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Results: 34
ROBO3s
Marcel Werner, Anna Dyas, Iwan Parfentev, Geske E Schmidt, Iga K Mieczkowska, Lukas C Müller-Kirschbaum, Claudia Müller, Stefan Kalkhof, Oliver Reinhardt, Henning Urlaub, Frauke Alves, Julia Gallwas, Evangelos Prokakis, Florian Wegwitz
Oct 04, 2022
Basal-like breast cancer (BLBC) is a highly aggressive breast cancer subtype frequently associated with poor prognosis. Due to the scarcity of targeted treatment options, conventional cytotoxic chemotherapies frequently remain...
ROBO3s
Marcel Werner, Anna Dyas, Iwan Parfentev, Geske E Schmidt, Iga K Mieczkowska, Lukas C Müller-Kirschbaum, Claudia Müller, Stefan Kalkhof, Oliver Reinhardt, Henning Urlaub, Frauke Alves, Julia Gallwas, Evangelos Prokakis, Florian Wegwitz
Sep 03, 2022
Basal-like breast cancer (BLBC) is a highly aggressive breast cancer subtype frequently associated with poor prognosis. Due to the scarcity of targeted treatment options, conventional cytotoxic chemotherapies frequently remain...
<em>Drosophila</em> embryos as model systems for monitoring bacterial infection in real time
Isabella Vlisidou, A J Dowling, Iwan R Evans, Nicholas Waterfield, Richard H ffrench-Constant, William Wood
Jul 17, 2009
Drosophila embryos are well studied developmental microcosms that have been used extensively as models for early development and more recently wound repair. Here we extend this work by looking at embryos as model systems for...
SCAR/WAVE-mediated processing of engulfed apoptotic corpses is essential for effective macrophage migration in <em>Drosophila</em>
In vitro studies have shown that SCAR/WAVE activates the Arp2/3 complex to generate actin filaments, which in many cell types are organised into lamellipodia that are thought to have an important role in cell migration. Here we...
Dihydroxylation-based approach for the asymmetric syntheses of hydroxy-gamma-butyrolactones
Jennifer Peed, Iwan R Davies, Lucy R Peacock, James E Taylor, Gabriele Kociok-Kohn, Steven D Bull
Jan 06, 2012
A method of preparing enantiopure hydroxy-gamma-butyrolactones containing multiple contiguous stereocenters in high yield with good diastereoselectivity has been developed. Osmium tetroxide mediated dihydroxylation of a range of...
<em>Drosophila</em> embryos as model systems for monitoring bacterial infection in real time
Isabella Vlisidou, A J Dowling, Iwan R Evans, Nicholas Waterfield, Richard H ffrench-Constant, William Wood
Jul 17, 2009
Drosophila embryos are well studied developmental microcosms that have been used extensively as models for early development and more recently wound repair. Here we extend this work by looking at embryos as model systems for...
Cerebral multimodality monitoring in adult neurocritical care patients with acute brain injury
Jeanette Tas, Marek Czosnyka, Iwan CC van der Horst, Soojin Park, Caroline van Heugten, Mypinder Sekhon, Chiara Robba, David K Menon, Frederick A Zeiler, Marcel JH Aries
Jan 22, 2023
Cerebral multimodality monitoring (MMM) is, even with a general lack of Class I evidence, increasingly recognized as a tool to support clinical decision-making in the neuroscience intensive care unit (NICU). However, literature...
SCAR/WAVE-mediated processing of engulfed apoptotic corpses is essential for effective macrophage migration in <em>Drosophila</em>
In vitro studies have shown that SCAR/WAVE activates the Arp2/3 complex to generate actin filaments, which in many cell types are organised into lamellipodia that are thought to have an important role in cell migration. Here we...
A fluorescent approach for identifying P2X1 ligands.
