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Regionalization of the mouse visceral endoderm as the blastocyst transforms into the egg cylinder.
Aitana Perea-Gomez, Sigolène M Meilhac, Karolina Piotrowska-Nitsche, Dionne Gray, Jérôme Collignon, Magdalena Zernicka-Goetz
Jun 14, 2011
Image Reconstruction in Light-Sheet Microscopy
Bogdan Toader, Jérôme Boulanger, Yury Korolev, Martin O Lenz, James Manton, Carola-Bibiane Schönlieb, Leila Mureşan
Dec 08, 2022
Numerical methods Deconvolution light-sheet microscopy Primal–dual Hybrid Gradient Poisson And Gaussian Noise
Published by: Journal of mathematical imaging and vision
An extended model of vesicle fusion at the plasma membrane to estimate protein lateral diffusion from TIRF microscopy images.
Antoine Basset, Patrick Bouthemy, Jérôme Boulanger, François Waharte, Jean Salamero, Charles Kervrann
Jul 25, 2017
BACKGROUND: Characterizing membrane dynamics is a key issue to understand cell exchanges with the extra-cellular medium. Total internal reflection fluorescence microscopy (TIRFM) is well suited to focus on the late steps of...
Sequences in the cytoplasmic tail of SARS-CoV-2 Spike facilitate expression at the cell surface and syncytia formation
Jérôme Cattin-Ortolá, Lawrence G. Welch, Sarah L. Maslen, Guido Papa, Leo C. James, Sean Munro
Sep 09, 2021
Abstract: The Spike (S) protein of SARS-CoV-2 binds ACE2 to direct fusion with host cells. S comprises a large external domain, a transmembrane domain, and a short cytoplasmic tail. Understanding the intracellular trafficking of...
Alpha rhythm collapse predicts iso-electric suppressions during anesthesia.
Could an overly deep sedation be anticipated from ElectroEncephaloGram (EEG) patterns? We report here motifs hidden in the EEG signal that predict the appearance of Iso-Electric Suppressions (IES), observed during epileptic...
Sequences in the cytoplasmic tail of SARS-CoV-2 Spike facilitate expression at the cell surface and syncytia formation.
Jérôme Cattin-Ortolá, Lawrence G Welch, Sarah L Maslen, Guido Papa, Leo C James, Sean Munro
Oct 13, 2021
The Spike (S) protein of SARS-CoV-2 binds ACE2 to direct fusion with host cells. S comprises a large external domain, a transmembrane domain, and a short cytoplasmic tail. Understanding the intracellular trafficking of S is...
Whole-genome, deep pyrosequencing analysis of a duck influenza A virus evolution in swine cells.
Vincent Bourret, Guillaume Croville, Jérôme Mariette, Christophe Klopp, Olivier Bouchez, Laurence Tiley, Jean-Luc Guérin
Jun 10, 2013
EMEM Eagle’s Minimum Essential Medium FCS Influenza A virus LB Luria–Bertani MID Mixed infection NPTr Newborn Pig Trachea Pyrosequencing Reassortment SD SNP Viral evolution Within-host diversity a.f.t. allele frequency threshold base pairs bp dNTP deoxyribonucleotides triphosphate fœtal calf serum multiplex identifier sequence single nucleotide polymorphism standard deviation Animals Animals Wild Cell Line Coinfection Ducks evolution Molecular High-Throughput Nucleotide Sequencing Influenza A virus Influenza in Birds Polymorphism Single Nucleotide RNA Viral Reverse Transcriptase Polymerase Chain Reaction Sequence Analysis DNA Swine
Diversity-oriented synthesis of heterocycles and macrocycles by controlled reactions of oxetanes with α-iminocarbenes.
Alejandro Guarnieri-Ibáñez, Florian Medina, Céline Besnard, Sarah L Kidd, David R Spring, Jérôme Lacour
Jan 24, 2018
Using N-sulfonyl triazoles as substrates, compounds as diverse as 2-imino tetrahydrofurans, 13- and 15-membered ring aza-macrocycles can be prepared selectively via formal [1 + 4], [5 + 4 + 4] and [3 + 4 + 4 + 4] condensations...
