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Leaky scanning translation generates a second A49 protein that contributes to vaccinia virus virulence.
Vaccinia virus (VACV) strain Western Reserve gene A49L encodes a small intracellular protein with a Bcl-2 fold that is expressed early during infection and has multiple functions. A49 co-precipitates with the E3 ubiquitin ligase...
Bcl2-fold NF-κB inhibitor gene A49R leaky scanning multiple functions vaccinia virus Virulence Animals Female HEK293 Cells Humans Mice Mice Inbred BALB C NF-KappaB Inhibitor alpha NF-kappa B Signal Transduction Ubiquitin-Protein Ligases Ubiquitination Vaccinia vaccinia virus Viral Proteins Virulence beta-Transducin Repeat-Containing Proteins
Increased attenuation but decreased immunogenicity by deletion of multiple vaccinia virus immunomodulators.
IRF3 inhibitor Immunogenicity NF-κB inhibitor Vaccine efficacy vaccinia virus Animals Antibodies Neutralizing Antibodies Viral CD8-Positive T-Lymphocytes Female Gene Deletion Genes Viral Immunogenicity Vaccine Immunologic Factors Immunologic Memory Mice Mice Inbred BALB C Mice Inbred C57BL Vaccine Potency vaccines Attenuated Vaccinia vaccinia virus Viral Proteins Viral Vaccines
NF-κB activation is a turn on for vaccinia virus phosphoprotein A49 to turn off NF-κB activation.
innate immunity nuclear factor kappa B vaccinia virus virus immune evasion Feedback Physiological Humans I-kappa B Kinase I-kappa B Proteins Molecular Mimicry NF-kappa B Phosphoproteins Phosphorylation Signal Transduction Ubiquitin-Protein Ligases Ubiquitination vaccinia virus Viral Proteins Virulence beta-Transducin Repeat-Containing Proteins
Pavla Strnadova, Hongwei Ren, Robert Valentine, Michela Mazzon, Trevor R Sweeney, Ian Brierley, Geoffrey L Smith
Sep 04, 2015
Adaptive Immunity Animals CD8-Positive T-Lymphocytes Cell Line Female Gene Deletion Gene Expression Regulation Host-Pathogen Interactions Humans Immunity Innate Immunologic Memory Mice Inbred BALB C Mice Inbred C57BL Peptide Chain Initiation Translational Recombinant Fusion Proteins Recombinant Proteins Ribosome Subunits Large Eukaryotic Ribosome Subunits Small Eukaryotic Vaccinia vaccinia virus Viral Proteins Virulence
Vaccinia Virus BBK E3 Ligase Adaptor A55 Targets Importin-Dependent NF-κB Activation and Inhibits CD8+ T-Cell Memory.
Mitchell A Pallett, Hongwei Ren, Rui-Yao Zhang, Simon R Scutts, Laura Gonzalez, Zihan Zhu, Carlos Maluquer de Motes, Geoffrey L Smith
Feb 19, 2019
BTB-Kelch E3 ligase NF-κB cullin-3 importins protein A55 vaccinia virus Animals BTB-POZ Domain Cell Line Cullin Proteins Female HEK293 Cells Humans Immune Evasion Immunity Innate Karyopherins Kelch Repeat Mice Mice Inbred C57BL NF-kappa B Poxviridae Signal Transduction T-Lymphocytes Ubiquitin-Protein Ligases Vaccinia vaccinia virus Viral Proteins Virulence Virus Replication alpha Karyopherins
DNA-PK Is Targeted by Multiple Vaccinia Virus Proteins to Inhibit DNA Sensing.
Simon R Scutts, Stuart W Ember, Hongwei Ren, Chao Ye, Christopher A Lovejoy, Michela Mazzon, David L Veyer, Rebecca P Sumner, Geoffrey L Smith
Dec 06, 2018
DNA protein kinase DNA sensing IRF3 signaling Immune Evasion pattern recognition receptor protein C4 vaccinia virus virulence factor Administration Intranasal Animals Cytokines DNA DNA-Activated Protein Kinase Female HEK293 Cells HeLa Cells Humans Immunity Innate Ku Autoantigen Lymphocyte Activation Mice Inbred BALB C Mice Inbred C57BL Mutagenesis Site-Directed Protein Binding Protein Multimerization T-Lymphocytes vaccinia virus Viral Proteins Virulence
LUBAC deficiency perturbs TLR3 signaling to cause immunodeficiency and autoinflammation
Julia Zinngrebe, Eva Rieser, Lucia Taraborrelli, Nieves Peltzer, Torsten Hartwig, Hongwei Ren, Ildikó Kovács, Cornelia Endres, Peter Draber, Maurice Darding, Silvia von Karstedt, Johannes Lemke, Balazs Dome, Michael Bergmann, Brian J Ferguson, Henning Walczak
Aug 16, 2017
Animals Cell Death Death Domain Receptor Signaling Adaptor Proteins Dermatitis Gene Silencing Host-Pathogen Interactions Humans Immunologic Deficiency Syndromes Inflammation Influenza A virus Keratinocytes Mice Nerve Tissue Proteins Poly I-C Signal Transduction Toll-Like Receptor 3 Transcription Factors Ubiquitin-Protein Ligases
Inhibition of apoptosis and NF-κB activation by vaccinia protein N1 occur via distinct binding surfaces and make different contributions to virulence.
