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Distinct features of dendritic cells and anti-Ig activated B cells as stimulators of the primary mixed leukocyte reaction
Highly enriched populations of B lymphoblasts have been isolated after culture with anti-Ig-Sepharose and compared with dendritic cells as stimulators of CD4+ T cells in the murine MLR. The two populations clearly differed in...
Published by: Rockefeller University
The structure of human EXD2 reveals a chimeric 3' to 5' exonuclease domain that discriminates substrates via metal coordination.
Jumi Park, Song-Yi Lee, Hanbin Jeong, Myeong-Gyun Kang, Lindsey Van Haute, Michal Minczuk, Jeong Kon Seo, Youngsoo Jun, Kyungjae Myung, Hyun-Woo Rhee, Changwook Lee
Jun 03, 2019
Amino Acid Sequence Catalytic Domain Crystallography X-Ray DNA DNA Breaks Double-Stranded Dimerization Exodeoxyribonucleases HEK293 Cells Humans Magnesium manganese Mitochondrial Membranes Models Molecular Protein Domains RNA Recombinant Proteins Sequence Alignment Sequence Homology Amino Acid Structure-Activity Relationship Substrate Specificity
Folding pathway of an Ig domain is conserved on and off the ribosome.
Pengfei Tian, Annette Steward, Renuka Kudva, Ting Su, Patrick J Shilling, Adrian A Nickson, Jeffrey J Hollins, Roland Beckmann, Gunnar von Heijne, Jane Clarke, Robert B Best
Dec 05, 2018
Proteins that fold cotranslationally may do so in a restricted configurational space, due to the volume occupied by the ribosome. How does this environment, coupled with the close proximity of the ribosome, affect the folding...
Influence of offshore fringing reefs on infragravity period oscillations within a harbor
The main objective of this paper is to systematically study the influence of offshore fringing reef topography on the infragravity-period harbor oscillations under the condition of wave breaking occurring over the reef. The...
Evaluation of a worldwide EQA scheme for complex clonality analysis of clinical lymphoproliferative cases demonstrates a learning effect.
Cleo Keppens, Elke Boone, Paula Gameiro, Véronique Tack, Elisabeth Moreau, Elizabeth Hodges, Paul Evans, Monika Brüggemann, Ian Carter, Dido Lenze, Maria Eugenia Sarasquete, Markus Möbs, Hongxiang Liu, Elisabeth MC Dequeker, Patricia JTA Groenen
Aug 14, 2021
Clonality analysis of immunoglobulin (IG) or T-cell receptor (TR) gene rearrangements is routine practice to assist diagnosis of lymphoid malignancies. Participation in external quality assessment (EQA) aids laboratories in...
Clonality analysis external quality assessment IG rearrangements TCR rearrangements Gene Rearrangement Genes Immunoglobulin Genes T-Cell Receptor Humans Laboratory Proficiency Testing Lymphoproliferative Disorders Molecular Diagnostic Techniques Observer Variation Polymerase Chain Reaction Predictive Value of Tests Quality Assurance Health Care Quality Control Reproducibility of Results
IGDB-2, an IG/FNIII Protein, Binds the ION Channel LGC-34 and Controls Sensory Compartment Morphogenesis in C. Elegans
Wendy Wang
Jan 01, 0001
Sensory organ glia surround neuronal receptive endings (NREs), forming a specialized extracellular space, or compartment, important for neuronal activity, and reminiscent of glia-ensheathed synapses in the central nervous...
Published by: Rockefeller University
Anti-D monoclonal antibodies from 23 human and rodent cell lines display diverse IgG Fc-glycosylation profiles that determine their clinical efficacy.