Marc-David Ruepp, James A Brozik, Iwan JP de Esch, Richard W Farndale, Ruth D Murrell-Lagnado, Andrew J Thompson
Jun 15, 2015
Alexa-647 Fluorescent Fragment-based drug discovery Ligand binding Ligand gated ion channel NF449 P2X1 Pharmacology Adenosine Triphosphate Benzenesulfonates Binding Sites Carbocyanines Dose-Response Relationship Drug Fluorescence Gene Expression HEK293 Cells Humans Ligands Microscopy Confocal Purinergic P2X Receptor Agonists Purinergic P2X Receptor Antagonists Receptors Purinergic P2X1 Transfection Voltage-Sensitive Dye Imaging
Detecting and managing partial shorts in Cochlear implants
Susan T Eitutis, Yu Chuen Tam, Iwan Roberts, Chloe Swords, James R Tysome, Neil P Donnelly, Patrick R Axon, Manohar L Bance
Aug 01, 2022
Dihydroxylation-based approach for the asymmetric syntheses of hydroxy-gamma-butyrolactones
Jennifer Peed, Iwan R Davies, Lucy R Peacock, James E Taylor, Gabriele Kociok-Kohn, Steven D Bull
Jan 06, 2012
A method of preparing enantiopure hydroxy-gamma-butyrolactones containing multiple contiguous stereocenters in high yield with good diastereoselectivity has been developed. Osmium tetroxide mediated dihydroxylation of a range of...
An Instrumented Cochlea Model for the Evaluation of Cochlear Implant Electrical Stimulus Spread.
Chen Jiang, Shreya Singhal, Thomas Landry, Iwan Roberts, Simone de Rijk, Tim Brochier, Tobias Goehring, Yu Tam, Robert Carlyon, George Malliaras, Manohar Bance
Feb 03, 2021
Cochlear implants use electrical stimulation of the auditory nerve to restore the sensation of hearing to deaf people. Unfortunately, the stimulation current spreads extensively within the cochlea, resulting in "blurring" of the...
The binding characteristics and orientation of a novel radioligand with distinct properties at 5-HT3A and 5-HT3AB receptors.
Andrew J Thompson, Mark HP Verheij, Joost Verbeek, Albert D Windhorst, Iwan JP de Esch, Sarah CR Lummis
Oct 22, 2014
5-HT(3) Agonist Antagonist Cys-loop Ion channel Radioligand Amino Acid Sequence Binding Competitive HEK293 Cells Humans Molecular Docking Simulation Molecular Sequence Data Mutagenesis Site-Directed Piperidines Quinoxalines Radioligand Assay Radiopharmaceuticals Receptors Serotonin 5-HT3 Sequence Alignment Tritium
Current provision of myelopathy education in medical schools in the UK
Oliver Mowforth, Benjamin Davies, Max Stewart, Sam Smith, Alice Willison, Shahzaib Ahmed, Michelle Starkey, Iwan Sadler, Ellen Sarewitz, Sybil Stacpoole, Mark Kotter
Jul 06, 2020
Recovery priorities in degenerative cervical myelopathy
Benjamin Davies, Oliver Mowforth, Iwan Sadler, Bizhan Aarabi, Brian Kwon, Shekar Kurpad, James S Harrop, Jefferson R Wilson, Robert Grossman, Michael G Fehlings, Mark Kotter
Aug 21, 2019
cervical degeneration disability disc herniation myelopathy ossification posterior longitudinal ligament patient and public involvement priority setting questionnaire recovery research wastage Spondylosis spondylotic Stenosis Cervical Vertebrae Cross-Sectional Studies Female Health Priorities Humans Male Middle Aged Recovery of Function Spinal Cord Diseases Surveys and Questionnaires Treatment Outcome
Impact of Scala Tympani Geometry on Insertion Forces during Implantation.
Filip Hrncirik, Iwan V Roberts, Chloe Swords, Peter J Christopher, Akil Chhabu, Andrew H Gee, Manohar L Bance
Dec 10, 2022
Increasing awareness of degenerative cervical myelopathy
Carl M Zipser, Konstantinos Margetis, Karlo M Pedro, Armin Curt, Michael Fehlings, Iwan Sadler, Lindsay Tetreault, Benjamin M Davies, AO Spine RECODE DCM Steering Committee, Members of the Diagnostic Criteria Working Group
Nov 02, 2021
Degenerative cervical myelopathy (DCM) is a common non-traumatic spinal cord disorder and characterized by progressive neurological impairment. Generally, it is still underdiagnosed and referral to spine specialists is often...
