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Results: 621
Monoamine oxidase-dependent endoplasmic reticulum-mitochondria dysfunction and mast cell degranulation lead to adverse cardiac remodeling in diabetes.
Soni Deshwal, Marleen Forkink, Chou-Hui Hu, Guido Buonincontri, Salvatore Antonucci, Moises Di Sante, Michael P Murphy, Nazareno Paolocci, Daria Mochly-Rosen, Thomas Krieg, Fabio Di Lisa, Nina Kaludercic
May 14, 2018
Monoamine oxidase (MAO) inhibitors ameliorate contractile function in diabetic animals, but the mechanisms remain unknown. Equally elusive is the interplay between the cardiomyocyte alterations induced by hyperglycemia and the...
Animals Cell Degranulation Diabetes mellitus Experimental Endoplasmic reticulum stress Glucose Interleukin-1beta Male Mice Mice Inbred C57BL Mitochondria Mitochondrial Membrane Transport Proteins Mitochondrial Permeability Transition Pore Monoamine Oxidase Monoamine Oxidase Inhibitors Muscle Cells Myocardium RNA Interference RNA Small Interfering Rats Reactive Oxygen Species Ventricular Remodeling
Tissue Mechanics Regulate Mitotic Nuclear Dynamics during Epithelial Development.
Cell divisions are essential for tissue growth. In pseudostratified epithelia, where nuclei are staggered across the tissue, each nucleus migrates apically before undergoing mitosis. Successful apical nuclear migration is...
Monoamine oxidase-A promotes protective autophagy in human SH-SY5Y neuroblastoma cells through Bcl-2 phosphorylation.
Aslihan Ugun-Klusek, Theodosis S Theodosi, Julia C Fitzgerald, Florence Burté, Christoph Ufer, David J Boocock, Patrick Yu-Wai-Man, Lynn Bedford, E Ellen Billett
Dec 07, 2018
Monoamine oxidases (MAOs) are located on the outer mitochondrial membrane and are drug targets for the treatment of neurological disorders. MAOs control the levels of neurotransmitters in the brain via oxidative deamination and...
Autophagy Monoamine Oxidase neurodegeneration Reactive Oxygen Species Autophagy Caspases Cell Line Tumor Cell Survival Fluorescent Antibody Technique Gene Expression Humans Immunohistochemistry Mitochondria Models Biological Monoamine Oxidase Neuroblastoma Oxidation-Reduction Oxidative Stress Phosphorylation Proteome Proteomics Proto-Oncogene Proteins c-bcl-2 Reactive Oxygen Species
microRNA-122 as a regulator of mitochondrial metabolic gene network in hepatocellular carcinoma.
Julja Burchard, Chunsheng Zhang, Angela M Liu, Ronnie TP Poon, Nikki PY Lee, Kwong-Fai Wong, Pak C Sham, Brian Y Lam, Mark D Ferguson, George Tokiwa, Ryan Smith, Brendan Leeson, Rebecca Beard, John R Lamb, Lee Lim, Mao Mao, Hongyue Dai, John M Luk
Aug 08, 2017
Tumorigenesis involves multistep genetic alterations. To elucidate the microRNA (miRNA)-gene interaction network in carcinogenesis, we examined their genome-wide expression profiles in 96 pairs of tumor/non-tumor tissues from...
Animals Carcinoma Hepatocellular Cell Line Tumor Down-Regulation Energy Metabolism Gene Expression Profiling Gene Expression Regulation Neoplastic Gene Regulatory Networks Genes Mitochondrial Humans Liver Liver Neoplasms Mice Mice Inbred C57BL MicroRNAs Mitochondria RNA Messenger Reproducibility of Results Sequence Homology Nucleic Acid Signal Transduction Survival Analysis Up-Regulation
The USTC co-opts an ancient machinery to drive piRNA transcription in C. elegans.
Chenchun Weng, Joanna Kosalka, Ahmet C Berkyurek, Przemyslaw Stempor, Xuezhu Feng, Hui Mao, Chenming Zeng, Wen-Jun Li, Yong-Hong Yan, Meng-Qiu Dong, Natalia Rosalía Morero, Cecilia Zuliani, Orsolya Barabas, Julie Ahringer, Shouhong Guang, Eric A Miska
Jan 08, 2019
Piwi-interacting RNAs (piRNAs) engage Piwi proteins to suppress transposons and nonself nucleic acids and maintain genome integrity and are essential for fertility in a variety of organisms. In Caenorhabditis elegans, most piRNA...
Exposing the Interplay Between Enzyme Turnover, Protein Dynamics and the Membrane Environment in Monoamine Oxidase B
Hannah B L Jones, Rory M Crean, Anna Mullen, Emanuele Kendrick, Steven D Bull, Stephen A Wells, David Ross Carbery, Fraser MacMillan, Marc W van der Kamp, Christopher Roland Pudney
May 07, 2019
There is an increasing realization that structure-based drug design may show improved success by understanding the ensemble of conformations accessible to an enzyme and how the environment affects this ensemble. Human...
