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Optimal Risk Transfer
Capital efficiency and asset/liability management are part of the Enterprise Risk Management Process of any insurance/reinsurance conglomerate and serve as quantitative methods to fulfill the strategic planning within an...
Optimal Risk Transfer
Capital efficiency and asset/liability management are part of the Enterprise Risk Management Process of any insurance/reinsurance conglomerate and serve as quantitative methods to fulfill the strategic planning within an...
A two-stage inter-rater approach for enrichment testing of variants associated with multiple traits.
Shared genetic aetiology may explain the co-occurrence of diseases in individuals more often than expected by chance. On identifying associated variants shared between two traits, one objective is to determine whether such...
Fine-mapping genetic associations.
Whilst thousands of genetic variants have been associated with human traits, identifying the subset of those variants that are causal requires a further 'fine-mapping' step. We review the basic fine-mapping approach, which is...
Trans-ethnic study design approaches for fine-mapping.
Jennifer L Asimit, Konstantinos Hatzikotoulas, Mark McCarthy, Andrew P Morris, Eleftheria Zeggini
Aug 15, 2018
Studies that traverse ancestrally diverse populations may increase power to detect novel loci and improve fine-mapping resolution of causal variants by leveraging linkage disequilibrium differences between ethnic groups. The...
Stochastic search and joint fine-mapping increases accuracy and identifies previously unreported associations in immune-mediated diseases
Jennifer L. Asimit, Daniel B. Rainbow, Mary D. Fortune, Nastasiya F. Grinberg, Linda S. Wicker, Chris Wallace
Jul 18, 2020
Abstract: Thousands of genetic variants are associated with human disease risk, but linkage disequilibrium (LD) hinders fine-mapping the causal variants. Both lack of power, and joint tagging of two or more distinct causal...
Stochastic search and joint fine-mapping increases accuracy and identifies previously unreported associations in immune-mediated diseases.
Jennifer L Asimit, Daniel B Rainbow, Mary D Fortune, Nastasiya F Grinberg, Linda S Wicker, Chris Wallace
Jul 17, 2019
Alleles Autoimmunity Bayes Theorem CD4-Positive T-Lymphocytes CTLA-4 Antigen Chromosome Mapping Gene Expression Regulation Genetic Association Studies Genetic Predisposition to Disease Genome-Wide Association Study Genotype Humans Interleukin-2 Receptor alpha Subunit Linkage Disequilibrium Models Genetic Phenotype Polymorphism Single Nucleotide
A Bayesian Approach to the Overlap Analysis of Epidemiologically Linked Traits.
Jennifer L Asimit, Kalliope Panoutsopoulou, Eleanor Wheeler, Sonja I Berndt, the arcOGEN consortium GIANT consortium, Heather J Cordell, Andrew P Morris, Eleftheria Zeggini, Inês Barroso
Aug 15, 2018
Diseases often cooccur in individuals more often than expected by chance, and may be explained by shared underlying genetic etiology. A common approach to genetic overlap analyses is to use summary genome-wide association study...
Bayes’ factor P-value obesity Osteoarthritis overlap analysis threshold calibration Bayes Theorem Body Mass Index Computer Simulation Data Interpretation Statistical Genome-Wide Association Study Humans Models Genetic obesity Osteoarthritis Phenotype Polymorphism Single Nucleotide Probability Quantitative Trait Heritable Sample Size
The Strange Use of דגל in Song of Songs 5
JL Andruska
May 16, 2017
The use of the word דגל in the Song of Songs 5:10 has caused considerable confusion among commentators. Most occurrences of the word in the Song are thought to be related to an army or host carrying banners, except in 5:10...
Computing the quasinormal modes and eigenfunctions for the Teukolsky equation using horizon penetrating, hyperboloidally compactified coordinates
JL Ripley
Jul 08, 2022
We study the quasinormal mode eigenvalues and eigenfunctions for the
Teukolsky equation in a horizon penetrating, hyperboloidally compactified
(HPHC) coordinate system. Following earlier work by Zengino\u{g}lu
(arXiv:1102.2451)...
Filopodia and their links with membrane traffic and cell adhesion.
JL Gallop
Dec 09, 2019
Filopodia are dynamic, narrow, plasma membrane protrusions filled with bundled actin filaments. Fresh actin monomers are incorporated at the tips furthest away from the cell body, where barbed end polymerases such as formins and...
Geometry driven type II higher dimensional blow-up for the critical heat equation
We consider the problem vt=Δv+|v|p−1vin Ω×(0,T),v=0on ∂Ω×(0,T),v>0in Ω×(0,T). In a domain Ω⊂Rd, d≥7 enjoying special symmetries, we find the first example of a solution with type II blow-up...
Geometry driven type II higher dimensional blow-up for the critical heat equation
We consider the problem vt=Δv+|v|p−1vin Ω×(0,T),v=0on ∂Ω×(0,T),v>0in Ω×(0,T). In a domain Ω⊂Rd, d≥7 enjoying special symmetries, we find the first example of a solution with type II blow-up...
Machine learning for target discovery in drug development.
Chemical probes Chemical proteomics Drug Discovery Machine Learning target identification Antineoplastic Agents Computer Simulation Drug Evaluation Preclinical Humans lipoxygenase Machine Learning Molecular Targeted Therapy Naphthoquinones Pentacyclic Triterpenes Proteomics Receptors Cannabinoid Sesquiterpenes Sesquiterpenes Guaiane Transient Receptor Potential Channels
Novel application of internal obturator and semitendinosus muscle flaps for rectal wall repair or reinforcement.
Internal obturator and/or semitendinosus muscle flaps were used to reinforce primary appositional rectal wall repair in three dogs and one cat in this case series. All three dogs incurred rectal wall compromise during surgical...
Microstructural alterations in the onychomycotic and psoriatic nail
E Cutrin Gomez, S. Anguiano Igea, Maria Delgado-Charro, JL Gomez Amoza, FJ Otero Espinar
Jul 31, 2018
Despite the important nail alterations caused by onychomycosis and psoriasis few studies have characterized the microstructure of the diseased nail plate and the diffusion and penetration of drugs through this altered...
Ciclopirox Clobetasol propionate Nail onychomycosis Porosity psoriasis /dk/atira/pure/subjectarea/asjc/1300/1305 name=Biotechnology /dk/atira/pure/subjectarea/asjc/3000/3003 name=Pharmaceutical Science /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Transcription of the apicoplast genome
Many members of the Apicomplexa contain a remnant chloroplast, known as an apicoplast. The apicoplast encodes numerous genes, and loss of the organelle is lethal. Here, we present a summary of what is known about apicoplast...
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