A scoping review of information provided within degenerative cervical myelopathy education resources
Rishi Umeria, Oliver Mowforth, Ben Grodzinski, Zahabiya Karimi, Iwan Sadler, Helen Wood, Irina Sangeorzan, Petrea Fagan, Rory Murphy, Angus McNair, Benjamin Davies
May 19, 2022
BACKGROUND: Degenerative cervical myelopathy (DCM) is a chronic neurological condition estimated to affect 1 in 50 adults. Due to its diverse impact, trajectory and management options, patient-centred care and shared decision...
Asymmetric synthesis of chiral delta-lactones containing multiple contiguous stereocenters
Jennifer Peed, I P Dominguez, Iwan R Davies, M Cheeseman, James E Taylor, Gabriele Kociok-Kohn, Steven D Bull
Jul 15, 2011
A versatile methodology for the asymmetric synthesis of chiral delta-lactones containing multiple contiguous stereocenters has been developed that relies on a series of Evans' aldol, hydroxyl-directed cyclopropanation...
Asymmetric synthesis of chiral delta-lactones containing multiple contiguous stereocenters
Jennifer Peed, I P Dominguez, Iwan R Davies, M Cheeseman, James E Taylor, Gabriele Kociok-Kohn, Steven D Bull
Jul 15, 2011
A versatile methodology for the asymmetric synthesis of chiral delta-lactones containing multiple contiguous stereocenters has been developed that relies on a series of Evans' aldol, hydroxyl-directed cyclopropanation...
Current provision of myelopathy education in medical schools in the UK
Oliver Mowforth, Benjamin Davies, Max Stewart, Sam Smith, Alice Willison, Shahzaib Ahmed, Michelle Starkey, Iwan Sadler, Ellen Sarewitz, Sybil Stacpoole, Mark Kotter
Aug 28, 2020
Introduction: Degenerative cervical myelopathy (DCM) is a common, disabling and progressive neurological condition triggered by chronic compression of the cervical spinal cord by surrounding degenerative changes. Early diagnosis...
CT imaging prior to transcatheter aortic valve implantation in the UK.
Iwan Harries, Jonathan R Weir-McCall, Michelle C Williams, James Shambrook, Giles Roditi, Russel Bull, Gareth J Morgan-Hughes, Edward D Nicol, Alastair J Moss
Sep 28, 2020
OBJECTIVE: This cross-sectional observational study sought to describe variations in CT in the context of transcatheter aortic valve implantation (CT-TAVI) as currently performed in the UK. METHODS: 408 members of the British...
CT scanning aortic valve disease percutaneous valve therapy Aortic Valve Cross-Sectional Studies Health Care Surveys Healthcare Disparities Heart Valve Diseases Hospitals High-Volume Hospitals Low-Volume Humans Practice Patterns Physicians' Predictive Value of Tests Radiation Dosage Radiation Exposure Tomography X-Ray Computed transcatheter aortic valve replacement United Kingdom
Provision and Perception of Physiotherapy in the Nonoperative Management of Degenerative Cervical Myelopathy (DCM)
Max B Butler, Oliver D Mowforth, Abdul Badran, Michelle Starkey, Timothy Boerger, Iwan Sadler, Julia Tabrah, Caroline Treanor, Lucy Cameron Grad Dip Phys, Sukhvinder Kalsi-Ryan, Rodney J Laing, Benjamin M Davies, Mark RN Kotter
Sep 04, 2020
STUDY DESIGN: Cross-sectional survey. OBJECTIVES: Degenerative cervical myelopathy (DCM) is a common syndrome of acquired spinal cord impairment caused by canal stenosis secondary to arthritic changes of the spine. International...
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