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Interview with Isabel Potter
Isabel Potter
Jan 01, 0001
In her April 22, 1980 interview with Jeff Clark, Isabel Potter shares her experience as a Biology instructor during the Depression. Potter recalls how budget changes affected her classes and the general atmosphere on campus....
Published by: Winthrop University
Membranous Glomerulonephritis With Crescents.
Aikaterini Nikolopoulou, Isabel Huang-Doran, Stephen P McAdoo, Megan E Griffith, H Terence Cook, Charles D Pusey
Feb 02, 2020
INTRODUCTION: Membranous glomerulonephritis (MGN) is rarely associated with necrotizing and crescentic glomerulonephritis (NCGN). METHODS: We report the clinical and pathologic findings in 15 patients with MGN and NCGN...
Glucagonoma-associated dilated cardiomyopathy refractory to somatostatin analogue therapy.
Michal Barabas, Isabel Huang-Doran, Debbie Pitfield, Hazel Philips, Manoj Goonewardene, Ruth T Casey, Benjamin G Challis
Apr 16, 2019
A 67-year-old woman presented with a generalised rash associated with weight loss and resting tachycardia. She had a recent diagnosis of diabetes mellitus. Biochemical evaluation revealed elevated levels of circulating glucagon...
2019 Adult ALENDRONATE Angiotensin Receptor Antagonists Angiotensin-Converting Enzyme Inhibitors BMI Beta-blockers Bisoprolol* bisphosphonates blood pressure Brain natriuretic peptide CD-56 CDX2* CT scan Calcium Cardiomyopathy Cardiomyopathy* Chromogranin B* echocardiogram electrocardiogram Endocrine-related cancer fatigue Female Furosemide Gliclazide Glucagon Glucagonoma Heart Heart Failure Hepatic metastases Hyperglucagonaemia Hyperglucogonaemia Hypotension Lanreotide Left ventricular ejection fraction* Left ventricular internal diameter* Losartan MRI March Necrolytic migratory erythema Neuroendocrine tumour Octreotide scan Oedema oncology PAX8* Palpitations Pancreas Ramipril Rash Somatostatin analogues Spironolactone Sulphonylureas Synaptophysin Tachycardia Ultrasound-guided biopsy United Kingdom vitamin D Weight Loss White
Leptin-Mediated Changes in the Human Metabolome.
Katherine Lawler, Isabel Huang-Doran, Takuhiro Sonoyama, Tinh-Hai Collet, Julia M Keogh, Elana Henning, Stephen O'Rahilly, Leonardo Bottolo, I Sadaf Farooqi
May 15, 2020
CONTEXT: While severe obesity due to congenital leptin deficiency is rare, studies in patients before and after treatment with leptin can provide unique insights into the role that leptin plays in metabolic and endocrine...
bile acids Leptin Lipids Metabolomics obesity Adolescent Child Child Preschool Chromatography Liquid Energy Intake Energy Metabolism Female Hormone Replacement Therapy Humans Leptin Lipolysis Loss of Function Mutation Male Metabolome Metabolomics obesity Recombinant Proteins Severity of Illness Index Tandem Mass Spectrometry Treatment Outcome
Truncation of POC1A associated with short stature and extreme insulin resistance.
Jian-Hua Chen, Maria Segni, Felicity Payne, Isabel Huang-Doran, Alison Sleigh, Claire Adams, UK10K consortium, David B Savage, Stephen O'Rahilly, Robert K Semple, Inês Barroso
Aug 19, 2015
POC1A centriole Centrosome Diabetes dyslipidaemia Insulin Resistance primary cilium short stature skeletal dysplasia Adult Amino Acid Sequence Body Height Cell Cycle Cell Cycle Proteins Centrioles Centrosome Cytoskeletal Proteins Dwarfism Facies Fatty Liver Female Frameshift Mutation Humans Insulin Resistance Mitosis Molecular Sequence Data Protein Isoforms Proteins Sequence Alignment Spindle Apparatus
The metabolic syndrome- associated small G protein ARL15 plays a role in adipocyte differentiation and adiponectin secretion.
Nuno Rocha, Felicity Payne, Isabel Huang-Doran, Alison Sleigh, Katherine Fawcett, Claire Adams, Anna Stears, Vladimir Saudek, Stephen O'Rahilly, Inês Barroso, Robert K Semple
Feb 14, 2018
Common genetic variants at the ARL15 locus are associated with plasma adiponectin, insulin and HDL cholesterol concentrations, obesity, and coronary atherosclerosis. The ARL15 gene encodes a small GTP-binding protein whose...
