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Results: 603
The structure of human EXD2 reveals a chimeric 3' to 5' exonuclease domain that discriminates substrates via metal coordination.
Jumi Park, Song-Yi Lee, Hanbin Jeong, Myeong-Gyun Kang, Lindsey Van Haute, Michal Minczuk, Jeong Kon Seo, Youngsoo Jun, Kyungjae Myung, Hyun-Woo Rhee, Changwook Lee
Jun 03, 2019
Amino Acid Sequence Catalytic Domain Crystallography X-Ray DNA DNA Breaks Double-Stranded Dimerization Exodeoxyribonucleases HEK293 Cells Humans Magnesium manganese Mitochondrial Membranes Models Molecular Protein Domains RNA Recombinant Proteins Sequence Alignment Sequence Homology Amino Acid Structure-Activity Relationship Substrate Specificity
Integrative Neuroinformatics for Precision Prognostication and Personalized Therapeutics in Moderate and Severe Traumatic Brain Injury.
Frederick A Zeiler, Yasser Iturria-Medina, Eric P Thelin, Alwyn Gomez, Jai J Shankar, Ji Hyun Ko, Chase R Figley, Galen EB Wright, Chris M Anderson
Sep 21, 2021
Despite changes in guideline-based management of moderate/severe traumatic brain injury (TBI) over the preceding decades, little impact on mortality and morbidity have been seen. This argues against the "one-treatment fits all"...
Exercise Training Attenuates Ovariectomy-Induced Alterations in Skeletal Muscle Remodeling, Apoptotic Signaling, and Atrophy Signaling in Rat Skeletal Muscle
Eun-Jeong Cho, Youngju Choi, Jiyeon Kim, Jun Hyun Bae, Jinkyung Cho, Dong-Ho Park, Ju-Hee Kang, Jin Hwan Yoon, Eunmi Park, Dae Yun Seo, Sukho Lee, Hyo-Bum Kwak
Nov 30, 2021
Purpose The effects of aerobic exercise training on soleus muscle morphology, mitochondria-mediated apoptotic signaling, and atrophy/hypertrophy signaling in ovariectomized rat skeletal muscle were investigated. Methods Female...
Published by: Digital Commons @ Texas A&M University-San Antonio
Exercise Training Attenuates Ovariectomy-Induced Alterations in Skeletal Muscle Remodeling, Apoptotic Signaling, and Atrophy Signaling in Rat Skeletal Muscle
Eun-Jeong Cho, Youngju Choi, Jiyeon Kim, Jun Hyun Bae, Jinkyung Cho, Dong-Ho Park, Ju-Hee Kang, Jin Hwan Yoon, Eunmi Park, Dae Yun Seo, Sukho Lee, Hyo-Bum Kwak
Nov 30, 2021
Purpose The effects of aerobic exercise training on soleus muscle morphology, mitochondria-mediated apoptotic signaling, and atrophy/hypertrophy signaling in ovariectomized rat skeletal muscle were investigated. Methods Female...
Published by: Digital Commons @ Texas A&M University-San Antonio
Paneth cells as a site of origin for intestinal inflammation.
Timon E Adolph, Michal F Tomczak, Lukas Niederreiter, Hyun-Jeong Ko, Janne Böck, Eduardo Martinez-Naves, Jonathan N Glickman, Markus Tschurtschenthaler, John Hartwig, Shuhei Hosomi, Magdalena B Flak, Jennifer L Cusick, Kenji Kohno, Takao Iwawaki, Susanne Billmann-Born, Tim Raine, Richa Bharti, Ralph Lucius, Mi-Na Kweon, Stefan J Marciniak, Augustine Choi, Susan J Hagen, Stefan Schreiber, Philip Rosenstiel, Arthur Kaser, Richard S Blumberg
May 18, 2018
The recognition of autophagy related 16-like 1 (ATG16L1) as a genetic risk factor has exposed the critical role of autophagy in Crohn's disease. Homozygosity for the highly prevalent ATG16L1 risk allele, or murine hypomorphic...
Animals Autophagy Autophagy-Related Proteins Carrier Proteins Cell Line DNA-Binding Proteins Endoplasmic reticulum stress Inflammation Intestinal Diseases Intestinal Mucosa Mice Paneth Cells Regulatory Factor X Transcription Factors Signal Transduction Transcription Factors Unfolded Protein Response X-Box Binding Protein 1 eIF-2 Kinase
Acute Iron Deprivation Reprograms Human Macrophage Metabolism and Reduces Inflammation In Vivo.
Biodegradable, flexible silicon nanomembrane-based NO x gas sensor system with record-high performance for transient environmental monitors and medical implants
Gwan-Jin Ko, Soo Deok Han, Jeong-Ki Kim, Jia Zhu, Won Bae Han, Jinmook Chung, Seung Min Yang, Huanyu Cheng, Dong-Hwee Kim, Chong-Yun Kang, Suk-Won Hwang
Nov 09, 2020
Abstract: A novel transient electronics technology that is capable of completely dissolving or decomposing in certain conditions after a period of operation offers unprecedented opportunities for medical implants, environmental...
