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Whither middle management? Empowering interface and the failure of organizational change
While there has been a distinct evolution in how middle managers participate in change, from resistors to facilitators, they often remain ineffective due to executive constraints. Emphasizing the crucial role middle managers...
Whither middle management? Empowering interface and the failure of organizational change
While there has been a distinct evolution in how middle managers participate in change, from resistors to facilitators, they often remain ineffective due to executive constraints. Emphasizing the crucial role middle managers...
Towards an Integrative Theory of Bullying in Residential Care for Youth.
To date, no theory of bullying in residential care for youth has been proposed. By drawing on the results of the existing research on bullying and peer violence in youth residential care and adapting the Multifactor Model of...
A Wnt1 regulated Frizzled-1/β-Catenin signaling pathway as a candidate regulatory circuit controlling mesencephalic dopaminergic neuron-astrocyte crosstalk
Francesca L'episcopo, Maria F Serapide, Cataldo Tirolo, Nunzio Testa, Salvatore Caniglia, Maria C Morale, Stefano Pluchino, Bianca Marchetti
Aug 26, 2011
Microglia Polarization, Gene-Environment Interactions and Wnt/β-Catenin Signaling
Francesca L'episcopo, Cataldo Tirolo, Maria F Serapide, Salvatore Caniglia, Nunzio Testa, Loredana Leggio, Silvia Vivarelli, Nunzio Iraci, Stefano Pluchino, Bianca Marchetti
May 25, 2018
Neuroinflammatory processes are recognized key contributory factors in Parkinson's disease (PD) physiopathology. While the causes responsible for the progressive loss of midbrain dopaminergic (mDA) neuronal cell bodies in the...
Commensal microbes and p53 in cancer progression.
Aetiogenesis of cancer has not been fully determined. Recent advances have clearly defined a role for microenvironmental factors in cancer progression and initiation; in this context, microbiome has recently emerged with a...
A reverse-engineering approach to dissect post-translational modulators of transcription factor's activity from transcriptional data.
Gennaro Gambardella, Ivana Peluso, Sandro Montefusco, Mukesh Bansal, Diego L Medina, Neil Lawrence, Diego di Bernardo
Jan 14, 2020
BACKGROUND: Transcription factors (TFs) act downstream of the major signalling pathways functioning as master regulators of cell fate. Their activity is tightly regulated at the transcriptional, post-transcriptional and...
Budgeting in International Humanitarian Organizations
Problem definition: International humanitarian organizations (IHOs) prepare a detailed annual allocation plan for operations that are conducted in the countries they serve. The annual plan is strongly affected by the available...
Humanitarian operations Donations Budgeting stochastic programming Benders decomposition /dk/atira/pure/subjectarea/asjc/1400/1400 name=General Business,Management and Accounting /dk/atira/pure/subjectarea/asjc/1800/1800 name=General Decision Sciences /dk/atira/pure/sustainabledevelopmentgoals/reduced_inequalities name=SDG 10 - Reduced Inequalities /dk/atira/pure/sustainabledevelopmentgoals/no_poverty name=SDG 1 - No Poverty
Enhancing folic acid metabolism suppresses defects associated with loss of Drosophila mitofusin.
Juan Garrido-Maraver, Ivana Celardo, Ana C Costa, Susann Lehmann, Samantha HY Loh, L Miguel Martins
Feb 27, 2019
Novelties and Benefits of Fintech in the Financial Industry
New technologies and innovations that are emerging and developing today through the financial industry can be called by one name and that is “FinTech”. The main feature of “FinTech” is "digital proximity", where the relationship...
Published by: IGI Global Scientific Publishing
Towards an Integrative Theory of Bullying in Residential Care for Youth.
To date, no theory of bullying in residential care for youth has been proposed. By drawing on the results of the existing research on bullying and peer violence in youth residential care and adapting the Multifactor Model of...
Budgeting in International Humanitarian Organizations
Problem definition: International humanitarian organizations (IHOs) prepare a detailed annual allocation plan for operations that are conducted in the countries they serve. The annual plan is strongly affected by the available...