3T3-L1 Cells ADP-Ribosylation Factors Adipocytes Adipogenesis Adiponectin Adult Animals Cell Differentiation Female Gene Expression Regulation Gene Knockdown Techniques Golgi Apparatus HEK293 Cells Haploinsufficiency Humans Insulin Resistance lipodystrophy Male Metabolic Syndrome Mice Middle Aged Protein Transport Young Adult
Truncation of Pik3r1 causes severe insulin resistance uncoupled from obesity and dyslipidaemia by increased energy expenditure.
Albert Kwok, Ilona Zvetkova, Sam Virtue, Ineke Luijten, Isabel Huang-Doran, Patsy Tomlinson, David A Bulger, James West, Steven Murfitt, Julian Griffin, Rafeah Alam, Daniel Hart, Rachel Knox, Peter Voshol, Antonio Vidal-Puig, Jørgen Jensen, Stephen O'Rahilly, Robert K Semple
Oct 08, 2020
OBJECTIVE: Insulin signalling via phosphoinositide 3-kinase (PI3K) requires PIK3R1-encoded regulatory subunits. C-terminal PIK3R1 mutations cause SHORT syndrome, as well as lipodystrophy and insulin resistance (IR), surprisingly...
Diabetes Insulin Resistance Lipids lipotoxicity PI 3-Kinase PIK3R1 p85 Adipose Tissue Brown Adiposity Animals Class Ia Phosphatidylinositol 3-Kinase Diet High-Fat Dyslipidemias Energy Metabolism Fatty Liver Growth Disorders hypercalcemia Inflammation Insulin Insulin Resistance Lipogenesis Liver Male Metabolic Diseases Mice Mice Inbred C57BL nephrocalcinosis obesity Phosphatidylinositol 3-Kinases
Insulin resistance uncoupled from dyslipidemia due to C-terminal PIK3R1 mutations.
Isabel Huang-Doran, Patsy Tomlinson, Felicity Payne, Alexandra Gast, Alison Sleigh, William Bottomley, Julie Harris, Allan Daly, Nuno Rocha, Simon Rudge, Jonathan Clark, Albert Kwok, Stefano Romeo, Emma McCann, Barbara Müksch, Mehul Dattani, Stefano Zucchini, Michael Wakelam, Lazaros C Foukas, David B Savage, Rinki Murphy, Stephen O'Rahilly, Inês Barroso, Robert K Semple
Nov 01, 2016
Implementation in Systematics
Robert M. Doran
Jun 30, 2010
Published by: Memorial University of Newfoundland
Digital Barriers and Individual Coping Behaviors in Distance Education During COVID-19
Information and communication technologies (ICT) have played a pivotal role in facilitating knowledge acquisition and enabling distance education. Yet, knowledge about digital divide in distance education remains limited. This...
Published by: IGI Global Scientific Publishing
Relationships between resting conductances, excitability, and t-system ionic homeostasis in skeletal muscle.
Activation of skeletal muscle fibers requires rapid sarcolemmal action potential (AP) conduction to ensure uniform excitation along the fiber length, as well as successful tubular excitation to initiate excitation-contraction...
Implementation in Systematics
Robert M. Doran
Jun 30, 2010
Published by: Memorial University of Newfoundland
Early GP Leavers Interim Report
Published by: University of Bath
Mirror Symmetry for Lattice Polarized del Pezzo Surfaces
We describe a notion of lattice polarization for rational elliptic surfaces
and weak del Pezzo surfaces, and describe the complex moduli of the former and
the K\"{a}hler cone of the latter. We then propose a version of mirror...
Zeta functions of alternate mirror Calabi–Yau families
Charles F Doran, Tyler L Kelly, Adriana Salerno, Steven Sperber, John Voight, Ursula Whitcher
May 15, 2018
We prove that if two Calabi-Yau invertible pencils have the same dual weights, then they share a common factor in their zeta functions. By using Dwork cohomology, we demonstrate that this common factor is related to a...
Early GP Leavers Interim Report
Published by: University of Bath
Hodge Numbers from Picard-Fuchs Equations
Given a variation of Hodge structure over $\mathbb{P}^1$ with Hodge numbers
$(1,1,\dots,1)$, we show how to compute the degrees of the Deligne extension of
its Hodge bundles, following Eskin-Kontsevich-M\"oller-Zorich, by using...
REFORM
Abstract: In this paper we tackle the problem of correspondence and rotor estimation between models composed of geometric primitives of different types. We frame this problem as searching for the rotor that takes a query model...
Counterspace Support for BIPOC Employees Within a Holistic JEDI Library Framework
This chapter presents a case study of how an academic library supports Black, Indigenous, and People of Color (BIPOC) employees with funding so these workers can find counterspaces (spaces where they can feel safe in community...
Gender & Diversity Library and Information Science Library Science Social Sciences and Humanities Education
Published by: IGI Global Scientific Publishing
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