Belinda M Kumpel, Radka Saldova, Carolien A M Koeleman, Jodie L Abrahams, Agnes Hipgrave Ederveen, Kathryn L Armour, Natalia I Olovnikova, Gestur Vidarsson, Rick Kapur, Pauline M Rudd, Manfred Wuhrer
Mar 02, 2020
Anti-D immunoglobulin (Anti-D Ig) prophylaxis prevents haemolytic disease of the fetus and newborn. Monoclonal IgG anti-Ds (mAb-Ds) would enable unlimited supplies but have differed in efficacy in FcγRIIIa-mediated ADCC assays...
Published by: Scientific reports
Influence of offshore fringing reefs on infragravity period oscillations within a harbor
The main objective of this paper is to systematically study the influence of offshore fringing reef topography on the infragravity-period harbor oscillations under the condition of wave breaking occurring over the reef. The...
Anti-D monoclonal antibodies from 23 human and rodent cell lines display diverse IgG Fc-glycosylation profiles that determine their clinical efficacy.
Belinda M Kumpel, Radka Saldova, Carolien AM Koeleman, Jodie L Abrahams, Agnes Hipgrave Ederveen, Kathryn L Armour, Natalia I Olovnikova, Gestur Vidarsson, Rick Kapur, Pauline M Rudd, Manfred Wuhrer
Jan 29, 2021
Anti-D immunoglobulin (Anti-D Ig) prophylaxis prevents haemolytic disease of the fetus and newborn. Monoclonal IgG anti-Ds (mAb-Ds) would enable unlimited supplies but have differed in efficacy in FcγRIIIa-mediated ADCC assays...
Efficient loading of identical viral peptide onto class II molecules by antigenized immunoglobulin and influenza virus
Several prior reports have identified peptides that are naturally associated with major histocompatibility complex (MHC) class II molecules on presenting cells. We have examined the delivery of a peptide from exogenous sources...
antigen presenting cell hybridoma Influenza virus major histocompatibility complex restriction protein isolation t lymphocyte activation
Published by: Rockefeller University
Can we modify maximal speed running posture? Implications for performance and hamstring injury management
Jurdan Mendiguchia, Adrian Castano-Zambudio, Pedro Jimenez-Reyes, Jean-Benoit Morin, Pascal Edouard, Filipe Conceicao, Jonas Dodoo, Steffi Colyer
Mar 31, 2022
Purpose: Sprint kinematics have been linked to hamstring injury and performance. This study aimed to examine if a specific 6-week multimodal intervention, combining lumbopelvic control and unning technique exercises, induced...
Can we modify maximal speed running posture? Implications for performance and hamstring injury management
Jurdan Mendiguchia, Adrian Castano-Zambudio, Pedro Jimenez-Reyes, Jean-Benoit Morin, Pascal Edouard, Filipe Conceicao, Jonas Dodoo, Steffi Colyer
Mar 31, 2022
Purpose: Sprint kinematics have been linked to hamstring injury and performance. This study aimed to examine if a specific 6-week multimodal intervention, combining lumbopelvic control and unning technique exercises, induced...
Role of AID and microRNA-155 in c-myc-IgH Translocations
Yair Dorsett
Jan 01, 0001
Chromosome translocations between oncogenes and the immunoglobulin (Ig) region spanning the variable (V), diversity (D) and joining (J) genes (Ig V-JH region) are found in a number of mature B cell lymphomas in humans and mice....
Published by: Rockefeller University
Crystal structure and molecular imaging of the Nav channel β3 subunit indicates a trimeric assembly.
Sivakumar Namadurai, Dilshan Balasuriya, Rajit Rajappa, Martin Wiemhöfer, Katherine Stott, Jurgen Klingauf, J Michael Edwardson, Dimitri Y Chirgadze, Antony P Jackson
Sep 20, 2018
The vertebrate sodium (Nav) channel is composed of an ion-conducting α subunit and associated β subunits. Here, we report the crystal structure of the human β3 subunit immunoglobulin (Ig) domain, a functionally important...