Humanitarian operations Donations Budgeting stochastic programming Benders decomposition /dk/atira/pure/subjectarea/asjc/1400/1400 name=General Business,Management and Accounting /dk/atira/pure/subjectarea/asjc/1800/1800 name=General Decision Sciences /dk/atira/pure/sustainabledevelopmentgoals/reduced_inequalities name=SDG 10 - Reduced Inequalities /dk/atira/pure/sustainabledevelopmentgoals/no_poverty name=SDG 1 - No Poverty
Parp mutations protect from mitochondrial toxicity in Alzheimer's disease.
Alzheimer's disease is the most common age-related neurodegenerative disorder. Familial forms of Alzheimer's disease associated with the accumulation of a toxic form of amyloid-β (Aβ) peptides are linked to mitochondrial...
Alzheimer Disease Amyloid beta-Peptides Animals Animals Genetically Modified Behavior Animal Disease Models Animal Drosophila Proteins Drosophila melanogaster Humans Metabolome Metabolomics Mitochondria Motor Activity Mutation NAD Nerve Degeneration Neurons Niacinamide Poly (ADP-Ribose) Polymerase-1 Polymorphism Single Nucleotide
Combined Transcriptomic and Proteomic Analysis of Perk Toxicity Pathways
Rebeka Popovic, Ivana Celardo, Yizhou Yu, Ana C. Costa, Samantha H. Y. Loh, L. Miguel Martins
Apr 29, 2021
In Drosophila, endoplasmic reticulum (ER) stress activates the protein kinase R-like endoplasmic reticulum kinase (dPerk). dPerk can also be activated by defective mitochondria in fly models of Parkinson’s disease caused by...
Parp mutations protect from mitochondrial toxicity in Alzheimer's disease.
Alzheimer's disease is the most common age-related neurodegenerative disorder. Familial forms of Alzheimer's disease associated with the accumulation of a toxic form of amyloid-β (Aβ) peptides are linked to mitochondrial...
Published by: Cell Death & Disease
dATF4 regulation of mitochondrial folate-mediated one-carbon metabolism is neuroprotective.
Neurons rely on mitochondria as their preferred source of energy. Mutations in PINK1 and PARKIN cause neuronal death in early-onset Parkinson's disease (PD), thought to be due to mitochondrial dysfunction. In Drosophila pink1...
Activating Transcription Factor 4 Animals Drosophila Drosophila Proteins Folic Acid Glycine Hydroxymethyltransferase Methylenetetrahydrofolate Dehydrogenase (NADP) Mitochondria Mutagenesis Neuroprotection Parkinson Disease Phenotype Protein Serine-Threonine Kinases RNA Interference RNA Small Interfering Ubiquitin-Protein Ligases Up-Regulation
Optineurin Deficiency and Insufficiency Lead to Higher Microglial TDP-43 Protein Levels.
Nikolina Prtenjaca, Matea Rob, Muhammad S Alam, Andrea Markovinovic, Cristiana Stuani, Emanuele Buratti, Ivana Munitic
Jul 24, 2022
Mutations in optineurin, a ubiquitin-binding adaptor protein, cause amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease of motor neurons linked to chronic inflammation and protein aggregation. The majority of...
Parp mutations protect from mitochondrial toxicity in Alzheimer’s disease
Abstract: Alzheimer’s disease is the most common age-related neurodegenerative disorder. Familial forms of Alzheimer’s disease associated with the accumulation of a toxic form of amyloid-β (Aβ) peptides are linked to...
The oral selective oestrogen receptor degrader (SERD) AZD9496 is comparable to fulvestrant in antagonising ER and circumventing endocrine resistance.
