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The Parkinson's disease-linked proteins Fbxo7 and Parkin interact to mediate mitophagy.
Victoria S Burchell, David E Nelson, Alvaro Sanchez-Martinez, Marta Delgado-Camprubi, Rachael M Ivatt, Joe H Pogson, Suzanne J Randle, Selina Wray, Patrick A Lewis, Henry Houlden, Andrey Y Abramov, John Hardy, Nicholas W Wood, Alexander J Whitworth, Heike Laman, Helene Plun-Favreau
Aug 08, 2017
Compelling evidence indicates that two autosomal recessive Parkinson's disease genes, PINK1 (PARK6) and Parkin (PARK2), cooperate to mediate the autophagic clearance of damaged mitochondria (mitophagy). Mutations in the F-box...
Animals Animals Genetically Modified Carbonyl Cyanide m-Chlorophenyl Hydrazone Cell Line Tumor Cells Cultured Drosophila F-Box Proteins Female Fertility FIBROBLASTS Humans Male Microtubule-Associated Proteins Mitochondria Mitochondrial Degradation Mutation Parkinson Disease Protein Transport Proton Ionophores RNA Small Interfering Time Factors Ubiquitin-Protein Ligases Ubiquitination
Parkin regulates adiposity by coordinating mitophagy with mitochondrial biogenesis in white adipocytes.
Timothy M Moore, Lijing Cheng, Dane M Wolf, Jennifer Ngo, Mayuko Segawa, Xiaopeng Zhu, Alexander R Strumwasser, Yang Cao, Bethan L Clifford, Alice Ma, Philip Scumpia, Orian S Shirihai, Thomas Q de Aguiar Vallim, Markku Laakso, Aldons J Lusis, Andrea L Hevener, Zhenqi Zhou
Dec 08, 2022
Parkin, an E3 ubiquitin ligase, plays an essential role in mitochondrial quality control. However, the mechanisms by which Parkin connects mitochondrial homeostasis with cellular metabolism in adipose tissue remain unclear....
The STING pathway does not contribute to behavioural or mitochondrial phenotypes in Drosophila Pink1/parkin or mtDNA mutator models.
Mutations in PINK1 and Parkin/PRKN cause the degeneration of dopaminergic neurons in familial forms of Parkinson's disease but the precise pathogenic mechanisms are unknown. The PINK1/Parkin pathway has been described to play a...
Mitofusin-mediated ER stress triggers neurodegeneration in pink1/parkin models of Parkinson's disease.
I Celardo, AC Costa, S Lehmann, C Jones, N Wood, NE Mencacci, GR Mallucci, SHY Loh, LM Martins
Nov 10, 2017
Mutations in PINK1 and PARKIN cause early-onset Parkinson's disease (PD), thought to be due to mitochondrial toxicity. Here, we show that in Drosophila pink1 and parkin mutants, defective mitochondria also give rise to...
Animals Disease Models Animal Drosophila Proteins Drosophila melanogaster Endoplasmic Reticulum Endoplasmic reticulum stress Humans Membrane Proteins Mitochondria Mutation Nerve Degeneration Neuroprotection Parkinson Disease Phosphorylation Protein Serine-Threonine Kinases Signal Transduction Ubiquitin-Protein Ligases Unfolded Protein Response eIF-2 Kinase
The STING pathway does not contribute to behavioural or mitochondrial phenotypes in Drosophila Pink1/parkin or mtDNA mutator models.
Mutations in PINK1 and Parkin/PRKN cause the degeneration of dopaminergic neurons in familial forms of Parkinson's disease but the precise pathogenic mechanisms are unknown. The PINK1/Parkin pathway has been described to play a...
Published by: Scientific reports
Myosin VI-Dependent Actin Cages Encapsulate Parkin-Positive Damaged Mitochondria.
Antonina J Kruppa, Chieko Kishi-Itakura, Thomas A Masters, Joanna E Rorbach, Guinevere L Grice, John Kendrick-Jones, James A Nathan, Michal Minczuk, Folma Buss
Mar 14, 2018
Mitochondrial quality control is essential to maintain cellular homeostasis and is achieved by removing damaged, ubiquitinated mitochondria via Parkin-mediated mitophagy. Here, we demonstrate that MYO6 (myosin VI), a unique...
An assessment of the rescue action of resveratrol in parkin loss of function-induced oxidative stress in Drosophila melanogaster.
Adeola O Adedara, Ayoade D Babalola, Flora Stephano, Ifeoluwa O Awogbindin, James O Olopade, João BT Rocha, Alexander J Whitworth, Amos O Abolaji
Mar 10, 2022
Loss-of-function mutations in parkin is associated with onset of juvenile Parkinson's disease (PD). Resveratrol is a polyphenolic stilbene with neuroprotective activity. Here, we evaluated the rescue action of resveratrol in...
The STING pathway does not contribute to behavioural or mitochondrial phenotypes in Drosophila Pink1/parkin or mtDNA mutator models
Abstract: Mutations in PINK1 and Parkin/PRKN cause the degeneration of dopaminergic neurons in familial forms of Parkinson’s disease but the precise pathogenic mechanisms are unknown. The PINK1/Parkin pathway has been described...
Superoxide dismutating molecules rescue the toxic effects of PINK1 and parkin loss.