Analytical Ultracentrifugation Atomic force microscopy in vivo imaging Photoactivated Localization Microscopy Protein Trimerization Sodium Channels X-ray crystallography Amino Acid Sequence Binding Sites Cloning Molecular Crystallization Crystallography X-Ray Dimerization HEK293 Cells Humans Immunoglobulins Microscopy Atomic Force Molecular Sequence Data NAV1.5 Voltage-Gated Sodium Channel Protein Conformation Ultracentrifugation Voltage-Gated Sodium Channel beta-3 Subunit
Bi-Functional Chicken Immunoglobulin-Like Receptors With a Single Extracellular Domain (ChIR-AB1)
El Kahina Meziane, Nicola D Potts, Birgit C Viertlboeck, Hanne Løvlie, Andrew P Krupa, Terry A Burke, Stewart Brown, Kellie A Watson, David S Richardson, Tommaso Pizzari, Thomas W Göbel, Jim Kaufman
Sep 04, 2019
The leukocyte receptor complex (LRC) in humans encodes many receptors with immunoglobulin-like (Ig-like) extracellular domains, including the killer Ig-like receptors (KIRs) expressed on natural killer (NK) cells among others...
Isolating residents including wandering residents in care and group homes
Kathleen Liddell, Alexander Ruck Keene, Anthony Holland, Julian Huppert, Benjamin R Underwood, Orna Clark, Stephen Ig Barclay
Apr 27, 2021
This article investigates the lawfulness of isolating residents of care and group homes during the COVID-19 pandemic. Many residents are mobile, and their freedom to move is a central ethical tenet and human right. It is not...
The future of image-guided radiotherapy-is image everything?
MR-based image-guided (IG) radiotherapy via all-in-one MR treatment units (MR-linacs) is one of the hottest topics in contemporary radiotherapy research. From ingenious engineering solutions to complex physical problems...
Fibroblast growth factor receptor 1 is principally responsible for fibroblast growth factor 2-induced catabolic activities in human articular chondrocytes.
Dongyao Yan, Di Chen, Simon M Cool, Andre J van Wijnen, Katalin Mikecz, Gillian Murphy, Hee-Jeong Im
Oct 12, 2011
Blotting Western Cartilage Articular Cell Proliferation Cell Separation Cells Cultured Chondrocytes Extracellular Signal-Regulated MAP Kinases Fibroblast Growth Factor 2 Flow Cytometry Humans Immunoprecipitation Osteoarthritis RNA Small Interfering Real-Time Polymerase Chain Reaction Receptor Fibroblast Growth Factor Type 1 Receptor Fibroblast Growth Factor Type 3 Signal Transduction Transfection
A randomised controlled trial of the effectiveness of a breastfeeding training DVD on improving breastfeeding knowledge and confidence among healthcare professionals in China.
Background: Despite almost all babies being breastfed initially, the rates of exclusive breastfeeding rate at six months is only 30% in China. Improving professionals' knowledge and practical skill is a key government strategy...
Treml4, an Ig superfamily member, mediates presentation of several antigens to T cells in vivo, including protective immunity to HER2 protein
Members of the triggering expressed on myeloid cells (Trem) receptor family fine-tune inflammatory responses. We previously identified one of these receptors, called Treml4, expressed mainly in the spleen, as well as at high...
Published by: Rockefeller University
A Context-Independent Ontological Linked Data Alignment Approach to Instance Matching
Linking data by finding matching instances in different datasets requires considering many characteristics, such as structural heterogeneity, implicit knowledge, and URI (Uniform Resource Identifier)-oriented identification. The...
Published by: IGI Global Scientific Publishing
HERWIG 6.5 Release Note
G Corcella, IG Knowles, G Marchesini, S Moretti, K Odagiri, P Richardson, MH Seymour, BR Webber
Jan 21, 2010
A new release of the Monte Carlo program HERWIG (version 6.5) is now
available. The main new features are: support for the Les Houches interface to
matrix element generators; additional SM and MSSM Higgs processes in...
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