Exposing the Interplay Between Enzyme Turnover, Protein Dynamics and the Membrane Environment in Monoamine Oxidase B
Hannah B L Jones, Rory M Crean, Anna Mullen, Emanuele Kendrick, Steven D Bull, Stephen A Wells, David Ross Carbery, Fraser MacMillan, Marc W van der Kamp, Christopher Roland Pudney
May 07, 2019
There is an increasing realization that structure-based drug design may show improved success by understanding the ensemble of conformations accessible to an enzyme and how the environment affects this ensemble. Human...
How Literal is the 1972 Translation Into English of J.L. Borges' Historia Universal de la Infamia?
Marcelo Sánchez
Jan 01, 2023
This article analyzes A Universal History of Infamy, the 1972 translation into English of Historia Universal de la Infamia (hereinafter, HUI). While assessing this translation's degree of literality, the authors also...
Published by: IGI Global Scientific Publishing
Moving the techno-science gap in Security Force Assistance
David Galbreath
Dec 31, 2019
This paper looks at the impact of military technology diffusion on military assistance operations (MAO), in the United States known as Security Force Assistance or SFA. The discussion looks conceptually at the role of...
Moving the techno-science gap in Security Force Assistance
David Galbreath
Dec 31, 2019
This paper looks at the impact of military technology diffusion on military assistance operations (MAO), in the United States known as Security Force Assistance or SFA. The discussion looks conceptually at the role of...
A recombinant modified vaccinia Ankara vaccine encoding Epstein-Barr virus (EBV) target antigens
Graham S. Taylor, Hui Jia, Kevin Harrington, Lip Wai Lee, James E Turner, Kristin Ladell, David A. Price, Manjit Tanday, Jen Matthews, Claudia Roberts, Ceri Edwards, Lesley McGuigan, Andrew Hartley, Steve Wilson, Edwin P. Hui, Anthony T. C. Chan, Alan B. Rickinson, Neil M. Steven
Oct 01, 2014
Purpose: Epstein-Barr virus (EBV) is associated with several cancers in which the tumour cells express EBV antigens EBNA1 and LMP2. A therapeutic vaccine comprising a recombinant vaccinia virus, MVA-EL, was designed to boost...
Capacitive Removal of Heavy Metal Ions from Wastewater via an Electro-Adsorption and Electro-Reaction Coupling Process
Heavy metals widely exist in wastewater, which is a serious threat to human health or water environment. Highly efficient removal of heavy metal ions from wastewater is a major challenge to wastewater treatment. In this work...
Can You Help Me Stay Fit?
The main purpose of this study is to reveal the impact of consumer satisfaction on continuance intention to use wearable fitness devices. Building upon the IS Continuance Intention Model, the authors explored the effects of...
Published by: IGI Global Scientific Publishing
Integration of Traditional Cultural Elements Into Civics Teaching Practice in Colleges and Universities Based on Internet Distance Education
Mao Li
Jan 01, 2024
This study uses questionnaire surveys to examine the real impact of incorporating traditional cultural elements into the practice of ideological and political education in colleges and universities. The integration of...
Published by: IGI Global Scientific Publishing
Towards a Text-World Approach to Translation and Its Pedagogical Implications
Although it is widely acknowledged that translation is a cognitive process, there is scarcely any study establishing connections between the text and mental representations and giving a systematic and comprehensive explanation...
Published by: IGI Global Scientific Publishing
Labeling of graphene, graphene oxides, and of their congeners
The area of biomedical imaging is fast becoming an active focus for the utilization of graphene within a variety of imaging modalities. Graphene can be oxidized to produce a material with a high degree of functionality and...
What Makes Consumers Adopt a Wearable Fitness Device?
Wearable fitness devices are equipped with internet connectivity and capable of tracking, storing, and transmitting health data. A research model is proposed and tested, which shows how cognitive, affective, social, and...
Published by: IGI Global Scientific Publishing
The Fornaldarsaga in a Dream
JYH Hui
Feb 09, 2017
Stjörnu-Odda draumr (‘Star-Oddi’s dream’) is a relatively little-known
Íslendingaþáttr (‘tale of Icelanders’) which dates from the latefourteenth century at the latest but which no longer survives in anymanuscripts predating...
Online Muscle Activation Onset Detection Using Likelihood of Conditional Heteroskedasticity of Electromyography Signals
Surface electromyography (sEMG) signals are crucial in developing human-machine interfaces, as they contain rich information about human neuromuscular activities. <italic>Objective:</italic> The real-time...
A recombinant modified vaccinia Ankara vaccine encoding Epstein-Barr virus (EBV) target antigens
Graham S. Taylor, Hui Jia, Kevin Harrington, Lip Wai Lee, James E Turner, Kristin Ladell, David A. Price, Manjit Tanday, Jen Matthews, Claudia Roberts, Ceri Edwards, Lesley McGuigan, Andrew Hartley, Steve Wilson, Edwin P. Hui, Anthony T. C. Chan, Alan B. Rickinson, Neil M. Steven
Oct 01, 2014
Purpose: Epstein-Barr virus (EBV) is associated with several cancers in which the tumour cells express EBV antigens EBNA1 and LMP2. A therapeutic vaccine comprising a recombinant vaccinia virus, MVA-EL, was designed to boost...
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