact binary
coalescences in LIGO's and Virgo's third observing run with properties
consistent with neutron star-black hole (NSBH) binaries. The two events are
named...
Search for Gravitational Waves Associated with Gamma-Ray Bursts Detected by Fermi and Swift during the LIGO-Virgo Run O3b
R Abbott, TD Abbott, F Acernese, K Ackley, C Adams, N Adhikari, RX Adhikari, VB Adya, C Affeldt, D Agarwal, M Agathos, K Agatsuma, N Aggarwal, OD Aguiar, L Aiello, A Ain, P Ajith, T Akutsu, S Albanesi, A Allocca, PA Altin, A Amato, C Anand, S Anand, A Ananyeva, SB Anderson, WG Anderson, M Ando, T Andrade, N Andres, T Andrić, SV Angelova, S Ansoldi, JM Antelis, S Antier, S Appert, K Arai, K Arai, Y Arai, S Araki, A Araya, MC Araya, JS Areeda, M Arène, N Aritomi, N Arnaud, SM Aronson, KG Arun, H Asada, Y Asali, G Ashton, Y Aso, M Assiduo, SM Aston, P Astone, F Aubin, C Austin, S Babak, F Badaracco, MKM Bader, C Badger, S Bae, Y Bae, AM Baer, S Bagnasco, Y Bai, L Baiotti, J Baird, R Bajpai, M Ball, G Ballardin, SW Ballmer, A Balsamo, G Baltus, S Banagiri, D Bankar, JC Barayoga, C Barbieri, BC Barish, D Barker, P Barneo, F Barone, B Barr, L Barsotti, M Barsuglia, D Barta, J Bartlett, MA Barton, I Bartos, R Bassiri, A Basti, M Bawaj, JC Bayley, AC Baylor, M Bazzan, B Bécsy, VM Bedakihale, M Bejger, I Belahcene, V Benedetto
Apr 13, 2022
We search for gravitational-wave signals associated with gamma-ray bursts
detected by the Fermi and Swift satellites during the second half of the third
observing run of Advanced LIGO and Advanced Virgo (1 November 2019 15:00...
The Forward Physics Facility at the High-Luminosity LHC
Abstract
High energy collisions at the High-Luminosity Large Hadron Collider (LHC) produce a large number of particles along the beam collision axis, outside of the acceptance of...
JL Feng, F Kling, MH Reno, J Rojo, D Soldin, LA Anchordoqui, J Boyd, A Ismail, L Harland-Lang, KJ Kelly, V Pandey, S Trojanowski, YD Tsai, JM Alameddine, T Araki, A Ariga, T Ariga, K Asai, A Bacchetta, K Balazs, AJ Barr, M Battistin, J Bian, C Bertone, W Bai, P Bakhti, A Baha Balantekin, B Barman, B Batell, M Bauer, B Bauer, M Becker, A Berlin, E Bertuzzo, A Bhattacharya, M Bonvini, ST Boogert, A Boyarsky, J Bramante, V Brdar, A Carmona, DW Casper, FG Celiberto, F Cerutti, G Chachamis, G Chauhan, M Citron, E Copello, JP Corso, L Darmé, RT D'Agnolo, N Darvishi, A Das, G De Lellis, A De Roeck, J De Vries, HP Dembinski, S Demidov, P Deniverville, PB Denton, FF Deppisch, PS Bhupal Dev, A Di Crescenzo, KR Dienes, MV Diwan, HK Dreiner, Y Du, B Dutta, P Duwentäster, L Elie, SAR Ellis, R Enberg, Y Farzan, M Fieg, AL Foguel, P Foldenauer, S Foroughi-Abari, JF Fortin, A Friedland, E Fuchs, M Fucilla, K Gallmeister, A Garcia, CAG Canal, MV Garzelli, R Gauld, S Ghosh, A Ghoshal, S Gibson, F Giuli, VP Gonçalves, D Gorbunov, S Goswami, S Grau, JY Günther, M Guzzi, A Haas, T Hakulinen, SP Harris, J Harz
Feb 13, 2023
The Forward Physics Facility at the High-Luminosity LHC
Abstract
High energy collisions at the High-Luminosity Large Hadron Collider (LHC) produce a large number of particles along the beam collision axis, outside of the acceptance of...
JL Feng, F Kling, MH Reno, J Rojo, D Soldin, LA Anchordoqui, J Boyd, A Ismail, L Harland-Lang, KJ Kelly, V Pandey, S Trojanowski, YD Tsai, JM Alameddine, T Araki, A Ariga, T Ariga, K Asai, A Bacchetta, K Balazs, AJ Barr, M Battistin, J Bian, C Bertone, W Bai, P Bakhti, A Baha Balantekin, B Barman, B Batell, M Bauer, B Bauer, M Becker, A Berlin, E Bertuzzo, A Bhattacharya, M Bonvini, ST Boogert, A Boyarsky, J Bramante, V Brdar, A Carmona, DW Casper, FG Celiberto, F Cerutti, G Chachamis, G Chauhan, M Citron, E Copello, JP Corso, L Darmé, RT D'Agnolo, N Darvishi, A Das, G De Lellis, A De Roeck, J De Vries, HP Dembinski, S Demidov, P Deniverville, PB Denton, FF Deppisch, PS Bhupal Dev, A Di Crescenzo, KR Dienes, MV Diwan, HK Dreiner, Y Du, B Dutta, P Duwentäster, L Elie, SAR Ellis, R Enberg, Y Farzan, M Fieg, AL Foguel, P Foldenauer, S Foroughi-Abari, JF Fortin, A Friedland, E Fuchs, M Fucilla, K Gallmeister, A Garcia, CAG Canal, MV Garzelli, R Gauld, S Ghosh, A Ghoshal, S Gibson, F Giuli, VP Gonçalves, D Gorbunov, S Goswami, S Grau, JY Günther, M Guzzi, A Haas, T Hakulinen, SP Harris, J Harz
Jan 20, 2023
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