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The organizational stressors encountered by athletes with a disability
Organisational stressors have been found to be prevalent and problematic for sport performers, with research identifying demographic differences in the stressors encountered. Nevertheless, extant sport psychology research on the...
The organizational stressors encountered by athletes with a disability
Organisational stressors have been found to be prevalent and problematic for sport performers, with research identifying demographic differences in the stressors encountered. Nevertheless, extant sport psychology research on the...
Bipartite binding and partial inhibition links DEPTOR and mTOR in a mutually antagonistic embrace.
Maren Heimhalt, Alex Berndt, Jane Wagstaff, Madhanagopal Anandapadamanaban, Olga Perisic, Sarah Maslen, Stephen McLaughlin, Conny Wing-Heng Yu, Glenn R Masson, Andreas Boland, Xiaodan Ni, Keitaro Yamashita, Garib N Murshudov, Mark Skehel, Stefan M Freund, Roger L Williams
Sep 14, 2021
The mTORC1 kinase complex regulates cell growth, proliferation, and survival. Because mis-regulation of DEPTOR, an endogenous mTORC1 inhibitor, is associated with some cancers, we reconstituted mTORC1 with DEPTOR to understand...
DEPTOR Biochemistry Cancer chemical biology cryo-EM human mTOR molecular biophysics partial inhibition Signal Transduction structural biology Binding Sites Cryoelectron Microscopy Escherichia coli Gene Expression Regulation Humans Image Processing Computer-Assisted Intracellular Signaling Peptides and Proteins Mechanistic Target of Rapamycin Complex 1 Models Molecular PDZ Domains Protein Binding Protein Conformation Recombinant Proteins TOR Serine-Threonine Kinases
The Strange Use of דגל in Song of Songs 5
JL Andruska
May 16, 2017
The use of the word דגל in the Song of Songs 5:10 has caused considerable confusion among commentators. Most occurrences of the word in the Song are thought to be related to an army or host carrying banners, except in 5:10...
Computing the quasinormal modes and eigenfunctions for the Teukolsky equation using horizon penetrating, hyperboloidally compactified coordinates
JL Ripley
Jul 08, 2022
We study the quasinormal mode eigenvalues and eigenfunctions for the
Teukolsky equation in a horizon penetrating, hyperboloidally compactified
(HPHC) coordinate system. Following earlier work by Zengino\u{g}lu
(arXiv:1102.2451)...
The CATFISH study protocol
Michaela Goodwin, Richard Emsley, Michael Kelly, Eric Rooney, Matthew Sutton, Martin Tickle, Rebecca Wagstaff, Tanya Walsh, William Whittaker, Iain A Pretty
Sep 29, 2016
Abstract
Background
Tooth decay is the commonest disease of childhood. We have known for over 90 years that fluoride can prevent tooth decay; it is present in nearly all toothpastes...
Filopodia and their links with membrane traffic and cell adhesion.
JL Gallop
Dec 09, 2019
Filopodia are dynamic, narrow, plasma membrane protrusions filled with bundled actin filaments. Fresh actin monomers are incorporated at the tips furthest away from the cell body, where barbed end polymerases such as formins and...
Geometry driven type II higher dimensional blow-up for the critical heat equation
We consider the problem vt=Δv+|v|p−1vin Ω×(0,T),v=0on ∂Ω×(0,T),v>0in Ω×(0,T). In a domain Ω⊂Rd, d≥7 enjoying special symmetries, we find the first example of a solution with type II blow-up...
Geometry driven type II higher dimensional blow-up for the critical heat equation
We consider the problem vt=Δv+|v|p−1vin Ω×(0,T),v=0on ∂Ω×(0,T),v>0in Ω×(0,T). In a domain Ω⊂Rd, d≥7 enjoying special symmetries, we find the first example of a solution with type II blow-up...
Novel application of internal obturator and semitendinosus muscle flaps for rectal wall repair or reinforcement.
Internal obturator and/or semitendinosus muscle flaps were used to reinforce primary appositional rectal wall repair in three dogs and one cat in this case series. All three dogs incurred rectal wall compromise during surgical...
Machine learning for target discovery in drug development.
Chemical probes Chemical proteomics Drug Discovery Machine Learning target identification Antineoplastic Agents Computer Simulation Drug Evaluation Preclinical Humans lipoxygenase Machine Learning Molecular Targeted Therapy Naphthoquinones Pentacyclic Triterpenes Proteomics Receptors Cannabinoid Sesquiterpenes Sesquiterpenes Guaiane Transient Receptor Potential Channels
Microstructural alterations in the onychomycotic and psoriatic nail
E Cutrin Gomez, S. Anguiano Igea, Maria Delgado-Charro, JL Gomez Amoza, FJ Otero Espinar
Jul 31, 2018
Despite the important nail alterations caused by onychomycosis and psoriasis few studies have characterized the microstructure of the diseased nail plate and the diffusion and penetration of drugs through this altered...
Ciclopirox Clobetasol propionate Nail onychomycosis Porosity psoriasis /dk/atira/pure/subjectarea/asjc/1300/1305 name=Biotechnology /dk/atira/pure/subjectarea/asjc/3000/3003 name=Pharmaceutical Science /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Failures of nerve regeneration caused by aging or chronic denervation are rescued by restoring Schwann cell c-Jun.
Laura J Wagstaff, Jose A Gomez-Sanchez, Shaline V Fazal, Georg W Otto, Alastair M Kilpatrick, Kirolos Michael, Liam YN Wong, Ki H Ma, Mark Turmaine, John Svaren, Tessa Gordon, Peter Arthur-Farraj, Sergio Velasco-Aviles, Hugo Cabedo, Cristina Benito, Rhona Mirsky, Kristjan R Jessen
Mar 15, 2021
After nerve injury, myelin and Remak Schwann cells reprogram to repair cells specialized for regeneration. Normally providing strong regenerative support, these cells fail in aging animals, and during chronic denervation that...
Transcription of the apicoplast genome
Many members of the Apicomplexa contain a remnant chloroplast, known as an apicoplast. The apicoplast encodes numerous genes, and loss of the organelle is lethal. Here, we present a summary of what is known about apicoplast...
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