A fully joint Bayesian quantitative trait locus mapping of human protein abundance in plasma
Hélène Ruffieux, Jérôme Carayol, Radu Popescu, Mary-Ellen Harper, Robert Dent, Wim H. M. Saris, Arne Astrup, Jörg Hager, Anthony C. Davison, Armand Valsesia
Jun 15, 2020
Molecular quantitative trait locus (QTL) analyses are increasingly popular to explore the genetic architecture of complex traits, but existing studies do not leverage shared regulatory patterns and suffer from a large...
Low-Cost Microfabrication Tool Box.
Jérôme Charmet, Rui Rodrigues, Ender Yildirim, Pavan Kumar Challa, Benjamin Roberts, Robert Dallmann, Yudan Whulanza
Apr 14, 2020
Microsystems are key enabling technologies, with applications found in almost every industrial field, including in vitro diagnostic, energy harvesting, automotive, telecommunication, drug screening, etc. Microsystems, such as...
Towards a cancer mission in Horizon Europe
Anton Berns, Ulrik Ringborg, Julio E Celis, Manuel Heitor, Neil K Aaronson, Nancy Abou-Zeid, Hans-Olov Adami, Kathi Apostolidis, Michael Baumann, Alberto Bardelli, René Bernards, Yvonne Brandberg, Carlos Caldas, Fabien Calvo, Caroline Dive, Angelika Eggert, Alexander Eggermont, Carolina Espina, Frederik Falkenburg, Jérôme Foucaud, Douglas Hanahan, Ulrike Helbig, Bengt Jönsson, Mette Kalager, Sakari Karjalainen, Miklós Kásler, Pamela Kearns, Klas Kärre, Denis Lacombe, Francesco de Lorenzo, Françoise Meunier, Gerd Nettekoven, Simon Oberst, Péter Nagy, Thierry Philip, Richard Price, Joachim Schüz, Eric Solary, Peter Strang, Josep Tabernero, Emile Voest
Sep 04, 2020
A comprehensive translational cancer research approach focused on personalized and precision medicine, and covering the entire cancer research-care-prevention continuum has the potential to achieve in 2030 a 10-year...
European healthcare systems cancer mission cancer research/care/prevention continuum comprehensive cancer centres patient empowerment Science policy Cancer Survivors Clinical Trials as Topic Europe Humans Neoplasms Organizational Innovation Palliative Care Patient Participation specialization Translational Research Biomedical
Furin cleavage of SARS-CoV-2 Spike promotes but is not essential for infection and cell-cell fusion
Guido Papa, Donna L. Mallery, Anna Albecka, Lawrence G. Welch, Jérôme Cattin-Ortolá, Jakub Luptak, David Paul, Harvey T. McMahon, Ian G. Goodfellow, Andrew Carter, Sean Munro, Leo C. James
Feb 04, 2021
Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) infects cells by binding to the host cell receptor ACE2 and undergoing virus-host membrane fusion. Fusion is triggered by the protease TMPRSS2, which processes the...
Strong Suppression of Thermal Conductivity in the Presence of Long Terminal Alkyl Chains in Low-Disorder Molecular Semiconductors.
A fully joint Bayesian quantitative trait locus mapping of human protein abundance in plasma.
Hélène Ruffieux, Jérôme Carayol, Radu Popescu, Mary-Ellen Harper, Robert Dent, Wim HM Saris, Arne Astrup, Jörg Hager, Anthony C Davison, Armand Valsesia
Jul 06, 2020
Molecular quantitative trait locus (QTL) analyses are increasingly popular to explore the genetic architecture of complex traits, but existing studies do not leverage shared regulatory patterns and suffer from a large...
Outcomes of adjunctive radiation therapy for the treatment of mast cell tumors in dogs and assessment of toxicity
Sarah L Mason, Charles Pittaway, Begona Pons Gil, Onne-Marju Russak, Katie Westlake, Davide Berlato, Jérôme Benoit, Joanna Morris, Jane Margaret Dobson
Oct 21, 2021
BACKGROUND: Radiation therapy is commonly used as an adjunct to incomplete surgical excision in dogs with mast cell tumors (MCT), but the optimal dose and fractionation regimen have yet to be determined. HYPOTHESIS: We assessed...
