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Flooding through the ages
The City of Bath is a historical UNESCO world-heritage site and is an instructive case study in how the history, architecture and development of a city can be closely connected to the city’s relationship with its river, the...
Flooding through the ages
The City of Bath is a historical UNESCO world-heritage site and is an instructive case study in how the history, architecture and development of a city can be closely connected to the city’s relationship with its river, the...
Selective D3 receptor antagonism modulates neural response during negative emotional processing in substance dependence.
Ioanna A Vamvakopoulou, Leon Fonville, Alexandra Hayes, John McGonigle, Rebecca Elliott, Karen D Ersche, Remy Flechais, Csaba Orban, Anna Murphy, Dana G Smith, John Suckling, Eleanor M Taylor, Bill Deakin, Trevor W Robbins, David J Nutt, Anne R Lingford-Hughes, Louise M Paterson
Dec 08, 2022
INTRODUCTION: Negative affective states contribute to the chronic-relapsing nature of addiction. Mesolimbic dopamine D3 receptors are well placed to modulate emotion and are dysregulated in substance dependence. Selective...
Selective D3 receptor antagonism modulates neural response during negative emotional processing in substance dependence.
Being in a loop
Chromatin architecture has a significant impact on gene expression. Evidence in the last two decades support RNA as an important component of chromatin structure [Genes Dev. (2005) 19, 1635–1655; PLoS ONE (2007) 2, e1182; Nat....
Being in a loop
Chromatin architecture has a significant impact on gene expression. Evidence in the last two decades support RNA as an important component of chromatin structure [Genes Dev. (2005) 19, 1635–1655; PLoS ONE (2007) 2, e1182; Nat....
High-flow nasal oxygen vs. standard oxygen therapy for patients undergoing transcatheter aortic valve replacement with conscious sedation
S Scheuermann, A Tan, P Govender, M Mckie, J Pack, G Martinez, F Falter, S George, A A. Klein
Apr 14, 2023
Study of dam break flow interaction with urban settlements over a sloping channel
This paper describes a dam break experiment on a sloped channel, carried out in a hydraulic flume at UCL for the purpose of computer model validations of extreme events, such as flash floods. An elevated reservoir was...
Study of dam break flow interaction with urban settlements over a sloping channel
This paper describes a dam break experiment on a sloped channel, carried out in a hydraulic flume at UCL for the purpose of computer model validations of extreme events, such as flash floods. An elevated reservoir was...
Recasting the multiple-wh typology
In this paper we revisit and revise the typology of multiple questions and multiple wh-fronting (MWF) in the light of data from Romeyka, a Greek variety spoken in Pontus, Turkey, and from another Pontic Greek variety spoken in...
Achieving robustness to aleatoric uncertainty with heteroscedastic Bayesian optimisation
Ryan-Rhys Griffiths, Alexander A Aldrick, Miguel Garcia-Ortegon, Vidhi Lalchand, Alpha A Lee
Nov 23, 2021
Abstract: Bayesian optimisation is a sample-efficient search methodology that holds great promise for accelerating drug and materials discovery programs. A frequently-overlooked modelling consideration in Bayesian optimisation...
Cardiac metabolism as a driver and therapeutic target of myocardial infarction.
Coert J Zuurbier, Luc Bertrand, Christoph R Beauloye, Ioanna Andreadou, Marisol Ruiz-Meana, Nichlas R Jespersen, Duvaraka Kula-Alwar, Hiran A Prag, Hans Eric Botker, Maija Dambrova, Christophe Montessuit, Tuuli Kaambre, Edgars Liepinsh, Paul S Brookes, Thomas Krieg
May 15, 2020
Reducing infarct size during a cardiac ischaemic-reperfusion episode is still of paramount importance, because the extension of myocardial necrosis is an important risk factor for developing heart failure. Cardiac...
Depression amongst interns working in a tertiary care teaching Hospital in Maharashtra
Background: Internship is a crucial stage of medical school regarding student stress which can affect the patient care negatively. Retrieving knowledge about presence of depression is therefore important in itself and if found...
