11C-UCB-J synaptic PET and multimodal imaging in dementia with Lewy bodies.
Nicolas Nicastro,
Negin Holland,
George Savulich,
Stephen F Carter,
Elijah Mak,
Young T Hong,
Selena Milicevic Sephton,
Tim D Fryer,
Franklin I Aigbirhio,
James B Rowe,
John T O'Brien
Nov 10, 2020
OBJECTIVE: Dementia with Lewy bodies (DLB) is a common cause of dementia, but atrophy is mild compared to Alzheimer's disease. We propose that DLB is associated instead with severe synaptic loss, and we test this hypothesis in...