Exercise Training Attenuates Ovariectomy-Induced Alterations in Skeletal Muscle Remodeling, Apoptotic Signaling, and Atrophy Signaling in Rat Skeletal Muscle
Eun-Jeong Cho, Youngju Choi, Jiyeon Kim, Jun Hyun Bae, Jinkyung Cho, Dong-Ho Park, Ju-Hee Kang, Jin Hwan Yoon, Eunmi Park, Dae Yun Seo, Sukho Lee, Hyo-Bum Kwak
Nov 30, 2021
Purpose The effects of aerobic exercise training on soleus muscle morphology, mitochondria-mediated apoptotic signaling, and atrophy/hypertrophy signaling in ovariectomized rat skeletal muscle were investigated. Methods Female...
Published by: Digital Commons @ Texas A&M University-San Antonio
Imprinted <i>Grb10,</i> encoding growth factor receptor bound protein 10, regulates fetal growth independently of the insulin-like growth factor type 1 receptor (<i>Igf1r</i>) and insulin receptor (<i>Insr</i>) genes
Background
Optimal size at birth dictates perinatal survival and long-term risk of developing common disorders such as obesity, type 2 diabetes and cardiovascular disease. The imprinted Grb10 gene encodes a signalling...
Optimal size at birth dictates perinatal survival and long-term risk of developing common disorders such as obesity, type 2 diabetes and cardiovascular disease. The imprinted Grb10 gene encodes a signalling...
Perturbed Redox Signaling Exacerbates a Mitochondrial Myopathy.
Sukru Anil Dogan, Raffaele Cerutti, Cristiane Benincá, Gloria Brea-Calvo, Howard Trevor Jacobs, Massimo Zeviani, Marten Szibor, Carlo Viscomi
Sep 08, 2018
Alternative oxidases (AOXs) bypass respiratory complexes III and IV by transferring electrons from coenzyme Q directly to O2. They have therefore been proposed as a potential therapeutic tool for mitochondrial diseases. We...
ROS alternative oxidase antioxidant Autophagy mitochondrial biogenesis mitochondrial disease redox signaling satellite cells stress responses Animals Autophagy Female Male Mice Mice Inbred C57BL Mice Knockout Mitochondrial Myopathies Mitochondrial Proteins Muscle Skeletal Organelle Biogenesis Oxidation-Reduction Oxidoreductases Plant Proteins Reactive Oxygen Species Signal Transduction
Imprinted <i>Grb10,</i> encoding growth factor receptor bound protein 10, regulates fetal growth independently of the insulin-like growth factor type 1 receptor (<i>Igf1r</i>) and insulin receptor (<i>Insr</i>) genes
Background
Optimal size at birth dictates perinatal survival and long-term risk of developing common disorders such as obesity, type 2 diabetes and cardiovascular disease. The imprinted Grb10 gene encodes a signalling...
Optimal size at birth dictates perinatal survival and long-term risk of developing common disorders such as obesity, type 2 diabetes and cardiovascular disease. The imprinted Grb10 gene encodes a signalling...
High-resolution label-free mapping of murine kidney vasculature by raster-scanning optoacoustic mesoscopy
Colin A Goebel, Emma Brown, Fabian B Fahlbusch, Alexandra L Wagner, Adrian Buehler, Thomas Raupach, Martin Hohmann, Moritz Späth, Neal Burton, Joachim Woelfle, Michael Schmidt, Andrea Hartner, Adrian P Regensburger, Ferdinand Knieling
Aug 06, 2022
BACKGROUND: Chronic kidney disease (CKD) is a global burden affecting both children and adults. Novel imaging modalities hold great promise to visualize and quantify structural, functional, and molecular organ damage. The aim of...
Interleukin-2 induces the in vitro maturation of human pluripotent stem cell-derived intestinal organoids.
Kwang Bo Jung, Hana Lee, Ye Seul Son, Mi-Ok Lee, Young-Dae Kim, Soo Jin Oh, Ohman Kwon, Sunwha Cho, Hyun-Soo Cho, Dae-Soo Kim, Jung-Hwa Oh, Matthias Zilbauer, Jeong-Ki Min, Cho-Rok Jung, Janghwan Kim, Mi-Young Son
Nov 21, 2018
Human pluripotent stem cell (hPSC)-derived intestinal organoids (hIOs) form 3D structures organized into crypt and villus domains, making them an excellent in vitro model system for studying human intestinal development and...
Modeling and Rescue of RP2 Retinitis Pigmentosa Using iPSC-Derived Retinal Organoids
Amelia Lane, Katarina Jovanovic, Ciara Shortall, Daniele Ottaviani, Anna Brugulat-Panes, Nele Schwarz, Rosellina Guarascio, Matthew J Hayes, Arpad Palfi, Naomi Chadderton, G Jane Farrar, Alison J Hardcastle, Michael E Cheetham
Jul 07, 2020
RP2 mutations cause a severe form of X-linked retinitis pigmentosa (XLRP). The mechanism of RP2-associated retinal degeneration in humans is unclear, and animal models of RP2 XLRP do not recapitulate this severe phenotype. Here...