Agostina Nardone, Hazel Weir, Oona Delpuech, Henry Brown, Carmine De Angelis, Maria Letizia Cataldo, Xiaoyong Fu, Martin J Shea, Tamika Mitchell, Jamunarani Veeraraghavan, Chandandeep Nagi, Mark Pilling, Mothaffar F Rimawi, Meghana Trivedi, Susan G Hilsenbeck, Gary C Chamness, Rinath Jeselsohn, C Kent Osborne, Rachel Schiff
Jan 02, 2020
BACKGROUND: The oestrogen receptor (ER) is an important therapeutic target in ER-positive (ER+) breast cancer. The selective ER degrader (SERD), fulvestrant, is effective in patients with metastatic breast cancer, but its...
Myeloid-Epithelial-Reproductive Receptor Tyrosine Kinase and Milk Fat Globule Epidermal Growth Factor 8 Coordinately Improve Remodeling After Myocardial Infarction via Local Delivery of Vascular Endothelial Growth Factor.
Kiave-Yune Howangyin, Ivana Zlatanova, Cristina Pinto, Anta Ngkelo, Clément Cochain, Marie Rouanet, José Vilar, Mathilde Lemitre, Christian Stockmann, Bernd K Fleischmann, Ziad Mallat, Jean-Sébastien Silvestre
Jun 21, 2018
BACKGROUND: In infarcted heart, improper clearance of dying cells by activated neighboring phagocytes may precipitate the transition to heart failure. We analyzed the coordinated role of 2 major mediators of efferocytosis, the...
Inflammation MACROPHAGES Myocardial Infarction myocarditis Neovascularization Physiologic Animals Antigens surface MACROPHAGES Mice Mice Inbred C57BL Mice Knockout Mice Transgenic Milk Proteins Myocardial Infarction Phagocytosis Proto-Oncogene Proteins Receptor Protein-Tyrosine Kinases Vascular Endothelial Growth Factor A Ventricular Remodeling c-Mer Tyrosine Kinase
Parp mutations protect from mitochondrial toxicity in Alzheimer’s disease
Abstract: Alzheimer’s disease is the most common age-related neurodegenerative disorder. Familial forms of Alzheimer’s disease associated with the accumulation of a toxic form of amyloid-β (Aβ) peptides are linked to...
Teenage-onset progressive myoclonic epilepsy due to a familial C9orf72 repeat expansion.
Jelle van den Ameele, Ivana Jedlickova, Anna Pristoupilova, Anne Sieben, Sara Van Mossevelde, Chantal Ceuterick-de Groote, Helena Hůlková, Radoslav Matej, Alfred Meurs, Christine Van Broeckhoven, Samuel F Berkovic, Patrick Santens, Stanislav Kmoch, Bart Dermaut
Dec 11, 2019
BACKGROUND: The progressive myoclonic epilepsies (PME) are a heterogeneous group of disorders in which a specific diagnosis cannot be made in a subset of patients, despite exhaustive investigation. C9orf72 repeat expansions are...
Combined Transcriptomic and Proteomic Analysis of Perk Toxicity Pathways.
Rebeka Popovic, Ivana Celardo, Yizhou Yu, Ana C Costa, Samantha HY Loh, L Miguel Martins
Jul 20, 2021
In Drosophila, endoplasmic reticulum (ER) stress activates the protein kinase R-like endoplasmic reticulum kinase (dPerk). dPerk can also be activated by defective mitochondria in fly models of Parkinson's disease caused by...
Drosophila Drosophila protein kinase RNA (PKR)-like ER kinase (dPerk) ER stress activating transcription factor 4 (ATF4) Unfolded Protein Response Activating Transcription Factor 4 Animals Cell Cycle Proteins Computational Biology Drosophila Proteins Drosophila melanogaster Endoplasmic Reticulum Endoplasmic reticulum stress Eukaryotic Initiation Factor-2 HEAT-SHOCK PROTEINS Mitochondria Neurodegenerative Diseases Phosphorylation Protein Processing Post-Translational Protein Serine-Threonine Kinases Proteomics Signal Transduction Transcription Factors Transcriptome Ubiquitin-Protein Ligases Unfolded Protein Response eIF-2 Kinase
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