Alice Biosa, Alvaro Sanchez-Martinez, Roberta Filograna, Ana Terriente-Felix, Sarah M Alam, Mariano Beltramini, Luigi Bubacco, Marco Bisaglia, Alexander J Whitworth
Jul 04, 2018
Reactive oxygen species exert important functions in regulating several cellular signalling pathways. However, an excessive accumulation of reactive oxygen species can perturb the redox homeostasis leading to oxidative stress, a...
Ian Rory Owen. Psychotherapy and Phenomenology: On Freud, Husserl, and Heidegger. Lincoln, N.E.,
[name unavailable]
May 04, 2009
Book Review. Ian Rory Owen. Psychotherapy and Phenomenology: On Freud, Husserl, and Heidegger. Lincoln, N.E.,: iUniverse, 2006.
Published by: Memorial University of Newfoundland
Ian Rory Owen. Psychotherapy and Phenomenology: On Freud, Husserl, and Heidegger. Lincoln, N.E.,
[name unavailable]
May 04, 2009
Book Review. Ian Rory Owen. Psychotherapy and Phenomenology: On Freud, Husserl, and Heidegger. Lincoln, N.E.,: iUniverse, 2006.
Published by: Memorial University of Newfoundland
Robot seeks public library websites
UKOLN has been active recently analysing UK Public Library websites. Brian Kelly, Sarah Ormes and Ian Peacock report on their findings.
G-Quadruplexes
Guanine (G)-rich sequences in nucleic acids can assemble into G-quadruplex structures that involve G-quartets linked by loop nucleotides. The structural and topological diversity of G-quadruplexes have attracted great attention...
Robot seeks public library websites
UKOLN has been active recently analysing UK Public Library websites. Brian Kelly, Sarah Ormes and Ian Peacock report on their findings.
Foreword to Ian Wishart’s Schleiermacher’s Interpretation of the Bible
Sean McGrath
Jan 07, 2020
When the following monograph first appeared, as a thesis successfully defended at the Toronto School of Theology in 1968, very little work had been done on Schleiermacher’s sermons. Ian Wishart produced one of the most careful...
Published by: Memorial University of Newfoundland
Foreword to Ian Wishart’s Schleiermacher’s Interpretation of the Bible
Sean McGrath
Jan 07, 2020
When the following monograph first appeared, as a thesis successfully defended at the Toronto School of Theology in 1968, very little work had been done on Schleiermacher’s sermons. Ian Wishart produced one of the most careful...
Published by: Memorial University of Newfoundland
Synthesis of Novel Regenerable 13X Zeolite-Polyimide Adsorbent Foams
A new generic synthesis method is presented for the production of a polyimide (PI)/adsorbent (80 wt% 13X zeolite) regenerable foam filter. The method uses a dual parallel reaction foaming process comprising CO 2...
Adsorbent foam Adsorption Air Filters Isotherms modelling Polyimide /dk/atira/pure/subjectarea/asjc/1600/1600 name=General Chemistry /dk/atira/pure/subjectarea/asjc/2300/2304 name=Environmental Chemistry /dk/atira/pure/subjectarea/asjc/1500/1500 name=General Chemical Engineering /dk/atira/pure/subjectarea/asjc/2200/2209 name=Industrial and Manufacturing Engineering
Board Recognizes Debra Boyd, President Search Advisory Committee, Ian Deas for Dedicated Service
Winthrop University
Jan 01, 0001
Trustees unanimously approved a resolution on June 19 thanking Acting President Debra Boyd for leading the institution during a year of transition. Also at the meeting, trustees approved a resolution to thank the 56-member...
Published by: Winthrop University
Remote stereocontrol in [3,3]-sigmatropic rearrangements
The Ireland - Claisen [3,3]-sigmatropic rearrangement has been used to access biologically important β,β′-dihydroxy α-amino acids. The rearrangement reported is highly stereoselective and offers excellent levels of remote...
Synthesis of Novel Regenerable 13X Zeolite-Polyimide Adsorbent Foams
A new generic synthesis method is presented for the production of a polyimide (PI)/adsorbent (80 wt% 13X zeolite) regenerable foam filter. The method uses a dual parallel reaction foaming process comprising CO 2...
Adsorbent foam Adsorption Air Filters Isotherms modelling Polyimide /dk/atira/pure/subjectarea/asjc/1600/1600 name=General Chemistry /dk/atira/pure/subjectarea/asjc/2300/2304 name=Environmental Chemistry /dk/atira/pure/subjectarea/asjc/1500/1500 name=General Chemical Engineering /dk/atira/pure/subjectarea/asjc/2200/2209 name=Industrial and Manufacturing Engineering
RNA promotes phase separation of glycolysis enzymes into yeast G bodies in hypoxia.
Gregory G Fuller, Ting Han, Mallory A Freeberg, James J Moresco, Amirhossein Ghanbari Niaki, Nathan P Roach, John R Yates, Sua Myong, John K Kim
Apr 17, 2020
In hypoxic stress conditions, glycolysis enzymes assemble into singular cytoplasmic granules called glycolytic (G) bodies. G body formation in yeast correlates with increased glucose consumption and cell survival. However, the...
Modelling and simulation of biased agonism dynamics at a G protein-coupled receptor.
Theoretical models of G protein-coupled receptor (GPCR) concentration-response relationships often assume an agonist producing a single functional response via a single active state of the receptor. These models have largely...
Remote stereocontrol in [3,3]-sigmatropic rearrangements
The Ireland - Claisen [3,3]-sigmatropic rearrangement has been used to access biologically important β,β′-dihydroxy α-amino acids. The rearrangement reported is highly stereoselective and offers excellent levels of remote...
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