AAV CRISPR gene editing Cell Death Disease Modeling gene therapy Genetic inherited disease Retinal Degeneration retinal organoid stem cell Cell Death Cell Survival Dependovirus GTP-Binding Proteins Gene Expression Regulation Gene Knockdown Techniques Humans Induced Pluripotent Stem Cells Membrane Proteins Models Biological Organoids Retina Retinal Rod Photoreceptor Cells Retinitis Pigmentosa
Central Role of Dendritic Cells in Pulmonary Arterial Hypertension in Human and Mice.
Denise van Uden, Thomas Koudstaal, Jennifer AC van Hulst, Ingrid M Bergen, Chelsea Gootjes, Nicholas W Morrell, Geert van Loo, Jan H von der Thüsen, Thierry PP van den Bosch, Maria-Rosa Ghigna, Frédéric Perros, David Montani, Mirjam Kool, Karin A Boomars, Rudi W Hendriks
Apr 26, 2021
The pathogenesis of idiopathic pulmonary arterial hypertension (IPAH) is not fully understood, but evidence is accumulating that immune dysfunction plays a significant role. We previously reported that 31-week-old...
BMPR2 Tnfaip3 Toll-like receptor Dendritic Cells Inflammation pulmonary arterial hypertension Animals Bone Morphogenetic Protein Receptors Type II Dendritic Cells Familial Primary Pulmonary Hypertension Gene Deletion Heart Ventricles Humans Immunity Innate Mice Mutation Toll-Like Receptor 4 Tumor Necrosis Factor alpha-Induced Protein 3
A Narrative Biographical Study of Faculty Collaboration in E-Portfolio Development
Since an e-portfolio system was adapted at the authors' college, the faculty has been encouraged to use e-portfolios in various areas from professional development to instructional purposes. In this paper, they describe two...
Published by: IGI Global Scientific Publishing
Long non-coding RNA ChRO1 facilitates ATRX/DAXX-dependent H3.3 deposition for transcription-associated heterochromatin reorganization.
Jinyoung Park, Hongmin Lee, Namshik Han, Sojung Kwak, Han-Teo Lee, Jae-Hwan Kim, Keonjin Kang, Byoung Ha Youn, Jae-Hyun Yang, Hyeon-Ju Jeong, Jong-Sun Kang, Seon-Young Kim, Jeung-Whan Han, Hong-Duk Youn, Eun-Jung Cho
Apr 11, 2019
Animals CRISPR-Cas Systems Carrier Proteins Cell Cycle Proteins Cell Differentiation Chromosomal Proteins Non-Histone Co-Repressor Proteins Female Gene Editing Gene Expression Regulation Developmental HEK293 Cells Heterochromatin Histone-Lysine N-Methyltransferase Histones Humans Intracellular Signaling Peptides and Proteins Male Methyl-CpG-Binding Protein 2 Mice Mice Inbred C57BL Molecular Chaperones Muscle Development Muscle Skeletal NIH 3T3 Cells Nuclear Proteins RNA Long Noncoding RNA Small Interfering Transcription Genetic X-linked Nuclear Protein
DNMT3A Loss Drives Enhancer Hypomethylation in FLT3-ITD-Associated Leukemias.
Liubin Yang, Benjamin Rodriguez, Allison Mayle, Hyun Jung Park, Xueqiu Lin, Min Luo, Mira Jeong, Choladda V Curry, Sang-Bae Kim, David Ruau, Xiaotian Zhang, Ting Zhou, Michael Zhou, Vivienne I Rebel, Grant A Challen, Berthold Gottgens, Ju-Seog Lee, Rachel Rau, Wei Li, Margaret A Goodell
Apr 08, 2016
p140Cap Controls Female Fertility in Mice Acting via Glutamatergic Afference on Hypothalamic Gonadotropin-Releasing Hormone Neurons.
Mattia Camera, Isabella Russo, Valentina Zamboni, Alessandra Ammoni, Simona Rando, Alessandro Morellato, Irene Cimino, Costanza Angelini, Paolo Giacobini, Roberto Oleari, Federica Amoruso, Anna Cariboni, Isabelle Franceschini, Emilia Turco, Paola Defilippi, Giorgio R Merlo
Feb 28, 2022
p140Cap, encoded by the gene SRCIN1 (SRC kinase signaling inhibitor 1), is an adaptor/scaffold protein highly expressed in the mouse brain, participating in several pre- and post-synaptic mechanisms. p140Cap knock-out (KO)...
Charity retailing in the United Kingdom
Nonprofit organizations are venturing into commercial activities due to the intense competition for the limited government funds and declining availability of donor funds for third-sector organizations that address social...
An integrated model of cause-related marketing strategy development
Researchers in the fields of marketing and corporate social responsibility have suggested that cause-related marketing (CRM) can provide firms with opportunities for managing their community relationships and for enhancing their...
A typology of Guanxi-based governance mechanisms for knowledge transfer in business networks of Chinese small- and medium-sized enterrpises
Guanxi has strong implications for interactions among individuals in Chinese society. This study investigates guanxi-based governance mechanisms in the context of knowledge transfer among Chinese small and medium-sized...
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