MAVS polymers smaller than 80 nm induce mitochondrial membrane remodeling and interferon signaling.
Ming-Shih Hwang, Jérôme Boulanger, Jonathan D Howe, Anna Albecka, Mathias Pasche, Leila Mureşan, Yorgo Modis
Feb 11, 2019
storm Cell Death innate immunity pathogen-associated molecular pattern Signal Transduction 3T3 Cells Adaptor Proteins Signal Transducing Animals Cell Death Cytosol FIBROBLASTS Interferon-Induced Helicase IFIH1 Interferon-beta Membrane Transport Proteins Mice Mice Knockout Microscopy Mitochondrial Membranes Mitochondrial Precursor Protein Import Complex Proteins Protein Domains RNA Double-Stranded Receptors Cell Surface Signal Transduction Single-Cell Analysis West Nile Fever
The logic of transcriptional regulator recruitment architecture at cis-regulatory modules controlling liver functions.
Julie Dubois-Chevalier, Vanessa Dubois, Hélène Dehondt, Parisa Mazrooei, Claire Mazuy, Aurélien A Sérandour, Céline Gheeraert, Penderia Guillaume, Eric Baugé, Bruno Derudas, Nathalie Hennuyer, Réjane Paumelle, Guillemette Marot, Jason S Carroll, Mathieu Lupien, Bart Staels, Philippe Lefebvre, Jérôme Eeckhoute
Jul 12, 2019
Control of gene transcription relies on concomitant regulation by multiple transcriptional regulators (TRs). However, how recruitment of a myriad of TRs is orchestrated at cis-regulatory modules (CRMs) to account for...
Platelet-derived extracellular vesicles in Huntington's disease.
Hélèna L Denis, Jérôme Lamontagne-Proulx, Isabelle St-Amour, Sarah L Mason, Andreas Weiss, Sylvain Chouinard, Roger A Barker, Eric Boilard, Francesca Cicchetti
Nov 12, 2018
Multiple Stellar Fly-Bys Sculpting the Circumstellar Architecture in RW
Aurigae
Joseph E Rodriguez, Ryan Loomis, Sylvie Cabrit, Thomas J Haworth, Stefano Facchini, Catherine Dougados, Richard A Booth, Eric LN Jensen, Cathie J Clarke, Keivan G Stassun, William RF Dent, Jérôme Pety
Sep 20, 2018
We present high-resolution ALMA Band 6 and 7 observations of the tidally
disrupted protoplanetary disks of the RW Aurigae binary. Our observations
reveal the presence of additional tidal streams to the previously observed
tidal...
Integration of hormonal signaling networks and mobile microRNAs is required for vascular patterning in Arabidopsis roots.
Daniele Muraro, Nathan Mellor, Michael P Pound, Hanna Help, Mikaël Lucas, Jérôme Chopard, Helen M Byrne, Christophe Godin, T Charlie Hodgman, John R King, Tony P Pridmore, Ykä Helariutta, Malcolm J Bennett, Anthony Bishopp
Oct 18, 2018
As multicellular organisms grow, positional information is continually needed to regulate the pattern in which cells are arranged. In the Arabidopsis root, most cell types are organized in a radially symmetric pattern; however...
A Genome-Wide Association Study for Regulators of Micronucleus Formation in Mice.
Rebecca E McIntyre, Jérôme Nicod, Carla Daniela Robles-Espinoza, John Maciejowski, Na Cai, Jennifer Hill, Ruth Verstraten, Vivek Iyer, Alistair G Rust, Gabriel Balmus, Richard Mott, Jonathan Flint, David J Adams
Jun 29, 2016
Micronuclei Outbred mice genetic mapping Genome-wide association study (GWAS) Genomic Instability Animals Chromosome Breakage Chromosome Mapping Female Genome-Wide Association Study Genomic Instability Genotype Male Mice Micronuclei Chromosome-Defective Phenotype Polymorphism Single Nucleotide Quantitative Trait Loci Sex Characteristics
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