Published by: IJHS Medical Association
A Model of Cloud Forensic Application With Assurance of Cloud Log
The key concepts of digital forensic investigation in cloud computing are examination and investigation. Cybercriminals target cloud-based web applications due to presence of vulnerabilities. Forensic investigation is a complex...
Published by: IGI Global Scientific Publishing
Depression amongst interns working in a tertiary care teaching Hospital in Maharashtra
Background: Internship is a crucial stage of medical school regarding student stress which can affect thepatient care negatively. Retrieving knowledge about presence of depression is therefore important in itself and iffound...
Published by: IJHS Medical Association
Nano-vehicles give new lease of life to existing antimicrobials.
Antibiotic resistance has become one of the greatest challenges for modern medicine, and new approaches for the treatment of bacterial infections are urgently needed to avoid widespread vulnerability again to infections that...
Purification of Recombinant ESCRT-III Proteins and Their Use in Atomic Force Microscopy and In Vitro Binding and Phosphorylation Assays.
Luisa Capalbo, Ioanna Mela, Maria Alba Abad, A Arockia Jeyaprakash, J Michael Edwardson, Pier Paolo D'Avino
Oct 30, 2019
The endosomal sorting complex required for transport (ESCRT)-III proteins are known to assemble into filaments that mediate membrane remodeling and fission in various biological processes, including the formation of endosomal...
Atomic force microscopy CHMP4C Kinase assay Protein Binding Protein purification Chromatography Affinity Chromatography Gel Cloning Molecular Drosophila Proteins Endosomal Sorting Complexes Required for Transport Genetic Vectors Lipid Bilayers Microscopy Atomic Force Phosphorylation Plasmids Protein Binding Recombinant Proteins Transformation Bacterial
Sentiment Analysis on Movie Reviews Dataset Using Support Vector Machines and Ensemble Learning
The internet makes it easier for people to connect to each other and has become a platform to express ideas and share information with the world. The growth of the internet has indirectly led to the development of social...
Published by: IGI Global Scientific Publishing
Right sided eventration of diaphragm with clinodactyly
A. Sareen and K. Mahajan
Apr 21, 2015
Diaphragmatic hernia can be of two types-absence or deficiency of the diaphragm, or eventration resulting in elevation of a portion of the diaphragm as a result of incomplete muscularization. Complete eventration almost...
Published by: IJHS Medical Association
Knowledge and Attitude among High School Students towards HIV / AIDS in Rural areas of Belagavi–A Cross Sectional Study
Asha A. Bellad and Rajesh R Kulkarni
Mar 25, 2015
Introduction Since its emergence in 1981, the HIV/AIDS pandemic, which poses a serious challenge to mankind, without doubt, has become one of the most serious infectious diseases. Many adolescents around the world are sexually...
Published by: IJHS Medical Association
Knowledge and Attitude among High School Students towards HIV / AIDS in Rural areas of Belagavi–A Cross Sectional Study
Asha A. Bellad and Rajesh R Kulkarni
Mar 25, 2015
Introduction Since its emergence in 1981, the HIV/AIDS pandemic, which poses a serious challenge to mankind, without doubt, has become one of the most serious infectious diseases. Many adolescents around the world are sexually...
Published by: IJHS Medical Association
Effect of Natural Graphite Fineness on the Performance and Electrical Conductivity of Cement Paste Mixes for Self-Sensing Structures
Cementitious composites are the most widely used construction materials; however, their poor durability necessitates frequent monitoring and repairs. The emergence of self-sensing composites could reduce the need for costly and...
Sustainable Supply Chain Management Practices in Ghana
The study assessed the sustainable supply chain management (SSCM) practices of 303 manufacturing firms in Ghana with an annual turnover of not less than $1,000,000, which were purposively selected for the study. A questionnaire...
Published by: Indonesia Strategic Sustainability
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