Carlos Maluquer de Motes, Samantha Cooray, Hongwei Ren, Gabriel MF Almeida, Kieran McGourty, Mohammad W Bahar, David I Stuart, Jonathan M Grimes, Stephen C Graham, Geoffrey L Smith
Aug 08, 2017
Vaccinia virus (VACV) protein N1 is an intracellular virulence factor and belongs to a family of VACV B-cell lymphoma (Bcl)-2-like proteins whose members inhibit apoptosis or activation of pro-inflammatory transcription factors...
Explicitness of Attribution in Academic Discourse
Academic discourse is a kind of dialogic interaction between scholars and the interplay of ‘averral’ and ‘attribution’. Citation, as source using, is the means of attributing the borrowed propositions to a particular source....
Published by: IGI Global Scientific Publishing
Odor-Induced Vomiting Is Combinatorially Triggered by Palp Olfactory Receptor Neurons That Project to the Lobus Glomerulatus in Locust Brain.
Liyuan Sun, Xueqin Pan, Hongwei Li, Xinyang Zhang, Xincheng Zhao, Liwei Zhang, Long Zhang
May 09, 2022
Although vomiting is commonly recognized as a protective reaction in response to toxic stimuli, the elaborate sensory processes and necessary molecular components are not fully clear, which is due to a lack of appropriate...
Novel rhenium(V) nitride complexes with dithiocarbimate ligands
Joanne Perils, Fernando Cortezon-Tamarit, Navaratnarajah Kuganathan, Gabriele Kociok-Köhn, Jonathan R Dilworth, Sofia I. Pascu
Apr 24, 2018
The application of rhenium complexes as therapeutic agents in nuclear medicine has propelled research into the chemistry of these compounds. In our effort to develop and investigate new therapeutic radiopharmaceuticals based...
Novel rhenium(V) nitride complexes with dithiocarbimate ligands
Joanne Perils, Fernando Cortezon-Tamarit, Navaratnarajah Kuganathan, Gabriele Kociok-Köhn, Jonathan R Dilworth, Sofia I. Pascu
Apr 24, 2018
The application of rhenium complexes as therapeutic agents in nuclear medicine has propelled research into the chemistry of these compounds. In our effort to develop and investigate new therapeutic radiopharmaceuticals based...
A Temporal and Spatial Priority With Global Cost Recharging Scheduling in Wireless Rechargeable Sensor Networks
Wireless power transfer technique provides a new and promising method for alleviating the limited energy capacity problem, thus receiving much attention. However, previous works usually consider temporal, spatial, or both...
Grid & High Performance Computing Computer Science and Information Technology High Performance Computing
Published by: IGI Global Scientific Publishing
Application of Artificial Intelligence Technology Optimized by Deep Learning to Rural Financial Development and Rural Governance
The aim of this article is to promote the development of rural finance and the further informatization of rural banks. Based on DL (deep learning) and artificial intelligence technology, data pre-processing and feature selection...
Published by: IGI Global Scientific Publishing
Applying Machine Learning to the Development of Prediction Models for Bank Deposit Subscription
It is not easy for banks to sell their term-deposit products to new clients because many factors will affect customers’ purchasing decision and because banks may have difficulties to identify their target customers. To address...
Published by: IGI Global Scientific Publishing
Impact of flaxseed gum on the aggregate structure, pasting properties, and rheological behavior of waxy rice starch
Xinping Zhang, Huishan Shen, Jingyue Qiao, Shuaihao Li, Xiaojuan Yang, Xingli Liu, Yanyan Zhang, Hua Zhang, Xuewei Zhao, Hongwei Wang, Fengwei Xie
Jun 30, 2024
This study examines the effects of flaxseed gum (FG) on the aggregate structure, pasting and rheological properties of waxy rice starch (WRS). Results display an increase in the ordered molecular structure...
Dynamic Light Scattering Based Microrheology of End-Functionalised Triblock Copolymer Solutions.
Nano-sized particles functionalised with short single-stranded (ss)DNAs can act as detectors of complementary DNA strands. Here we consider tri-block-copolymer-based, self-assembling DNA-coated nanoparticles. The copolymers are...
DNA Dynamic Light Scattering Microrheology Telechelic Polymers Transient Hydrogels Competing Self-assembly Triblock-copolymer
Published by: Polymers
Book Review
Yuan Ren
Jan 01, 2023
This book explores how blockchain technology is disrupting economies and transforming societies. It offers detailed insights into the synergistic and complementary effects of blockchain and other new and emerging technologies...
Published by: IGI Global Scientific Publishing
Impact of flaxseed gum on the aggregate structure, pasting properties, and rheological behavior of waxy rice starch
Xinping Zhang, Huishan Shen, Jingyue Qiao, Shuaihao Li, Xiaojuan Yang, Xingli Liu, Yanyan Zhang, Hua Zhang, Xuewei Zhao, Hongwei Wang, Fengwei Xie
Jun 30, 2024
This study examines the effects of flaxseed gum (FG) on the aggregate structure, pasting and rheological properties of waxy rice starch (WRS). Results display an increase in the ordered molecular structure...
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